CN1158127A - 新的n-聚代萘并稠合内酰胺 - Google Patents

新的n-聚代萘并稠合内酰胺 Download PDF

Info

Publication number
CN1158127A
CN1158127A CN95195133A CN95195133A CN1158127A CN 1158127 A CN1158127 A CN 1158127A CN 95195133 A CN95195133 A CN 95195133A CN 95195133 A CN95195133 A CN 95195133A CN 1158127 A CN1158127 A CN 1158127A
Authority
CN
China
Prior art keywords
alkyl
hydrogen
amino
oxo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN95195133A
Other languages
English (en)
Chinese (zh)
Inventor
H-洛格森
B·S·汉森
B·比施克
T·K·汉森
K·E·安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN1158127A publication Critical patent/CN1158127A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN95195133A 1994-08-17 1995-08-17 新的n-聚代萘并稠合内酰胺 Pending CN1158127A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK0952/94 1994-08-17
DK95294 1994-08-17

Publications (1)

Publication Number Publication Date
CN1158127A true CN1158127A (zh) 1997-08-27

Family

ID=8099355

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95195133A Pending CN1158127A (zh) 1994-08-17 1995-08-17 新的n-聚代萘并稠合内酰胺

Country Status (16)

Country Link
US (1) US5817654A (cg-RX-API-DMAC10.html)
EP (1) EP0777668A1 (cg-RX-API-DMAC10.html)
JP (1) JPH10504293A (cg-RX-API-DMAC10.html)
CN (1) CN1158127A (cg-RX-API-DMAC10.html)
AU (1) AU697003B2 (cg-RX-API-DMAC10.html)
BR (1) BR9508805A (cg-RX-API-DMAC10.html)
CA (1) CA2196877A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ45897A3 (cg-RX-API-DMAC10.html)
HU (1) HUT76645A (cg-RX-API-DMAC10.html)
IL (1) IL114955A (cg-RX-API-DMAC10.html)
MX (1) MX9701187A (cg-RX-API-DMAC10.html)
NO (1) NO970684L (cg-RX-API-DMAC10.html)
PL (1) PL318633A1 (cg-RX-API-DMAC10.html)
TW (1) TW321640B (cg-RX-API-DMAC10.html)
WO (1) WO1996005195A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA956869B (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6211174B1 (en) 1997-10-31 2001-04-03 Merck & Co., Inc. Naphtho-fused lactams promote release of growth hormone
US6380184B1 (en) 1998-10-28 2002-04-30 Bristol-Myers Squibb Co. Benzoazepines and analogs thereof useful as growth hormone secretagogues
KR100699404B1 (ko) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
US6518292B1 (en) 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US6525203B1 (en) 1999-03-12 2003-02-25 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
ES2252230T3 (es) 2000-05-11 2006-05-16 Bristol-Myers Squibb Company Analogos de tetrahidroisoquinolina utiles como secretores de la hormona del crecimiento.
CN1473061A (zh) * 2000-09-08 2004-02-04 ���ܶ�����ҽԺ�о���չ���޹�˾ 抗血栓形成的组合物
WO2003041641A2 (en) 2001-11-09 2003-05-22 Bristol-Myers Squibb Company Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
MY196648A (en) 2016-02-05 2023-04-27 Denali Therapeutics Inc Inhibitors of Receptor-Interacting Protein Kinase 1
CN110383066B (zh) 2016-12-09 2023-03-31 戴纳立制药公司 化合物、组合物和方法
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone

Also Published As

Publication number Publication date
TW321640B (cg-RX-API-DMAC10.html) 1997-12-01
AU697003B2 (en) 1998-09-24
MX9701187A (es) 1997-05-31
WO1996005195A1 (en) 1996-02-22
IL114955A0 (en) 1995-12-08
JPH10504293A (ja) 1998-04-28
NO970684D0 (no) 1997-02-14
CA2196877A1 (en) 1996-02-22
HUT76645A (en) 1997-10-28
ZA956869B (en) 1996-04-10
US5817654A (en) 1998-10-06
EP0777668A1 (en) 1997-06-11
IL114955A (en) 1999-12-22
PL318633A1 (en) 1997-06-23
AU3161895A (en) 1996-03-07
CZ45897A3 (en) 1997-10-15
BR9508805A (pt) 1998-01-06
NO970684L (no) 1997-04-17

Similar Documents

Publication Publication Date Title
DE69331197T2 (de) Die freisetzung von wachstumshormon stimulierende benzoverknüpfte lactame
AU676501B2 (en) Benzo-fused lactams promote release of growth hormone
CN1158127A (zh) 新的n-聚代萘并稠合内酰胺
BG61448B1 (en) Benzocondensated lactams increasing the release of the growth hormone
EP0703222A1 (en) 3-aminoazepine compound and pharmaceutical use thereof
JPH08506579A (ja) 成長ホルモンの放出を促進するベンゾ縮合ラクタム類
JPH08502251A (ja) 成長ホルモンの放出を促進するベンゾ縮合ラクタム類
EP1060190B1 (en) New salt forms of (2e)- 5-amino-5- methylhex-2- enoic acid n-methyl-n-((1r)-1-(n- methyl-n-((1r)-1-(methylcarbamoyl)-2- phenylethyl)carbamoyl)-2- (2-naphtyl)ethyl)amide
US5438136A (en) Benzo-fused macrocycles promote release of growth hormone
JP2001513565A (ja) 新規なアミド誘導体
JP2002518482A (ja) β−アミロイドペプチド放出および／またはその合成を阻害する化合物
CN1269806A (zh) 用于治疗骨代谢疾病的含有一种精氨酸模拟物的肽,其制备方法,和含有这种化合物的药物
EP0508799A1 (en) Cholecystokinin antagonists
KR100753005B1 (ko) 1,5-벤조디아제핀 유도체 칼슘염 및 그의 제조법 및 이화합물을 유효 성분으로 하는 의약
JP2002542151A (ja) 成長ホルモン分泌促進物質としての新規なアミド誘導体
GB2330834A (en) Naphtho-fused lactams that stimulate release of growth hormone
JPH1072444A (ja) ベンゼン縮合ラクタム誘導体
JPWO1995021856A1 (ja) カルバモイルメチルウレア誘導体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication