CN110755389A - Compound low-temperature vacuum drying extraction powder and extraction method thereof - Google Patents
Compound low-temperature vacuum drying extraction powder and extraction method thereof Download PDFInfo
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Abstract
The invention discloses a compound low-temperature vacuum drying extraction powder and an extraction method thereof, wherein the compound low-temperature vacuum drying extraction powder comprises the following raw material components in parts by weight: 80-150 parts of compound main material, 3-8 parts of thickening agent, 5-15 parts of plasticizer, 1-5 parts of antioxidant, 3-8 parts of emulsifier, 120 parts of purified water, 8-15 parts of trace elements and 3-5 parts of vitamin.
Description
Technical Field
The invention belongs to the technical field of chemical processes, and mainly relates to compound low-temperature vacuum drying extraction powder and an extraction method thereof.
Background
The low-temperature vacuum drying method effectively prevents the physicochemical and biological characteristics of the product from being changed, has small damage to the structure and the characteristics of biological tissues and cells, enables the biological tissues and the cells to quickly enter a dormant state, and effectively protects the stability of active ingredients of a plurality of thermosensitive drug biological products. The raw material extraction powder can maximally extract effective components in the raw materials, and improves the use efficiency of the raw materials. Meanwhile, the water content of the freeze-dried product is very low, so that the stability of the product is improved, the chance of pollution is reduced, the transportation is convenient, and the storage life of the product is prolonged.
Honeysuckle flower: it is good at resolving toxicity, so it is indicated for abscess, deep-rooted carbuncle, swelling and toxicity, sores and ringworm. Honeysuckle flower is commonly used for clearing away heat and toxic material, and treating epidemic febrile disease, fever, bloody dysentery, carbuncle and ulcer. The book Ben Cao gang mu records that jin Yin Hua is good at resolving toxicity, so it is indicated for abscess, deep rooted carbuncle, swollen toxicity, sore and tinea … …. Since ancient times, honeysuckle is commonly used for clearing heat and removing toxicity, and treating epidemic febrile disease, fever, bloody dysentery, carbuncle and ulcer. Modern pharmacological research shows that the honeysuckle has the effects of bacteriostasis, antivirus, anti-inflammation, antipyresis, immunity regulation and the like. Has effects of clearing heat, removing toxic substances, cooling wind and clearing heat, and has broad-spectrum antibacterial and antioxidant effects. It is also used for treating wind-heat type common cold and bronchitis. The research shows that: the chlorogenic acid contained in flos Lonicerae has antibacterial, antimutagenic, anticancer and immunity enhancing effects. The mechanism of the anticancer action is that the formation of carcinogen-DNA adduct and oxygen free radical is inhibited by the pro-oxidation action. And (3) antibiosis: experiments show that the honeysuckle has the inhibiting effect on typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus, pseudomonas aeruginosa, bordetella pertussis, vibrio cholerae, staphylococcus, streptococcus, diplococcus pneumoniae, meningococcus and the like.
The ginseng is called 'the king of the hundred grass', the cultivated is 'garden ginseng' and the wild is 'mountain ginseng', and has the functions and main functions of greatly reinforcing primordial qi, restoring pulse, relieving depletion, reinforcing spleen, benefiting lung, promoting fluid production and calming the nerves. The main chemical components of ginseng include saponins, volatile components, organic acids and esters, sterols and their glycosides, nitrogen-containing compounds, vitamins, flavonoids, saccharides, etc. The extraction method of ginsenoside mainly comprises water decoction, warm soaking, ethanol reflux extraction, microwave extraction, and percolation. The ginsenoside is extracted from root, stem and leaf of Ginseng radix, is rich in eighteen ginsenoside monomers, and is soluble in water at 80 deg.C and ethanol. The ginseng stem and leaf saponin can obviously inhibit the formation of lipid peroxide in brain and liver, reduce the content of lipofuscin in cerebral cortex and liver, and increase the content of superoxide dismutase and catalase in blood, and the result shows that the ginseng stem and leaf saponin has an antioxidant effect. Ginsenoside has the functions of resisting aging and fatigue, activating skin cells, improving skin elasticity, reducing wrinkles, etc. The ginseng stem and leaf extract is one of the most widely used ginseng extracts at present.
