CN115804744A

CN115804744A - Essence capable of reducing skin pruritus and erythema

Info

Publication number: CN115804744A
Application number: CN202211682518.9A
Authority: CN
Inventors: 王正汉; 任巍; 王正亚
Original assignee: Guangzhou Yanzhi Cosmetics Co ltd
Current assignee: Guangzhou Yanzhi Cosmetics Co ltd
Priority date: 2022-12-27
Filing date: 2022-12-27
Publication date: 2023-03-17
Anticipated expiration: 2042-12-27
Also published as: CN115804744B

Abstract

The invention discloses an essence capable of reducing skin pruritus and erythema, which comprises the following components in percentage by weight: 1-10wt% of golden flower white tea extract; 0.25-1.25wt% of Quercus variabilis bark extract; coconut oil 0.7-3.5wt%; 3-10wt% of lake water of the brook river; 0.2-2wt% of phytosterol/octyldodecanol lauroyl glutamate. The invention adopts the golden flower white tea extract, the quercus robur bark extract, the coconut oil, the mountain stream lake water and the phytosterol/octyldodecanol lauroyl glutamate with specific contents, and all components are mutually interacted and synergized, so that the prepared essence has excellent effects of relieving itching, repairing and reducing skin redness; each component has irreplaceability, the addition range of each component is also an optimal range, and the components are optimal ranges in the effects of relieving itching, repairing and reducing skin redness and the cost.

Description

Essence capable of reducing skin pruritus and erythema

Technical Field

The invention relates to the field of cosmetics, and particularly relates to essence capable of reducing skin pruritus and erythema.

Background

According to the incomprehensible sensitivity degree of skin, people with sensitive muscle can be classified into weak/light/moderate/severe sensitivity, and the skin sensitivity degree of 67.7% of sensitive muscle women in China is weak or mild at present and is expressed as pruritus/stabbing pain/redness; while 32.4% of women with sensitive muscles are moderately or severely sensitive and have sensitive manifestations of redness/inflammation. The main contributing factors that lead to an increasing incidence of skin sensitivity include: 1) External environment: affected by external factors such as season changes, living habits, overtime, and the like; 2) Curing and beautifying injuries: after medical and beauty treatment, the skin barrier is damaged in a short period, and sensitive phenomena are easily caused; 3) Wearing a mask: the mask can cause skin closure after being worn for a long time, and is easy to cause sensitivity, mouth closure and acne growth. The problem of sensitive muscles with the skin quality exceeding seven can be improved through daily maintenance and skin care, nearly five elements in the population with sensitive skins are slightly sensitive, stabbing pain, flushing and itching are main symptoms of the population with slight sensitivity, and as the incidence rate of skin sensitivity is continuously improved, the nursing consciousness of consumers is improved, so that high discussion degree is caused. The market demands products specially aiming at reducing the initial pruritus and redness of skin, and solves the skin problem of consumers in a mild sensitive period.

However, the anti-allergy soothing essence which is well sold in the market at present is declared, and the anti-inflammatory and anti-allergy component dipotassium glycyrrhizinate or the repairing component ceramide contained in the anti-allergy soothing essence cannot achieve the effects of better repairing skin barriers, reducing skin moisture loss, reducing skin erythema and reducing itching feeling.

Disclosure of Invention

In view of the above, in order to overcome the defects of the prior art, the invention provides an essence capable of reducing skin pruritus and erythema.

The technical problem of the invention is solved by the following technical scheme:

the essence capable of reducing skin pruritus and erythema comprises the following components in percentage by weight:

in some embodiments of the invention, the essence for reducing skin pruritus and erythema comprises the following components in percentage by weight:

0.5-1.5wt% of phytosterol/octyldodecanol lauroyl glutamate.

