CN115487102A - High-concentration alpha-arbutin relieving composition and preparation method and application thereof - Google Patents
High-concentration alpha-arbutin relieving composition and preparation method and application thereof Download PDFInfo
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- CN115487102A CN115487102A CN202111281094.0A CN202111281094A CN115487102A CN 115487102 A CN115487102 A CN 115487102A CN 202111281094 A CN202111281094 A CN 202111281094A CN 115487102 A CN115487102 A CN 115487102A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention provides a high-concentration alpha-arbutin relieving composition and application thereof, and the preparation raw materials comprise citrus fruit extract, gentian extract, tetrandra root extract, oat beta-glucan, alpha-arbutin, nicotinamide, emulsifier, humectant, xanthan gum, squalane, polydimethylsiloxane, glyceryl polyether-26, deionized water and the like. The prepared soothing composition has good skin tolerance and stability, has soothing and anti-allergy effects, and can be applied to various skin care products and cosmetics such as emulsion, cream, essence water, facial mask and the like.
Description
Technical Field
The invention belongs to the technical field of A61Q19/00, and particularly relates to a high-concentration alpha-arbutin relieving composition as well as a preparation method and application thereof.
Background
In the commercial arbutin products, beta-arbutin is mostly added, and because the beta-arbutin has the residue of chemical substances such as hydroquinone and the like in the synthesis process, the addition amount of the beta-arbutin in the cosmetics is generally not more than 7 percent under the limitation of substances limited by the cosmetics. In recent years, people find that alpha-arbutin with a spatial structure different from that of beta-arbutin can inhibit the activity of the tyrosinase by more than 9 times that of the beta-arbutin under the condition of low concentration, and the whitening effect is excellent.
Chinese patent CN112043653A discloses an anti-allergy soothing mask, wherein 0.1-0.4 part of alpha-arbutin is added into the mask liquid, and a soothing composition with the content 15-30 times that of the alpha-arbutin is added for achieving the anti-allergy soothing effect, but the effect of the composition on whitening and spot lightening is limited.
Based on the composition, the high-concentration alpha-arbutin relieving composition and the application thereof are provided, the high-concentration alpha-arbutin with the mass fraction of more than 2% is added, and the tolerance of the skin to the alpha-arbutin is improved through the combined action of the relieving agents with different mechanisms, so that the effect of the alpha-arbutin is better exerted.
Disclosure of Invention
The invention provides a high-concentration alpha-arbutin relieving composition, which is characterized in that a preparation raw material comprises plant extracts, wherein the plant extracts comprise a mixed substance of a citrus fruit extract, a gentian extract and a tetrandra root extract.
In a preferred embodiment, the mass ratio of the mixture of the citrus fruit extract, the gentian extract and the tetrandra root extract is (0.1-1.2): (0.5-1.5).
In a preferred embodiment, the mass ratio of the mixture of the citrus fruit extract, the gentian extract and the tetrandra root extract is 1.
In a preferred embodiment, the mass ratio of the gentian extract to the tetrandra root extract in the mixed substance of the gentian extract and the tetrandra root extract is 1:1.
in a preferred embodiment, the preparation raw materials further comprise oat beta-glucan, alpha-arbutin, nicotinamide and a preservative.
In a preferred embodiment, the preparation raw materials further comprise an emulsifier, a humectant, a thickener, synthetic oil, a softening agent, a pH regulator and deionized water.
In a preferred embodiment, the emulsifier is selected from at least one of cetearyl olive oleate, sorbitan olive oleate, cetearyl ethylhexanoate, PEG-7 olive oleate, PEG-4 olive oleate, isocetyl myristate, cetyl palmitate, polyglyceryl-3 methyl glucose distearate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
In a preferred embodiment, the emulsifier comprises cetearyl olivate, sorbitan olivate, cetearyl ethylhexanoate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
In a preferred embodiment, the mass ratio of cetearyl ethyl hexanoate to hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is 3:0.4.
in a preferred embodiment, the cetearyl olivate, sorbitan olivate, cetearyl ethylhexanoate are in the mass ratio (0.5-0.8): (0.1-0.4): 3.
in a preferred embodiment, the mass ratio of cetearyl olive oleate, sorbitan olive oleate, cetearyl ethyl hexanoate is 0.6:0.4:3.
in a preferred embodiment, the humectant comprises hydrolyzed corn starch and sodium hyaluronate, and the mass ratio of the hydrolyzed corn starch to the sodium hyaluronate is (0.8-2.5): 0.1.
in a preferred embodiment, the mass ratio of the hydrolyzed corn starch to the sodium hyaluronate is 1:0.1.
in a preferred embodiment, the thickening agent is selected from at least one of hyaluronic acid, xanthan gum, methyl cellulose, sodium alginate, carrageenan.
In a preferred embodiment, the thickener is xanthan gum.
In a preferred embodiment, the emollient is selected from at least one of glyceryl polyether-26, caprylic/capric triglyceride, isopropyl lanolate, cetyl palmitate, myristyl myristate, coco glucoside.
In a preferred embodiment, the emollient is glyceryl polyether-26.
In a preferred embodiment, the preservatives are p-hydroxyacetophenone, glyceryl caprylate, caprylyl hydroxamic acid, ethylhexyl glycerol, and 1, 2-hexanediol.
In a preferred embodiment, the mass ratio of the mixed substance of the glyceryl caprylate, the caprylyl hydroxamic acid, the ethylhexyl glycerol and the 1, 2-hexanediol to the p-hydroxyacetophenone is 3.
In a preferable embodiment, the preparation raw materials comprise, by mass, 1.5-3.5% of plant extract, 2-3% of oat beta-glucan, 2-5% of alpha-arbutin, 1.2-2.2% of nicotinamide, 1.5-8% of emulsifier, 1-5% of humectant, 0.1-0.5% of thickener, 2-8% of synthetic oil and fat, 0.1-1.5% of emollient, 0.1% of pH regulator, 0.2-1% of preservative, and the balance of deionized water.
In a preferred embodiment, the preparation raw materials comprise, by mass, 2% of plant extract, 2% of oat beta-glucan, 4% of alpha-arbutin, 2% of nicotinamide, 4.4% of emulsifier, 3.1% of humectant, 0.1% of thickener, 5% of synthetic oil, 2% of emollient, 0.1% of pH regulator, 0.8% of preservative, and the balance of deionized water.
In a preferred embodiment, the synthetic oil is selected from at least one of squalane, polydimethylsiloxane, octyl polydimethylsiloxane, cyclic polysiloxane and isomeric alkanol.
In a preferred embodiment, the synthetic oil is squalane and polydimethylsiloxane, and the mass ratio of squalane to polydimethylsiloxane is 2.
In a preferred embodiment, the pH adjusting agent is EDTA-2Na.
The applicant finds that the skin tolerance and stability of alpha-arbutin can be improved by adding the citrus fruit extract, the mixed substance of the radix gentianae extract and the radix stephaniae tetrandrae extract, the oat beta-glucan and the like in the experimental process, and supposes that the possible reasons are that the addition of the mixed substance of the citrus fruit extract, the radix gentianae extract and the radix stephaniae tetrandrae extract can reduce the generation of substances which have irritation on the skin in a system and improve the tolerance of the skin on the alpha-arbutin by inhibiting the decomposition of the alpha-arbutin, and the addition of the raw materials of the citrus fruit extract, the radix gentianae extract, the radix stephaniae tetrandrae extract, the oat beta-glucan and the like can promote skin cells to secrete sterol and protein substances, improve the activity and tolerance of the skin cells and improve the whitening and spot-lightening effect of the soothing composition.
The applicant also finds in the experimental process that the soothing composition prepared by the application has good stability, and supposes that the possible reason is that the dispersibility and compatibility of the oil-soluble raw material in the system are improved and the stability of the composition is improved by adding the water-soluble raw material such as the glyceryl polyether-26, the sodium hyaluronate, the xanthan gum and the like and the oil-soluble raw material through the action between the active group and the molecular chain.
The second aspect of the invention provides a preparation method of a high-concentration alpha-arbutin relieving composition, which comprises the following steps:
(1) Adding deionized water and a pH regulator into a preparation pot, heating, and uniformly stirring to obtain a phase A;
(2) Adding phase B composed of part of emulsifier, humectant, thickener, emollient, and part of antiseptic into phase A, and stirring;
(3) Adding synthetic oil and the rest emulsifier into an oil phase pot, heating, and uniformly stirring to obtain a phase C;
(4) Adding the phase C into the step (2), homogenizing, emulsifying and cooling;
(5) Cooling to below 50 deg.C, adding plant extract, oat beta-dextran, alpha-arbutin, nicotinamide and the rest antiseptic, and stirring to obtain the soothing composition.
In a preferred embodiment, the method of preparing the soothing composition comprises the steps of:
(1) Adding deionized water and EDTA-2Na into a preparation pot, heating to 80-85 ℃, and uniformly stirring to obtain phase A;
(2) Adding phase B composed of cetearyl olive oleate, sorbitan olive oleate, humectant, thickener, emollient, and p-hydroxyacetophenone into phase A, and stirring;
(3) Adding synthetic oil, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, and cetearyl ethyl hexanoate into an oil phase pan, heating to 80-85 deg.C, and stirring to obtain phase C;
(4) Adding the phase C into the step (2), homogenizing, emulsifying and cooling;
(5) Cooling to below 50 deg.C, adding plant extract, oat beta-dextran, alpha-arbutin, nicotinamide and glyceryl caprylate, caprylyl hydroxamic acid, 1, 2-hexanediol, and ethylhexyl glycerin, and stirring to obtain the soothing composition.
In a third aspect, the present invention provides a use of a soothing composition, wherein the soothing composition is applied to a lotion, a cream, an essence lotion, and a mask.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the soothing composition provided by the invention, the specific plant extract and other raw materials are added, the tolerance of the skin to alpha-arbutin is improved by improving the activity of skin cells and inhibiting the decomposition and combined action of the alpha-arbutin, and the whitening and spot-lightening effects of the soothing composition on the skin are improved.
2. The soothing composition provided by the invention improves the compatibility between the oil-soluble raw material and the water-soluble raw material in the system, promotes the dispersing capacity among the raw materials in the system and further improves the stability of the system by adding the raw materials such as the glyceryl polyether-26 and the sodium hyaluronate.
3. The soothing composition provided by the invention has good soothing and anti-allergy effects, and can be applied to various skin care products and cosmetics such as emulsion, cream, essence water, facial mask and the like.
Detailed Description
Example 1
In the first aspect of the embodiment, a high-concentration alpha-arbutin soothing composition is provided, which is prepared from 2% by mass of plant extract, 2% by mass of oat beta-glucan, 4% by mass of alpha-arbutin, 2% by mass of nicotinamide, 4.4% by mass of emulsifier, 1.1% by mass of humectant, 0.1% by mass of xanthan gum, 2% by mass of squalane, 3% by mass of polydimethylsiloxane, 26% by mass of glyceryl polyether-26, 0.1% by mass of EDTA-2Na0, 0.8% by mass of preservative, and the balance being deionized water.
The plant extract is a mixed substance of a citrus fruit extract, a radix gentianae extract and a radix stephaniae tetrandrae extract, the mass ratio of the citrus fruit extract to the mixed substance of the radix gentianae extract and the radix stephaniae tetrandrae extract is 1. Citrus fruit extracts were purchased from Kalima Biotech Co., ltd. The mixture of gentian extract and tetrandra root extract was purchased from gaoney biotechnology limited, guangzhou.
The humectant is hydrolyzed corn starch and sodium hyaluronate, and the mass ratio of the hydrolyzed corn starch to the sodium hyaluronate is 1:0.1.
the emulsifier is cetearyl olive oleate, sorbitan olive oleate, cetearyl ethyl hexanoate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, the mass ratio of the cetearyl olive oleate, the sorbitan olive oleate, the cetearyl ethyl hexanoate to the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is 0.6:0.4:3:0.4.
hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymers were purchased from Shanghai Baihabo chemical Co., ltd; cetearyl olive oleate, sorbitan olive oleate are purchased from Shanghai Hayage Biotech, inc.; cetearyl ethylhexanoate was purchased from Shanghai Hatch Biotech, inc.
The preservative is a mixed substance of p-hydroxyacetophenone, caprylic acid ester, caprylyl hydroximic acid, ethylhexyl glycerol and 1, 2-hexanediol, which is purchased from Ezem Biotech, guangzhou, and the mass ratio of the mixed substance of caprylic acid ester, caprylic hydroximic acid, ethylhexyl glycerol and 1, 2-hexanediol to p-hydroxyacetophenone is 3, and the mass ratio of caprylic acid ester, 1, 2-hexanediol, caprylyl hydroximic acid and ethylhexyl glycerol is 0.55.
In a second aspect, this example provides a method for preparing a high concentration α -arbutin soothing composition, comprising the steps of:
(1) Adding deionized water and EDTA-2Na into a preparation pot, heating to 82 ℃, and uniformly stirring to obtain a phase A;
(2) Adding phase B composed of cetearyl olive oleate, sorbitan olive oleate, hydrolyzed corn starch, sodium hyaluronate, xanthan gum, glyceryl polyether-26, and p-hydroxyacetophenone into phase A, and stirring;
(3) Adding squalane, polydimethylsiloxane, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and cetearyl ethyl hexanoate into an oil phase pot, heating to 82 ℃, and uniformly stirring to obtain a phase C;
(4) Adding the phase C into the step (2), homogenizing, emulsifying and cooling;
(5) Cooling to 48 deg.C, adding Mandarin orange fruit extract, radix Gentianae extract, radix Stephaniae Japonicae extract, oat beta-dextran, alpha-arbutin, nicotinamide and glyceryl caprylate, caprylyl hydroximic acid, 1, 2-hexanediol, and ethylhexyl glycerin, and stirring to obtain the soothing composition.
In a third aspect, the present invention provides a use of a high concentration α -arbutin soothing composition in lotions, creams, essences, lotions, masks.
Example 2
The first aspect of this example proposes a high concentration α -arbutin-soothing composition, the second aspect of this example proposes a method for preparing a high concentration α -arbutin-soothing composition, and the third aspect of this example proposes the use of a high concentration α -arbutin-soothing composition, specifically using the same raw materials and embodiments as in example 1, except that the mixture of citrus fruit extract, gentian extract and tetrandra root extract is not added.
Example 3
The first aspect of this example proposes a high concentration α -arbutin-soothing composition, the second aspect of this example proposes a method for preparing a high concentration α -arbutin-soothing composition, and the third aspect of this example proposes the use of a high concentration α -arbutin-soothing composition, specifically using the same raw materials and embodiments as example 1, except that no glyceryl polyether-26 is added.
Example 4
The first aspect of this example proposes a high concentration α -arbutin-soothing composition, the second aspect of this example proposes a method for preparing a high concentration α -arbutin-soothing composition, and the third aspect of this example proposes the use of a high concentration α -arbutin-soothing composition, specifically using the same raw materials and embodiments as in example 1, except that xanthan gum, sodium hyaluronate, and hydrolyzed corn starch are not added.
Performance testing
1. And (5) carrying out a tolerance test.
The soothing composition prepared in example 1 was subjected to acute eye irritation test and skin tolerance test. The test animal was a New Zealand rabbit.
Acute eye irritation test: 0.1ml of the soothing composition was dropped into the conjunctival sac of one eye of the rabbit, the upper and lower eyelids were passively closed, and the other eye was left untreated as a control group. The eyes of the animals were examined 1h, 24h, 48h, 72h, day 4, day 7 after instillation of the soothing composition. If the stimulus response does not appear within 72 hours, the test can be stopped; if stimulation is found and no recovery occurs within 7 days, the observation time is prolonged. The test results are reported in table 1.
TABLE 1
Skin tolerance test: removing hair from two sides of the spine of the back of the rabbit, wherein the hair removing range is respectively 3cm × 3cm, and the smearing area is 2.5cm × 2.5cm. 0.5ml of the soothing composition was applied to one side of the skin and the other side was used as a control and applied 1 time per day for 14 consecutive days. The irritation results were observed 1 hour after each day of application. The test results are reported in table 2.
TABLE 2
2. And (5) testing the stability.
The soothing composition prepared in the examples was left at-10 ℃ for 30 days at 45 ℃ and then returned to normal temperature, and the stability of the soothing composition was tested by observing the change of the soothing composition from that before the stability test. The test results are recorded in table 3.
TABLE 3
| -10℃ | 45℃ | |
| Example 1 | Stabilization of | Stabilization |
| Example 2 | Stabilization of | Stabilization |
| Example 3 | Instability of the film | Stabilization |
| Example 4 | Instability of the film | Instability of the film |
Claims (10)
1. A high concentration alpha-arbutin soothing composition is characterized in that the preparation raw material comprises plant extracts, wherein the plant extracts comprise a mixed substance of citrus fruit extract, gentian extract and tetrandra root extract; the mass ratio of the mixed substances of the citrus fruit extract, the gentian extract and the tetrandra root extract is (0.1-1.2): (0.5-1.5).
2. The soothing composition of claim 1, wherein the mass ratio of the gentian extract to the tetrandra root extract in the mixture of gentian extract and tetrandra root extract is 1:1.
3. a soothing composition according to claim 1, wherein the raw materials of preparation further comprise oat beta-glucan, alpha-arbutin, niacinamide, preservatives.
4. A soothing composition according to claim 3, wherein the raw materials for preparation further comprise an emulsifier, a humectant, a thickener, a synthetic oil, a emollient, a pH adjuster, deionized water.
5. A soothing composition according to claim 4, wherein the emulsifier is selected from at least one of cetearyl olive oleate, sorbitan olive oleate, cetearyl ethyl hexanoate, PEG-7 olive oleate, PEG-4 olive oleate, isocetyl myristate, cetyl palmitate, polyglyceryl-3 methyl glucose distearate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
6. A soothing composition according to claim 4, wherein the moisturizing agent comprises hydrolyzed corn starch and sodium hyaluronate, and the mass ratio of the hydrolyzed corn starch to the sodium hyaluronate is (0.8-2.5): 0.1.
7. a soothing composition according to claim 4, wherein the raw materials for preparation comprise, by mass, 1.5-3.5% of plant extract, 2-3% of oat beta-glucan, 2-5% of alpha-arbutin, 1.2-2.2% of nicotinamide, 1.5-8% of emulsifier, 1-5% of humectant, 0.1-0.5% of thickener, 2-8% of synthetic oil, 0.1-1.5% of emollient, 0.1% of pH regulator, 0.2-1% of preservative, and the balance of deionized water.
8. A soothing composition according to claim 7, wherein the synthetic oil is selected from at least one of squalane, dimethicone, octyldimethicone, cyclopolysiloxane, an isomeric alkanol.
9. A process for preparing a soothing composition according to any of claims 7 to 8, comprising the steps of:
(1) Adding deionized water and a pH regulator into a preparation pot, heating, and uniformly stirring to obtain a phase A;
(2) Adding phase B composed of part of emulsifier, humectant, thickener, emollient, and part of antiseptic into phase A, and stirring;
(3) Adding synthetic oil and the rest emulsifier into an oil phase pot, heating, and uniformly stirring to obtain a phase C;
(4) Adding the phase C into the step (2), homogenizing, emulsifying and cooling;
(5) Cooling to below 50 deg.C, adding plant extract, oat beta-dextran, alpha-arbutin, nicotinamide and the rest antiseptic, and stirring to obtain the soothing composition.
10. Use of a soothing composition according to any of claims 4 to 8 in a lotion, cream, serum or mask.
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| CN202111281094.0A CN115487102A (en) | 2021-11-03 | 2021-11-03 | High-concentration alpha-arbutin relieving composition and preparation method and application thereof |
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| CN202111281094.0A CN115487102A (en) | 2021-11-03 | 2021-11-03 | High-concentration alpha-arbutin relieving composition and preparation method and application thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101227889A (en) * | 2005-06-21 | 2008-07-23 | 陶氏康宁东丽株式会社 | Cosmetics comprising a modified organopolysiloxane |
| CN113576939A (en) * | 2021-08-03 | 2021-11-02 | 北京清大赛尔生物科技有限公司 | Biological essence polypeptide composition, and preparation method and application of lipidosome nanocrystallization thereof |
-
2021
- 2021-11-03 CN CN202111281094.0A patent/CN115487102A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101227889A (en) * | 2005-06-21 | 2008-07-23 | 陶氏康宁东丽株式会社 | Cosmetics comprising a modified organopolysiloxane |
| CN113576939A (en) * | 2021-08-03 | 2021-11-02 | 北京清大赛尔生物科技有限公司 | Biological essence polypeptide composition, and preparation method and application of lipidosome nanocrystallization thereof |
Non-Patent Citations (1)
| Title |
|---|
| 上海丽舒丹医药科技有限公司: "丽舒丹熊果苷精华液", pages 1 - 2, Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=986273225321218048&gb=G> * |
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