CN106309616A - Medicine with hypolipidemic effect - Google Patents
Medicine with hypolipidemic effect Download PDFInfo
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- CN106309616A CN106309616A CN201610950085.9A CN201610950085A CN106309616A CN 106309616 A CN106309616 A CN 106309616A CN 201610950085 A CN201610950085 A CN 201610950085A CN 106309616 A CN106309616 A CN 106309616A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine with hypolipidemic effect. The medicine is characterized by being prepared from the following raw materials in parts by weight: loquat, hawthorn, mulberry leaf, chrysanthemum and pueraria lobate at the ratio of 1:1:1:1:1. A preparation method comprises the following steps of: 1) grinding and evenly mixing raw materials taken according to the proportion of raw materials, boiling with water, then filtering, performing alcohol cooking and then filtering, and combining the filtrates of twice; or grinding and evenly mixing raw materials taken according to the proportion of raw materials, performing alcohol cooking, then filtering, boiling with water and then filtering, and combining the filtrates of twice; and 2) performing alcohol removal on the filtrate and concentrating, and adding or adding no pharmaceutical excipients according to the dosage of finished products, thus producing the finished medicine. Experiments proved that the medicine has the hypolipidemic effect.
Description
Technical field
The present invention relates to biomedicine technical field, particularly to a kind of medicine with lipid-lowering effect.
Background technology
Hyperlipidemia is a kind of common disease, is that human body lipid metabolism is not normal caused, refers mainly to T-CHOL in serum, sweet
Oil three esters and low-density lipoprotein white level is too high or hdl level is too low.Hyperlipidemia is the most clinical
Symptom, it is invisible, gradually row to the infringement of health, and is general.Because hyperlipidemia can accelerate tremulous pulse medicated porridge sample
Hardening, once artery occlusion, a lot of disease will be caused, such as cardiovascular and cerebrovascular disease, nephropathy, hepatic disease etc..Cardiovascular and cerebrovascular vessel
Disease is the main cause that middle-aged and elderly people is lethal, is the number one killer threatening human health.Add up according to World Health Organization (WHO), every year
About 17,000,000 people die from this chronic disease, account for about the 30% of the total death toll in the whole world.In other words, the most every 3 the dead
In, just there is 1 to be caused by cardiovascular disease.
The medicine being currently used for blood fat reducing is a lot, but in clinic, does not highlight the medicine of curative effect, therefore market in urgent need
Exploitation one treats hyperlipidemic conditions medicine.
Folium Eriobotryae, the ancient entitled reed Fructus Citri tangerinae of Chinese, have another name called gold ball or reed branch, it is a genus of the Maloideae in Rosaceae, for
Evergreen dungarunga.The Folium Eriobotryae of research display at present has reduction body fat, anti-inflammatory, antitumor, blood sugar lowering and improves abnormal generation
The curative effect thanked.
Fructus Crataegi is natural lipid lowerers, mainly contains Crataegolic acid, citric acid, steatolysis acid, vitamin C, flavone, carbon water
The compositions such as compound, have expansion blood vessel, improve microcirculation, reduce blood pressure, promote that Cholesterol Excretion reduces the diseases prevention of blood fat
Health preserving effect.
Folium Mori are the dried leaves of moraceae plants Mulberry, and Folium Mori are just answered by the traditional Chinese medical science as the Chinese medicine for the treatment of diabetes since ancient times
For clinic.A lot of to the research report of Folium Mori in recent years, wherein polysaccharides of Folium Mori and polypeptide have good blood sugar lowering and blood fat reducing
Effect.
Flos Chrysanthemi, is the perennial root herbaceous plant of Compositae, Chrysanthemum in Plant Taxonomy.For anemopyretic cold, headache
Dizziness, conjunctival congestion and swelling pain search, eyes is dim-sighted.
Radix Puerariae has the effect improving brain blood circulation, to the headache caused because of hypertension, dizziness, tinnitus and pain in the low back and legs
Have etc. symptom and preferably alleviate effect.
Summary of the invention
The present invention comes from theory of Chinese medical science, sums up experience in many ways, has been developed into a kind of medicine with lipid-lowering effect, this medicine
Thing is pure Chinese medicinal preparation, and experiment proof can be substantially reduced T-CHOL in blood, triglyceride, low density lipoprotein, LDL and high density
Lipoprotein, and determined curative effect, safely and effectively.
Present invention aim at providing a kind of medicine with lipid-lowering effect, to provide one safely and effectively medicine to select
Selecting, in terms of blood fat reducing treatment, application is clinically.
A kind of medicine with lipid-lowering effect, it is characterised in that be prepared from by the raw material of following weight portion:
Folium Eriobotryae: Fructus Crataegi: Folium Mori: Flos Chrysanthemi: Radix Puerariae=1:1:1:1:1.
There is the medicine of lipid-lowering effect, it is characterised in that preparation method comprises the steps of
1) take raw material pulverizing mixing by material rate, filter with filtering after decocting in water after alcohol boils again, merge the filtrate of twice；
Or after taking raw material pulverizing mixing by material rate, after the side filtered successively extracts, merge after boiling after filtering again decocting in water with alcohol
The filtrate of twice；Described alcohol is the ethanol water of 70%-100% volume ratio.
2) carry out filtrate, except alcohol, concentration, adding further according to finished dosage forms or making finished product without excipient substance.
It is the ethanol water of 70%-100% in described alcohol.
Detailed description of the invention
In order to make content of the present invention easily facilitate understanding, below in conjunction with detailed description of the invention to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Embodiment 1
Pharmaceutical composition extracts
Take Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, Flos Chrysanthemi 10g, Radix Puerariae 10g, pulverize mixing, with 1000 mL (1:20 solid-liquid ratio)
70% ethanol percolation 1h, afterwards 90 DEG C of oil bath reflux, extract, 2h, stands 12h, filters away residue.
Take Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, Flos Chrysanthemi 10g, Radix Puerariae 10g, pulverize mixing, by 1500 mL (1:30 feed liquid
Than) water percolation 1h, afterwards 100 DEG C of oil bath reflux, extract, 2h, stand 12h, filter away residue.
Then twice extract filtrate being merged, rotation is evaporated off ethanol and is concentrated into suitable concn.
According to the method described above, Folium Eriobotryae, Fructus Crataegi and Folium Mori are extracted respectively.
Zoopery
The kunming mice of 20-30g is randomly divided into normal group, matched group, Folium Eriobotryae group, Fructus Crataegi group, Folium Mori group, high dose group, in
Dosage group, low dose group, simvastatin group, often group 5, every day, free diet high lipid food, gave with each 200ul dosage every day
Medicine once, successive administration 2 weeks.Eyeball takes blood, with T-CHOL (TC), triglyceride (TG), high density lipoprotein (HDL-C),
Low density lipoprotein, LDL (LDL-C) test kit detects each value, detects T-CHOL and the suction of triglyceride at microplate reader 510 nm
Light value, detects high density lipoprotein and low density lipoprotein, LDL light absorption value at 546 nm, calculates mice according to the formula of test kit
The value of T-CHOL, triglyceride, high density lipoprotein and low density lipoprotein, LDL, result is as shown in table 1.
Shown in chart 1, between Folium Eriobotryae group, Fructus Crataegi group and Folium Mori group group, indices does not has significant difference, and hyperlipidemia model group is each
Index is compared, and relatively has rising more by a small margin；But compositions high dose group relatively in dosage group, low dose group and pungent cut down him
Spit of fland group, it is possible to significantly decrease T-CHOL, triglyceride and low density lipoprotein, LDL content, high density lipoprotein increasing content.
To sum up, compositions high dose can effective effect for reducing fat.
Embodiment 2
Beverage
Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, Flos Chrysanthemi 10g, Radix Puerariae 10g, mix homogeneously after pulverizing, (1:20 expects to use water-boiling method
Liquor ratio) extract, after by filtering residue with after 70% ethanol water (1:30 solid-liquid ratio) reflux, extract, filtration, united extraction liquid, be concentrated into
In right amount, extract thick paste, drying under reduced pressure, pulverize, obtain dry extract.
Take above-mentioned dry extract, routinely process, i.e. comprise allotment-homogenizing-degassing-pasteurize-
The steps such as fill-cooling, i.e. can get finished beverage.