In some embodiments of the present invention, the essence for reducing skin pruritus and erythema further comprises the following components:

in some embodiments of the present invention, the effective components of the golden flower white tea extract are flavone and polysaccharide, and the content range is more than 0.7%. Ancient people had relatively accurate knowledge of the most basic medicinal value of white tea, and the white tea is considered to be cool in nature and capable of bringing down a fever, reducing internal heat, dispelling summer heat and detoxifying. The Qingren Zhou Liang Gong is written in Min Xiao Ji: it is a holy drug for measles because it is cold in nature and acts like rhinoceros horn. The golden flower white tea is prepared by selecting a first-class aged white tea raw material, introducing golden flowers on the traditional production process of the white tea, and grinding by adopting a natural flower growing process. The golden flower is also called golden flower fungus, is known as eurotium cristatum, belongs to probiotics, is a national secondary protection confidential strain, contains more than 450 components beneficial to human bodies, can effectively inhibit the breeding of other harmful bacteria, and is natural probiotic bacteria grown in tea leaves through an innovative flowering process under the condition of specific temperature and humidity. Has antioxidant and antibacterial effects. The Camellia Chysantha extract has effects of inhibiting macrophage inflammatory factor transcription expression and secretion, inhibiting neutrophil aggregation, reducing excessive skin sensitivity, increasing skin tolerance threshold, and resisting inflammation; also has the efficacy of promoting healing and repairing of injured tissues.

In some embodiments of the present invention, the functional component of the quercus variabilis bark extract is a triterpene compound, such as β -sitosterol, friedelane, betulin, etc., with a content of more than 50%. Quercus suber (the source of suberin, the major component of cork) is a botanical name, named a slow-growing, evergreen oak tree that grows in Mediterranean areas and usually lives for over 130-200 years. The extract of the bark of the European cork oak is obtained by performing a series of treatment modes on the Quercus suber, performing supercritical carbon dioxide extraction and 100% ecological technology, is rich in anti-inflammatory molecules, beta-sitosterol, friedelane, betulin and the like, and has the skin care effects of resisting free radicals, reducing the secretion of a cell inflammatory factor TNF-alpha, preventing skin erythema and increasing the content of collagen in the skin.

In some embodiments of the invention, the mountain water of the mountain stream lake water is rich in minerals and trace elements, the total amount of the minerals is 2.5-3.5%, the minerals contain 1015mg/L of sulfur, magnesium is more than 1000ppm, potassium is more than 220ppm, sodium is more than 7500ppm, calcium is more than 215mg/L, and the mountain water has the effects of refreshing, purifying and relaxing the skin and can relieve the hyperemia symptom of the skin.

In some embodiments of the invention, the phytosterol/octyldodecanol lauroyl glutamate has a structure similar to intercellular lipid, can supplement intercellular lipid to achieve an effect superior to that of ceramide, and the product utilizes a high-pressure emulsification mode to enable the particle size of the phytosterol/octyldodecanol lauroyl glutamate to reach 50-200nm, so that the product efficacy is greatly improved, and the product is convenient to use in an aqueous solution.

In some embodiments of the present invention, the coconut oil is cocoa coconut, which is a green industrially produced medium-chain length triglyceride through a cold pressing process, has high tolerance with skin, is very easy to be absorbed on skin, and can promote the absorption and permeation of the quercus variabilis bark extract on skin. The coconut oil has the chain length of C6-C12 and the melting point of 26-32 ℃.

Compared with the prior art, the invention has the following beneficial effects:

1) According to the invention, the golden flower white tea extract, the quercus suber bark extract, the coconut oil, the river lake water and the phytosterol/octyldodecanol lauroyl glutamate with specific contents are adopted, and the components interact with each other to realize synergistic interaction, so that the prepared essence has excellent effects of relieving itching, repairing and reducing skin redness, and is a very excellent product for sensitive muscles.

2) A large number of experiments prove that the essence has effectiveness, each component cannot be replaced, the addition range of each component in the essence is also an optimal range, and the optimal range is provided in the effects of relieving itching, repairing and reducing skin redness and the cost. In conclusion, the essence disclosed by the invention is economical and effective and has the function of reducing skin pruritus and erythema.

Drawings

FIG. 1 is a section of an arm of a volunteer during an experiment;

FIG. 2 shows the skin redness of volunteers at 0 hour, 24 hours and 48 hours after using example 2 of the present invention;

FIG. 3 shows the skin redness of volunteers at 0 hour, 24 hours and 48 hours after using example 1 of the present invention;

FIG. 4 shows the skin redness of the volunteers at 0 hour, 24 hours and 48 hours after the application of example 3 of the present invention.

