CN115486538A - Composition with female reproductive system protection effect and preparation method and application thereof - Google Patents
Composition with female reproductive system protection effect and preparation method and application thereof Download PDFInfo
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- CN115486538A CN115486538A CN202211117738.7A CN202211117738A CN115486538A CN 115486538 A CN115486538 A CN 115486538A CN 202211117738 A CN202211117738 A CN 202211117738A CN 115486538 A CN115486538 A CN 115486538A
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- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 235000004330 tyrosol Nutrition 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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Abstract
The invention provides a composition with female reproductive system protection effect, and a preparation method and application thereof, wherein the composition is prepared from raw materials including ginseng extract, cranberry extract and coenzyme Q10. The ginseng extract, the cranberry extract and the coenzyme Q10 are creatively matched to protect the female reproductive system, supplement each other and synergically, and have the effects of resisting oxidation and bacteria, enhancing the physique, delaying the ovarian senescence, preventing the urogenital system infection, promoting the intestinal tract movement and defecation and protecting the female reproductive system.
Description
Technical Field
The invention belongs to the field of female health care products, and particularly relates to a composition with female reproductive system protection effect, and a preparation method and application thereof.
Background
Female genitalia include uterus, fallopian tube, ovary and the like, and the ovary is a very important reproductive organ of a female and mainly has two functions including reproductive function and endocrine function. Reproductive functions of the ovary include the development, maturation and ovulation of follicles and the formation and degeneration of the corpus luteum. The normal functioning of this process is essential for the formation of mature oocytes for human reproduction. The endocrine function of the ovary refers to the secretion of sex hormones (estrogen, progestogen, androgen) and polypeptide hormones and growth factors which are extremely important for reproduction and the body. Ovarian reserve function refers to the number and quality of follicles in the ovary and is the most important factor in female fertility. There are many factors that affect ovarian reserve function, including mainly: genetic factors, immunological factors, age factors, iatrogenic factors (ovarian surgery, etc.), environmental factors, psychological factors, etc. Diminished ovarian reserve means a decreased number or quality of follicles within the ovary, which can reduce pregnancy rates, increase miscarriage rates and increase the incidence of obstetric complications, as well as a low ovarian response in the practice of assisted reproductive techniques. The long-term deficiency of the ovarian endocrine hormones causes a number of systemic disorders in women, including the nervous system, cardiovascular and cerebrovascular systems, the cutaneous system, the urogenital system, and the skeletal system. The direction of protecting ovarian function can be roughly divided into three categories, namely, hormone supplement, antioxidation and microcirculation improvement.
CN113041312A discloses a traditional Chinese medicine composition for treating premature ovarian failure, which is prepared from the following raw materials in parts by weight: 8-20 parts of prepared rhizome of rehmannia, 6-10 parts of pulp of dogwood fruit, 10-30 parts of yam, 10-15 parts of medlar, 6-10 parts of tortoise-plastron glue, 6-10 parts of deerhorn glue, 10-25 parts of dodder, 6-10 parts of medicinal cyathula root, 10-15 parts of malaytea scurfpea fruit, 10-15 parts of parasitic loranthus, 10-15 parts of teasel root, 6-10 parts of ginseng, 10-30 parts of astragalus root, 6-10 parts of bighead atractylodes rhizome, 10-15 parts of angelica, 10-15 parts of white paeony root, 6-10 parts of dried orange peel and 6-10 parts of honey-fried licorice root. The traditional Chinese medicine composition for treating premature ovarian failure provided by the invention can effectively inhibit apoptosis of granulosa cells, promote follicular development and maturity, improve ovarian reserve capacity and is high in safety.
CN113244272A discloses a composition for improving premature ovarian failure, and a preparation method and an application thereof. The composition for improving premature ovarian failure provided by the invention is characterized in that a human endometrial stem cell membrane constructed in vitro and a mesenchymal stem cell exosome are compounded for use, so that follicular development can be promoted, the ovary can be promoted to secrete anti-mullerian hormone, the level of follicle stimulating hormone can be regulated, ovarian cell apoptosis can be inhibited, ovarian reserve dysfunction diseases can be improved, primary or secondary premature ovarian failure can be improved, and a new idea is provided for clinically treating ovarian insufficiency and polycystic ovarian syndrome.
At present, hormone replacement therapy is mostly used for relieving premature ovarian failure symptoms, although the hormone replacement therapy is effective, the premature ovarian failure symptoms cannot be cured radically, the functions of ovaries cannot be recovered again after drug withdrawal, and estrogen can increase the probability of endometrial cancer, so that the search for safer preparations for relieving premature ovarian failure symptoms for human bodies is very meaningful.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a composition and a preparation method and application thereof, and particularly provides a composition with the effect of protecting a female reproductive system and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a composition having an effect of protecting a female reproductive system, which is prepared from raw materials including ginseng extract, cranberry extract and coenzyme Q10.
The raw materials for preparing the composition comprise ginseng extract, the main active component of ginseng is ginsenoside, and the composition has the effects of tonifying spleen and lung, promoting the production of body fluid and nourishing blood, soothing nerves and promoting intelligence, greatly tonifying primordial qi, and recovering pulse and relieving depletion; researches show that the life of fruit flies can be prolonged by taking the cranberry, the effect is particularly obvious on female fruit flies, the reproductive rate and the motility can be improved, the life of caenorhabditis elegans can be obviously prolonged by dietary intervention of the cranberry, the cranberry is also a food with low calorie, high dietary fiber, multiple vitamins and minerals, the high-content dietary fiber has the effects of promoting intestinal tract peristalsis and detoxification, preventing colon cancer, assisting in preventing and treating diabetes and the like, and rich vitamin C plays roles of preventing scurvy, resisting oxidation, promoting growth and development, enhancing physique, relieving fatigue and the like, and in addition, the vitamin A and beta-carotene content in the cranberry is also rich, so that the cranberry has the effects of preventing and treating hypopsia, maintaining the function of skin cells, maintaining the function of a normal immune system and the like; coenzyme Q10 is taken as a proton and an electron carrier in the mitochondrial inner membrane, has the function of biological energy, is an endogenous lipophilic antioxidant, is widely present in the biomembrane, mainly participates in electron transport and oxidative phosphorylation in the mitochondrial respiratory chain, can resist oxidation, remove free radicals, improve the ovarian reserve function, increase the number of follicles and improve the quality of follicles.
The ginseng extract, the cranberry extract and the coenzyme Q10 are creatively matched to protect the female reproductive system, supplement each other and synergically, and have the obvious effects of resisting oxidation and bacteria, enhancing the physique, delaying the ovarian senescence, preventing the urogenital system infection, promoting the intestinal tract movement and defecation and protecting the female reproductive system.
Preferably, the raw materials for preparing the composition comprise, by mass, 20-200 parts of a ginseng extract, 10-100 parts of a cranberry extract and 0.5-3 parts of coenzyme Q.
The ginseng extract can be 20 parts, 40 parts, 60 parts, 80 parts, 100 parts, 120 parts, 140 parts, 160 parts, 180 parts or 200 parts by mass.
The cranberry extract can be 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, 90 parts or 100 parts by weight.
The coenzyme Q10 can be 0.5 part, 0.8 part, 1.1 part, 1.4 parts, 1.7 parts, 2 parts, 2.3 parts, 2.6 parts, 2.9 parts or 3 parts by mass and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the composition is prepared from raw materials comprising wolfberry extract.
The raw materials for preparing the composition also comprise a medlar extract, wherein the medlar contains carotene, thiamine, riboflavin, nicotinic acid and ascorbic acid, and the medlar has the effects of nourishing kidney, moistening lung, tonifying liver and improving eyesight.
Preferably, the composition further comprises 5-30 parts of a Chinese wolfberry extract in parts by mass.
The wolfberry extract can be prepared from 5 parts, 9 parts, 13 parts, 17 parts, 21 parts, 25 parts, 29 parts or 30 parts by weight. Other specific values within the above ranges can be selected, and are not described in detail herein.
Preferably, the composition further comprises rhodiola rosea extract.
The raw materials for preparing the composition also comprise rhodiola rosea extract, wherein the rhodiola rosea contains salidroside, aglycon tyrosol and rhodiola rosea polysaccharide, and contains fat, sterol, phenolic compounds, organic acid, tannin, various vitamins, water-soluble volatile oil and the like, and has the effects of tonifying qi and activating blood, and dredging collaterals and relieving asthma.
Preferably, the composition further comprises 3-20 parts of rhodiola rosea extract by mass.
The rhodiola rosea extract can be prepared into the dosage forms of 3 parts, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, 15 parts, 17 parts, 19 parts or 20 parts by mass. Other specific values within the above ranges can be selected, and are not described in detail herein.
In a second aspect, the present invention provides a method for preparing a composition having an effect of protecting a female reproductive system according to the first aspect, wherein the method comprises: (1) Chopping Ginseng radix, soaking in ethanol water solution a, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain Ginseng radix extract; cutting cranberry, soaking in ethanol water solution b, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain cranberry extract; (2) Mixing Ginseng radix extract, cranberry extract and coenzyme Q10 to obtain the composition with female reproductive system protecting effect.
The preparation method of the composition with the effect of protecting the female reproductive system is simple and easy to operate, is very suitable for large-scale industrial production, and can be obtained by respectively extracting and mixing the components.
Preferably, the volume fraction of ethanol in the ethanol aqueous solution a in the step (1) is 80-95%.
The specific value of 80-95% may be selected from 80%, 82%, 84%, 86%, 88%, 90%, 92% or 95%, etc. Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the volume fraction of ethanol in the ethanol aqueous solution b in the step (1) is 60-80%.
The specific value of 60-80% may be selected from 60%, 63%, 66%, 69%, 72%, 75%, 77%, 80%, etc. Other specific values within the above ranges can be selected, and are not described in detail herein.
Preferably, the reflux extraction in step (1) is independently repeated 1 to 3 times, and the 1 to 3 times include 1 time, 2 times and 3 times.
Preferably, the mesh number of the screen mesh for sieving in step (1) is independently 70-90 meshes, for example, 70 meshes, 75 meshes, 80 meshes, 85 meshes or 90 meshes, and other specific point values within the above numerical ranges can be selected, and are not described herein again.
Preferably, the mixing in step (2) further comprises mixing with an extract of lycium barbarum.
Preferably, the mixing in step (2) further comprises mixing with rhodiola rosea extract.
Preferably, the preparation method of the composition with the effect of protecting the female reproductive system also comprises an extraction method of the medlar extract, and the extraction method of the medlar extract comprises the following steps: chopping fructus Lycii, soaking in ethanol water solution c, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain fructus Lycii extract.
Preferably, the volume fraction of ethanol in the ethanol aqueous solution c is 60-90%.
The specific value of 60-90% can be selected from 60%, 65%, 70%, 75%, 80%, 85%, 90%, etc. Other specific values within the above ranges can be selected, and are not described in detail herein.
Preferably, the reflux extraction is repeated 1 to 3 times, the 1 to 3 times including 1 time, 2 times and 3 times.
Preferably, the mesh number of the screen for sieving is 70-90 meshes, for example, 70 meshes, 75 meshes, 80 meshes, 85 meshes or 90 meshes, and other specific point values within the above numerical range can be selected, and are not repeated herein.
Preferably, the preparation method of the composition with female reproductive system protecting effect further comprises an extraction method of the rhodiola rosea extract, and the extraction method of the rhodiola rosea extract comprises the following steps: cutting radix Rhodiolae, soaking in ethanol water solution d, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain radix Rhodiolae extract.
Preferably, the volume fraction of ethanol in the ethanol aqueous solution d is 60-80%.
The specific value of 60-80% can be selected from 60%, 64%, 68%, 72%, 76%, 80% and the like. Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the reflux extraction is repeated 1 to 3 times, the 1 to 3 times including 1 time, 2 times and 3 times.
Preferably, the mesh number of the screen for sieving is 70-90 meshes, for example, 70 meshes, 75 meshes, 80 meshes, 85 meshes or 90 meshes, and other specific point values within the above numerical range can be selected, and are not repeated herein.
In the preparation process of the ginseng extract, the cranberry extract, the medlar extract and the rhodiola rosea extract, when the volume fractions of the selected ethanol aqueous solution are 80-95%, 60-80%, 60-90% and 60-80%, respectively, the reproductive health care effect of the composition is stronger, and the antioxidant and bacteriostatic effects are better.
In a third aspect, the present invention provides a formulation having the effect of protecting the female reproductive system, the formulation comprising the composition having the effect of protecting the female reproductive system according to the first aspect.
Preferably, the preparation raw materials of the preparation also comprise an acidity agent, a sweetening agent, an acidity regulator and a microbial preparation.
Preferably, the microbial preparation comprises any one or combination of at least two of lactobacillus acidophilus, bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium longum, lactobacillus bulgaricus, bifidobacterium adolescentis or streptococcus thermophilus, and the combination of at least two of the lactobacillus acidophilus, the bifidobacterium bifidum, the bifidobacterium infantis, the bifidobacterium longum and the lactobacillus bulgaricus and the like, and any combination can be selected, which is not described in detail herein.
Preferably, the probiotic formulation is a combination of lactobacillus acidophilus, bifidobacterium longum and lactobacillus bulgaricus.
The preparation of the invention is added with the sour agent and the sweetening agent, so that the preparation has better mouthfeel; an acid-base regulator is added into the preparation, and the pH value of the preparation can be flexibly regulated according to different types of selected dosage forms; the microbial preparation which is beneficial and harmless to human bodies is added into the preparation, so that the bacterial colony balance of organisms is favorably adjusted, the health state of the organisms is improved, and the effect of promoting the original effect of the preparation is achieved. Lactobacillus acidophilus (Lactobacillus acidophilus), bifidobacterium bifidum (Bifidobacterium bifidum), bifidobacterium infantis (Bifidobacterium infantis), bifidobacterium longum (Bifidobacterium longum), lactobacillus bulgaricus (Lactobacillus bulgaricus), bifidobacterium adolescentis (Bifidobacterium adolescentis) or Streptococcus thermophilus (Streptococcus thermophilus) are probiotics which have been included in the list of strains available for food use, are healthy and have no side effects on the human body, and when a combination of Lactobacillus acidophilus, bifidobacterium longum and Lactobacillus bulgaricus is specifically selected for the microbial preparation, the preparation has a stronger effect of protecting the female reproductive system, inhibiting bacteria and resisting oxidation.
