CN115487103A - Plant-derived sunscreen synergist composition and application thereof - Google Patents
Plant-derived sunscreen synergist composition and application thereof Download PDFInfo
- Publication number
- CN115487103A CN115487103A CN202111287191.0A CN202111287191A CN115487103A CN 115487103 A CN115487103 A CN 115487103A CN 202111287191 A CN202111287191 A CN 202111287191A CN 115487103 A CN115487103 A CN 115487103A
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- Prior art keywords
- sunscreen
- root extract
- composition
- plant
- skin
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention belongs to the technical field of A61K, and particularly relates to a plant-derived sun-screening synergist composition and application thereof. A plant-derived sunscreen synergist composition is prepared from plant root extract and hesperidin; the plant root extract is at least one of extracts of glycyrrhiza inflate, scutellaria baicalensis, sophora flavescens, dandelion and peony. When the sunscreen synergistic composition prepared by the invention faces to the sun high-intensity radiation, the sunscreen capability of the skin can be ensured, the damage of strong sunlight to the skin is avoided, and the skin aging phenomenon caused by exposure is avoided; the sun protection cream provided by the invention has the sun protection index increased by 2-10%, has a good sun protection effect, can greatly improve the protection of the sun protection cream on the skin, avoids the damage to the skin under the strong sunlight condition, and still has a good sun protection effect especially when being used in summer and under the strong sunlight condition.
Description
Technical Field
The invention belongs to the technical field of A61K, and particularly relates to a plant-derived sunscreen synergist composition and application thereof.
Background
With the progress of society and the improvement of living standard of people, the concept of skin care and sun protection is more and more important in the consciousness of consumers, and with the improvement of the consciousness of consumers, the requirements on the performance of products are gradually improved. At the present stage, various types of skin care products and sun-proof skin care products exist in the market, and particularly the sun-proof skin care products have the effects of better moisturizing, moistening, anti-aging and the like on the skin while having the better sun-proof effect.
In order to further optimize the effect of sunscreen skin care products and reduce the usage amount of chemical substances, sunscreen agents prepared by taking plants as main components begin to appear on the market, and for example, chinese patent application with application number 201811546479.3 discloses a natural plant sunscreen composition, a preparation method thereof and application thereof in sunscreen cosmetics. In the disclosed patent, a sunscreen composition is prepared by taking broadleaf holly leaf extract, scutellaria baicalensis extract, rosa roxburghii fruit extract, lespedeza extract, saffron extract and sophora flower bud extract as main plant components and matching alcohol, a humectant, a rheology modifier and nano hemp stem core powder, and the prepared sunscreen composition has a broad-spectrum sunscreen effect. However, by using saffron extract as a raw material for preparation in the patent publication, it has a significant limitation effect on pregnant women, resulting in a limitation of the applicable range of sunscreen agents prepared therefrom.
In order to further optimize the sun-screening effect of the sun-screening agent, ensure better using effect of the sun-screening agent and have no special limitation on pregnant women, researchers still need to optimize preparation raw materials.
Disclosure of Invention
In order to solve the above technical problems, the present invention provides in a first aspect a plant-derived sunscreen potentiator composition prepared from raw materials including a plant root extract and hesperidin; the plant root extract is at least one of extracts of glycyrrhiza inflate, scutellaria baicalensis, sophora flavescens, dandelion and peony.
In some preferred embodiments, the plant root extract comprises glycyrrhiza inflata root extract, scutellaria baicalensis root extract.
In some preferred embodiments, the weight ratio of the glycyrrhiza inflata root extract, the scutellaria baicalensis root extract and the hesperidin is (3-7): (5-10): (2-6).
Further preferably, the weight ratio of the glycyrrhiza inflata root extract, the scutellaria baicalensis root extract and the hesperidin is 6:8:5.
glycyrrhiza inflata root extract, INCI: glycyrrhizia INFLATA ROOT EXTRACT, available from Kai Biotech Co., ltd, shanghai Gai.
Scutellaria root extract, INCI: SCUTELLARIA BAICALENSIS ROOT EXTRACT, CAS:94279-99-9.
Hesperidin, also known as nobiletin or flavanone glycoside, has a molecular formula of C 28 H 34 O 15 。
In the experimental process, the applicant researches through a large number of creative experiments and discovers that in the system, the weight ratio of the glycyrrhiza inflata root extract to the scutellaria baicalensis root extract to hesperidin is controlled to be (3-7): (5-10): (2-6), the sunscreen effect of the composition can be greatly improved, and the reason why this phenomenon occurs is presumed by the applicant to be that: the glycyrrhiza uralensis root extract contains glycyrrhizin, the glycyrrhizin can act with arachidonic acid generated by physiological activity to further combine with lipoxygenase generating inflammatory mediators, and selectively block phosphorylation of the enzymes to inhibit activation of the enzymes, so that metabolism of the arachidonic acid is inhibited, and inflammatory reaction is relieved; however, glycyrrhizin is hydrolyzed to produce glycyrrhizic acid, which weakens the effect of arachidonic acid. In the system, the weight ratio of the glycyrrhiza inflata root extract, the scutellaria baicalensis root extract and the hesperidin is (3-7): (5-10): (2-6), 5,2,6 '-trihydroxy-7, 8-dimethoxy brass-2' -O-beta-D-glucopyranoside, 7-glucuronic acid-5, 6, 7-trihydroxy ketone and flavonoid in hesperidin in the root of scutellaria can be used, so that the activity is high, the hydrolysis of glycyrrhizin can be inhibited, sunlight can be absorbed, the generation of free radicals can be reduced, and the sun-screening effect of the sun-screening composition can be further improved.
The invention provides an application of a plant-derived sunscreen synergist composition in preparation of sunscreen cream, skin care emulsion and sunscreen spray.
In a third aspect of the invention, there is provided a sunscreen comprising a sunscreen builder composition of plant origin.
In some preferred embodiments, the preparation raw materials of the sunscreen cream comprise a component A, a component B and a component C;
the preparation raw materials of the component A comprise a humectant, a skin conditioner A, a thickening agent and an emulsifying agent;
the raw materials for preparing the component B comprise a skin conditioner B and ester substances;
the raw materials for preparing the component C comprise a sun-screening synergist composition.
In some preferred embodiments, the skin conditioning agent a comprises allantoin and hydrolyzed starch.
In some preferred embodiments, the weight ratio of allantoin to hydrolyzed starch is 1: (3-10).
Further preferably, the weight ratio of the allantoin to the hydrolyzed starch is 1: (3-6).
More preferably, the weight ratio of allantoin to hydrolyzed starch is 1:5.
allantoin is a nontoxic, tasteless, non-irritating, non-allergenic substance that is of interest and popularity in skin care products, but is generally used only rarely as a sunscreen under sun exposure conditions because it disintegrates in sunlight.
Further preferably, the hydrolyzed starch is at least one selected from the group consisting of hydrolyzed corn starch and hydrolyzed wheat starch.
Further preferably, the hydrolyzed starch is hydrolyzed corn starch.
In the experimental process, the applicant finds that the hydrolyzed corn starch is added into the system, and can show better skin care effect when reacting with allantoin, particularly when the weight ratio of the allantoin to the hydrolyzed corn starch is 1: (3-6), the inventors speculate that the skin elasticity can be further improved, the phenomena such as skin peeling and water shortage can be avoided, and the allantoin decomposition can be avoided: when the hydrolyzed corn starch and the allantoin are compounded for use, the good load of the allantoin in the hydrolyzed corn starch can be ensured, the exposure of the allantoin on the skin surface is reduced, and a reaction basis is provided for the allantoin to play a role; in addition, the weight ratio of allantoin to hydrolyzed corn starch was 1: and (3) a lubricating film can be quickly formed on the surface layer of the skin within the range of (3-6), and at the moment, the glycyrrhiza inflata extract, the scutellaria baicalensis root extract and the hesperidin existing in a matching system can enhance the sealing effect of allantoin on the moisture on the surface layer of the skin on the premise of weakening the solar irradiation intensity, further improve the elasticity of the skin and avoid the phenomena of peeling, water shortage and the like of the skin.
In addition, the applicants have found that the addition of hydrolyzed wheat starch to the present system is less effective than hydrolyzed corn starch, presumably because the cellulose molecules in the hydrolyzed wheat starch are relatively small and less effective in loading and coating allantoin than hydrolyzed corn starch, and thus, in the present application, the hydrolyzed corn starch must be added to enhance skin moisturization and protection while ensuring protection from sunlight.
In some preferred embodiments, the humectant in component A comprises glyceryl polyether-26.
In some preferred embodiments, the thickener in component A is selected from at least one of potassium cetyl phosphate, xanthan gum, sodium carboxymethylcellulose, cross-linked polymers of acrylic acid/C10-30 alkanol acrylate.
Further preferably, the thickening agent in the component A is potassium cetyl phosphate.
In some preferred embodiments, the emulsifier of component a includes cetearyl glucoside, sorbitan olivate.
In some preferred embodiments, the raw materials for preparing the component A also comprise a composition A, and the raw materials for preparing the composition A comprise water, butanediol and PEG-240/HDI copolymer bis-decyl tetradecanol polyether-20 ether.
The composition A is purchased from Shanghai Mega-Heng industries, inc.
In some preferred embodiments, the ester in component B comprises ethylhexyl methoxycinnamate, ethylhexyl salicylate, C12-15 alcohol benzoate, tridecyl alcohol stearate.
In some preferred embodiments, the preparation raw materials in the component B also comprise bis-ethylhexyloxyphenol methoxyphenyl triazine, polysiloxane-15, shea butter and a composition B.
Shea butter, INCI: butYROSPERUM PARKII (SHEA BUTTER), CAS: 194043-92-0.
In some preferred embodiments, the raw materials for preparing the composition B comprise polyisobutylene, acrylamide/ammonium acrylate copolymer and polysorbate-20.
The composition B is purchased from Shanghai Baihabo chemical Co Ltd.
In some preferred embodiments, the skin conditioning agent B comprises phytosterol oleate, dimethicone.
In some preferred embodiments, the raw materials for preparing component C further comprise composition C, composition D and extract of Sophora flavescens ait.
In some preferred embodiments, the raw materials for preparing the composition C comprise water, methylene bis-benzotriazolyl tetramethyl butyl phenol, decyl glucoside, propylene glycol, xanthan gum.
The composition C was purchased from shanghai synehringer industries development ltd.
In some preferred embodiments, the raw materials for preparing composition D comprise glyceryl caprylate, caprylyl hydroxamic acid, 1, 2-hexanediol, and ethylhexyl glycerin.
The composition D was purchased from Egyptian Biotechnology, inc., guangzhou.
In some preferred embodiments, the raw materials for preparing the sunscreen cream also comprise water.
In some preferred embodiments, the sunscreen cream is prepared from the following raw materials in percentage by weight: 1-5% glyceryl polyether-26, 0.1-1% potassium cetyl phosphate, 1-5% emulsifier, 0.1-0.8% composition A, 0.05-0.5% allantoin, 0.5-2% hydrolyzed corn starch, 5-15% ethylhexyl methoxycinnamate, 2-5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 2-6% ethylhexyl salicylate, 1-5% C12-15 alcohol benzoate, 1-3% polysiloxane-15, 1-5% tridecyl alcohol stearate, 0.2-1% phytosterol oleate, 1-3.5% polydimethylsiloxane, 1-3% shea butter, 0.1-1% composition B, 1-5% composition C, 0.3-1% composition D, 0.06% radix Sophorae Flavescentis extract, 0.2% sunscreen synergist composition, and water to make up the balance to 100%.
Further preferably, the weight of the sunscreen synergist composition is 0.2% of the total weight of the raw materials for preparing the sunscreen cream.
During the experiment, the applicant finds that the addition amount of the sunscreen synergist composition in the system has a great influence on the stability and the sunscreen effect of the system, and after a great amount of creative experiments and researches, the applicant has found that when the weight of the sunscreen synergist composition added in the system is 0.2% of the total weight of raw materials for preparing sunscreen cream, the sunscreen synergist composition has better storage stability and sunscreen effect, and the applicant speculates that the phenomenon is caused by the following phenomenon: with the addition of the sunscreen agent, the interaction strength between the sunscreen agent and polar groups of substances such as an emulsifier and the like in a system is enhanced, so that the mutual cooperativity among the substances is promoted, the precipitation and migration of solids are avoided due to the mutual cooperativity among the substances in the placing process, the storage stability of the sunscreen cream is further improved, the sunscreen effect is ensured, the service life of the sunscreen cream is prolonged, the service life can be ensured to be within the range of 1.5-2 years, and the product waste caused by long-term use imperfection is reduced.
The fourth aspect of the invention provides a preparation method of sunscreen cream, which comprises the following steps:
s1: adding the component A into a preparation pot to prepare raw materials, stirring and heating to 80-85 ℃, and uniformly stirring;
s3: adding the raw materials for preparing the component B into the oil phase pot, stirring and heating to 80-85 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the material pumping is finished, and then starting cooling water to cool;
s4: cooling to 40-50 deg.C, adding component C, stirring at 40r/min, homogenizing at the bottom for 3-10min, and stirring for 5-20 min;
s5: after being stirred uniformly, the temperature is reduced to below 45 ℃ after the inspection is qualified, and the material is discharged, thus obtaining the product.
Has the beneficial effects that: the plant-derived sunscreen synergist composition and the sunscreen cream prepared from the composition have the following advantages:
1. when the sunscreen synergistic composition prepared by the invention faces to the sun high-intensity radiation, the sunscreen capability of the skin can be ensured, the damage of strong sunlight to the skin is avoided, and the skin aging phenomenon caused by exposure is avoided;
2. the sunscreen cream prepared by the invention can avoid the defect that the sunscreen cream cannot be irradiated by the sun due to the addition of allantoin, can further improve the skin elasticity, and avoids the phenomena of peeling, water shortage and the like of the skin;
3. the sunscreen cream prepared by the method can ensure that the storage stability of the sunscreen cream reaches 1.5-2 years, avoids the phenomenon of product waste caused by incomplete product use, and has higher use value;
4. the sun protection cream provided by the invention has the sun protection index increased by 2-10%, has a good sun protection effect, can greatly improve the protection of the sun protection cream on the skin, avoids the damage to the skin under the strong sunlight condition, and still has a good sun protection effect especially when being used in summer and under the strong sunlight condition.
Drawings
FIG. 1 is a diagram of the results of the skin patch test;
figure 2 is a graph of SPF test results.
Detailed Description
Examples
Example 1
A plant-derived sunscreen synergist composition is prepared from the following raw materials: radix Glycyrrhizae Inflatae extract, radix Scutellariae extract, and hesperidin.
Comprises the following components in parts by weight: 6 parts of liquorice root extract, 8 parts of scutellaria root extract and 5 parts of hesperidin.
Glycyrrhiza inflata root extract, INCI: glycyrrhiza INFLATA ROOT EXTRACT, available from Shanghai Kai Biotech Co., ltd.
Scutellaria root extract, INCI: SCUTELLARIA BAICALENSIS ROOT EXTRACT, CAS:94279-99-9.
Hesperidin, also known as nobiletin or flavanone glycoside, has a molecular formula of C 28 H 34 O 15 。
Example 2
A sunscreen cream is prepared from the following raw materials in percentage by weight: 3% glyceryl polyether-26, 0.5% potassium cetyl phosphate, 3% emulsifier, 0.5% composition A, 0.2% allantoin, 1% hydrolyzed corn starch, 8% ethylhexyl methoxycinnamate, 3.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 4% ethylhexyl salicylate, 3% C12-15 alcohol benzoate, 2% polysiloxane-15, 3% tridecyl stearate, 0.5% phytosterol oleate, 2% polydimethylsiloxane, 2% shea butter, 0.5% composition B, 3% composition C, 0.6% composition D, 0.06% extract of Sophora flavescens root, 0.2% sunscreen synergist composition, water to make up the balance to 100%.
The composition A is purchased from Shanghai Mega-Heng industries, inc.; the composition B is purchased from Shanghai Baihabo chemical industry Co., ltd; the composition C is purchased from Shanghai collaborative industry development company, inc.; the composition D was purchased from Ezepine Biotechnology, inc., guangzhou;
glyceryl polyether-26, available from clariant chemical (china) ltd; hydrolyzed corn starch, purchased from Shanghai Ruimeu chemical technology Co., ltd; polysiloxane-15, available from Shanghai Baihabo chemical Co., ltd.; polydimethylsiloxanes, available from Shanghai to flexibility chemical Co., ltd; the extract of radix Sophorae Flavescentis is obtained from Shanghai Jiaojia Biotech limited; butyrospermum parkii resin purchased from Shanghai Xiehui industry development Co., ltd;
a preparation method of sunscreen cream comprises the following steps:
s1: adding the component A preparation raw material into a preparation pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: adding the raw material preparation B into the oil phase pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the pumping is finished, and then starting cooling water to cool;
s4: cooling to 48 deg.C, adding component C, stirring at 40r/min, homogenizing at the bottom for 5min, and stirring for 10 min;
s5: after being stirred uniformly, the mixture is cooled to 35 ℃ after being checked to be qualified, and the product is obtained.
Example 3
A sunscreen cream is prepared from the following raw materials in percentage by weight: 3% glyceryl polyether-26, 0.5% potassium cetyl phosphate, 3% emulsifier, 0.5% composition A, 0.2% allantoin, 1% hydrolyzed corn starch, 8% ethylhexyl methoxycinnamate, 3.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 4% ethylhexyl salicylate, 3% C12-15 alcohol benzoate, 2% polysiloxane-15, 3% tridecyl stearate, 0.5% phytosterol oleate, 2% polydimethylsiloxane, 2% shea butter, 0.5% composition B, 3% composition C, 0.6% composition D, 0.06% extract of Sophora flavescens, water make-up to 100%.
The composition A is purchased from Shanghai Mega-Heng industry Co., ltd; the composition B is purchased from Shanghai Baihabo chemical industry Co., ltd; the composition C is purchased from Shanghai collaborative industry development company, inc.; the composition D was purchased from Ezepine Biotechnology, inc., guangzhou;
glyceryl polyether-26, available from clariant chemical (china) ltd; hydrolyzed corn starch, purchased from Shanghai Ruimeu chemical technology Co., ltd; polysiloxane-15, available from Baihaobo chemical Co., ltd, shanghai; polydimethylsiloxane, available from Shanghai to flexibility chemical Co., ltd; radix Sophorae Flavescentis extract obtained from Shanghai JiaKai Biotech limited; butyrospermum parkii resin purchased from Shanghai Xiehui industry development Co., ltd;
a preparation method of sunscreen cream comprises the following steps:
s1: adding the component A preparation raw material into a preparation pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: adding the raw material preparation B into the oil phase pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the pumping is finished, and then starting cooling water to cool;
s4: cooling to 48 deg.C, adding component C, stirring at 40r/min, homogenizing for 5min, and stirring for 10 min;
s5: after being stirred uniformly, the mixture is cooled to 35 ℃ after being checked to be qualified, and the product is obtained.
Example 4
A sunscreen cream is prepared from the following raw materials in percentage by weight: 3% glyceryl polyether-26, 0.5% potassium cetyl phosphate, 3% emulsifier, 0.5% composition A, 0.2% allantoin, 1% hydrolyzed corn starch, 8% ethylhexyl methoxycinnamate, 3.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 4% ethylhexyl salicylate, 3% C12-15 alcohol benzoate, 2% polysiloxane-15, 3% tridecyl alcohol stearate, 0.5% phytosterol oleate, 2% polydimethylsiloxane, 2% shea butter, 0.5% composition B, 3% composition C, 0.6% composition D, 0.06% bitter ginseng root extract, 0.05% sunscreen synergist composition, water make up the balance to 100%.
The composition A is purchased from Shanghai Mega-Heng industry Co., ltd; the composition B is purchased from Shanghai Baihabo chemical industry Co., ltd; the composition C is purchased from Shanghai collaborative industry development Limited; the composition D is purchased from Izod Biotechnology, inc. of Guangzhou;
glyceryl polyether-26, available from clariant chemical (china) ltd; hydrolyzed corn starch, purchased from Shanghai Ruimeu chemical technology Co., ltd; polysiloxane-15, available from Shanghai Baihabo chemical Co., ltd.; polydimethylsiloxane, available from Shanghai to flexibility chemical Co., ltd; radix Sophorae Flavescentis extract obtained from Shanghai JiaKai Biotech limited; butyrospermum parkii resin purchased from Shanghai Xiehui industry development Co., ltd;
a preparation method of sunscreen cream comprises the following steps:
s1: adding the component A preparation raw material into a preparation pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: adding the raw material preparation B into the oil phase pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the pumping is finished, and then starting cooling water to cool;
s4: cooling to 48 deg.C, adding component C, stirring at 40r/min, homogenizing for 5min, and stirring for 10 min;
s5: after being stirred uniformly, the mixture is cooled to 35 ℃ after being checked to be qualified, and the product is obtained.
Example 5
A sunscreen cream is prepared from the following raw materials in percentage by weight: 3% glyceryl polyether-26, 0.5% potassium cetyl phosphate, 3% emulsifier, 0.5% composition A, 0.2% allantoin, 1% hydrolyzed wheat starch, 8% ethylhexyl methoxycinnamate, 3.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 4% ethylhexyl salicylate, 3% C12-15 alcohol benzoate, 2% polysiloxane-15, 3% tridecyl stearate, 0.5% phytosterol oleate, 2% polydimethylsiloxane, 2% shea butter, 0.5% composition B, 3% composition C, 0.6% composition D, 0.06% extract of Sophora flavescens root, 0.2% sunscreen synergist composition, water to make up the balance to 100%.
The composition A is purchased from Shanghai Mega-Heng industries, inc.; the composition B is purchased from Shanghai Baihabo chemical industry Co., ltd; the composition C is purchased from Shanghai collaborative industry development company, inc.; the composition D was purchased from Ezepine Biotechnology, inc., guangzhou;
glyceryl polyether-26, available from clariant chemical (china) ltd; hydrolyzed wheat starch purchased from Shanghai Ruimei chemical science and technology Co., ltd; polysiloxane-15, available from Shanghai Baihabo chemical Co., ltd.; polydimethylsiloxane, available from Shanghai to flexibility chemical Co., ltd; the extract of radix Sophorae Flavescentis is obtained from Shanghai Jiaojia Biotech limited; butyrospermum parkii resin, purchased from Shanghai Xiehui industry development Limited;
a preparation method of sunscreen cream comprises the following steps:
s1: adding the component A preparation raw material into a preparation pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: adding the raw material preparation B into the oil phase pot, stirring and heating to 82 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the pumping is finished, and then starting cooling water to cool;
s4: cooling to 48 deg.C, adding component C, stirring at 40r/min, homogenizing for 5min, and stirring for 10 min;
s5: after being stirred uniformly, the mixture is cooled to 35 ℃ after being checked to be qualified, and the product is obtained.
And (3) performance testing:
1. skin patch experiment: the sunscreen prepared in example 2 was used in a patch test, and the test results were recorded in the following fig. 1.
The specific test method is as follows:
1. the test substance: the sunscreen cream prepared in example 2 of the present application.
2. Negative control: blank control;
3. subject: the total of 30 people, 10 men and 20 women, the age of 31-59 years, the average age of 49 +/-9 years, and the volunteer enrollment of the subjects.
4. The spot test method comprises the following steps: selecting qualified spot test equipment, placing 0.02-0.025g of a test object in a spot tester by a closed spot test method, externally applying hypoallergenic adhesive tape to the back of the test object, removing the test object after 24 hours, observing skin reactions respectively at 0.5, 24 and 48 hours after removal, and recording the results according to the skin reaction grading standard in the 2015 edition of the technical Specification for cosmetic safety, see fig. 1.
Spf test: the sunscreen prepared in example 2 was used for SPF testing:
1. and (3) measuring an object to be measured: example 2 the resulting sunscreen cream was prepared;
2. comparison products: the SPF value is 16.1 +/-2.4, and the composition is prepared according to a standard formula of a high SPF standard (P2) in technical Specification for safety of cosmetics (2015 edition).
3. Subject: the total of 10 people, 7 men and 3 women, the age is 19 to 49 years, the average age is 32.1 +/-11.9 years, and the inclusion criteria of the testee's mental apparatus are met.
4. Light source: various performance indexes of the xenon arc lamp of the sunlight simulator meet the requirement of measurement specification.
5. The detection method comprises the following steps: the test was carried out according to the specific requirements of the technical Specification for cosmetic safety (2015 edition). The back part of the subject is taken for irradiation. The minimum amount of erythema (MED) of the skin of the subject irradiated with ultraviolet rays is predicted 24 hours before the test, and the ultraviolet irradiation dose is adjusted according to the prediction result to test the object. On the test day, first, a specimen is selected from the back of a subject to be tested to a size of not less than 30cm 2 In the normal skin area of (2.00 + 0.05) mg/cm 2 Uniformly coating the object to be detected or the reference substance in the area, selecting the irradiation dose according to the standard requirement, and irradiating according to three conditions: (1) the skin of the subject is not coated with the test object; (2) coating a reference substance; (3) coating the test object. The results were observed after 24 hours and the MED was recorded for each of the three cases.
6, SPF value calculation method: the SPF value of the test or control article to protect an individual subject is expressed by the formula:
MED value of protective skin
Spf = MED value of protected skin/MED value of unprotected skin
The individual SPF value is required to be accurate to one digit after a decimal point, the arithmetic mean of the SPF values of all tested testees protected by the tested object is calculated, and the integral part of the arithmetic mean is the SPF value of the tested sample. The sampling error of the estimated mean can be calculated as the standard deviation and standard error of the group of data. The 95% confidence interval (95% CI) for the mean number is required not to exceed 17% of the mean number, otherwise the number of subjects should be increased (not to exceed 25) until the above requirements are met.
The results of the experiment are recorded in the following figure, see fig. 2:
the results of the human body test show that the SPF value of the product prepared by the method is 31.
3. And (3) testing the stability: the sunscreen creams prepared in examples 2-4 were used for stability testing by placing the sunscreen cream at-10 deg.C for 30 days, then taking out and placing at 45 deg.C for 30 days, observing the change after returning to room temperature, and the results are reported in Table 3 below.
Table 3:
| experiment of | Stability of |
| Example 2 | Without any change |
| Example 3 | Without any change |
| Example 4 | Without any change |
| Example 5 | The caking phenomenon appears |
Claims (10)
1. A plant-derived sunscreen synergist composition is characterized in that the preparation raw materials comprise plant root extract and hesperidin; the plant root extract is at least one selected from the group consisting of glycyrrhiza inflate root extract, scutellaria baicalensis root extract, sophora flavescens root extract, dandelion root extract and peony root extract.
2. The plant-derived sunscreen potentiator composition of claim 1, wherein said plant root extract comprises glycyrrhiza inflata root extract, scutellaria baicalensis root extract.
3. The plant-derived sunscreen/synergist composition according to claim 1 or 2, wherein the weight ratio of glycyrrhiza inflata root extract, scutellaria baicalensis root extract and hesperidin is (3-7): (5-10): (2-6).
4. Use of a plant-derived sunscreen builder composition according to any of claims 1 to 3 for the preparation of a sunscreen cream, a skin cream, a sunscreen spray.
5. A sunscreen comprising the plant-derived sunscreen builder composition of any one of claims 1 to 3.
6. The sunscreen cream according to claim 5, wherein the preparation raw materials comprise a component A, a component B and a component C;
the preparation raw materials of the component A comprise a humectant, a skin conditioner A, a thickening agent and an emulsifying agent;
the raw materials for preparing the component B comprise a skin conditioner B and an ester substance;
the raw materials for preparing the component C comprise a sunscreen synergist composition.
7. The sunscreen of claim 6 wherein said skin conditioning agent A comprises allantoin and hydrolyzed starch.
8. The sunscreen cream of claim 7, wherein the weight ratio of allantoin to hydrolyzed starch is 1: (3-10); preferably, the weight ratio is 1: (3-6).
9. The sunscreen cream of claim 6, wherein said skin conditioner B comprises phytosterol oleate, dimethicone.
10. A method for preparing a sunscreen according to any of claims 5-9 comprising the steps of:
s1: adding the raw materials for preparing the component A into a preparation pot, stirring and heating to 80-85 ℃, and uniformly stirring;
s3: adding the raw material preparation of the component B into the oil phase pot, stirring and heating to 80-85 ℃, and uniformly stirring;
s3: pumping the oil phase materials into a preparation pot, continuing homogenizing and emulsifying for 3-10min after the pumping is finished, and then starting cooling water to cool;
s4: cooling to 40-50 deg.C, adding component C, stirring at 40r/min, homogenizing at the bottom for 3-10min, and stirring for 5-20 min;
s5: after being stirred uniformly, the temperature is reduced to below 45 ℃ after the inspection is qualified, and the material is discharged, thus obtaining the product.
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