CN1159322A - 半胱氨酸前体作为皮肤脱色和/或增白剂的用途 - Google Patents

半胱氨酸前体作为皮肤脱色和/或增白剂的用途 Download PDF

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CN1159322A
CN1159322A CN96123166A CN96123166A CN1159322A CN 1159322 A CN1159322 A CN 1159322A CN 96123166 A CN96123166 A CN 96123166A CN 96123166 A CN96123166 A CN 96123166A CN 1159322 A CN1159322 A CN 1159322A
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purposes
composition
skin
carboxylic acid
oxo thiazolidine
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J·B·加莱
L·马罗
C·科斯
R·施密特
M·雷尼耶
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LOreal SA
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LOreal SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明涉及L-2-氧代噻唑烷-4-羧酸在化妆组合物中作为脱色或增白剂的用途，本发明还涉及使皮肤脱色或增白的方法，其特征在于其中包括在皮肤上涂抹包括L-2-氧化噻唑烷-4-羧酸的组合物。

Description

半胱氨酸前体作为皮肤脱色和/或增白剂的用途
本发明涉及L-2-氧代噻唑烷-4-羧酸在化妆和/或皮肤或皮肤病用组合物中作为褪色或脱色素和/或增白剂的用途。
皮肤的颜色取决于许多因素，尤其是季节，种族和性别，并且主要由黑素细胞产生的黑素浓度确定。
但是，多年来还一直在寻求减少和/或放慢这种黑素生成量的办法以使皮肤脱色或增白，其中涉及到细胞间生化合成黑素的过程中的一或多个点。
因此，多年来已采用不同的分子并试验其作为脱色或增白剂的效果。
更具体地讲，已将维生素C，维生素C衍生物或维生素E衍生物，熊果苷，氢醌，曲酸，胎盘衍生物，谷胱甘肽(gluthation)及其衍生物等化合物加入组合物中。
已知这些化合物可作用于酪氨酸酶，即有助于合成黑素的酶的合成过程和/或其活性，或已知可减少生成的黑素量或已知可通过角化细胞而刺激黑素的去除。不幸的是，这些化合物涂抹到皮肤上的时候，在氢醌的情况下是有毒的，或者是在维生素C和曲酸的情况下在溶液中又不稳定，这从某种程度上使得该组合物的制备过程复杂化，或者是这些化合物会带来令人不快的味道，尤其是在谷胱甘肽情况下会有硫磺味，因此这限制了其用途。而且，这些化合物数量有限。
所以说，需要开发新的皮肤增白剂，在其作用过程中效果与已知制剂一样好，但没有已知化合物的缺点，即在组合物中稳定，对皮肤无毒并且不会带来令人不快的味道，尤其是将该制剂涂抹到皮肤上的时候不会有令人不快的味道。
当然，已知采用L-2-氧代噻唑烷-4-羧酸，也称为“半胱氨酸前体(procystéine)作为治疗脱发的制剂(EP656201)。但是，还没有人提出用其作为脱色剂。
因此，本发明目的是提出L-2-氧代噻唑烷-4-羧酸在化妆组合物中作为脱色或增白剂的用途。
本发明另一目的是提出L-2-氧代噻唑烷-4-羧酸用于制备使皮肤脱色或增白的皮肤或皮肤病用组合物的用途。
将该酸与皮肤接触时的优点是不会产生令人不快的硫磺味。
该酸的存在量为该组合物总重量的0.1-10wt％(重量百分比)，优选为2-5wt％。
本发明组合物中还可包括常用浓度的常用于或者和/或皮肤或皮肤病领域的任何成分。这些成分尤其可选自脂肪物质，防腐剂，维生素，胶凝剂，香料，表面活性剂，水，抗氧化剂，填料，润肤剂和滤光剂及其混合物。
脂肪物质可选自矿物油或合成油，蜡，(聚)硅氧烷，脂肪醇或脂肪酸。油可选自凡士林油和西蒙德木油，而蜡可选自sipol蜡。这些油和蜡均可为天然或合成的。
表面活性剂可选自双甘油-硬脂酸的钠盐，硬脂酸钠，而胶凝剂可选自任选氧乙烯化或环氧乙烷化的聚乙二醇。
本发明组合物可制成水、水-醇或油溶液，水包油或油包水乳液，水或油胶体或囊体或泡体，尤其是脂囊体或脂泡体分散液形式。该组合物可或多或少具有流体性质并且具有乳油或乳液，软膏，奶液，洗液，浆液或泡沫外观。该组合物还可任选以气溶胶的形式涂抹到皮肤上。
本发明还涉及使皮肤褪色或脱色素或增白的化妆和/或皮肤或皮肤病学处理或治疗方法，其中包括在皮肤上涂抹包括L-2-氧代噻唑烷-4-羧酸的组合物。
以下实施例详述本发明，其中浓度以重量百分比给出。
实施例1
面部增白膏L-2-氧代噻唑烷-4-羧酸                              2硬脂酸钠                                           3凡士林油                                           6羟苯甲酸烷基酯                                  0.05山梨酸钾                                          10硬脂醇                                  1香料                                    1水             适量至(psp)            100
实施例2
身体增白膏L-2-氧代噻唑烷-4-羧酸                   5西蒙德木油                             13sipol蜡                                 6棕榈酸异丙酯                            2甘油                                   15羟苯甲酸烷基酯                        0.5香料                                    1水    适量至(psp)                     100

Claims (9)

