CN115487103B

CN115487103B - Plant-derived sun-screening synergistic agent composition and application thereof

Info

Publication number: CN115487103B
Application number: CN202111287191.0A
Authority: CN
Inventors: 方武荣; 张岷; 骆丹
Original assignee: Shanghai Lishudan Pharmaceutical Technology Co ltd
Current assignee: Shanghai Lishudan Pharmaceutical Technology Co ltd
Priority date: 2021-11-02
Filing date: 2021-11-02
Publication date: 2024-02-23
Anticipated expiration: 2041-11-02
Also published as: CN115487103A

Abstract

The invention belongs to the technical field of A61K, and particularly relates to a plant-derived sun-screening synergistic agent composition and application thereof. A plant-derived sunscreen synergistic agent composition is prepared from plant root extract and hesperidin; the plant root extract is selected from at least one of Glycyrrhiza uralensis root extract, scutellaria baicalensis root extract, sophora flavescens root extract, taraxacum mongolicum root extract and Paeonia suffruticosa root extract. The sun-proof synergistic composition prepared by the invention can ensure the sun-proof capability of the skin when facing the sun high-intensity radiation, avoid the damage of the strong sunlight to the skin and avoid the skin aging phenomenon caused by insolation; the sun cream provided by the invention has the advantages that the sun protection index is improved by 2% -10%, the sun cream has a better sun protection effect, the protection of the sun cream to the skin can be greatly improved, the damage to the skin under the condition of strong sunlight is avoided, and the sun cream still has a better sun protection effect especially when used under the conditions of strong sunlight in summer.

Description

Plant-derived sun-screening synergistic agent composition and application thereof

Technical Field

The invention belongs to the technical field of A61K, and particularly relates to a plant-derived sun-screening synergistic agent composition and application thereof.

Background

With the improvement of society and the improvement of living standard of people, the concepts of skin care and sun protection are more and more important in the consciousness of consumers, and with the improvement of the consciousness of consumers, the requirements on the performance of products are also gradually improved. At present, various skin care products and types of sun protection skin care products exist on the market, and particularly the sun protection skin care products have better effects of moisturizing, moistening, resisting aging and the like on skin while having better sun protection effect.

In order to further optimize the effect of the sun-screening skin care product and reduce the use amount of chemical substances, sun-screening agents prepared by taking plants as main components begin to appear on the market, for example, chinese patent application No. 201811546479.3 discloses a natural plant sun-screening composition, a preparation method thereof and application thereof in sun-screening cosmetics. In the disclosed patent, the sun-proof composition is prepared by taking kudingcha extract, baical skullcap root extract, rosa roxburghii tratt fruit extract, lespedeza extract, saffron extract and pagodatree flower bud extract as main plant components and matching alcohol, humectant, rheology modifier and nano hemp stalk core powder, and the prepared sun-proof composition has a broad-spectrum sun-proof effect. However, in the disclosed patent, by using saffron extract as a preparation raw material, there is a remarkable limitation on pregnant women, resulting in a limitation on the applicable range of sunscreens prepared therefrom.

In order to further optimize the sun protection effect of the sun protection agent, ensure the better use effect of the sun protection agent, and have no special restrictions on pregnant women, researchers are still required to optimize the preparation raw materials.

Disclosure of Invention

In order to solve the technical problems, a first aspect of the present invention provides a plant-derived sunscreen synergistic composition, wherein the preparation raw materials comprise plant root extract and hesperidin; the plant root extract is selected from at least one of Glycyrrhiza uralensis root extract, scutellaria baicalensis root extract, sophora flavescens root extract, taraxacum mongolicum root extract and Paeonia suffruticosa root extract.

In some preferred embodiments, the plant root extract comprises licorice root extract, scutellaria root extract.

In some preferred embodiments, the weight ratio of the licorice root extract, the scutellaria root extract and the hesperidin is (3-7): (5-10): (2-6).

Further preferably, the weight ratio of the licorice root extract, the baicalin extract and the hesperidin is 6:8:5.

glycyrrhiza glabra root extract, INCI: GLYCYRRHIZA INFLATA ROOT EXTRACT from Shanghai Jia Kai Biotech Co.

Radix Scutellariae extract, INCI: SCUTELLARIA BAICALENSIS ROOT EXTRACT, CAS:94279-99-9.

Hesperidin, also called nobiletin or dihydroflavone glycoside, has molecular formula of C ₂₈ H ₃₄ O ₁₅ 。

In the experimental process, the applicant has found through a great deal of creative experiments that in the system, the weight ratio of the licorice root extract, the baicalin root extract and the hesperidin is controlled to be (3-7): (5-10): (2-6) the sunscreen effect of the composition can be greatly improved, the reason why the applicant speculates that this phenomenon may be due to: the licorice root extract contains glycyrrhizin, and the glycyrrhizin can act with arachidonic acid generated by physiological activity, so that the glycyrrhizin is combined with lipoxygenase for generating inflammatory mediators, and the phosphorylation of the enzymes is selectively blocked to inhibit the activation of the enzymes, so that the metabolism of the arachidonic acid is inhibited, and the inflammatory reaction is reduced; however, glycyrrhizin is hydrolyzed to generate glycyrrhizic acid, so that the action with arachidonic acid is weakened. In the system, the weight ratio of the licorice root extract, the baicalin root extract and the hesperidin is (3-7): (5-10): in the process (2-6), the flavonoid substances in 5,2,6 '-trihydroxy-7, 8-dimethoxy brass-2' -O-beta-D-glucopyranoside, 7-glucuronic acid-5, 6, 7-trihydroxy ketone and hesperidin existing in the root of scutellaria baicalensis can have higher activity, so that the hydrolysis of glycyrrhizin can be inhibited, sunlight can be absorbed, the generation of free radicals is reduced, and the sun-screening effect of the sun-screening composition is further improved.

In a second aspect, the invention provides the use of a plant-derived sunscreen synergistic composition for the preparation of sunscreens, skin care milks, sun protection sprays.

In a third aspect the present invention provides a sunscreen comprising a plant derived sunscreen synergistic composition.

In some preferred embodiments, the preparation raw materials of the sun cream comprise a component A, a component B and a component C;

the preparation raw materials of the component A comprise a humectant, a skin conditioner A, a thickener and an emulsifier;

the preparation raw materials of the component B comprise a skin conditioner B and an ester substance;

the preparation raw materials of the component C comprise a sun-proof synergistic agent composition.

In some preferred embodiments, the skin conditioning agent a comprises allantoin and hydrolyzed starch.

In some preferred embodiments, the weight ratio of allantoin to hydrolyzed starch is 1: (3-10).

Further preferably, the weight ratio of allantoin to hydrolyzed starch is 1: (3-6).

More preferably, the weight ratio of allantoin to hydrolyzed starch is 1:5.

allantoin, which is a nontoxic, odorless, non-irritating, non-allergenic substance, is of interest and popularity in skin care products, but is rarely used as a sunscreen under sun conditions when used, because it is decomposable under sun exposure.

Further preferably, the hydrolyzed starch is at least one selected from the group consisting of hydrolyzed corn starch and hydrolyzed wheat starch.

Further preferably, the hydrolyzed starch is hydrolyzed corn starch.

During the experiment, the applicant found that the addition of hydrolyzed cornstarch to the system, when acting with allantoin, can exhibit better skin care effect, especially when the weight ratio of allantoin to hydrolyzed cornstarch is 1: in the range of (3-6), skin elasticity can be further improved, skin peeling, water shortage and the like can be avoided, and allantoin decomposition can be avoided, and the reasons for the phenomenon are presumed by the applicant: when the hydrolyzed corn starch and the allantoin are compounded for use, good load of the allantoin in the hydrolyzed corn starch can be ensured, the exposure of the allantoin on the skin surface is reduced, and a reaction foundation is provided for the action of the allantoin; in addition, the weight ratio of allantoin to hydrolyzed corn starch is 1: in the range of (3-6), a lubricating film can be formed on the surface layer of the skin rapidly, and at the moment, the licorice root extract, the baical skullcap root extract and the hesperidin substance which are present in the system are matched, so that the sealing effect of allantoin on the moisture on the surface layer of the skin can be enhanced on the premise of weakening the irradiation intensity of sunlight, the skin elasticity is further improved, and the phenomena of skinning, water shortage and the like of the skin are avoided.

In addition, the applicant found that the addition of hydrolyzed wheat starch to the stock system was less effective than hydrolyzed corn starch, presumably because the cellulose molecules in hydrolyzed wheat starch were relatively smaller, and the load and coating effect on allantoin was less effective than hydrolyzed corn starch, and therefore, in this application, hydrolyzed corn starch must be added to enhance the moisturizing and protecting effect on skin while ensuring sun protection.

In some preferred embodiments, the humectant described in component A comprises glycereth-26.

In some preferred embodiments, the thickener in component A is selected from at least one of potassium cetyl phosphate, xanthan gum, sodium carboxymethylcellulose, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymers.

Further preferably, the thickener in component A is potassium cetyl phosphate.

In some preferred embodiments, the emulsifier described in component a comprises cetostearyl glucoside, sorbitan olive oleate.

In some preferred embodiments, the preparation of component A further comprises composition A, which comprises water, butanediol, PEG-240/HDI copolymer bis-decyl tetradecyl polyether-20 ether.

The composition A is purchased from Shanghai megabalance industries, inc.

In some preferred embodiments, the esters of component B include ethylhexyl methoxycinnamate, ethylhexyl salicylate, C12-15 alcohol benzoate, tridecyl alcohol stearate.

In some preferred embodiments, the preparation materials in component B further comprise bis-ethylhexyloxyphenol methoxyphenyl triazine, polysiloxane-15, shea butter and composition B.

Butter tree fruit fat, INCI: BUTYROSPERMUM PARKII (SHEA BUTTER), CAS: 194043-92-0.

In some preferred embodiments, the composition B is prepared from a material comprising polyisobutylene, acrylamide/ammonium acrylate copolymer, polysorbate-20.

The composition B is purchased from Shanghai Bai Hao chemical industry Co.

In some preferred embodiments, the skin conditioning agent B comprises a phytosterol oleate, a polydimethylsiloxane.

In some preferred embodiments, the preparation materials of component C further comprise composition C, composition D, and radix Sophorae Flavescentis extract.

In some preferred embodiments, the composition C is prepared from water, methylene bis-benzotriazolyltetramethyl butyl phenol, decyl glucoside, propylene glycol, and xanthan gum.

The composition C is purchased from Shanghai Xierui industry development Co.

In some preferred embodiments, the composition D is prepared from materials including caprylic acid glyceride, octanoyl hydroxamic acid, 1, 2-hexanediol, and ethylhexyl glycerol.

Composition D was purchased from the biotechnology company, ai Zhuo, guangzhou.

In some preferred embodiments, the sunscreen preparation further comprises water.

In some preferred embodiments, the sun cream is prepared from the following raw materials in percentage by weight: 1-5% glycerol polyether-26, 0.1-1% potassium cetyl phosphate, 1-5% emulsifier, 0.1-0.8% composition A, 0.05-0.5% allantoin, 0.5-2% hydrolyzed corn starch, 5-15% ethylhexyl methoxycinnamate, 2-5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 2-6% ethylhexyl salicylate, 1-5% C12-15 alcohol benzoate, 1-3% polysiloxane-15, 1-5% tridecyl alcohol stearate, 0.2-1% phytosterol oleate, 1-3.5% polydimethylsiloxane, 1-3% shea butter, 0.1-1% composition B, 1-5% composition C, 0.3-1% composition D, 0.06% radix Sophorae Flavescentis extract, 0.2% enhancer composition, water balance to 100%.

Further preferably, the weight of the sun protection synergistic agent composition is 0.2% of the total weight of the sun protection cream preparation raw materials.

In the experimental process, the applicant finds that the addition amount of the sun-screening synergistic agent composition in the system has a great influence on the stability and sun-screening effect of the system, and through a great amount of creative experimental researches by the applicant, the sun-screening synergistic agent composition added in the system has better storage stability and sun-screening effect when the weight of the sun-screening synergistic agent composition is 0.2% of the total weight of the sun-screening cream preparation raw material, and the applicant speculates that the phenomenon occurs: with the addition of the sun-screening agent, the interaction strength between the sun-screening agent and polar groups of substances such as an emulsifier in the system is enhanced, so that the interaction between the substances is promoted, and in the placing process, the precipitation and migration of solid substances are avoided due to the interaction between the substances, so that the storage stability of the sun-screening agent is improved, the service life of the sun-screening agent is prolonged while the sun-screening effect is ensured, the service life is ensured to be in the range of 1.5-2 years, and the waste of products caused by incomplete long-time use is reduced.

According to a fourth aspect of the present invention, there is provided a method of preparing a sunscreen comprising the steps of:

s1: adding the component A into a preparation pot to prepare raw materials, stirring and heating to 80-85 ℃, and uniformly stirring;

s3: adding the component B into the oil phase pot to prepare raw materials, stirring and heating to 80-85 ℃, and uniformly stirring;

s3: pumping the oil phase material into a preparation pot, continuously homogenizing and emulsifying for 3-10min after the material is pumped, and then starting cooling water for cooling;

s4: cooling to 40-50deg.C, adding component C, controlling stirring speed to 40r/min, homogenizing at bottom for 3-10min, and stirring for 5-20 min;

s5: and (5) uniformly stirring, checking, cooling to below 45 ℃ and discharging to obtain the finished product.

The beneficial effects are that: the plant-derived sun-screening synergistic agent composition and the sun-screening cream prepared by the composition have the following advantages:

1. the sun-proof synergistic composition prepared by the invention can ensure the sun-proof capability of the skin when facing the sun high-intensity radiation, avoid the damage of the strong sunlight to the skin and avoid the skin aging phenomenon caused by insolation;

2. the sun cream prepared by the method can avoid the defect that the sun cream cannot be irradiated by sunlight caused by the addition of allantoin, further improve the skin elasticity and avoid the phenomena of skin peeling, water shortage and the like;

3. the sun cream prepared by the invention can ensure the storage stability of the sun cream to be as long as 1.5-2 years, avoids the waste phenomenon of products caused by incomplete use of the products, and has higher use value;

4. the sun cream provided by the invention has the advantages that the sun protection index is improved by 2% -10%, the sun cream has a better sun protection effect, the protection of the sun cream to the skin can be greatly improved, the damage to the skin under the condition of strong sunlight is avoided, and the sun cream still has a better sun protection effect especially when used under the conditions of strong sunlight in summer.

Drawings

FIG. 1 is a graph of skin patch test performance test results;

fig. 2 is a graph of SPF test results.

Detailed Description

Examples

Example 1

A plant-derived sun-screening synergistic agent composition is prepared from the following raw materials: licorice root extract, scutellaria root extract, hesperidin.

Comprises the following components in parts by weight: 6 parts of licorice root extract, 8 parts of baicalin root extract and 5 parts of hesperidin.

Example 2

A sun cream is prepared from the following raw materials in percentage by weight: 3% of glycerol polyether-26, 0.5% of potassium cetyl phosphate, 3% of emulsifier, 0.5% of composition A, 0.2% of allantoin, 1% of hydrolyzed corn starch, 8% of ethylhexyl methoxycinnamate, 3.5% of bis-ethylhexyl oxyphenol methoxyphenyl triazine, 4% of ethylhexyl salicylate, 3% of C12-15 alcohol benzoate, 2% of polysiloxane-15, 3% of tridecyl alcohol stearate, 0.5% of phytosterol oleate, 2% of polydimethylsiloxane, 2% of shea butter, 0.5% of composition B, 3% of composition C, 0.6% of composition D, 0.06% of radix sophorae flavescentis extract, 0.2% of sun-screening enhancer composition, and the balance of water to 100%.

The composition A is purchased from Shanghai megascale industry Co., ltd; the composition B is purchased from Shanghai Bai Hao chemical industry Co., ltd; the composition C is purchased and purchased from Shanghai Xierui industry development Co., ltd; composition D was purchased from the biotechnology company Ai Zhuo, guangzhou;

glycerolyether-26, available from clariant chemical (china) limited; hydrolyzed corn starch, purchased from Shanghai Remu chemical technology Co., ltd; polysiloxane-15, purchased from Shanghai Bai Hao chemical Co., ltd; polydimethylsiloxane, commercially available from Shanghai to Flexible Co., ltd; kuh-seng root extract, purchased from Shanghai Jiakai biotechnology Co., ltd; butyrospermum parkii fruit fat purchased from Shanghai Xierui industry development Co., ltd;

a preparation method of the sun cream comprises the following steps:

s1: adding the component A into a preparation pot to prepare raw materials, stirring and heating to 82 ℃, and uniformly stirring;

s3: adding the component B into the oil phase pot to prepare raw materials, stirring and heating to 82 ℃, and uniformly stirring;

s4: cooling to 48 ℃, adding the component C, controlling the stirring speed to be 40r/min, starting the bottom to homogenize for 5min, and continuing stirring for 10min until uniform;

s5: and (5) uniformly stirring, checking, and cooling to 35 ℃ after the checking is qualified.

Example 3

A sun cream is prepared from the following raw materials in percentage by weight: 3% glycerol polyether-26, 0.5% potassium cetyl phosphate, 3% emulsifier, 0.5% composition A, 0.2% allantoin, 1% hydrolyzed corn starch, 8% ethylhexyl methoxycinnamate, 3.5% bis-ethylhexyl oxyphenol methoxyphenyl triazine, 4% ethylhexyl salicylate, 3% C12-15 alcohol benzoate, 2% polysiloxane-15, 3% tridecyl alcohol stearate, 0.5% phytosterol oleate, 2% dimethicone, 2% shea butter, 0.5% composition B, 3% composition C, 0.6% composition D, 0.06% radix Sophorae Flavescentis, the balance being water to 100%.

a preparation method of the sun cream comprises the following steps:

Example 4

A sun cream is prepared from the following raw materials in percentage by weight: 3% of glycerol polyether-26, 0.5% of potassium cetyl phosphate, 3% of emulsifier, 0.5% of composition A, 0.2% of allantoin, 1% of hydrolyzed corn starch, 8% of ethylhexyl methoxycinnamate, 3.5% of bis-ethylhexyl oxyphenol methoxyphenyl triazine, 4% of ethylhexyl salicylate, 3% of C12-15 alcohol benzoate, 2% of polysiloxane-15, 3% of tridecyl alcohol stearate, 0.5% of phytosterol oleate, 2% of polydimethylsiloxane, 2% of shea butter, 0.5% of composition B, 3% of composition C, 0.6% of composition D, 0.06% of radix sophorae flavescentis extract, 0.05% of sun-screening enhancer composition, and the balance of water to 100%.

a preparation method of the sun cream comprises the following steps:

Example 5

A sun cream is prepared from the following raw materials in percentage by weight: 3% of glycerol polyether-26, 0.5% of potassium cetyl phosphate, 3% of emulsifier, 0.5% of composition A, 0.2% of allantoin, 1% of hydrolyzed wheat starch, 8% of ethylhexyl methoxycinnamate, 3.5% of bis-ethylhexyl oxyphenol methoxyphenyl triazine, 4% of ethylhexyl salicylate, 3% of C12-15 alcohol benzoate, 2% of polysiloxane-15, 3% of tridecyl alcohol stearate, 0.5% of phytosterol oleate, 2% of polydimethylsiloxane, 2% of shea butter, 0.5% of composition B, 3% of composition C, 0.6% of composition D, 0.06% of kuh-seng extract, 0.2% of sun-screening enhancer composition, and the balance of water to 100%.

glycerolyether-26, available from clariant chemical (china) limited; hydrolyzed wheat starch, purchased from Shanghai Remu chemical technology Co., ltd; polysiloxane-15, purchased from Shanghai Bai Hao chemical Co., ltd; polydimethylsiloxane, commercially available from Shanghai to Flexible Co., ltd; kuh-seng root extract, purchased from Shanghai Jiakai biotechnology Co., ltd; butyrospermum parkii fruit fat purchased from Shanghai Xierui industry development Co., ltd;

a preparation method of the sun cream comprises the following steps:

Performance test:

1. skin patch test: the sunscreen prepared in example 2 was used in the skin patch test and the test results were recorded in fig. 1 below.

The specific test method is as follows:

1. test article: the sun cream prepared in example 2 of the application.

2. Negative control: blank control;

3. the subject: 30 people, 10 men and 20 women, with ages 31-59, and average age of 49+ -9, meet the volunteer selection standard of the subjects.

4. Plaque test method: selecting qualified plaque test equipment, placing about 0.02-0.025g of the test object into the plaque test equipment by a closed plaque test method, applying the test object to the back of a subject by using a hypoallergenic tape externally, removing the test object after 24 hours, observing skin reactions respectively after 0.5, 24 and 48 hours of removal, and recording the results according to the skin reaction grading standard in the 2015 edition of cosmetic safety technical Specification, as shown in figure 1.

SPF test: the sunscreen prepared in example 2 was used for SPF testing:

1. the object to be measured: the sunscreen cream prepared in example 2;

2. control: SPF value 16.1+ -2.4, according to the standard formulation of the medium and high SPF standard (P2) of cosmetic safety technical Specification (2015 edition).

3. The subject: 10 people total, 7 men and 3 women, aged 19 to 49 years, and average age 32.1+ -11.9 years, meet the subject's indicia inclusion criteria.

4. Light source: the xenon arc lamp of the sunlight simulator meets the measurement specification requirements in each performance index.

5. The inspection method comprises the following steps: the test was carried out according to the specific requirements of cosmetic safety Specification (2015 edition). The back of the subject is irradiated. The minimum erythema dose (MED value) of the subject's skin to ultraviolet irradiation was predicted 24 hours before the test, and the ultraviolet irradiation dose was adjusted based on the prediction result, for testing the test object. On the day of testing, first, a test subject was selected for a time of not less than 30cm on his back ² Is measured in terms of (2.00+0.05) mg/cm ² Uniformly coating the object to be detected or the reference substance in the area, selecting the irradiation dose according to the standard requirement, and irradiating in three conditions: (1) the skin of the subject is not coated with the test object; (2) coating a reference substance; (3) coating the measured object. After 24 hours, the experimental results were observed and MED values were recorded for the three cases, respectively.

SPF value calculation method: the SPF value of the test object or the reference object for protecting the single subject is expressed by the following formula:

MED value of skin protection

Spdi = MED value of protected skin/MED value of unprotected skin

The SPF value of the individual is required to be accurate to one digit after the decimal point, the arithmetic mean of the SPF values of all the tested objects protected by the tested objects is calculated, and the integer part of the arithmetic mean is taken as the SPF value of the tested sample. The sampling error of the estimated mean may calculate the standard deviation and standard error for the set of data. The 95% confidence interval (95% ci) of the mean is required to be no more than 17% of the mean, otherwise the number of subjects should be increased (no more than 25) until the above requirement is met.

The experimental results are recorded in the following graph, see fig. 2:

the human body test results show that the SPF value of the product prepared by the method is 31.

3. Stability test: the sunscreens prepared in examples 2-4 were used for stability testing by placing the prepared sunscreens at-10 ℃ for 30 days, then taking out and placing at 45 ℃ for 30 days again, observing the change after restoring to room temperature, and recording the results in table 3 below.

Table 3:

experiment	Stability of
		Example 2	Without any change
Example 3	Without any change
		Example 4	Without any change
Example 5	Agglomeration phenomenon occurs

Claims

1. The sun cream is characterized by comprising the following preparation raw materials in percentage by weight:

a component: 1-5% of glycerolyether-26, 0.1-1% of cetyl phosphate potassium, 1-5% of emulsifying agent, 0.1-0.8% of composition A, 0.05-0.5% of allantoin and 0.5-2% of hydrolyzed corn starch;

and the component B comprises the following components: 5-8% ethylhexyl methoxycinnamate, 2-5% bis-ethylhexyl oxyphenol methoxyphenyl triazine, 2-4% ethylhexyl salicylate, 1-5% C12-15 alcohol benzoate, 1-3% polysiloxane-15, 1-5% tridecyl stearate, 0.2-1% phytosterol oleate, 1-3.5% polydimethylsiloxane, 1-3% shea butter, 0.1-1% composition B;

and C, component: 1-5% of composition C, 0.3-1% of composition D, 0.06% of radix sophorae flavescentis extract and 0.2% of sun-screening synergistic agent composition; water is supplemented to 100 percent;

the emulsifier in the component A comprises cetostearyl glucoside and sorbitan olive oleate;

the preparation raw materials of the composition A comprise water, butanediol, PEG-240/HDI copolymer bis-decyl tetradecyl polyether-20 ether;

the preparation raw materials of the composition B comprise polyisobutene, acrylamide/ammonium acrylate copolymer and polysorbate-20;

the preparation raw materials of the composition C comprise water, methylene bis-benzotriazole-based tetramethyl butyl phenol, decyl glucoside, propylene glycol and xanthan gum;

the preparation raw materials of the composition D comprise glycerol octanoate, octanoyl hydroxamic acid, 1, 2-hexanediol and ethylhexyl glycerol;

the sun-proof synergistic agent composition is prepared from plant root extract and hesperidin; the plant root extract comprises a licorice root extract and a scutellaria root extract; the weight ratio of the licorice root extract, the baical skullcap root extract and the hesperidin is 6:8:5.

2. a method of preparing a sunscreen according to claim 1, comprising the steps of:

s2: adding the component B into the oil phase pot to prepare raw materials, stirring and heating to 80-85 ℃, and uniformly stirring;