Embodiment 3
Mixture
Take mix homogeneously after Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, each two parts of pulverizing of Flos Chrysanthemi 10g, Radix Puerariae 10g, be respectively adopted water
Decocting method (1:15 solid-liquid ratio) and ethanol solution (95%) (1:20 solid-liquid ratio) cooking method united extraction liquid, recovered under reduced pressure second after filtration
Alcohol, to without ethanol taste, cold preservation 24h, Aspirate supernatant, adds sodium benzoate 0.3%, ethyl hydroxybenzoate 0.02%, boils little half
Time, with distilled water regulation to total amount, cooling, filter, sterilizing, thus obtaining the product.
Embodiment 4
Capsule
After taking Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, each two parts of pulverizing of Flos Chrysanthemi 10g, Radix Puerariae 10g, mix homogeneously is equally divided into two
Part, it is respectively adopted decocting cooking method (1:18 solid-liquid ratio) and ethanol solution (85%) (1:25 solid-liquid ratio) cooking method united extraction liquid, concentrates
To in right amount, extract thick paste, drying under reduced pressure, pulverize, obtain dry extract.
Take above-mentioned dry extract, add Pulvis Talci, starch, mix homogeneously according to common process, pelletize, encapsulated, to obtain final product
Capsule.
Embodiment 5
Tablet
Take mix homogeneously after Folium Eriobotryae 10g, Fructus Crataegi 10g, Folium Mori 10g, each two parts of pulverizing of Flos Chrysanthemi 10g, Radix Puerariae 10g, use ethanol molten
Liquid (80%) boil (1:27 solid-liquid ratio) extract, after by filtering residue with decocting in water (1:20 solid-liquid ratio) extract after filter, merging filtrate afterwards,
Being concentrated into appropriate, be spray-dried, dried cream powder adds right amount of auxiliary materials, and mixing is crossed 60 mesh sieves, tabletting, coating, to be obtained final product.
Claims (3)
1. a medicine with lipid-lowering effect, it is characterised in that be prepared from by the raw material of following weight portion:
Folium Eriobotryae: Fructus Crataegi: Folium Mori: Flos Chrysanthemi: Radix Puerariae=1:1:1:1:1.
There is the medicine of lipid-lowering effect the most as claimed in claim 1, it is characterised in that preparation method comprises the steps of
1) by material rate take raw material pulverizing mixing, be equally divided into two parts, after portion decocting in water after filtration, another part of alcohol boil after mistake
Filter, merges the filtrate of twice；
Or after taking the pulverizing mixing of raw material pulverizing blend feedstock by material rate, filter or decocting in water after filtering again decocting in water with alcohol after boiling
After the method that rear filtration is filtered after alcohol boils again is successively extracted, merge the filtrate of twice；
2) carry out filtrate, except alcohol, concentration, adding or without pharmaceutically acceptable excipient substance system further according to finished dosage forms
Become finished product.
There is the medicine of lipid-lowering effect the most as claimed in claim 2, it is characterised in that described alcohol is 70%-100% volume
The ethanol water of ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610950085.9A CN106309616A (en) | 2016-11-03 | 2016-11-03 | Medicine with hypolipidemic effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610950085.9A CN106309616A (en) | 2016-11-03 | 2016-11-03 | Medicine with hypolipidemic effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309616A true CN106309616A (en) | 2017-01-11 |
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ID=57818747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610950085.9A Pending CN106309616A (en) | 2016-11-03 | 2016-11-03 | Medicine with hypolipidemic effect |
Country Status (1)
| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110771761A (en) * | 2019-11-06 | 2020-02-11 | 合肥工业大学 | Radix puerariae and chrysanthemum morifolium compound beverage with auxiliary blood fat reducing effect |
-
2016
- 2016-11-03 CN CN201610950085.9A patent/CN106309616A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| WONDER_2012X: "妙用山楂可降脂", 《HTTPS://WENKU.BAIDU.COM/VIEW/E4F354E7D15ABE23482F4DB7.HTML》 * |
| 刘庆春: "《糖尿病就这样吃》", 31 March 2013, 中华工商联合出版社 * |
| 陈冰等: "《肥胖症药膳》", 28 February 2003, 科学技术文献出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110771761A (en) * | 2019-11-06 | 2020-02-11 | 合肥工业大学 | Radix puerariae and chrysanthemum morifolium compound beverage with auxiliary blood fat reducing effect |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |
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| RJ01 | Rejection of invention patent application after publication |