CN104547909B - A kind of Chinese medicine composition of reducing blood lipid and preparation method and application - Google Patents
A kind of Chinese medicine composition of reducing blood lipid and preparation method and application Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition of reducing blood lipid, is made up of following components according to parts by weight：3~8 parts of gynostemma pentaphylla, 3~8 parts of rhizoma atractylodis, 3~8 parts of Poria cocos, 3~8 parts of dried orange peel, 0.1~0.5 part of grape seed extract, 0.02~0.08 part of Turmeric P.E, 0.1~0.5 part of green-tea extract, 0~10 part of auxiliary material.Chinese medicine composition provided by the present invention passes through dialectical compatibility, can effectively play invigorating spleen to remove dampness, the effect of dissipating phlegm and removing blood stasis, available for reducing blood lipid.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to it is a kind of can the Chinese medicine composition of reducing blood lipid, preparation method and application.
Background technology
High fat of blood, hyperlipidemia being called, it refers to that the fat metabolism in human body causes blood fat in blood to raise extremely, or
The change of blood lipid level fat is beyond normal range (NR).Common high fat of blood change shows as following one or more Indexes Abnormalities：
Serum total cholesterol level raises；Serum triglyceride level raises；Serum High Density Lipoprotein Cholesterol horizontal abnormality lowers.
High fat of blood is formed as the disorder of visceral dysfunction class excretory system.In terms of diet, the fat content of absorption is high, human body
Activity is small, immunologic hypofunction, makes the fat of body absorption is normal to decompose and drain, so as to cause unnecessary fat to be deposited
Accumulate in liver, liver is born burdens, ultimately form the various complication such as fatty liver.It fact proved by clinical practice, high blood
Fat is the prelude of cardiovascular and cerebrovascular disease, is the most hazards for causing coronary heart disease, artery sclerosis, apoplexy, hemiplegia, is to trigger heart and brain
The arch-criminal of vascular diseases.Investigation display, high fat of blood have become the common disease of the elderly, and the various hearts thus triggered
Cerebrovascular disease turns into the disease for threatening middle-aged and old life.
The traditional Chinese medical science thinks that high fat of blood is pathological product, is also pathogenic factor, the pathology category of subordination traditional Chinese medicine " phlegm ", but phlegm
Implication is very wide, and hyperlipidemia is only the part in phlegm syndrome, and hyperlipemia is present among blood vessels.Phlegm has broad sense, narrow sense, had
Shape, invisible point, and high fat of blood can be determined by detecting, and be for narrow sense visible phlegm.And the cloudy essenceization of blood fat system, have viscous
Thick, calm property, it is more sticky if Hyperlipemia, it is calm, it is different from normal grease again, therefore it is " clearly from turbid that can conclude it
Change, fat given birth to by phlegm " disease.
Prior art discloses a variety of Chinese medicine compositions for possessing reducing blood lipid, such as China's application CN102462826B is disclosed
A kind of Chinese medicinal composition for reducing blood fat and its preparation method and application.Wherein described Chinese medicinal composition for reducing blood fat includes following components：
Rhizoma alismatis 60-104 parts, grape pip 56-100 parts, fruit of glossy privet 49-88 parts, gynostemma pentaphylla 33-66 parts, turmeric 33-66 parts, sea-buckthorn 30-61
Part, green tea 12-34 parts.It is molten without extraction, functional component although above-mentioned Chinese medicine composition possesses certain hypolipemic function
Extracting rate is low, and effect can not be given full play to；And complicated component, it is unfavorable for the health after absorption of human body.In addition, prior art carries
Other prescriptions supplied are not good enough for the combined therapy effect of reducing blood lipid, to invigorating spleen to remove dampness, dissipating phlegm and removing blood stasis is that the dialectical of the rules for the treatment of is matched somebody with somebody
5 prescriptions there is no report.
The content of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition, by the dialectical compatibility of prescription, can effectively played
Invigorating spleen to remove dampness, the effect of dissipating phlegm and removing blood stasis, it can be used for reducing blood fat.
To achieve the above object, the invention provides a kind of Chinese medicine composition of reducing blood lipid, the composition by including with
The raw material of lower parts by weight is prepared：3~8 parts of gynostemma pentaphylla, 3~8 parts of rhizoma atractylodis, 3~8 parts of Poria cocos, 3~8 parts of dried orange peel, grape pip carry
Take 0.1~0.5 part of thing, 0.02~0.08 part of Turmeric P.E, 0.1~0.5 part of green-tea extract, 0~10 part of auxiliary material.
Wherein, preferably described composition is prepared by the raw material including following parts by weight：4~6 parts of gynostemma pentaphylla, rhizoma atractylodis 4
~6 parts, it is 4~6 parts of Poria cocos, 4~6 parts of dried orange peel, 0.2~0.4 part of grape seed extract, 0.04~0.06 part of Turmeric P.E, green
0.2~0.4 part of tea extraction, 5~8 parts of auxiliary material.
It is highly preferred that the composition is prepared by the raw material including following parts by weight：5 parts of gynostemma pentaphylla, 5 parts of rhizoma atractylodis,
5 parts of Poria cocos, 5 parts of dried orange peel, 0.2 part of grape seed extract, 0.05 part of Turmeric P.E, 0.3 part of green-tea extract, 7 parts of auxiliary material.
Unit of weight or its times known to field of medicaments such as parts by weight of the present invention can be μm, mg, g, kg
Number, such as 1/10,1/100,10 times, 100 times.
Chinese medicine composition of the present invention, wherein each component are using known Chinese medicine, such as gynostemma pentaphylla, rhizoma atractylodis, Fu
Siberian cocklebur, dried orange peel etc., grape seed extract and Turmeric P.E and green-tea extract can be by commercially available purchases, but in order to realize more preferably
Effect, grape seed extract of the present invention using ethanol extraction, concentration, spray drying form；The turmeric extraction
Thing is concentrated and dried after being extracted using ethanol and formed；The green-tea extract is dried using concentrated spray after water extraction and formed, and is gone forward side by side
One step is preferred to be implemented as follows mode：
The preparation of grape seed extract：Grape pip powder is broken into coarse powder, extracted 2 times, each 1h with 60% alcohol reflux, it is molten
Agent is than 1:40, grape pip procyanidin extract solution is obtained, using spray drying, the activity of reservation active ingredient OPC.
The preparation of Turmeric P.E：Extracted 2 times using 80% alcohol reflux, each 8 times of amount ethanol of dosing material, extract 1h,
Solvent is than 1:35, extract solution is collected, Turmeric P.E is both obtained after spray drying.
The preparation of green-tea extract：Water extracts twice, solvent multiple 1:20, Extracting temperature is 90 DEG C, each extraction time
40min, collect extract solution after be spray-dried both green-tea extract.
Auxiliary material of the present invention can select to add according to the needs of formulation；Specifically, the auxiliary material is pasted including malt
Essence, lactose, glucose, microcrystalline cellulose, methylcellulose, sodium carboxymethylcellulose, magnesium stearate, silica, talcum powder,
One or more in polyethylene glycol or starch.
Composition of the present invention can be prepared into the regular dosage form of field of medicaments, as decoction, powder agent, tablet, capsule,
Syrup etc..
Composition of the present invention is preferably powder agent, and the formulation method is simple and is easy to patient and takes and absorb,
Auxiliary material in the powder agent is preferably maltodextrin.
The component of Chinese medicine composition of the present invention uses natural Chinese medicine material and ordinary food raw material, its preparation simplicity,
Medicine source is wide, and lipid-lowering effect is notable, and has no toxic side effect.
The second object of the present invention is the preparation method for providing above-mentioned Chinese medicine composition.
Chinese medicine composition of the present invention is generally prepared as decoction, powder agent, tablet, capsule, syrup etc..When described
When composition is decoction, it can directly weigh medicinal material and conventionally decoct and form.
