CN115645484B - Traditional Chinese medicine composition for treating bone fracture diseases and preparation method, preparation and application thereof - Google Patents
Traditional Chinese medicine composition for treating bone fracture diseases and preparation method, preparation and application thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a traditional Chinese medicine composition for treating bone fracture diseases, and a preparation method, a preparation and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: radix Paeoniae Rubra, polyporus, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Akebiae, radix et rhizoma Rhei, rhizoma corydalis, myrrha, carthami flos, sanguis Draxonis, scutellariae radix, and Glycyrrhrizae radix. The Chinese medicinal composition can promote blood circulation, remove blood stasis, reduce swelling and relieve pain; relieving pain of the patient and promoting porosis and remodeling; meanwhile, the Chinese medicinal composition has the effects of clearing away heat, protecting spleen and stomach, tonifying middle-jiao and Qi, and preventing diseases. Can be used for treating bone injury with good therapeutic effect and low adverse side effect.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating bone fracture diseases, and a preparation method, a preparation and application thereof.
Background
Bone fracture diseases are common and frequently encountered diseases in clinic, and the common bone fracture diseases comprise fracture, muscle and bone contusion, joint injury, acute and chronic soft tissue injury, joint muscle strain, neck, shoulder, waist, leg pain and the like. About one fifth of the population in China suffers from bone fracture every year, and patients are temporarily disabled or disabled for life. Severely affecting the quality of life of the patient's individuals and families. Bone fracture diseases are often divided into hematoma mechanized stage, poroma forming stage and poroma remodelling stage, and the three stages are treated by differentiation: in early injury (hematoma mechanized stage), due to qi stagnation and blood stasis, local swelling and pain, the medicine is used for promoting blood circulation and removing blood stasis, and relieving swelling and pain (elimination method); although the blood stasis and swelling in the middle stage of injury (callus formation stage) are reduced, the blood stasis and swelling are not removed, and the medicine is used for paying attention to and earn a living new bone reunion (and method); later stage of injury (callus remodelling stage) is to connect tendons and bones, and tonify liver and kidney (tonic method). The haematoma mechanized stage is a fibrous healing stage, mainly because peripheral blood vessels are broken and bleeding occurs after bone injury, so that haematoma is formed, and finally, a blood clot containing reticular cellulose is formed. The haematoma mechanized stage is a key stage of healing of the fibrous system of a patient. When the angiogenesis of a patient breaks, a certain hematoma phenomenon can be formed, the hematoma phenomenon can be coagulated in 6-8 hours of illness, the blood clot presents reticular cellulose, the traditional Chinese medicine records that the blood is not alive, the blood stasis cannot be connected, the phenomena of blood stasis swelling, qi and blood movement obstruction and the like can occur at the injury part of the patient in the hematoma mechanized stage, the effective treatment of activating blood and dissolving stasis can not be carried out, and the formation and remodeling of the callus in the middle and later stages can be seriously influenced. Therefore, the effective treatment of activating blood circulation to dissipate blood stasis is particularly important when the patient is subjected to hematoma in the mechanized stage.
At present, the diagnosis and treatment thought of Western medicine on bone fracture diseases mainly comprises medicine pain relieving and operation resetting, or plaster is used for fixing diseased parts, and the Western medicine is often matched with infusion or oral antibacterial and anti-inflammatory medicines, and mainly depends on the healing capacity of a patient body. In many cases, surgical incision, reduction and internal fixation are also needed, even antibiotics are applied, the pain of patients is hard in the healing process, the healing effect is different from person to person, and the patients cannot heal or have poor healing effect; on the other hand, the patients can not exercise early functions due to pain and swelling or plaster fixation, and the affected parts often remain problems of limited functional recovery, sequelae such as pain, damage to other tissues and organs of the organism caused by antibiotics and the like after treatment.
Therefore, the invention is very necessary to provide a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis in time aiming at bone fracture diseases, which not only can detumescence, analgesia and relieving pain of patients, but also can promote blood circulation to remove blood stasis and promote poroma formation and remodeling, and can also prevent and treat other organism problems possibly occurring in the course of the patients through the traditional Chinese medicine composition.
Disclosure of Invention
The invention aims at providing a traditional Chinese medicine composition.
The second aspect of the present invention is to provide a method for preparing the traditional Chinese medicine composition of the first aspect of the present invention.
The invention aims at providing the application of the traditional Chinese medicine composition in the preparation of the medicine for treating bone fracture diseases.
The fourth aspect of the present invention aims to provide a preparation comprising the traditional Chinese medicine composition of the first aspect of the present invention.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
The invention provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 6 to 24 parts of red paeony root, 6 to 24 parts of grifola, 6 to 24 parts of angelica, 3 to 20 parts of szechuan lovage rhizome, 3 to 12 parts of akebia stem, 3 to 30 parts of rhubarb, 3 to 20 parts of rhizoma corydalis, 3 to 10 parts of myrrh, 3 to 20 parts of safflower, 3 to 12 parts of dragon's blood, 3 to 20 parts of baical skullcap root and 2 to 20 parts of liquoric root.
According to a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 24 parts of red paeony root, 10 to 20 parts of grifola, 10 to 24 parts of angelica, 6 to 18 parts of szechuan lovage rhizome, 5 to 10 parts of akebia stem, 8 to 25 parts of rhubarb, 6 to 20 parts of rhizoma corydalis, 5 to 10 parts of myrrh, 5 to 15 parts of safflower, 5 to 10 parts of dragon's blood, 6 to 18 parts of baical skullcap root and 3 to 15 parts of liquoric root.
According to a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of red paeony root, 15 parts of polyporus umbellatus, 15 parts of Chinese angelica, 12 parts of szechuan lovage rhizome, 8 parts of akebia stem, 15 parts of rhubarb, 12 parts of rhizoma corydalis, 6 parts of myrrh, 10 parts of safflower, 8 parts of dragon's blood, 12 parts of baical skullcap root and 10 parts of liquoric root.
According to a preferred embodiment of the present invention, the angelica is wine angelica.
According to a preferred embodiment of the present invention, the rhubarb is charcoal.
According to a preferred embodiment of the present invention, the rhizoma corydalis is vinegar-processed rhizoma corydalis.
According to a preferred embodiment of the present invention, the myrrh is a vinegar myrrh.
According to a preferred embodiment of the present invention, the baikal skullcap root is baikal skullcap root.
In a second aspect of the present invention, there is provided a method for preparing the Chinese medicinal composition of the first aspect, wherein the method comprises extracting radix Paeoniae Rubra, polyporus, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Akebiae, radix et rhizoma Rhei, rhizoma corydalis, myrrha, carthami flos, sanguis Draxonis, scutellariae radix, and Glycyrrhrizae radix with water or ethanol to obtain the Chinese medicinal composition.
According to a preferred embodiment of the present invention, the alcohol content of the alcohol extract is 55-75%.
According to a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the raw materials with water, extracting for 2-4 times to obtain the traditional Chinese medicine composition.
According to a preferred embodiment of the present invention, the radix paeoniae rubra, polyporus, rhizoma ligustici wallichii, rheum officinale and liquorice are cut into 2-4 mm thick slices before mixing.
According to a preferred embodiment of the present invention, the angelica, akebia stem and baikal skullcap root are cut into 1-2 mm slices before mixing.
According to a preferred embodiment of the present invention, the rhizoma corydalis and the dragon's blood are smashed to 80-150 meshes before mixing.
According to a preferred embodiment of the invention, the mass ratio of the raw materials to water is 1 (4-10); further 1 (6.5-6.8).
According to a preferred embodiment of the invention, the mixing further comprises soaking for 1 to 1.5 hours.
According to a preferred embodiment of the invention, the extraction time is between 0.5 and 1 h/time.
According to a preferred embodiment of the present invention, the extraction method is at least one of decoction, impregnation, percolation, reflux, continuous reflux, and ultrasonic.
In a third aspect, the invention provides the use of the Chinese medicinal composition of the first aspect of the invention in the preparation of a medicament for treating bone fracture diseases.
According to a preferred embodiment of the invention, the bone fracture disease is a hematoma mechanized bone fracture disease.
In a fourth aspect of the present invention, there is provided a formulation of the Chinese medicinal composition of the first aspect of the present invention.
According to a preferred embodiment of the invention, the formulation further comprises pharmaceutically acceptable excipients.
According to a preferred embodiment of the present invention, the pharmaceutically acceptable auxiliary material is at least one of a diluent, a filler, a wetting agent, an adhesive, a disintegrant, a lubricant, a plasticizer, a colorant, an excipient, a flavoring agent, a preservative, a surfactant, a permeation enhancer, and an emulsifier.
According to a preferred embodiment of the present invention, the formulation is in the form of one of powder, decoction, mixture, granule, tablet, pill, capsule, bath agent, medicated wine, tincture, ointment, decoction, cream, paste, plaster, emplastrum, aerosol, spray, powder mist and film.
The beneficial effects of the invention are as follows:
The invention provides a traditional Chinese medicine composition, which is prepared from the following raw materials: radix Paeoniae Rubra, polyporus, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, caulis Akebiae, radix et rhizoma Rhei, rhizoma corydalis, myrrha, carthami flos, sanguis Draxonis, scutellariae radix, and Glycyrrhrizae radix; the traditional Chinese medicine composition can be used for treating bone fracture diseases, and can quickly and effectively activate blood circulation to dissipate blood stasis, reduce swelling and relieve pain; relieving pain of the patient and promoting porosis and remodeling; meanwhile, the Chinese medicinal composition has the effects of clearing away heat, protecting spleen and stomach, tonifying middle-jiao and Qi, and preventing diseases.
The invention has the advantages of quick and obvious curative effect on fracture, dislocation, injury of tendons (soft tissue injury) and other diseases by carrying various dosage forms through long-term clinical verification, and can be effectively applied to the treatment of bone injury diseases.
Detailed Description
The invention is further illustrated, but is not limited in any way, by the following examples, and any alterations or substitutions based on the teachings of the invention are within the scope of the invention.
In the traditional Chinese medicine composition provided by the invention, chinese angelica, red paeony root, safflower, szechuan lovage rhizome, myrrh, dragon's blood and rhubarb are used together, so that the effect of promoting blood circulation and removing blood stasis is greatly improved; the akebia stem has the effects of removing dampness, inducing diuresis and relieving swelling; rhizoma corydalis is used together with radix Paeoniae Rubra, myrrha, carthami flos and Glycyrrhrizae radix, and has analgesic effect; rhubarb, baical skullcap root and liquoric root remove stasis and heat, and prevent the disease; licorice root, radix Glycyrrhizae Praeparata, has the effects of protecting the spleen and stomach, invigorating the middle warmer and replenishing qi, and harmonizing the drugs; the five groups of medicines are reasonable in compatibility and complement each other, and together play the roles of removing blood stasis, reducing swelling and relieving pain. Can be used for treating fracture, dislocation, injury of tendons, and early stage of injury with high pertinence. Has strong effects of removing blood stasis, detumescence and relieving pain, and can remove blood stasis and heat, care spleen and stomach, tonify middle-jiao and replenish qi, and prevent diseases.
Radix paeoniae rubra: is dried root of Paeonia lactiflora Paeonia lactiflora pall. Or Paeonia suffruticosa VEITCHII LYNCH belonging to Ranunculaceae. Bitter and slightly cold. Enter liver meridian. Clear heat and cool blood, dissipate blood stasis and relieve pain. Can be used for treating heat-induced ying blood, toxic heat, speckle, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling and sore.
Polyporus umbellatus). Is dried sclerotium of Polyporaceae fungus Polyporus Polyporus umbellatus (Pers.) Fries. Sweet, light and flat. Enter kidney and bladder meridians. Induce diuresis and excrete dampness. Can be used for treating dysuria, edema, diarrhea, stranguria with turbid urine, and leukorrhagia.
Chinese angelica root: is the dry root of Angelica sinensis ANGELICA SINENSIS (Oliv.) Diels of Umbelliferae. Sweet, pungent and warm. It enters liver, heart and spleen meridians. Replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, skin ulcer, and constipation due to intestinal dryness. The wine angelica can promote blood circulation and promote menstruation. Can be used for treating amenorrhea dysmenorrhea, rheumatalgia, traumatic injury.
Ligusticum wallichii: is dried rhizome of Ligusticum chuanxiong Ligusticum chuanxiong Hort belonging to Umbelliferae. Pungent and warm. Enter liver, gallbladder and pericardium meridians. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for treating chest pain, hypochondrium pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal pain, headache, and rheumatalgia.
Akebia stem: is dried rattan of Akebia stem Akebia quinata (thunder.) of family Akebiaceae, decne, akebia trifoliata Akebia trifoliata (thunder.) of family Akebiaceae, koidz, or Akebia alba Akebia trifoliata (thunder.) Koidz, var, australis (Diels) Red. Bitter and cold. It enters heart, small intestine and bladder meridians. Induce diuresis to treat stranguria, clear heart and relieve restlessness, and promote menstruation and promote lactation. Can be used for treating stranguria, edema, vexation, dark urine, aphtha, amenorrhea, oliguria, and damp-heat arthralgia.
Rhubarb: is the dry root and rhizome of Rheum palmatum L.Thunb Rheum tanguticum Maxim. Ex Bal.Thermopsis glabra of Polygonaceae or Rheum officinale bail1. The dry root and rhizome of Rheum officinale. Bitter and cold. It enters spleen, stomach, large intestine, liver and pericardium meridians. Purgation and accumulation, clearing heat and purging fire, cooling blood and detoxicating, removing blood stasis and dredging channels, promoting diuresis and removing jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, acute carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it is used for treating burn and scald. The upper jiao blood system heat toxin of the wine is Huang Shanqing and is used for conjunctival congestion, pharyngeal swelling and gingival swelling and pain. The cooked rhubarb has the functions of purging the lower power, purging the pathogenic fire and removing toxin, and is used for treating sores and ulcers caused by fire toxin. The rhubarb charcoal is used for cooling blood, removing blood stasis and stopping bleeding and is used for treating bleeding caused by blood heat and blood stasis.
Rhizoma corydalis: is dried tuber of corydalis tuber Corydalis yanhusuo W.T.Wang of Papaveraceae. Pungent and bitter, warm. Enter liver and spleen meridians. Promoting blood circulation, promoting qi circulation, and relieving pain. Can be used for treating chest pain, hypochondrium pain, abdominal pain, chest pain, amenorrhea, dysmenorrhea, puerperal stagnation, and traumatic injury.
Myrrh: is a dry resin of the olive plant Ding Shu Commiphora myrrha Engl. Or the Hadi Ding Shu Commiphora molmol Engl. In the family of Oleraceae. Pungent, bitter and flat. It enters heart, liver and spleen meridians. Removing blood stasis, relieving pain, detumescence and promoting granulation. Can be used for treating chest pain, pain in stomach, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, abdominal pain, rheumatalgia, traumatic injury, carbuncle, swelling and ulcer.
Safflower: is dried flower of safflower Carthamus tinctorius L. Pungent and warm. It enters heart and liver meridians. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochia, abdominal mass, chest pain, abdominal pain due to blood stasis, thorny chest and hypochondrium, traumatic injury, and swelling and pain.
Dragon's blood: is resin extracted from lipid-containing wood of Broussonetia kazinoki Dranaenacochinchinensis (Lour.) S.C.Chen of Liliaceae. Sweet, spicy, salty, warm, enter lung, spleen and kidney meridians. Promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, healing sore and promoting tissue regeneration. Can be used for treating traumatic injury, pain due to blood stasis, stagnation of qi and blood, traumatic hemorrhage, and persistent abscess.
Radix Scutellariae Baicalensis: is dry root of Scutellaria baicalensis Georgi Scutellaria baicalensis Georgi belonging to Labiatae. Bitter and cold. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Clear heat and dry dampness, purge fire and detoxify, stop bleeding and prevent abortion. Can be used for treating damp-heat, summer-heat, chest distress, emesis, damp-heat distention and fullness, dysentery, jaundice, cough due to lung heat, polydipsia due to high fever, hematemesis, epistaxis, carbuncle, swelling, sore, and fetal movement.
Licorice root: is the dry root and rhizome of Glycyrrhiza uralensis Glycyrrhiza uralensis Fisch. Glycyrrhiza uralensis Glycyrrhiza inflata bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Of Leguminosae. Sweet and flat. It enters heart, lung, spleen and stomach meridians. Spleen invigorating, qi replenishing, heat and toxic materials clearing away, phlegm eliminating, cough relieving, pain relieving, and medicines regulating. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity.
Example 1A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 24 parts of red paeony root, 15 parts of polyporus umbellatus, 24 parts of Chinese angelica, 20 parts of szechuan lovage rhizome, 8 parts of akebia stem, 30 parts of rhubarb, 12 parts of rhizoma corydalis, 10 parts of myrrh, 20 parts of safflower, 12 parts of dragon's blood, 12 parts of baical skullcap root and 11 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) Taking 24g of red paeony root, 15g of Polyporus, 24g of Chinese angelica, 20g of szechuan lovage rhizome, 8g of akebia stem, 30g of rhubarb, 12g of rhizoma corydalis, 10g of myrrh, 20g of safflower, 12g of dragon's blood, 12g of baical skullcap root and 11g of liquorice;
(2) Treating the above raw materials (except myrrh and safflower): cutting radix Paeoniae Rubra, polyporus, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, and Glycyrrhrizae radix to 4mm thick pieces, cutting radix Angelicae sinensis, caulis Akebiae, and Scutellariae radix to 2mm thin pieces, mashing rhizoma corydalis and sanguis Draxonis to 80 mesh; placing the treated raw materials, myrrh and safflower into a decocting container;
(3) Adding 1280ml of water, soaking for 1.5h, heating to boiling with strong fire, decocting with slow fire for 1h, and filtering to obtain filtrate; repeating for 2 times, mixing the filtrates, and making into Chinese medicinal composition.
Example 2A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 6 parts of red paeony root, 24 parts of Polyporus, 6 parts of Chinese angelica, 3 parts of szechuan lovage rhizome, 12 parts of akebia stem, 3 parts of rhubarb, 3 parts of rhizoma corydalis, 3 parts of myrrh, 3 parts of safflower, 3 parts of dragon's blood, 3 parts of baical skullcap root and 2 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) Taking 6g of red paeony root, 24g of Polyporus, 6g of Chinese angelica, 3g of szechuan lovage rhizome, 12g of akebia stem, 3g of rhubarb, 3g of rhizoma corydalis, 3g of myrrh, 3g of safflower, 3g of dragon's blood, 3g of baical skullcap root and 2g of liquorice;
(2) Treating the above raw materials (except myrrh and safflower): cutting radix Paeoniae Rubra, polyporus, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, and Glycyrrhrizae radix to 2mm thick pieces, cutting radix Angelicae sinensis, caulis Akebiae, and Scutellariae radix to 1mm thin pieces, mashing rhizoma corydalis and sanguis Draxonis to 150 mesh; placing the treated raw materials, myrrh and safflower into a decocting container;
(3) Adding 430ml of water, soaking for 1h, heating to boiling with strong fire, decocting with slow fire for 0.5h, and filtering to obtain filtrate; repeating for 4 times, and mixing the filtrates to obtain the final product.
Example 3A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 15 parts of red paeony root, 18 parts of polyporus umbellatus, 15 parts of Chinese angelica, 12 parts of szechuan lovage rhizome, 9 parts of akebia stem, 16 parts of rhubarb, 3 parts of rhizoma corydalis, 12 parts of myrrh, 12 parts of safflower, 8 parts of dragon's blood, 20 parts of baical skullcap root and 20 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) 15g of red paeony root, 18g of polyporus umbellatus, 15g of Chinese angelica, 12g of szechuan lovage rhizome, 9g of akebia stem, 16g of rhubarb, 3g of rhizoma corydalis, 12g of myrrh, 12g of safflower, 8g of dragon's blood, 20g of baical skullcap root and 20g of liquoric root;
(2) Treating the above raw materials (except myrrh and safflower): cutting radix Paeoniae Rubra, polyporus, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, and Glycyrrhrizae radix to 3mm thick pieces, cutting radix Angelicae sinensis, caulis Akebiae, and Scutellariae radix to 1.5mm thin pieces, mashing rhizoma corydalis and sanguis Draxonis to 80 mesh; placing the treated raw materials, myrrh and safflower into a decocting container;
(3) Adding 960ml of water, soaking for 1.5h, heating to boiling with strong fire, decocting with slow fire for 1h, and filtering to obtain filtrate; repeating for 2 times, mixing the filtrates, and making into Chinese medicinal composition.
Example 4A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 18 parts of red paeony root, 6 parts of polyporus umbellatus, 18 parts of Chinese angelica, 14 parts of szechuan lovage rhizome, 3 parts of akebia stem, 22 parts of rhubarb, 20 parts of rhizoma corydalis, 8 parts of myrrh, 14 parts of safflower, 8 parts of dragon's blood, 14 parts of baical skullcap root and 16 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) Taking 18g of red paeony root, 6g of Polyporus, 18g of Chinese angelica, 14g of szechuan lovage rhizome, 3g of akebia stem, 22g of rhubarb, 20g of rhizoma corydalis, 8g of myrrh, 14g of safflower, 8g of dragon's blood, 14g of baical skullcap root and 16g of liquorice;
(2) Treating the above raw materials (except myrrh and safflower): cutting radix Paeoniae Rubra, polyporus, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, and Glycyrrhrizae radix to 2mm thick pieces, cutting radix Angelicae sinensis, caulis Akebiae, and Scutellariae radix to 1mm thin pieces, mashing rhizoma corydalis and sanguis Draxonis to 80 mesh; placing the treated raw materials, myrrh and safflower into a decocting container;
(3) Adding 1100ml of water, soaking for 1h, heating to boiling with strong fire, decocting with slow fire for 0.5h, and filtering to obtain filtrate; repeating for 4 times, and mixing the filtrates to obtain the final product.
Example 5A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 6 parts of red paeony root, 6 parts of polyporus umbellatus, 6 parts of Chinese angelica, 12 parts of szechuan lovage rhizome, 8 parts of akebia stem, 16 parts of rhubarb, 18 parts of rhizoma corydalis, 7 parts of myrrh, 13 parts of safflower, 7 parts of dragon's blood, 12 parts of baical skullcap root and 10 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) Taking 6g of red paeony root, 6g of Polyporus, 6g of Chinese angelica, 12g of szechuan lovage rhizome, 8g of akebia stem, 16g of rhubarb, 18g of rhizoma corydalis, 7g of myrrh, 13g of safflower, 7g of dragon's blood, 12g of baical skullcap root and 10g of liquorice;
(2) The twelve raw materials are evenly mixed and crushed into coarse powder of 20 meshes, so as to obtain the traditional Chinese medicine composition.
Example 6A Chinese medicinal composition for treating bone injury
1. The traditional Chinese medicine composition for treating bone fracture diseases is prepared from the following raw materials in parts by weight: 24 parts of red paeony root, 18 parts of polyporus umbellatus, 24 parts of Chinese angelica, 20 parts of szechuan lovage rhizome, 9 parts of akebia stem, 30 parts of rhubarb, 12 parts of rhizoma corydalis, 10 parts of myrrh, 20 parts of safflower, 12 parts of dragon's blood, 3 parts of baical skullcap root and 2 parts of liquoric root.
2. A preparation method of a traditional Chinese medicine composition for treating bone fracture diseases comprises the following steps:
(1) Taking 24g of red paeony root, 18g of polyporus umbellatus, 24g of Chinese angelica, 20g of szechuan lovage rhizome, 9g of akebia stem, 30g of rhubarb, 12g of rhizoma corydalis, 10g of myrrh, 20g of safflower, 12g of dragon's blood, 3g of baical skullcap root and 2g of liquorice;
(2) The twelve raw materials are evenly mixed and crushed into coarse powder of 20 meshes, so as to obtain the traditional Chinese medicine composition.
Example 7A decoction for the treatment of bone injury
A preparation method of a decoction for treating bone fracture diseases comprises the following steps:
(1) The filtrate (Chinese medicinal composition) obtained in example 1 was concentrated to 400ml. Obtaining decoction.
Example 8A mixture for the treatment of bone injury
A preparation method of a mixture for treating bone fracture diseases, which comprises the following steps:
(1) Concentrating the filtrate (Chinese medicinal composition) obtained in example 3 to obtain fluid extract with relative density of 1.18-1.22 (65deg.C);
(2) Adding ethanol to reach alcohol content of 55%, and standing for 24 hr;
(3) Filtering, recovering ethanol, concentrating to obtain thick paste with relative density of 1.26-1.30 (65 ℃);
(4) Adding sodium benzoate 0.5g and sucrose 6g, adding water to 160ml, filtering, bottling, and sterilizing to obtain mixture.
Example 9A decoction for the treatment of bone injury
A preparation method of a soft extract for treating bone injury diseases comprises the following steps:
(1) Concentrating the filtrate (Chinese medicinal composition) obtained in example 2 to obtain fluid extract with relative density of 1.21-1.25 (70deg.C);
(2) Taking brown sugar (the mass is 2 times of the mass of the fluid extract);
(3) Heating brown sugar with direct fire, decocting, stirring to yellow, adding fluid extract, and concentrating to relative density of 1.4 (70deg.C) to obtain soft extract.
Example 10A medicated liquor for treating bone injury
A preparation method of a medicated wine for treating bone injury diseases comprises the following steps:
(1) Immersing the coarse powder (Chinese medicinal composition) obtained in the example 5 in a mixed solution of 1200ml of white spirit and 4000ml of yellow wine for 48 hours;
(2) Slowly percolating, and collecting percolate;
(3) Adding 450g of sucrose, stirring for dissolving, standing, and filtering to obtain medicated liquor.
Example 11 tincture for treating bone injury disease
A preparation method of tincture for treating bone injury diseases comprises the following steps:
(1) The coarse powder (Chinese medicinal composition) obtained in example 5 was immersed in 4000ml of 70% ethanol for 24 hours;
(2) Slowly percolating, collecting percolate to 1500ml, and stirring to obtain tincture.
Example 12A Black plaster for treating bone injury diseases
A preparation method of a black plaster for treating bone fracture diseases comprises the following steps:
(1) Frying the coarse powder (Chinese medicinal composition) obtained in example 6 and 700g of edible vegetable oil in a pot, removing residues, filtering, and refining to obtain dripping beads;
(2) Adding 220g of Plumbum Preparatium into oil, stirring, collecting paste, and soaking in water;
(3) Melting the paste with slow fire, and spreading on cloth to obtain black plaster.
Example 13A powder for the treatment of bone injury
A preparation method of powder for treating bone fracture diseases, which comprises the following steps:
(1) The coarse powder (Chinese medicinal composition) obtained in example 5 was pulverized to 100 mesh to obtain a powder.
EXAMPLE 14 Honey bolus for treating bone injury disease
A preparation method of a honeyed pill for treating bone injury diseases comprises the following steps:
(1) Pulverizing the coarse powder (Chinese medicinal composition) obtained in example 6 into 100 mesh fine powder;
(2) Adding refined Mel (1.2 times of the fine powder), and making into honeyed pill.
Example 15A granule for the treatment of bone injury
A preparation method of granules for treating bone fracture diseases comprises the following steps:
(1) The filtrate (Chinese medicinal composition) obtained in example 4 was concentrated to a relative density of 1.20 (50 ℃);
(2) Adding ethanol to make the ethanol content reach 60%, stirring, and standing for 24 hr;
(3) Collecting supernatant, recovering ethanol, concentrating to obtain fluid extract with relative density of 1.35-1.40 (50deg.C), drying under reduced pressure, and pulverizing;
(4) Mixing dry extract powder 1 part, sucrose 4.5 parts and dextrin 1.5 parts, granulating with ethanol, drying at 75deg.C, and granulating to obtain granule.
Example 16A capsule for the treatment of bone injury
A preparation method of a capsule for treating bone fracture diseases comprises the following steps:
(1) Encapsulating the granule obtained in example 14 to obtain capsule.
Example 17A tablet for treating bone injury disease
A method for preparing a tablet for treating bone fracture diseases, comprising the following steps:
(1) The granules obtained in example 14 were compressed into tablets to obtain tablets.
Example 18A spray for treating bone injury disease
A method for preparing a spray for treating bone fracture diseases, which comprises the following steps:
(1) Immersing the coarse powder (Chinese medicinal composition) obtained in example 6 in 75% ethanol for 2 times, each for 48 hr;
(2) 200ml of impregnating solution is collected altogether and filtered to obtain filtrate;
(3) Adding Borneolum Syntheticum (0.5% of the filtrate), stirring, sealing, standing for 24 hr, and packaging to obtain spray.
The traditional Chinese medicine composition for treating bone fracture is applied to actual clinical treatment, and partial cases are as follows:
1. Zhang Mou, male, age 48. Bilateral distal radius fracture, pain and swelling of the wrist. The decoction prepared in example 7 is taken orally, and the pain is obviously relieved and the swelling is slight after the decoction is treated for 3 days.
2. Liu Mou women, 58 years old. Distal radius fracture on the left side, pain and swelling on the left wrist. The mixture prepared in example 8 is taken orally, and the pain is obviously relieved and the swelling is slight after 2 days of treatment.
3. Wang Mou women, 64 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The decoction prepared in example 9 is taken orally, and the pain is obviously relieved and the swelling is slight after the decoction is treated for 4 days.
4. Mou women, 58 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The powder prepared in example 13 was taken orally, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
5. Wang Mou women, 63 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The honeyed pill prepared in example 14 is taken orally, and the pain is obviously relieved and the swelling is slight after 5 days of treatment.
6. Liu Mou Male, 16 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The granules prepared in example 15 are taken orally, and the pain is obviously relieved and the swelling is slight after the granules are treated for 3 days.
7. Xu Mou, female, 48 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The capsule prepared in example 16 is taken orally, and the pain is obviously relieved and the swelling is slight after 5 days of treatment.
8. Xia Mou women, 68 years old. Distal radius fracture on the right, pain and swelling on the right wrist. The tablets prepared in example 17 were taken orally, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
9. Gu Mou women, 72 years old. The right ulna styloid fracture is accompanied by distal radius fracture, pain and swelling of the right wrist. The wine prepared in example 10 was used for external application, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
10. Li Mou women, 68 years old. Left ulna styloid fracture accompanies distal radius fracture, left wrist pain and swelling. The spray prepared in example 18 was applied for 2 days, with significantly reduced pain and minimal swelling.
11. Wu Mou women, 68 years old. Left ulna styloid fracture accompanies distal radius fracture, left wrist pain and swelling. The decoction prepared in example 7 is taken orally, and the pain is obviously relieved and the swelling is slight after the decoction is treated for 3 days.
12. Fan Mou women, 65 years old. The right ulna styloid fracture is accompanied by distal radius fracture, pain and swelling of the right wrist. The powder prepared in example 13 was taken orally, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
13. Zhao Mou, male, 22 years old. The right ulna styloid fracture is accompanied by distal radius fracture, pain and swelling of the right wrist. The wine prepared in the example 10 is taken orally, and the pain is obviously relieved and the swelling is slight after the treatment for 4 days.
14. Guo Mou women, 76 years old. Left ulna styloid fracture accompanies distal radius fracture, left wrist pain and swelling. The spray prepared in example 18 was used for external application, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
15. Li Mou Male, 50 years old. Left ulna styloid fracture accompanies distal radius fracture, left wrist pain and swelling. The tincture prepared in example 11 was taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
16. Wang Mou, male, 44 years old. Nasal bone fracture, nasal and facial pain and swelling. The granules prepared in example 15 are taken orally, and the pain is obviously relieved and the swelling is slight after 2 days of treatment.
17. Wang Mou women, 52 years old. Comminuted fracture of right lateral malleolus, pain and swelling of right ankle. The black plaster prepared in example 12 was used for external application, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
18. Wang Mou, male, 59 years old. Multiple fractures of the right rib, pain in the right chest and back. The mixture prepared in example 8 was taken orally, and the pain was slight after 4 days of treatment.
19. Liu Mou, male, 47 years old. Multiple fractures of the double ribs and pain of the double chest and back. The decoction prepared in example 9 was taken orally, and the pain was slight after 3 days of treatment.
20. Zhu Mou, male, 57 years old. Multiple fractures of the right rib, pain in the right chest and back. The wine prepared in example 10 was taken orally, and the pain was slight after 3 days of treatment.
21. Li Mou women, 53 years old. Left tibial plateau fracture, left knee pain, swelling. The wine prepared in example 10 was used for external application, and pain was relieved and swelling was resolved after 2 days of treatment.
22. Liu Mou women, 59 years old. Left humeral surgical neck fracture, left shoulder pain, swelling and bluish violet. The honeyed pill prepared in example 14 is taken orally, and after 3 days of treatment, the pain is relieved, the swelling is resolved, and the bluish violet is absorbed.
23. Deng Mou women, 63 years old. Proximal fracture of right humerus, pain, swelling and bluish-purple right shoulder. The capsule prepared in example 16 was taken orally, and after 4 days of treatment, the pain was relieved, the swelling was resolved, and the bluish violet was absorbed.
24. Zhang Mou women, 59 years old. Proximal fracture of left humerus, pain, swelling and bluish-purple left shoulder. The tablet prepared in example 17 was taken orally, and after 4 days of treatment, the pain was relieved, the swelling was resolved, and bluish violet was absorbed.
25. Chen Mou, female, 26 years old. Fracture of lower left humerus, pain, swelling and bluish-purple left upper arm. The decoction prepared in example 7 was taken orally, and pain was relieved after 3 days of treatment, swelling resolved, and bluish violet absorbed.
26. Chen Mou, male, 17 years old. Left 2 th to 4 th metatarsal bone fracture, pain and swelling of the left foot. The black plaster prepared in example 12 was used for external application, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
27. Wang Mou women, 45 years old. Left 1 st metatarsal basal fracture, pain and swelling of the left foot. The mixture prepared in example 8 is taken orally, and the pain is obviously relieved and the swelling is slight after the treatment is carried out for 3 days.
28. Chen Mou Male, 58 years old. Left 2 th to 4 th metatarsal basal portion fracture, left foot pain, swelling. The decoction prepared in example 9 is taken orally, and the pain is obviously relieved and the swelling is slight after the decoction is treated for 3 days.
29. Wu Mou, male, 28 years old. Left 2 nd metatarsal basal fracture, pain and swelling of the left foot. The tincture prepared in example 11 was taken orally, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
30. Guo Mou Male, 24 years old. The right 3 rd metatarsal basal portion fracture, pain and swelling of the right foot. The wine prepared in the example 10 is taken orally, and the pain is obviously relieved and the swelling is slight after the treatment for 3 days.
31. Lv Mou women, 63 years old. Comminuted fracture of right ilium, pain, swelling and bluish violet of right hip. The wine prepared in example 10 was used for external application, pain was relieved after 4 days of treatment, swelling was resolved, and bluish violet was absorbed.
32. Zhang Mou, male, 57 years old. Comminuted fracture of right ilium, pain, swelling and bluish violet of right hip. The tincture prepared in example 11 was taken orally, and after 3 days of treatment, the pain was relieved, the swelling resolved, and the bluish violet absorbed.
33. Yang Mou, male, 45 years old. Comminuted fracture of right ilium, pain, swelling and bluish violet of right hip. The black plaster prepared in example 12 was applied for 2 days with pain relief, swelling resolution and bluish violet absorption.
34. Li Mou, male, 23 years old. Fracture of the left talus, pain and swelling of the left foot. The powder prepared in example 13 was taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
35. Lei Mou Male, 53 years old. The right calcaneus is fractured, and the right heel is painful and swollen. The honeyed pill prepared in example 14 is taken orally, and the pain is obviously relieved and the swelling is slight after the pill is treated for 3 days.
36. Zhou Mou women, 44 years old. Left calcaneus fracture, left heel pain, swelling. The granules prepared in example 15 are taken orally, and the pain is obviously relieved and the swelling is slight after the granules are treated for 4 days.
37. Liu Mou women, 52 years old. Left calcaneus fracture, left heel pain, swelling. The capsule prepared in example 16 was taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
38. Tang Mou women, 36 years old. Fracture of left patella, pain, swelling and blushing of left knee. The tablets prepared in example 17 were taken orally, and after 3 days of treatment, the pain was relieved, the swelling was resolved, and bluish violet absorption was observed.
39. Zhang Mou, women, 49 years old. Fracture of the right patella, pain, swelling and blushing of the right knee. The spray prepared in example 18 was applied for 2 days with pain relief, swelling resolution and bluish violet absorption.
40. Huang Mou Male, 37 years old. Comminuted fracture of left scapula, pain, swelling and bluish violet of left shoulder. The decoction prepared in example 7 was taken orally, and pain was relieved after 3 days of treatment, swelling resolved, and bluish violet absorbed.
41. Zhu Mou, male, age 48. Comminuted fracture of left scapula, pain, swelling and bluish violet of left shoulder. The mixture prepared in example 8 was taken orally, and after 3 days of treatment, the pain was relieved, the swelling was resolved, and the bluish violet was absorbed.
42. Liu Mou women, 58 years old. Distal radius fracture on the left side, pain and swelling on the left wrist. The decoction prepared in example 9 is taken orally, and the pain is obviously relieved and the swelling is slight after 2 days of treatment.
43. Qin certain, male, 32 years old. Fracture of the 5 th metacarpal bone on the left side, pain and swelling of the left palm. The wine prepared in the example 10 is taken orally, and the pain is obviously relieved and the swelling is slight after 2 days of treatment.
44. Gao Mou, male, 56 years old. Left clavicle fracture, pain and swelling of the left shoulder. The wine prepared in example 10 was used for external application, and after 3 days of treatment, no obvious effect was obtained.
45. Liu Mou women, 65 years old. Right clavicle fracture, pain and swelling of the right shoulder. The powder prepared in example 13 was taken orally, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
46. Zeng Mou women, 66 years old. Left clavicle fracture, pain and swelling of the left shoulder. The honeyed pill prepared in example 14 is taken orally, and the pain is obviously relieved and the swelling is slight after the treatment for 4 days.
47. Wang Mou, female, 55 years old. Right clavicle fracture, pain and swelling of the right shoulder. The granules prepared in example 15 are taken orally, and the pain is obviously relieved and the swelling is slight after the granules are treated for 3 days.