Compared with the prior art, the invention has the following beneficial effects:
the ginseng extract, the cranberry extract and the coenzyme Q10 are creatively matched to protect the female reproductive system, supplement each other and synergically, and have the effects of resisting oxidation and bacteria, enhancing the physique, delaying the ovarian senescence, preventing the urogenital system infection, promoting the intestinal tract movement and defecation and protecting the female reproductive system.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The following examples, comparative examples and test examples relate to lactobacillus acidophilus lyophilized powder which is a product purchased from zheng hou bacon food additives ltd; the Bifidobacterium longum lyophilized powder is purchased from GmbH of Kajiayi Nutrition medicine (Shandong) Microecological research institute; the Lactobacillus bulgaricus lyophilized powder is a product purchased from Shandong Junle Biotech Limited.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
Preparation example 1
The preparation example provides a ginseng extract, and the preparation method comprises the following steps: chopping Ginseng radix, sterilizing, soaking in 90% ethanol water solution for 30 hr, reflux extracting for 3 times, each for 2 hr, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain Ginseng radix extract.
Preparation example 2
The preparation example provides a ginseng extract, and the preparation method comprises the following steps: chopping Ginseng radix, sterilizing, soaking in 75% ethanol water solution for 30 hr, reflux extracting for 3 times, each for 2 hr, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain Ginseng radix extract.
Preparation example 3
The preparation example provides a ginseng extract, and the preparation method comprises the following steps: cutting Ginseng radix, sterilizing, soaking in 98% ethanol water solution for 30 hr, reflux extracting for 3 times, each for 2 hr, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain Ginseng radix extract.
Preparation example 4
The preparation example provides a cranberry extract, and the preparation method comprises the following steps: chopping cranberry, sterilizing, soaking in 70% ethanol water solution for 30 hr, reflux extracting for 3 times (2 hr each time), concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain cranberry extract.
Preparation example 5
The preparation example provides a cranberry extract, and the preparation method comprises the following steps: chopping cranberry, sterilizing, soaking in 50% ethanol water solution for 30 hr, reflux extracting for 3 times (2 hr each time), concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain cranberry extract.
Preparation example 6
The preparation example provides a cranberry extract, and the preparation method comprises the following steps: chopping cranberry, sterilizing, soaking in 85% ethanol water solution for 30 hr, reflux extracting for 3 times (2 hr each time), concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain cranberry extract.
Preparation example 7
The preparation example provides a Chinese wolfberry extract, and the preparation method comprises the following steps: cutting fructus Lycii, sterilizing, soaking in 80% ethanol water solution for 30 hr, reflux extracting for 3 times, 2 hr each time, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain fructus Lycii extract.
Preparation example 8
The preparation example provides a medlar extract, and the preparation method comprises the following steps: cutting fructus Lycii, sterilizing, soaking in 50% ethanol water solution for 30 hr, reflux extracting for 3 times, 2 hr each time, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain fructus Lycii extract.
Preparation example 9
The preparation example provides a Chinese wolfberry extract, and the preparation method comprises the following steps: cutting fructus Lycii, sterilizing, soaking in 95% ethanol water solution for 30 hr, reflux extracting for 3 times, 2 hr each time, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain fructus Lycii extract.
Preparation example 10
The preparation example provides a rhodiola root extract, and the preparation method comprises the following steps: cutting radix Rhodiolae, sterilizing, soaking in 70% ethanol water solution for 30 hr, reflux extracting for 3 times, each for 2 hr, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain radix Rhodiolae extract.
Preparation example 11
The preparation example provides a rhodiola root extract, and the preparation method comprises the following steps: cutting radix Rhodiolae, sterilizing, soaking in 55% ethanol water solution for 30 hr, reflux extracting for 3 times, each for 2 hr, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain radix Rhodiolae extract.
Preparation example 12
The preparation example provides a rhodiola root extract, and the preparation method comprises the following steps: cutting radix Rhodiolae, sterilizing, soaking in 85% ethanol water solution for 30 hr, reflux extracting for 3 times, 2 hr each time, concentrating the ethanol extractive solution under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain radix Rhodiolae extract.
Example 1
The embodiment provides a composition with the effect of protecting the female reproductive system, and the preparation method comprises the following steps: 100 parts of the ginseng extract prepared in preparation example 1, 1 part of coenzyme Q10, 80 parts of the cranberry extract prepared in preparation example 4, 20 parts of the medlar extract prepared in preparation example 7 and 5 parts of the rhodiola rosea extract prepared in preparation example 10 are sterilized at 120 ℃ and then mixed to obtain the composition with the effect of protecting female reproductive systems.
Example 2
This example provides a composition for protecting female reproductive system, which is prepared by the following steps: and (2) sterilizing and mixing 90 parts of the ginseng extract prepared in the preparation example 1, 0.5 part of coenzyme Q10, 50 parts of the cranberry extract prepared in the preparation example 4, 30 parts of the medlar extract prepared in the preparation example 7 and 20 parts of the rhodiola rosea extract prepared in the preparation example 10 at 120 ℃ to obtain the composition with the female reproductive system protection effect.
Example 3
The embodiment provides a composition with the effect of protecting the female reproductive system, and the preparation method comprises the following steps: and (2) sterilizing 200 parts of the ginseng extract prepared in the preparation example 1, 2 parts of coenzyme Q10, 100 parts of the cranberry extract prepared in the preparation example 4, 5 parts of the medlar extract prepared in the preparation example 7 and 3 parts of the rhodiola rosea extract prepared in the preparation example 10 at 120 ℃, and mixing to obtain the composition with the effect of protecting the female reproductive system.
Example 4
This example provides a composition for protecting female reproductive system, which is prepared by the same method as in example 1 except that rhodiola rosea extract is absent from the raw materials.
Example 5
This example provides a composition for protecting the female reproductive system, which is prepared by the same method as in example 1 except that the extract of Lycium barbarum is absent from the starting materials.
Example 6
This example provides a composition having an effect of protecting the female reproductive system, which is prepared by the same method as in example 1 except that the ginseng extract prepared in preparation example 1, the cranberry extract prepared in preparation example 4, the lycium barbarum extract prepared in preparation example 7, and the rhodiola rosea extract prepared in preparation example 10 in the raw materials are replaced with the ginseng extract prepared in preparation example 2, the cranberry extract prepared in preparation example 5, the lycium barbarum extract prepared in preparation example 8, and the rhodiola rosea extract prepared in preparation example 11, and the rest are the same as in example 1.
Example 7
This example provides a composition having an effect of protecting female reproductive system, which was prepared by the same method as in example 1 except that the ginseng extract prepared in preparation example 1, the cranberry extract prepared in preparation example 4, the lycium barbarum extract prepared in preparation example 7, and the rhodiola rosea extract prepared in preparation example 10 in raw materials were replaced with the ginseng extract prepared in preparation example 3, the cranberry extract prepared in preparation example 6, the lycium barbarum extract prepared in preparation example 9, and the rhodiola rosea extract prepared in preparation example 12, and the rest were the same as in example 1.
Comparative example 1
This comparative example provides a composition having the effect of protecting female reproductive system, which was prepared by the same method as example 1 except that the raw material lacks ginseng extract, and parts of ginseng extract were distributed into cranberry extract, the rest being the same as example 1.
Comparative example 2
This comparative example provides a composition having the effect of protecting the female reproductive system, which is prepared by the same method as in example 1 except that the coenzyme Q10 is absent from the raw material, and the fraction of the coenzyme Q10 is proportionally distributed to the ginseng extract and the cranberry extract, and the rest is the same as in example 1.
Comparative example 3
This comparative example provides a composition having an effect of protecting female reproductive system, which is prepared by the same method as in example 1 except that the raw material lacks of cranberry extract and parts of the cranberry extract are distributed to ginseng extract, and the rest is the same as in example 1.
Comparative example 4
The comparative example provides a composition with the effect of protecting female reproductive systems, and the preparation method of the composition is only different from that of example 1 in that the ginseng extract, the coenzyme Q10 and the cranberry extract in the raw materials are all replaced by rhodiola rosea extracts in equal parts by mass, and the rest is the same as that of example 1.
Comparative example 5
The comparative example provides a composition with the effect of protecting female reproductive systems, and the preparation method of the composition is only different from that of example 1 in that ginseng extract, coenzyme Q10 and cranberry extract in the raw materials are all replaced by wolfberry extract with equal mass parts, and the rest is the same as that of example 1.
Application example 1
The application example provides a beverage with the effect of protecting female reproductive system, and the preparation method comprises the following steps: 50 parts of the composition having the effect of protecting the female reproductive system prepared in example 1, 3 parts of citric acid, 3 parts of fructose, 3 parts of sodium bicarbonate, 1 part of freeze-dried powder of lactobacillus acidophilus, 2 parts of freeze-dried powder of bifidobacterium longum, 5 parts of freeze-dried powder of lactobacillus bulgaricus and 933 parts of water are mixed.
Application examples 2 to 5
Application examples 2 to 5 provide four drinks having the effect of protecting the female reproductive system, and the preparation method thereof is different from that of application example 1 only in that the composition having the effect of protecting the female reproductive system prepared in example 1 is replaced with the composition having the effect of protecting the female reproductive system prepared in examples 4 to 7, and the rest is the same as application example 1.
Application example 6
The application example provides a beverage with the effect of protecting female reproductive systems, and the preparation method of the beverage is only different from the application example 1 in that 1 part of lactobacillus acidophilus freeze-dried powder, 2 parts of bifidobacterium longum freeze-dried powder and 5 parts of lactobacillus bulgaricus freeze-dried powder in the raw materials are replaced by 2.3 parts of bifidobacterium longum freeze-dried powder and 5.7 parts of lactobacillus bulgaricus freeze-dried powder, and the rest is the same as the application example 1.
Application example 7
The preparation method of the drink is only different from the application example 1 in that 1 part of lactobacillus acidophilus freeze-dried powder, 2 parts of bifidobacterium longum freeze-dried powder and 5 parts of lactobacillus bulgaricus freeze-dried powder in the raw materials are replaced by 1.3 parts of lactobacillus acidophilus freeze-dried powder and 6.7 parts of lactobacillus bulgaricus freeze-dried powder, and the rest is the same as the application example 1.
Application example 8
The application example provides a beverage with the effect of protecting female reproductive systems, and the preparation method of the beverage is only different from the application example 1 in that 1 part of lactobacillus acidophilus freeze-dried powder, 2 parts of bifidobacterium longum freeze-dried powder and 5 parts of lactobacillus bulgaricus freeze-dried powder in the raw materials are replaced by 2.7 parts of lactobacillus acidophilus freeze-dried powder and 5.3 parts of bifidobacterium longum freeze-dried powder, and the rest is the same as the application example 1.
Application of comparative examples 1 to 5
Application comparative examples 1 to 5 provide a drink having the effect of protecting the female reproductive system, which is prepared by a method different from that of application example 1 only in that the composition having the effect of protecting the female reproductive system prepared in example 1 is replaced with the composition having the effect of protecting the female reproductive system prepared in comparative examples 1 to 5, and the rest is the same as in application example 1.
Comparative application example 6
The application comparative example provides a beverage with the effect of protecting female reproductive system, and the preparation method of the beverage is different from that of the application example 1 only in that the microbial preparation is absent in the raw materials, and the rest is the same as that of the application example 1.
Test example 1
The compositions prepared in examples 1 to 7 and comparative examples 1 to 5 were evaluated for antioxidant properties by testing the removal efficiency of DPPH. The specific evaluation method comprises the following steps: the composition was ground well using a mortar, and 0.5g of the composition was added to 4mL of a DPPH (100. Mu.M in 99wt% ethanol) solution, mixed well, and incubated in the dark for 60min. The absorbance value of the mixed solution at 517nm was then measured using a uv-vis spectrophotometer (DPPH only solution was used as a control). Calculated using the following equation: DPPH clearance = (control absorbance-absorbance of each example or comparative example)/control absorbance × 100%.
TABLE 1
As can be seen from the data in table 1, the volume fractions of the ethanol aqueous solutions used for extracting the ginseng extract, the cranberry extract, the medlar extract and the rhodiola rosea extract in the preparation processes of the compositions in examples 6 and 7 are outside the preferred ranges, and the DPPH clearance rates of the ethanol aqueous solutions in examples 6 and 7 are lower than that in example 1, which indicates that the antioxidant capacity of the compositions is stronger when the ethanol aqueous solutions with the volume fractions of 80-95%, 60-80%, 60-90% and 60-80% are respectively used for the ginseng extract, the cranberry extract, the medlar extract and the rhodiola rosea extract; comparative examples 1-3 compared to example 1, the compositions were prepared without ginseng extract, cranberry extract and coenzyme Q10 in the starting materials, respectively, and comparative examples 1-3 all showed lower DPPH clearance than example 1, indicating that the lack of one of ginseng extract, cranberry extract and coenzyme Q10 in the compositions affected the antioxidant properties of the resulting compositions.
Test example 2
And evaluating reproductive function effect of the drinks prepared in the application examples 1-8 and the application comparative examples 1-6. The specific evaluation method comprises the following steps: (1) Dividing 135SPF mice (8-9 weeks, weight of 20-25 g) into 15 groups including 14 groups corresponding to control group and application example or application comparative example; (2) Preparing 10mg/mL cyclophosphamide solution by using physiological saline under a dark condition, fully and uniformly mixing, weighing the weight of each mouse, and preparing a chemotherapeutic ovarian injury mouse model according to 120mg/kg intraperitoneal injection administration; (3) Each group comprises 6 female mice and 3 male mice, wherein 3 female mice and 3 male mice are selected for cage combination, each cage is used for placing one female mouse and one male mouse, and the rest 3 female mice are not subjected to cage combination treatment; (4) Performing intragastric administration on female rats of each group every day, wherein the intragastric administration amount is 200mg/kg, the intragastric administration is performed 1 time every day, the intragastric administration of normal saline with the same volume is performed on a control group, and the intragastric administration of the beverages prepared in each embodiment or comparative example is performed on the other groups; (5) For the mice in the cage, male mice were taken out after 10 days, and then the number of calving times of female mice was recorded 20 days, 1 cycle every 30 days, for 6 cycles. Evaluating the influence of the drink on the recovery of the reproductive function of the mice according to the average difference rate of the farrowing times of 6 periods (the difference rate of the reproductive performance = the farrowing times of the application example or the application comparative example/the farrowing times of the application example 1 x 100%); (6) And (3) weighing the weight of the unhatched female mouse 14 days after administration, killing the mouse at the estrus interval, weighing the ovary, and calculating the ovarian organ coefficient.
TABLE 2
| Difference ratio of reproductive Performance (%) | Ovarian organ coefficient (%) | |
| Application example 1 | 100 | 0.028 |
| Application example 2 | 54.5 | 0.015 |
| Application example 3 | 72.7 | 0.019 |
| Application example 4 | 63.6 | 0.024 |
| Application example 5 | 54.5 | 0.016 |
| Application example 6 | 90.7 | 0.019 |
| Application example 7 | 72.7 | 0.017 |
| Application example 8 | 81.8 | 0.022 |
| Application comparative example 1 | 54.5 | 0.013 |
| Comparative application example 2 | 54.5 | 0.016 |
| Comparative application example 3 | 63.6 | 0.011 |
| Application comparative example 4 | 45.5 | 0.012 |
| Comparative application example 5 | 45.5 | 0.011 |
| Comparative application example 6 | 54.5 | 0.016 |
| Control group | 45.5 | 0.010 |
As can be seen from the data in table 2, the compositions of application examples 2 and 3 do not contain the rhodiola rosea or wolfberry extract compared with application example 1, and the compositions of application examples 4 and 5 only contain the rhodiola rosea or wolfberry extract, so that the reproductive performance difference rate is lower, which indicates that the rhodiola rosea and wolfberry extract have a synergistic effect on improving reproductive performance with other components of the composition; in the preparation process of the composition of application examples 4 and 5, when the ginseng extract, the cranberry extract, the medlar extract and the rhodiola rosea extract are extracted, the volume fraction of the used ethanol water solution is out of the preferable range, the reproductive performance difference rate of the application examples 4 and 5 is lower than 100%, and the ovarian organ coefficient is smaller than that of the application example 1, so that the reproductive and health-care function of the composition is stronger when the ginseng extract, the cranberry extract, the medlar extract and the rhodiola rosea extract are respectively 80-95%, 60-80%, 60-90% and 60-80% of the ethanol water solution; compared with the application example 1, the application comparative example 6 does not contain the microbial preparation, the reproductive performance difference rate of the microbial preparation is less than 100 percent and is higher than that of a control group, and the microbial preparation has a synergistic effect with the composition in the aspect of protecting the female reproductive system; compared with the application example 1, the microbial preparations of the application examples 6-8 lack lactobacillus acidophilus, bifidobacterium longum and lactobacillus bulgaricus respectively, the fertility performance difference rate and the ovarian index of mice in the application examples 6-8 groups are lower than those of the application example 1, and the fact that when the microbial preparations specifically select the combination of the lactobacillus acidophilus, the bifidobacterium longum and the lactobacillus bulgaricus shows that the beverage with the female reproductive system protection effect has a more excellent reproductive performance protection effect; compared with the application example 1, the composition in the application comparative examples 1-3 is respectively lack of the ginseng extract, the cranberry extract and the coenzyme Q10, and the reproductive performance difference rate of the beverage corresponding to the application comparative examples 1-3 is less than 100%, so that the lack of one of the ginseng extract, the cranberry extract and the coenzyme Q10 in the composition in the raw materials of the preparation can influence the protection effect of the prepared product on the female reproductive system.
Test example 3
The anti-infection effect of the mice in vivo is evaluated on the drinks prepared in the application examples 1, 4-8 and the application comparative examples 1-3 and 6. The specific evaluation method is as follows: (1) Weighing 110 mice (8-9 weeks, weight of about 20-25 g) and dividing into 11 groups including 10 groups corresponding to control group and application example or application comparative example; (2) Inoculating staphylococcus aureus (ATCC 6538) into a common broth liquid culture medium, culturing at 37 ℃ for 18h, taking out, and diluting with 5% gastrodin diluent to obtain a bacterial suspension with the dilution of one percent; (3) Injecting bacterial liquid into the abdominal cavity of the mouse, wherein the injection amount is 0.5mL/20g; (4) The experimental animals of each group are administrated once by each intragastric administration in lh, 6h and 12h, the control group is administrated with normal saline, the other groups are administrated with the prepared drink of each group, and the survival number of 48h is observed and recorded. And calculating the difference rate of the anti-infection performance according to the survival number. (rate of difference in anti-infective properties = number of survivors of application example or application comparative example/number of survivors of application example 1 × 100%)
TABLE 3
| Rate of difference in anti-infective Properties (%) | |
| Application example 1 | 100 |
| Application example 4 | 75 |
| Application example 5 | 50 |
| Application example 6 | 50 |
| Application example 7 | 75 |
| Application example 8 | 50 |
| Application comparative example 1 | 0 |
| Comparative application example 2 | 25 |
| Comparative application example 3 | 25 |
| Comparative application example 6 | 0 |
| Control group | 0 |
As can be seen from the data in Table 3, compared with the application example 1, the application comparative example 6 does not contain the microbial preparation, and the anti-infection performance difference rate of the application comparative example 6 is smaller than that of the application example 1 and higher than that of a control group, which indicates that the microbial preparation has synergistic effect with the composition in the aspects of bacteriostasis and anti-infection; compared with the microbial preparation of application example 1, the microbial preparation of application examples 6-8 lacks lactobacillus acidophilus, bifidobacterium longum and lactobacillus bulgaricus respectively, and the difference rate of the anti-infection performance of the mice in the application examples 6-8 is less than 100%, which shows that when the microbial preparation specifically selects the combination of lactobacillus acidophilus, bifidobacterium longum and lactobacillus bulgaricus, the drink with the effect of protecting the female reproductive system has more excellent anti-infection performance. Compared with the application example 1, the composition in the application comparative examples 1-3 is respectively lack of the ginseng extract, the cranberry extract and the coenzyme Q10, and the difference rate of the anti-infection performance of the beverage corresponding to the application comparative examples 1-3 is less than 100%, which shows that the lack of any one of the ginseng extract, the cranberry extract and the coenzyme Q10 in the composition in the raw materials of the preparation can influence the bacteriostatic action of the prepared product.
The applicant states that the present invention is illustrated by the above examples, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, but the present invention is not limited to the details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are all within the protection scope of the present invention.
It should be noted that, in the above embodiments, the various features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, the present invention does not separately describe various possible combinations.
Claims (10)
1. A composition for protecting female reproductive system is prepared from Ginseng radix extract, cranberry extract and coenzyme Q10.
2. The composition with the effect of protecting the female reproductive system according to claim 1, wherein the composition is prepared from 20 to 200 parts of ginseng extract, 10 to 100 parts of cranberry extract and 0.5 to 3 parts of coenzyme Q in parts by mass.
3. The composition for protecting female reproductive system according to claim 1 or 2 wherein the composition is prepared from a starting material further comprising an extract of lycium barbarum.
4. The composition with effect of protecting female reproductive system according to claim 3, wherein the composition further comprises 5 to 30 parts by weight of an extract of Lycium barbarum.
5. The composition with female reproductive system protecting effect according to any one of claims 1 to 4, wherein the composition further comprises rhodiola rosea extract.
6. The composition with female reproductive system protecting effect according to claim 5, wherein the composition further comprises 3 to 20 parts by weight of rhodiola rosea extract.
7. A process for the preparation of a composition having the effect of protecting a female reproductive system as claimed in claim 1 or 2, wherein the process comprises:
(1) Cutting Ginseng radix, soaking in ethanol water solution a, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain Ginseng radix extract;
chopping cranberries, soaking in ethanol water solution b, extracting under reflux, concentrating the ethanol extract, drying, and sieving to obtain cranberry extract;
(2) Mixing Ginseng radix extract, cranberry extract and coenzyme Q10 to obtain the composition with female reproductive system protecting effect.
8. The method for preparing a composition with female reproductive system protecting effect according to claim 7, wherein the ethanol in the ethanol aqueous solution a in the step (1) has a volume fraction of 80-95%;
preferably, the volume fraction of ethanol in the ethanol water solution b in the step (1) is 60-80%;
preferably, the reflux extraction in step (1) is independently repeated 1-3 times;
preferably, the mesh number of the sieving screen in the step (1) is independently 70-90 meshes;
preferably, the mixing in step (2) further comprises mixing with an extract of lycium barbarum;
preferably, the mixing in step (2) further comprises mixing with rhodiola rosea extract;
preferably, the preparation method of the composition further comprises an extraction method of the medlar extract, and the extraction method of the medlar extract comprises the following steps: cutting fructus Lycii, soaking in ethanol water solution c, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain fructus Lycii extract;
preferably, the volume fraction of ethanol in the ethanol aqueous solution c is 60-90%;
preferably, the reflux extraction is repeated 1-3 times;
preferably, the mesh number of the screen for sieving is 70-90 meshes;
preferably, the preparation method of the composition further comprises an extraction method of the rhodiola rosea extract, and the extraction method of the rhodiola rosea extract comprises the following steps: cutting radix Rhodiolae, soaking in ethanol water solution d, reflux extracting, concentrating the ethanol extractive solution, drying, and sieving to obtain radix Rhodiolae extract;
preferably, the volume fraction of ethanol in the ethanol water solution d is 60-80%;
preferably, the reflux extraction is repeated 1-3 times;
preferably, the mesh number of the screen for sieving is 70-90 meshes.
9. A preparation having a female reproductive system protecting effect, which comprises the composition according to any one of claims 1 to 6.
10. The preparation with female reproductive system protecting effect as claimed in claim 9, wherein the preparation is prepared from materials further comprising an acidulant, a sweetener, an acid-base modifier and a microbial agent;
preferably, the microbial preparation comprises any one or combination of at least two of lactobacillus acidophilus, bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium longum, lactobacillus bulgaricus, bifidobacterium adolescentis or streptococcus thermophilus;
preferably, the microbial agent is a combination of lactobacillus acidophilus, bifidobacterium longum and lactobacillus bulgaricus.
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| CN116139157A (en) * | 2023-04-19 | 2023-05-23 | 中国农业大学 | Application of salidroside in promoting growth and development of ovarian follicles and preparing ovulation promoting medicine |
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