Detailed Description

The present invention is further described in detail below with reference to specific examples, which are provided for illustration only and are not intended to limit the scope of the present invention. The test methods used in the following examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are, unless otherwise specified, commercially available reagents and materials.

The Camellia Chysantha extract is purchased from International medicine and health limited of Chinese medicine (Guangzhou);

bark extract of Quercus suber, purchased from Hallstar yield AND Personal CARESOLUTIONS COMPANY;

coconut oil, purchased from HALSTAR BEAUTY AND PERSONAL CARE SOLUTION SCOMPANY;

rivastigmine lake waters, purchased from Xianting (Guangzhou) trade Limited;

phytosterol/octyldodecanol lauroyl glutamate, purchased from AJINOMOTO co, INC.

Examples 1 to 3 and comparative examples 1 to 9: preparation of essence capable of reducing skin pruritus and erythema

The essence capable of reducing skin pruritus and erythema is obtained according to the proportion and the operation steps in the table 1, and is specifically shown in the table 1.

TABLE 1

Description of the invention:

1. the comparative example 1 is the essence obtained by replacing the golden flower white tea extract in the essence of the embodiment 1 of the invention with the commonly used anti-inflammatory and anti-allergy ingredient dipotassium glycyrrhizinate;

2. comparative example 2 is an essence obtained by replacing the oak bark extract and coconut oil of cork oak bark, which are anti-inflammatory and anti-allergic ingredients commonly used in industry, with dipotassium glycyrrhizinate, which is an essential oil of example 1 of the present invention;

3. comparative example 3 is an essence obtained by replacing phytosterol/octyldodecanol lauroyl glutamate and the water of the stream lagoon with a repair ingredient ceramide commonly used in the industry in the essence of example 1 of the present invention;

4. comparative examples 4 to 8 are the essences obtained by adding only one of the active ingredients of the present invention to the maximum amount;

5. comparative example 9 is an essence obtained by adding each of the active ingredients of the present invention in an amount higher than the maximum concentration of the present invention;

6. comparative example 10 is a commercially available anti-allergy soothing essence in a good amount.

Verification of essence solutions described in examples 1 to 3 and comparative examples 1 to 10 for reducing skin itch and erythema

1. Testing the instrument:

1. the invention uses a finland Delfin vapoMeter SWL5201 percutaneous water loss measuring instrument, and the vapoMeter uses a closed cavity measuring principle, so that the measurement is not influenced by indoor air flow. The measurement time is short, ensuring the minimum of the blockage of normal evaporation.

2. Photographs were taken using Delfin antra 3D, finland, the antra 3D using innovative optical methods and complex mathematical algorithms to acquire three-dimensional images. This allows data to be extracted from the image relating to the three-dimensional shape of the skin, which will enable quantification of the effect of the treatment and monitoring of the condition over time. For example, the texture, smoothness of the skin, and depth and width of fine lines and wrinkles are measured. With its multispectral analysis, the Antera software can also measure pigmentation and redness, which will provide meaningful information about sun damage, veins, etc.

2. The experimental principle is as follows:

TEWL value, transdermal water loss (TEWL), measures the change in the vapor pressure of moisture near the surface of the skin. TEWL values represent the loss of water from the stratum corneum and are an important criterion for evaluating the barrier function of the stratum corneum. A lower TEWL value of the skin indicates a better barrier function of the skin, whereas the opposite is the worse. The efficacy of the moisturizing and repairing cosmetic can be evaluated by testing the TEWL value of the skin moisture loss, and the method can also be applied to allergic patch test, contact dermatitis, physical therapy, burn and monitoring of new tissues, so as to find out whether the protective function of the skin is damaged or not in time. Wherein the unit of TEWL is: g/hm ³ . 3. Testing the population:

40 persons in each group, 3 groups in total, and volunteers with the age of 18-60 years according with the experimental requirements.

4. And (3) testing conditions are as follows:

subjects rested for 30 minutes at room temperature 20 ± 2 ℃ and relative humidity 50 ± 10% and were monitored dynamically in real time and were retested for relevant data.