48. Yue Mou Male, 54 years old. Right clavicle fracture, pain and swelling of the right shoulder. The capsule prepared in example 16 was taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
49. Lei Mou women, 41 years old. Left clavicle fracture, pain and swelling of the left shoulder. The tablets prepared in example 17 were taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
50. Zhang Mou Male, 53 years old. Left clavicle fracture, pain and swelling of the left shoulder. The spray prepared in example 18 was used for external application, and the pain was significantly reduced and the swelling was slight after 3 days of treatment.
51. Ren Mou Male, 33 years old. Right clavicle fracture, pain and swelling of the right shoulder. The tincture prepared in example 11 was taken orally, and the pain was significantly reduced and the swelling was slight after treatment for 4 days.
52. Du Mou, male, 57 years old. Left clavicle fracture, pain and swelling of the left shoulder. The decoction prepared in example 7 is taken orally, and the pain is obviously relieved and the swelling is slight after 2 days of treatment.
53. Meng Mou Male, 67 years old. Left clavicle fracture, pain and swelling of the left shoulder. The mixture prepared in example 8 is taken orally, and the pain is obviously relieved and the swelling is slight after the treatment is carried out for 3 days.
54. Hu Mou, male, 52 years old. Left clavicle fracture, pain and swelling of the left shoulder. The tincture prepared in example 11 was taken orally, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
55. Meng Mou, female, 37 years old. Left tibiofibular fracture, pain and swelling of the left calf. The black plaster prepared in example 12 was used for external application, and the pain was significantly reduced and the swelling was slight after 2 days of treatment.
56. Lei Mou, male, 59 years old. Upper left ulna fracture, pain and swelling of the left forearm. The granules prepared in example 15 are taken orally, and the pain is obviously relieved and the swelling is slight after the granules are treated for 3 days.
57. Yang Mou, male, 45 years old. Lumbar transverse process fracture, lumbar pain in the back and waist, 1 st, 3 rd. The capsule prepared in example 16 was taken orally, and the pain was slight after 4 days of treatment.
58. Wang Mou, male, 43 years old. Lumbar vertebral fracture 1, pain in the back and waist. The decoction prepared in example 9 was taken orally, and the pain was slight after 3 days of treatment.
59. Rao Mou Male, 58 years old. Lumbar vertebral body fracture, lumbago and dorsum pain. The powder prepared in example 13 was taken orally and the pain was slight after 2 days of treatment.
60. Cudrania tricuspidata, male, 49 years old. Lumbar transverse process fracture, lumbago and back pain of the 2 nd to 3 rd lumbar vertebrae. The black plaster prepared in example 12 was applied externally, and the pain was slight after 3 days of treatment.
The traditional Chinese medicine composition for treating bone fracture diseases is applied to 60 practical clinical treatment cases, wherein 59 cases are effective, 1 case is not obvious in effect, the effective rate is 98.3%, and no toxic or side effect occurs.
Claims (10)
1. The traditional Chinese medicine composition for treating hematoma mechanized bone injury diseases is characterized by being prepared from the following raw materials in parts by weight: 6 to 24 parts of red paeony root, 6 to 24 parts of grifola, 6 to 24 parts of angelica, 3 to 20 parts of szechuan lovage rhizome, 3 to 12 parts of akebia stem, 3 to 30 parts of rhubarb, 3 to 20 parts of rhizoma corydalis, 3 to 10 parts of myrrh, 3 to 20 parts of safflower, 3 to 12 parts of dragon's blood, 3 to 20 parts of baical skullcap root and 2 to 20 parts of liquoric root.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 24 parts of red paeony root, 10 to 20 parts of grifola, 10 to 24 parts of angelica, 6 to 18 parts of szechuan lovage rhizome, 5 to 10 parts of akebia stem, 8 to 25 parts of rhubarb, 6 to 20 parts of rhizoma corydalis, 5 to 10 parts of myrrh, 5 to 15 parts of safflower, 5 to 10 parts of dragon's blood, 6 to 18 parts of baical skullcap root and 3 to 15 parts of liquoric root.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of red paeony root, 15 parts of polyporus umbellatus, 15 parts of Chinese angelica, 12 parts of szechuan lovage rhizome, 8 parts of akebia stem, 15 parts of rhubarb, 12 parts of rhizoma corydalis, 6 parts of myrrh, 10 parts of safflower, 8 parts of dragon's blood, 12 parts of baical skullcap root and 10 parts of liquoric root.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the corydalis tuber is a vinegar corydalis tuber.
5. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, which is characterized in that red paeony root, grifola, angelica, szechuan lovage rhizome, akebia stem, rhubarb, rhizoma corydalis, myrrh, safflower, dragon's blood, baical skullcap root and liquoric root are taken as raw materials, and water extraction or alcohol extraction is carried out to obtain the traditional Chinese medicine composition.
6. The method according to claim 5, wherein the alcohol content of the alcohol extract is 55-75%.
7. Use of a traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a medicament for treating hematoma mechanized bone fracture diseases.
8. A formulation of a traditional Chinese medicinal composition according to any one of claims 1 to 3, further comprising pharmaceutically acceptable excipients.
9. The formulation of claim 8, wherein the pharmaceutically acceptable adjuvant is at least one of a diluent, a humectant, a binder, a disintegrant, a lubricant, a plasticizer, a colorant, a flavoring agent, a preservative, a surfactant, and a permeation enhancer.
10. The formulation of claim 8, wherein the formulation is in the form of one of a powder, a decoction, a mixture, a granule, a tablet, a pill, a capsule, a bath agent, a wine, a tincture, an ointment, a decoction, a cream, a paste, a plaster, an aerosol, a spray, a powder mist, a film.
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