CN115997026A - 通过拜尔-维利格单加氧酶将法呢基丙酮转化成乙酸高法呢基酯 - Google Patents

通过拜尔-维利格单加氧酶将法呢基丙酮转化成乙酸高法呢基酯 Download PDF

Info

Publication number
CN115997026A
CN115997026A CN202180045757.0A CN202180045757A CN115997026A CN 115997026 A CN115997026 A CN 115997026A CN 202180045757 A CN202180045757 A CN 202180045757A CN 115997026 A CN115997026 A CN 115997026A
Authority
CN
China
Prior art keywords
formula
bvmo
conversion
acetate
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180045757.0A
Other languages
English (en)
Chinese (zh)
Inventor
E·艾克霍恩
A·格克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Givaudan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN115997026A publication Critical patent/CN115997026A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/54—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202180045757.0A 2020-07-01 2021-06-30 通过拜尔-维利格单加氧酶将法呢基丙酮转化成乙酸高法呢基酯 Pending CN115997026A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2010072.3 2020-07-01
GBGB2010072.3A GB202010072D0 (en) 2020-07-01 2020-07-01 Enzyme-mediated process
PCT/EP2021/067983 WO2022003017A1 (en) 2020-07-01 2021-06-30 Conversion of farnesylacetone to homofarnesylacetate by baeyer-villiger monooxygenase

Publications (1)

Publication Number Publication Date
CN115997026A true CN115997026A (zh) 2023-04-21

Family

ID=71949647

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180045757.0A Pending CN115997026A (zh) 2020-07-01 2021-06-30 通过拜尔-维利格单加氧酶将法呢基丙酮转化成乙酸高法呢基酯

Country Status (7)

Country Link
US (1) US12391965B2 (https=)
EP (1) EP4176067A1 (https=)
JP (1) JP7698032B2 (https=)
CN (1) CN115997026A (https=)
BR (1) BR112022022851A2 (https=)
GB (1) GB202010072D0 (https=)
WO (1) WO2022003017A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119876059A (zh) * 2025-01-25 2025-04-25 天津大学浙江研究院(绍兴) 一种降龙涎醚的生物催化合成方法
CN121495734A (zh) * 2026-01-09 2026-02-10 天津凯莱英生物科技有限公司 工程菌及合成香紫苏二醇的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4724593A2 (en) * 2023-06-12 2026-04-15 Firmenich SA Polypeptides for preparing terpenoid compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326888A (en) 1990-10-09 1994-07-05 Henkel Research Corporation Carbonylation of allylic alcohols and synthesis of an ambergris fragance compound
EP2835425B1 (en) 2012-04-06 2018-05-30 Ewha University-Industry Collaboration Foundation Use of BVMO (Baeyer-Villiger monooxygenases) and fatty acids
WO2013156398A1 (de) 2012-04-16 2013-10-24 Basf Se Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol
US20130273619A1 (en) * 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
GB201209425D0 (en) 2012-05-28 2012-07-11 Lucite Int Uk Ltd Process for production of methyl methacrylate
GB201223271D0 (en) 2012-12-21 2013-02-06 Lucite Int Uk Ltd Process for production of an alkylmethacrylate
GB201318894D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements in or relating to organic compounds
GB201917694D0 (en) 2019-12-04 2020-01-15 Givaudan Sa Enzyme mediated process
GB202005468D0 (en) 2020-04-15 2020-05-27 Givaudan Sa Enzyme-media process

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119876059A (zh) * 2025-01-25 2025-04-25 天津大学浙江研究院(绍兴) 一种降龙涎醚的生物催化合成方法
CN121495734A (zh) * 2026-01-09 2026-02-10 天津凯莱英生物科技有限公司 工程菌及合成香紫苏二醇的方法

Also Published As

Publication number Publication date
WO2022003017A1 (en) 2022-01-06
JP2023532966A (ja) 2023-08-01
BR112022022851A2 (pt) 2023-01-17
US12391965B2 (en) 2025-08-19
EP4176067A1 (en) 2023-05-10
GB202010072D0 (en) 2020-08-12
JP7698032B2 (ja) 2025-06-24
US20230203548A1 (en) 2023-06-29

Similar Documents

Publication Publication Date Title
Wang et al. Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor
JP7698032B2 (ja) バイヤービリガーモノオキシゲナーゼによるファルネシルアセトンのホモファルネシルアセタートへの変換
MXPA06001718A (es) Procedimiento enzimatico para la produccion de derivados de acido 3-hidroxibutirico 4-sustituido y esteres de acido carboxilico sustituido con ciano e hidroxi vecinales.
EP1151125A1 (en) Biocatalytic synthesis of quinic acid and conversion to hydroquinone
WO2007142210A1 (ja) 光学活性アルコールの製造方法
Knaus et al. Ene‐reductases and their Applications
CN105624125A (zh) 醛酮还原酶及其在合成(2s,3r)-2-苯甲酰氨甲基-3-羟基丁酸酯中的应用
US8980592B2 (en) Process for the enantioselective enzymatic reduction of hydroxy keto compounds
JP6093427B2 (ja) エノン化合物
JP3919918B2 (ja) 光学活性２−ハロ−１−（置換フェニル）エタノールの製造法
JP2013511498A (ja) 水性生体変換混合物からのアルカノールの単離方法
EP1323827A2 (en) Method for producing optically active 2-hydroxycycloalkanecarboxylic acid ester
JP6844073B1 (ja) （１ｒ，３ｒ）−３−（トリフルオロメチル）シクロヘキサン−１−オール及びその中間体の製造法
JPWO2003018523A1 (ja) 光学活性ハロプロパンジオール誘導体の製造法
JP2008507989A (ja) 第一級アルコールを生成するための方法
WO2008074506A1 (en) Optical resolution of a mixture of enantiomers of butynol or butenol
EP1298119A1 (en) Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same
WO2009153325A1 (en) Optical resolution of a mixture of enantiomers of butynol or butenol
EP1382683B1 (en) Process for producing 3-hydroxycyclohexanone
JP4744916B2 (ja) 光学活性アルキルアルコール誘導体の単離取得方法
CN118685378B (zh) 一种羰基还原酶突变体及其在4-aa手性中间体合成中的应用
JP4898129B2 (ja) 光学活性ビニルアルコール類の製造方法
JP2007274901A (ja) 光学活性プロパルギルアルコールの製造方法
US20160186217A1 (en) Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation
JP4536484B2 (ja) 光学活性２−ヒドロキシ−５−（４−メトキシフェニル）−ペンタン酸エステルの製造方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination