CN101822705A - Total platycodin and application of monomer platycodin D in antialcoholic drugs - Google Patents
Total platycodin and application of monomer platycodin D in antialcoholic drugs Download PDFInfo
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- CN101822705A CN101822705A CN200910119133A CN200910119133A CN101822705A CN 101822705 A CN101822705 A CN 101822705A CN 200910119133 A CN200910119133 A CN 200910119133A CN 200910119133 A CN200910119133 A CN 200910119133A CN 101822705 A CN101822705 A CN 101822705A
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- platycodin
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- total saponins
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Abstract
The invention provides a total platycodin and an application of the monomer platycodin D in antialcoholic drugs. The total platycodin has obvious antialcoholic effect and can be used for preparing antialcoholic drugs and health care products.
Description
Technical field
The present invention relates to field of medicaments, providing a kind of is the relieve the effect of alcohol medicine of effect of feedstock production with Radix Platycodi total saponins and monomer Platycodin D.
Background technology
Radix Platycodonis is the dry root of campanulaceae perennial plant Radix Platycodonis (Platycodon grandiflorum (Jacp.) A.DC.), and is on the books in Shennong's Herbal.Radix Platycodonis nature and flavor hardship, suffering, flat are returned lung meridian, and lung qi dispersing gas is arranged out, and the effect of the evacuation of pus of eliminating the phlegm is usually used in diseases such as exogenous cough, expectoration are unclear, laryngopharynx swelling and pain, abdominal distention uncomfortable in chest, dysentery stomachache, blood stasis edema, the difficulty in urination, is conventional Chinese medicine.
Radix Platycodonis is distributed widely in China, the Korea peninsula and Japan; In China northeast and North China, Radix Platycodonis is extensively planted, aboundresources.The Radix Platycodonis per mu yield is generally at the 450-600 kilogram, and good quality and high output person can reach 800 kilograms.Studies show that and mainly contain triterpene saponin componds in the Radix Platycodonis, its content is 2%-6% (g/g), and Radix Platycodonis also contains fatty acid, aminoacid, trace element etc. in addition.
Effects such as modern pharmacology studies show that the triterpene saponin chemical constituent of Radix Platycodonis has antiinflammatory, eliminates the phlegm, protects the liver, diuresis, blood vessel dilating, blood sugar lowering, inhibition fat absorption, antioxidation, antibiotic, antitumor.Aspect it protected the liver, the platycodin constituents that studies show that in recent years had anti-hepatic fibrosis, anti-liver lipid peroxidation, the protection hepatocyte, promote the matter and energy metabolism of liver to quicken the hepatic injury recovery, improve liver microcirculation, suppress effects such as tumor cell of liver; Radix Platycodi total saponins all has therapeutical effect to various medicines (carbon tetrachloride) liver injury model.
At present, domestic exploitation to Radix Platycodonis is mostly in the clinical prescription application facet.In the health functional food field, less relatively to the further investigation exploitation of Radix Platycodonis.But Radix Platycodi total saponins and Platycodin D directly are used as the medicine that relieves the effect of alcohol as medicine to still belong to the first time.
Summary of the invention
The new purposes that head of the present invention provides Radix Platycodi total saponins and the conduct of monomer Platycodin D to relieve the effect of alcohol medicine.The pharmacological results shows that it has the effect of significantly relieving the effect of alcohol as the medicine that relieves the effect of alcohol.
Therefore, raw material of the present invention can be prepared into tablet, granule, capsule, suspension, forms of pharmaceutical compositions such as oral liquid with pharmaceutically useful adjuvant pharmaceutically.Raw material of the present invention also can be prepared into different health product combinations with edible various adjuvants.
Technical solution of the present invention may further comprise the steps:
The preparation of Radix Platycodi total saponins, this is not subjected to right claimed:
A, get dry traditional Chinese medicine Radix Platycodonis medical material, with 70% alcohol reflux of 5 times of amounts 3 times, each two hours, filter, merge three times extracting solution.
B, extracting solution is transferred alcoholic degree with dehydrated alcohol is 95%, leaves standstill 12 hours, filters, and gets filtrate, and being evaporated to does not have the alcohol flavor, extractum.
C, with the extractum deionized water dissolving, cross the AB-8 purification by macroporous resin, be washed till colourlessly with deionized water, use 60% ethanol elution, the eluent concentrating under reduced pressure, lyophilizing both must Radix Platycodi total saponins.
The prepared Radix Platycodi total saponins of the present invention has significant sober-up function, can be used for alleviating excessive consumption of alcohol and crapulent crowd's treatment.
Below further describe beneficial effect of the present invention by example, these examples only are used for better explaining the present invention, never limit the scope of the invention.
The specific embodiment
Embodiment 1, get the Radix Platycodonis medical material 1kg of drying and crushing, add 5000ml 70% ethanol, reflux, extract,, triplicate filters, and gets filtrate, filtrate is transferred alcoholic degree to 95% with dehydrated alcohol, left standstill 12 hours, filter, filtrate is concentrated into does not have the alcohol flavor, gets extractum 278g, with deionized water extractum is dissolved, cross AB-8 macroporous resin column (the macroporous resin consumption is 3kg) purification, be eluted to deionized water colourless, with 5L 60% ethanol elution, eluent is concentrated into dried, gets total saponins (153g).
Embodiment 2, mice are divided into 7 groups at random, it is model control group, Radix Platycodi total saponins group (low dosage 150mg/kg, middle dosage 200mg/kg, high dose 250mg/kg), Platycodin D group (low dosage 75mg/kg, middle dosage 150mg/kg, high dose 225mg/kg), 10 every group.The stable raising three days, fasting 12h before the administration.Each organizes equal gastric infusion, and model control group is irritated stomach with isopyknic distilled water.Each group is all irritated stomach and is given 60% ethanol 15ml/kg after 30 minutes.Observe it and right disappearance and recovery situation.The results are shown in down:
Table 1 Radix Platycodi total saponins and monomer Platycodin D right the influence of disappearance and recovery situation to the mice of drinking
Conclusion
This experimental result prove oral middle and high various dose Radix Platycodi total saponins and monomer Platycodin D to mice after drinking drunk phenomenon inhibitory action arranged, it does not right extinction tests, and inhibitory action and drug dose are obvious dose-effect relationship.Radix Platycodi total saponins and monomer Platycodin D have sober-up function.
Claims (4)
1. Radix Platycodi total saponins and the application of monomer Platycodin D in the medicine that relieves the effect of alcohol.
2. the medicine with antialcoholism action is characterized in that Radix Platycodi total saponins or saponin D are active component.
3. the drug regimen with antialcoholism action is characterized in that the preparation of Radix Platycodi total saponins or Platycodin D and pharmaceutically acceptable auxiliaries.
4. the health product with antialcoholism action is characterized in that Radix Platycodi total saponins or Platycodin D and can use the adjuvant preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910119133A CN101822705A (en) | 2009-03-04 | 2009-03-04 | Total platycodin and application of monomer platycodin D in antialcoholic drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910119133A CN101822705A (en) | 2009-03-04 | 2009-03-04 | Total platycodin and application of monomer platycodin D in antialcoholic drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101822705A true CN101822705A (en) | 2010-09-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910119133A Pending CN101822705A (en) | 2009-03-04 | 2009-03-04 | Total platycodin and application of monomer platycodin D in antialcoholic drugs |
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| CN (1) | CN101822705A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103222998A (en) * | 2012-01-30 | 2013-07-31 | 苏州九龙医院有限公司 | Comprehensive extracting method for platycodin and polysaccharide |
| CN103479707A (en) * | 2013-07-12 | 2014-01-01 | 中国农业科学院作物科学研究所 | Preparation method of total platycodin capable of dispelling effects of alcohol |
| CN104257788A (en) * | 2014-09-29 | 2015-01-07 | 中国农业科学院农业质量标准与检测技术研究所 | Composition with functions of dispelling effects of alcohol and protecting liver and beverage comprising composition |
| CN106834037A (en) * | 2017-03-09 | 2017-06-13 | 安徽瑞思威尔科技有限公司 | A kind of polypeptide health care wine and preparation method thereof |
-
2009
- 2009-03-04 CN CN200910119133A patent/CN101822705A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103222998A (en) * | 2012-01-30 | 2013-07-31 | 苏州九龙医院有限公司 | Comprehensive extracting method for platycodin and polysaccharide |
| CN103479707A (en) * | 2013-07-12 | 2014-01-01 | 中国农业科学院作物科学研究所 | Preparation method of total platycodin capable of dispelling effects of alcohol |
| CN103479707B (en) * | 2013-07-12 | 2015-06-10 | 中国农业科学院作物科学研究所 | Preparation method of total platycodin capable of dispelling effects of alcohol |
| CN104257788A (en) * | 2014-09-29 | 2015-01-07 | 中国农业科学院农业质量标准与检测技术研究所 | Composition with functions of dispelling effects of alcohol and protecting liver and beverage comprising composition |
| CN106834037A (en) * | 2017-03-09 | 2017-06-13 | 安徽瑞思威尔科技有限公司 | A kind of polypeptide health care wine and preparation method thereof |
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Open date: 20100908 |