5. The experimental process comprises the following steps:

1. establishment of impaired skin barrier

Injecting 200 μ L + -10 μ L sodium dodecyl sulfate solution 1% (w/w) into the cell, infiltrating the filter paper sheet, applying to the left and right forearm of the subject with hypoallergenic tape, wherein the edge distance between adjacent cells is not less than 3cm, and applying to skin by pressing with palm for 24 hr.

2. After removing the spot tester, the testee sits still for 30min in a standard test environment (after the indentation disappears), a tester uses a Delfin Vapometer to measure TEWL values at the central position of each spot test area of the testee, each area is measured, and the measurement result is expressed by the average value of the TEWL values of three spot test areas and is used as an initial value (TEWL 0); photographing each spot test area of the subject by using a Delfin Antera3D camera, analyzing by using an instrument, and setting the average value of the measurement of the three spot test areas as a redness initial value as RED0;

3. randomly smearing samples on the left and right arms to ensure that the balance is achieved statistically;

4. samples were distributed to subjects and allowed to smear according to the instructions, the sample application required complete coverage of the entire plaque area. Measuring the using amount of the sample by using an analytical balance for 48 hours;

5. before each test, cleaning the tested part with clear water, drying with a non-scrap absorbent dry paper towel, and resting in a constant-temperature and constant-humidity environment (temperature: 20-22 ℃, relative humidity 40-60%) for 30min, so that water and beverage can not be drunk, the tested person keeps relaxed, and the spot sticking area is prevented from being touched;

6. according to the use requirements, the test subject makes a return visit at 24h and 48h after using the sample, the volunteers fill in questionnaires, the skin condition of the tested area of the volunteers is recorded, the test room is entered 30 minutes in advance for rest, and the test step of T0 is repeated;

7. testing parts: experiments were performed with arm zones as shown in FIG. 1

The first set of zone Z1 used example 1, zone Z2 used comparative example 3, zone Z3 used comparative example 1, zone Z4 used comparative example 2, and zone Z5 blank;

the second set of zone Z1 used example 1, zone Z2 used example 3, zone Z3 used comparative example 10, zone Z4 used example 2, zone Z5 blank, zone Z6 used comparative example 9;

the third set of zone Z1 used example 1, zone Z2 used comparative example 5, zone Z3 used comparative example 7, zone Z4 used comparative example 4, zone Z5 used comparative example 6, and zone Z6 used comparative example 8.

6. The experimental results are as follows:

1. skin transdermal Water loss Rate (TEWL) test

The test sets the subject's measured TEWL on day 0 as TEWL0, TEWL after 24 hours as TEWL1, TEWL after 48 hours as TEWL2, TEWL variance as Δ TEWL,. DELTA.tewl = TEWL2-TEWL0, TEWL variance =Δtewl/TEWL0 100%, TEWL variance is negative and the lower the number, the less water lost from the skin after 48 hours, the better the skin barrier function repaired and the healthier the skin, table 1 shows the average Δ TEWL values for each group as shown in table 2 below:

TABLE 2

First group	TEWL Change Rate (%)	Second group	TEWL Change Rate (%)	Third group	TEWL Change Rate (%)
						Example 1	-15.350	Example 1	-17.516	Example 1	-16.427
Comparative example 1	-9.851	Example 2	-31.084	Comparative example 4	-12.184
						Comparative example 2	-8.273	Example 3	-43.118	Comparative example 5	-10.837
Comparative example 3	-11.715	Comparative example 9	-29.764	Comparative example 6	-6.912
						Blank group	-5.341	Comparative example 10	-12.416	Comparative example 7	-6.435
		Blank group	-6.284	Comparative example 8	-9.331

2. Average skin redness results analysis

The test set the average RED-burning value RED of the skin on the 0 th day measured by the subject as RED0, RED1 after 24 hours, RED2 after 48 hours, RED change value as Δ RED = RED2-RED0, RED change rate =Δred/RED0 x 100%, RED change rate is negative, and the lower the value, the smaller the RED-burning degree of the skin after 48 hours, i.e. the less the inflammatory reaction inside the skin, the lower the allergic symptoms, the better the product relieves the allergy, and reduces the erythema. Table 2 shows the average Δ RED values for each set, as shown in table 3 below;

TABLE 3

3. Volunteer questionnaire

According to the statistics of the questionnaire of the volunteers, 100% of the volunteers using the examples considered that the product had reduced itching and tingling sensation, and wanted to scratch the test area without subjective will; the use of comparative example in 50% of volunteers was considered to reduce the itching, tingling sensation, and 50% of volunteers had the sensation of trying to scratch the test area.