1.L-2-氧代噻唑烷-4-羧酸在化妆组合物中作为皮肤脱色或增白剂的用途。
2.L-2-氧代噻唑烷-4-羧酸用于制备使皮肤脱色或增白的皮肤用组合物的用途。
3.权利要求1或2的用途，其特征在于L-2-氧代噻唑烷-4-羧酸的存在量为该组合物总重量的0.1-10wt％.
4.上一权利要求的用途，其特征在于L-2-氧代噻唑烷-4-羧酸的存在量为该组合物总重量的2-5wt％.
5.权利要求1或2的用途，其特征在于该组合物还包括至少一种选自脂肪物质，防腐剂，维生素，胶凝剂，香料，表面活性剂，水，抗氧化剂，填料，滤光剂，润肤剂及其混合物的成分。
6.上一权利要求的用途，其特征在于脂肪物质选自油和蜡。
7.权利要求5的用途，其特征在于表面活性剂选自双甘油一硬脂酸的钠盐和硬脂酸钠。
8.权利要求5的用途，其特征在于胶凝剂选自任选氧乙烯化的聚乙二醇。
9.使皮肤脱色或增白的方法，其特征在于其中包括在皮肤上涂抹包括L-2-氧代噻唑烷-4-羧酸的组合物。
CN96123166A 1995-12-22 1996-12-21 半胱氨酸前体作为皮肤脱色和/或增白剂的用途 Pending CN1159322A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515335A FR2742658B1 (fr) 1995-12-22 1995-12-22 Utilisation de la procysteine comme agent depigmentant
FR9515335 1995-12-22

Publications (1)

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CN1159322A true CN1159322A (zh) 1997-09-17

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US (1) US6007827A (zh)
EP (1) EP0780120B1 (zh)
JP (1) JP2885747B2 (zh)
KR (1) KR100229696B1 (zh)
CN (1) CN1159322A (zh)
AT (1) ATE168005T1 (zh)
CA (1) CA2193520C (zh)
DE (1) DE69600410T2 (zh)
ES (1) ES2121463T3 (zh)
FR (1) FR2742658B1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063389A (en) * 1995-12-22 2000-05-16 L'oreal Composition for depigmenting or bleaching mammalian skin containing L-2-oxothiazolidine-4-carboxylic acid and a polyol
FR2751331A1 (fr) * 1996-07-18 1998-01-23 Oreal Nouveau derive de l'acide kojique et son utilisation comme agent depigmentant
FR2773323B1 (fr) * 1998-01-05 2000-02-11 Oreal Composition contenant une association de procysteine et de polyol
FR2790953B1 (fr) * 1999-03-19 2002-08-09 Oreal Composition a phase aqueuse continue renfermant de l'acide l-2-oxothiazolidine 4-carboxylique
FR2816838B1 (fr) * 2000-11-17 2004-12-03 Oreal Utilisation de derives de l'acide 2-oxothiazolidine- 4-carboxylique comme agents prodesquamants
CN100434062C (zh) * 2006-08-28 2008-11-19 卢小明 L-2-氧代硫氮杂戍环烷-4-羧酸及其酯类衍生物作为皮肤药妆品的应用
FR2921257B1 (fr) 2007-09-21 2009-11-06 Exsymol Sa Utilisation topique de derives thiazolidines contre les consequences du stress oxydatif de la peau
US10239847B1 (en) * 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione

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US4434158A (en) * 1981-02-11 1984-02-28 Cornell Research Foundation Cysteine delivery system
US4665082A (en) * 1981-02-11 1987-05-12 Cornell Research Foundation Cysteine delivery system
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FR2540872B1 (fr) * 1983-02-14 1985-07-12 Fabre Sa Pierre Le l-thiazolidine-4 carboxylate de zinc, sa preparation, les compositions topiques le contenant et son utilisation
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JP2565513B2 (ja) * 1987-09-25 1996-12-18 三省製薬株式会社 メラニン生成抑制外用薬剤
JP2593714B2 (ja) * 1989-09-20 1997-03-26 株式会社 林原生物化学研究所 色白剤
JP2954634B2 (ja) * 1990-02-13 1999-09-27 協和醗酵工業株式会社 化粧料
US5208249A (en) * 1992-08-20 1993-05-04 Clintec Nutrition Co. Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate
JPH0665297A (ja) * 1992-08-21 1994-03-08 Hayashibara Biochem Lab Inc メラニン合成抑制蛋白質とその製造方法並びに用途
EP0650725A1 (en) * 1993-11-03 1995-05-03 FREE RADICAL SCIENCES Inc Compositions containing salts of L-2-oxothiazolidine-4-carboxylic acid and their use for stimulating intracellular glutathione
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US5624955A (en) * 1995-05-03 1997-04-29 Regents Of The University Of Minnesota Compounds that enhance the concentration of glutathione in tissues

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Publication number Publication date
ATE168005T1 (de) 1998-07-15
US6007827A (en) 1999-12-28
FR2742658A1 (fr) 1997-06-27
EP0780120B1 (fr) 1998-07-08
CA2193520C (fr) 2001-08-07
JPH09175927A (ja) 1997-07-08
KR100229696B1 (ko) 1999-11-15
ES2121463T3 (es) 1998-11-16
JP2885747B2 (ja) 1999-04-26
DE69600410T2 (de) 1998-10-29
DE69600410D1 (de) 1998-08-13
EP0780120A1 (fr) 1997-06-25
KR970032829A (ko) 1997-07-22
FR2742658B1 (fr) 1998-01-30
CA2193520A1 (fr) 1997-06-23

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