When the composition is prepared into other formulations, it can conventionally be processed by adding auxiliary material and be prepared,
It is preferred that methods described specifically includes following steps：
(1) gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel are taken, is mixed after crushing, the water of 8~12 times of volumes of addition, immersion 20~
40min, 100~150min is decocted, is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
The water being preferably added to is 10 times of volumes, soak time 30min, decocting time 120min；
(2) water of 6~10 times of volumes is added in the dregs of a decoction obtained by step (1), 40~80min is decocted, is filtered under diminished pressure, is filtered
Liquid is standby；
The water being preferably added to is 8 times of volumes, decocting time 60min；
(3) step (1) is merged with filtrate obtained by step (2), crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to phase successively
To density 1.0~1.5, preferably 1.2；Grape seed extract, Turmeric P.E, green-tea extract are added, adds auxiliary material, is prepared
Into the Chinese medicine composition.
When composition is powder agent, step (3) described auxiliary material is maltodextrin, after being routinely spray-dried, is prepared
Into powder agent Chinese medicine composition.
As most preferably scheme, the preparation method of composition of the present invention comprises the following steps：
(1) gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel are taken, is mixed after crushing, adds the water of 10 times of volumes, soaks 30min, is decocted
120min, it is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
(2) water of 8 times of volumes is added in the dregs of a decoction obtained by step (1), 60min is decocted, is filtered under diminished pressure, filtrate is standby；
(3) step (1) is merged with filtrate obtained by step (2), crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to phase successively
To density 1.2, grape seed extract, Turmeric P.E, green-tea extract are added, maltodextrin is added, is spray-dried to obtain powder,
It is prepared into powder agent Chinese medicine composition.
Preparation method science of the present invention is simple, and functional component dissolution rate is high, maximizes and plays product efficacy.
The present invention further protects application of the composition in blood lipid-lowering medicine.
Chinese medicine composition provided by the invention, has invigorating spleen to remove dampness, the effect of dissipating phlegm and removing blood stasis, and all medicinal materials are helped according to the monarch and his subjects
The principle made plays drug effect jointly.
Specifically：Gynostemma pentaphylla, bitter, micro-sweet are cool in nature, have replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, it is clearing heat and detoxicating the effect of；It is grey
Art, it is pungent, bitter, it is warm-natured, have it is drying damp and strengthening spleen, ward off it is dirty, the effect of wind-damp dispelling；Poria cocos, it is sweet, light, it is mild-natured, there is clearing damp and promoting diuresis,
Invigorating the spleen, the effect of calming heart；Dried orange peel, it is bitter, pungent, it is warm-natured, there is the effect of regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm；Meanwhile modern pharmacology is ground
Study carefully proof, grape seed extract, Turmeric P.E and green-tea extract have the function that reducing blood lipid.All medicine compatibilities, both prevent to give birth to
The source of phlegm, divide dissolving phlegm wet again, giving consideration to both the incidental and fundamental, have and replenish qi to invigorate the spleen, dispelling phlegm and eliminating dampness, the work(for the dissolving stasis that helps digestion.
During above-mentioned concrete application, the composition can be taken using routine dose, can also be with the medicine such as the blue capsule of silver
Thing coordinates together to be taken to realize more preferably lipid-lowering effect, and the high fat of blood application effect for being triggered by traditional Chinese medical science phlegm syndrome is more
To be notable.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.Unless otherwise specified, embodiment
In the conventional meanses that are well known to those skilled in the art of used technological means, raw materials used is commercial goods.
The preparation of the grape seed extract of embodiment 1
Grape pip powder is broken into coarse powder, extracted 2 times with 60% alcohol reflux, each 1h, solvent is than 1:40, obtain grape pip
OPC extract solution, using spray drying, the activity of reservation active ingredient OPC.
The preparation of the Turmeric P.E of embodiment 2
The preparation of Turmeric P.E：Extracted 2 times using 80% alcohol reflux, each 8 times of amount ethanol of dosing material, extract 1h,
Solvent is than 1:35, extract solution is collected, Turmeric P.E is both obtained after spray drying.
The preparation of the green-tea extract of embodiment 3
The preparation of green-tea extract：Water extracts twice, solvent multiple 1:20, Extracting temperature is 90 DEG C, each extraction time
40min, collect extract solution after be spray-dried both green-tea extract.
The Chinese medicine composition of embodiment 4
1st, raw material forms：Gynostemma pentaphylla 5g, rhizoma atractylodis 5g, Poria cocos 5g, dried orange peel 5g, grape seed extract 0.2g, Turmeric P.E
0.05g, green-tea extract 0.3g, auxiliary material maltodextrin 7g.
2nd, preparation process：
(1) by with gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel is measured, mixed after crushing, add 248ml water, soak 30min, decocted
120min is boiled, is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
(2) 186ml water is added in the dregs of a decoction obtained by step (1), 60min is decocted, is filtered under diminished pressure, filtrate is standby；
(3) step (1) is merged with filtrate obtained by step (2), crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to phase successively
To density 1.2, grape seed extract, Turmeric P.E and green-tea extract (embodiment 1-3 is prepared) are added, adds malt
Dextrin, powder is spray-dried to obtain, produces composition.
Embodiment 5
1st, raw material forms：Gynostemma pentaphylla 5g, rhizoma atractylodis 5g, Poria cocos 5g, dried orange peel 5g, grape seed extract 0.2g, Turmeric P.E
0.05g, green-tea extract 0.3g, auxiliary material 7g.
2nd, preparation process：
Compared with Example 1, differ only in, it is 150ml that step (1), which adds water, and step (2) adds water and is
120ml。
Embodiment 6
1st, raw material forms：Gynostemma pentaphylla 5g, rhizoma atractylodis 5g, Poria cocos 5g, dried orange peel 5g, grape seed extract 0.2g, Turmeric P.E
0.05g, green-tea extract 0.3g, auxiliary material 7g.
2nd, preparation process：
Compared with Example 1, differ only in, it is 550ml that step (1), which adds water, and step (2) adds water and is
440ml。
Embodiment 7
1st, raw material forms：With embodiment 1.
2nd, preparation process：
(1) by with gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel is measured, mixed after crushing, add 310ml water, soak 40min, decocted
100min is boiled, is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
(2) 248ml water is added in the dregs of a decoction obtained by step (1), 60min is decocted, is filtered under diminished pressure, filtrate is standby；
(3) step (1) is merged with filtrate obtained by step (2), crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to phase successively
To density 1.0, grape seed extract, Turmeric P.E and green-tea extract are added, maltodextrin is added, is spray-dried to obtain powder
End, produce composition.
Embodiment 8
1st, raw material forms：With embodiment 1.
2nd, preparation process：
(1) by with gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel is measured, mixed after crushing, add 279ml water, soak 20min, decocted
150min is boiled, is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
(2) 217ml water is added in the dregs of a decoction obtained by step (1), 40min is decocted, is filtered under diminished pressure, filtrate is standby；
(3) step (1) is merged with filtrate obtained by step (2), crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to phase successively
To density 1.5, grape seed extract, Turmeric P.E and green-tea extract are added, maltodextrin is added, is spray-dried to obtain powder
End, produce composition.
Embodiment 9
Compared with Example 1, distinctive points are only that：
Composition described in the present embodiment is capsule, is prepared according to a conventional method by the raw material including following weight g：Twist
The blue 3g of stock, rhizoma atractylodis 3g, Poria cocos 3g, dried orange peel 3g, grape seed extract 0.1g, Turmeric P.E 0.02g, green-tea extract 0.1g,
Auxiliary material 6g.
Embodiment 10
Compared with Example 1, distinctive points are only that：
Composition described in the present embodiment is tablet, is prepared according to a conventional method by the raw material including following weight g：Strand
It is blue 8g, rhizoma atractylodis 8g, Poria cocos 8g, dried orange peel 8g, grape seed extract 0.5g, Turmeric P.E 0.08g, green-tea extract 0.5g, auxiliary
Expect 5g.
Embodiment 11
Compared with Example 1, distinctive points are only that：
Composition described in the present embodiment is syrup, is prepared according to a conventional method by the raw material including following weight g：Twist
The blue 6g of stock, rhizoma atractylodis 6g, Poria cocos 6g, dried orange peel 6g, grape seed extract 0.4g, Turmeric P.E 0.06g, green-tea extract 0.4g,
Auxiliary material 3g.
To verify the application effect of above-mentioned composition, the present invention has further spread out a large amount of special experiments, and length is limited, this
Place is only exemplified by the test example of part most convincingness.
The reducing blood lipid of test example 1 is tested
Test method：
1. hyperlipidemia model：Take 50 rats, feed high lipid food (basal feed 78.6%, yolk powder 10%, cholesterol 1%,
Cholate 0.2%, lard 10%, Frentirox piece 0.2%) 30d, daily free water and feeding, after 30d fasting can't help water, 12h
Tail vein blood surveys serum lipid concentrations afterwards, and hyperlipidemia model is used as after detection is qualified；
2. Toxicity Analysis：High blood lipid model rat 50 is only randomly divided into 5 groups, every group 10, is arranged to：Model group, it is low,
Middle and high dosage group (take pulvis described in embodiment 4, dosage is is followed successively by 0.1,0.5,1g/kg body weight) with Zhibituo control group,
Blank control group is only used as with the healthy rat 10 synchronously raised, day gastric infusion 1 time, blank group is to normal saline.Give
After medicine after the 28th day, water 12h is can't help in all mouse fasting, weighs, takes a blood sample, and surveys serum lipid concentrations (being average value).
Result of the test：
Table 1：Influence (mmoL-1) to lipid of mice
As can be seen from Table 1, compared with model group, the TC of each administration group, TG, LDL-C are significantly reduced, and HDL-C significantly rises
Height, illustrate that there is good effect for reducing blood fat, three dosage groups compare, and the effect of high dose group is more apparent.
Test example 2
In order to verify therapeutic effect of the Chinese medicine composition of the present invention to hyperlipemia, the present invention is simultaneously to 98 patients
(wherein experimental group and control group half and half) has carried out the clinical observation of practical application and system.In the process of above-mentioned clinical observation
In, to above-mentioned patient record the work of its medical history, the state of an illness, age and curative effect.
The criterion of clinical therapeutic efficacy is：
Cure：Symptom, sign all disappear, and laboratory indexes are in normal range (NR).
Take a turn for the better：The basic disappearances such as subjective symptoms is for example uncomfortable in chest, abdominal distension, lassitude hypodynamia, dizziness headache, chemical examination blood fat is close to normally
Value.
It is invalid：Symptom, sign, laboratory indexes are not improved.
Experimental subjects and instructions of taking：
Experimental group 1：Composition described in the embodiment of the present invention 1；Instructions of taking is daily 6g, and warm water is taken after mixing it with water, and 45 days are one
The course for the treatment of, normal diet.
Control group 1：Patient's agreement is obtained, uses Zhibituo in therapeutic process, other conditions are the same.
Treatment results：
Experimental group：Chinese medicine composition of the present invention to 49 hyperlipemias through treating, and 12 recoveries from illness, 30 good
Turn, 7 invalid, and total effective rate is up to 86%.
Control group：Zhibituo is treated to 49 hyperlipemias, and 10 recoveries from illness, 26 improvements, 13 invalid, always
It is efficient up to 73%.
Above-mentioned test example explanation：Chinese medicine composition lipid-lowering effect of the present invention is notable.
The beneficial effects of the invention are as follows：Chinese medicine of the present invention is pure natural medical, have it is rapid-action, cure rate is high, without pair make
The advantages of using.General hyperlipemic patients take 45 months fruits that take effect, and evident in efficacy, total effective rate is up to 86%.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (10)
1. a kind of Chinese medicine composition of reducing blood lipid, it is characterised in that the composition is prepared by the raw material of following parts by weight：
3 ~ 8 parts of gynostemma pentaphylla, 3 ~ 8 parts of rhizoma atractylodis, 3 ~ 8 parts of Poria cocos, 3 ~ 8 parts of dried orange peel, 0.1 ~ 0.5 part of grape seed extract, Turmeric P.E
0.02 ~ 0.08 part, 0.1 ~ 0.5 part of green-tea extract, 0 ~ 10 part of auxiliary material；The grape seed extract using ethanol extraction, concentration,
Spray drying forms；The Turmeric P.E is concentrated and dried after being extracted using ethanol and formed；The green-tea extract uses water extraction
Take rear concentrated spray to dry to form.
2. composition according to claim 1, it is characterised in that the composition by following parts by weight raw material prepare and
Into：4 ~ 6 parts of gynostemma pentaphylla, 4 ~ 6 parts of rhizoma atractylodis, 4 ~ 6 parts of Poria cocos, 4 ~ 6 parts of dried orange peel, 0.2 ~ 0.4 part of grape seed extract, Turmeric P.E
0.04 ~ 0.06 part, 0.2 ~ 0.4 part of green-tea extract, 5 ~ 8 parts of auxiliary material.
3. composition according to claim 2, it is characterised in that the composition by following parts by weight raw material prepare and
Into：5 parts of gynostemma pentaphylla, 5 parts of rhizoma atractylodis, 5 parts of Poria cocos, 5 parts of dried orange peel, 0.2 part of grape seed extract, 0.05 part of Turmeric P.E, green tea
0.3 part of extract, 7 parts of auxiliary material.
4. according to the composition described in claim any one of 1-3, it is characterised in that the auxiliary material be selected from maltodextrin, lactose,
Glucose, microcrystalline cellulose, methylcellulose, sodium carboxymethylcellulose, magnesium stearate, silica, talcum powder, polyethylene glycol
Or the one or more in starch.
5. composition according to claim 4, it is characterised in that the auxiliary material is maltodextrin.
6. the composition according to claim 4 or 5, it is characterised in that：The composition is decoction, powder agent, tablet, glue
Wafer or syrup.
7. composition according to claim 6, it is characterised in that：The composition is powder agent.
8. the preparation method of composition described in claim 1 ~ 7 any one, it is characterised in that comprise the following steps：
（1）Gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel are taken, is mixed after crushing, adds the water of 8 ~ 12 times of volumes, soaks 20 ~ 40min, is decocted
100 ~ 150min is boiled, is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
（2）In step（1）The water of 6 ~ 10 times of volumes is added in the gained dregs of a decoction, 40 ~ 80min is decocted, is filtered under diminished pressure, filtrate is standby
With；
（3）By step（1）With step（2）Gained filtrate merges, and crosses 200 mesh sieves and 400 mesh sieves successively, and concentration filtrate is to relatively close
Degree 1.0 ~ 1.5, grape seed extract, Turmeric P.E, green-tea extract and auxiliary material are added, is prepared into the Chinese traditional medicine composition
Thing.
9. preparation method according to claim 8, it is characterised in that composition is powder agent, its preparation method include with
Lower step：
1）Gynostemma pentaphylla, rhizoma atractylodis, Poria cocos, dried orange peel are taken, is mixed after crushing, adds the water of 10 times of volumes, soaks 30min, is decocted
120min, it is filtered under diminished pressure, filtrate is standby, retains the dregs of a decoction；
2）In step 1）The water of 8 times of volumes is added in the gained dregs of a decoction, 60min is decocted, is filtered under diminished pressure, filtrate is standby；
3）By step 1）With step 2）Gained filtrate merges, and crosses 200 mesh sieves and 400 mesh sieves, concentration filtrate to relative density successively
1.2, grape seed extract, Turmeric P.E, green-tea extract are added, maltodextrin is added, is spray dried to powder, is prepared into
Chinese medicine composition.
10. the group that composition described in claim 1 ~ 7 any one or claim 8 ~ 9 any one methods described are prepared
Application of the compound in blood lipid-lowering medicine is prepared.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462826A (en) * | 2010-11-04 | 2012-05-23 | 北京润康普瑞生物技术有限公司 | Chinese medicinal composition for reducing blood lipids and preparation method and application thereof |
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2014
- 2014-12-25 CN CN201410828910.9A patent/CN104547909B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462826A (en) * | 2010-11-04 | 2012-05-23 | 北京润康普瑞生物技术有限公司 | Chinese medicinal composition for reducing blood lipids and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 润康普瑞牌平脂康胶囊辅助降血脂功能实验研究;王志文等;《北方药学》;20111231;第8卷(第11期);13,22 * |
| 降脂中药的研究进展;黎海彬;《广州城市职业学院学报》;20080630;第2卷(第02期);34-38 * |
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