The experimental results show that:

according to the above experimental conclusion, it can be seen that:

1. the first group of results, namely the TEWL change rate and the RED change rate, are comparative examples 1-3 and example 1, and show that the active ingredients in the essence provided by the invention are arbitrarily changed into the common ingredients with good anti-allergy and repairing effects, so that the effects of better repairing skin barriers, reducing skin moisture loss, reducing skin erythema and reducing itching feeling cannot be achieved.

2. The second group of results, the TEWL change rate and the RED change rate, the comparative example 10, the example 1, the comparative example 9, the example 2 and the example 3 show that the TEWL change rate and the RED change rate become smaller correspondingly as the addition amount of the active ingredients of the essence liquid is higher, namely, the skin moisture loss is smaller, the skin redness symptom is smaller, the stratum corneum barrier function of the skin is more complete, the skin is not easy to lose moisture, and the effect of reducing the skin erythema is better. The comparative example 9 is to improve the active ingredients of the essence of the invention, but the experimental results prove that the content of each ingredient is improved blindly, so that the skin barrier can not be repaired better and the skin redness symptom can not be relieved, and therefore, the content interval of the essence of the invention is the interval with the best effect. The essence of comparative example 10 is inferior to the essence of the present invention in terms of repairing skin barrier and reducing redness, thus indicating that the essence of the present invention is a very excellent product for reducing skin sensitivity symptoms, and reducing skin redness and itching.

3. The third group of results, the TEWL change rate and the RED change rate, comparative examples 4-8 and example 1 show that the effect of repairing skin barrier, reducing erythema and reducing skin pruritus is not as good as that of the essence of the invention when only one active ingredient in the essence of the invention is added and the instant addition amount reaches the maximum value.

4. Test Picture comparison

Before and after selecting partial arm redness images of volunteers using examples 1-3 of the present invention, detailed images are shown in fig. 2-4 respectively, and it can be seen from the figures that the reduction of skin redness is more obvious using examples 1 and 2 as shown in fig. 2 and 3, and the reduction of skin redness is most obvious using example 3 as shown in fig. 3, which shows that the ability of the essence of the present invention to reduce skin redness is very excellent.

Claims

1. The essence capable of reducing skin pruritus and erythema is characterized by comprising the following components in percentage by weight:

2. the essence capable of reducing skin pruritus and erythema according to claim 1, which is characterized by comprising the following components in percentage by weight:

3. the essence capable of reducing skin itch and erythema according to claim 1 or 2, wherein the essence further comprises the following basic components:

4. the essence capable of reducing skin itch and erythema according to claim 1 or 2, wherein the effective components of the Camellia Chysantha extract are flavones and polysaccharides, and the content range is more than 0.7%.

5. The essence for reducing skin itch and erythema according to claim 1 or 2, wherein the functional component of the quercus suber bark extract is a triterpene compound with a content of more than 50%.

6. The essence capable of reducing skin itch and erythema according to claim 1 or 2, wherein the total amount of minerals in the stream lake waters is 2.5-3.5%, contains 1015mg/L of sulfur, 1000ppm of magnesium, 220ppm of potassium, 7500ppm of sodium, and 215mg/L of calcium.

7. The essence capable of reducing skin itch and erythema according to claim 1 or 2, characterized in that the particle size of the phytosterol/octyldodecanol lauroyl glutamate is 50-200nm.

8. The essence capable of reducing skin itch and erythema according to claim 1 or 2, wherein the coconut oil has a chain length of C6-C12 and a melting point of 26-32 ℃.