Ganoderma lucidum is a treasure in the traditional Chinese medicine treasury, and has the reputation of 'immortal grass' and 'Ruicao', and the 'Shennong Ben Cao Jing' and 'Ben Cao gang mu' have detailed and very definite records on the efficacy of Ganoderma lucidum. More than 150 compounds have been isolated from ganoderma lucidum and fall into 10 broad categories: polysaccharides, nucleosides, furans, sterols, alkaloids, amino acids, proteins, enzymes, triterpenes, inorganic ions, and organic substances. Among them, ganoderan is an important active ingredient. The ganoderma lucidum polysaccharide has the function of delaying senility, and experiments prove that the ganoderma lucidum polysaccharide has the functions of inhibiting the generation of oxygen free radicals and the lipid peroxidation of erythrocytes and removing hydroxyl free radicals. The research of cell and gene level of Yangshaoqiong and the like in China proves that the ganoderma lucidum polysaccharide can promote cell proliferation, relieve oxidative stress injury of keratinocytes and has the function of resisting epidermal cell aging.
Vitamin A, a nutrient essential to the body, which affects almost all tissue cells of the body in different ways, although it was the first found vitamin, its physiological functions have not been completely uncovered so far, as far as it is known, the most important physiological functions of vitamin A include ① maintenance of vision, vitamin A promoting the formation of photochromic pigments in the visual cells, vitamin A regulating the ability of the eye to adapt to external light, reducing the occurrence of night blindness and visual deterioration, maintaining the normal visual response, helping to treat various eye diseases (such as xerophthalmia and conjunctivitis, etc.), vitamin A, the action of vision is the earliest found and most understood function, ② promoting growth and development, retinol also has the action equivalent to steroid hormones in relation to the regulation of retinol genes, promoting the synthesis of glycoproteins, promoting growth and development, strengthening the bone, maintaining the health of the teeth and dental beds, ③ maintaining the health of the epithelial structures and the maintenance of the epithelial structures, and the maintenance of epithelial cells, increasing the ability of epidermal growth of corneal epithelium, increasing the ability of corneal epithelial cells to maintain the skin, increasing the epithelial cell functions of corneal epithelium, increasing the skin epithelial cells of corneal epithelium, increasing the skin ulceration, increasing the skin elasticity of corneal epithelium, corneal edema.
Vitamin B1: thiamine, also known as thiamine, is converted into thiamine pyrophosphate in the human body and is involved in the metabolism of sugars in the body. Thus, in the absence of vitamin B1, sugar oxidation in the tissue is affected. It also has the effect of inhibiting cholinesterase activity, and in the absence of vitamin B1, the enzyme activity is too high, and acetylcholine (one of neurotransmitters) is largely destroyed to affect nerve conduction, which can cause gastrointestinal motility retardation, digestive tract secretion reduction, anorexia, dyspepsia, etc.
Vitamin B2: riboflavin, also known as an orange yellow needle crystal, is slightly bitter in taste, has yellow-green fluorescence in aqueous solution, and is very easy to decompose under alkaline or illumination conditions. The human body is lack of it and is easy to suffer from stomatitis, dermatitis, microvascular hyperplasia and the like. Adults should ingest 2-4 mg daily, and a large amount of it exists in food such as grains, vegetables, cow milk, fish, and the like.
Vitamin B3: nicotinic acid, not only is it a vitamin that maintains the health of the digestive system, but it is also an essential substance for sex hormone synthesis. For modern people with pressure on life, nicotinic acid has the efficacy of maintaining the health of nervous system and normal operation of brain function, and is absolutely not negligible. Recommended daily intake: the recommended daily intake for adults is 13-19 mg. The pregnant woman (pregnant woman product, pregnant woman information) is 20 mg; the amount of the composition is 22mg for lactating women.
Vitamin B6: pyridoxols have the functions of inhibiting vomiting, promoting development and the like, and lack of pyridoxols can cause symptoms of vomiting, cramps and the like. Including three substances, pyridoxine, pyridoxal and pyridoxamine. Pyridoxine is converted into pyridoxal in vivo, and pyridoxal and pyridoxamine are converted into each other. The yeast, liver, lean meat, grain, cabbage and other food are all rich in vitamin B6. Vitamin B6 is readily soluble in water and alcohol, slightly soluble in fatty solvents; it is easy to be destroyed by light and alkali, and it is not high temperature resistant. Vitamin B6 binds to phosphate in vivo to pyridoxal phosphate or pyridoxamine phosphate. They are coenzymes of many enzymes involved in amino acid metabolism and are therefore important for amino acid metabolism.
Vitamin B9: also known as folic acid. Folic acid is a water-soluble B-group vitamin consisting of pteridine, p-aminobenzoic acid and glutamic acid residues, also known as vitamin BC or vitamin M; it is rich in vegetable leaf and liver. Folic acid is a B-group vitamin widely found in green vegetables and was named "folic acid" because it was first extracted from plant leaves. Folic acid, chemically known as "pteroylglutamic acid", is made by combining pteridinoic acid, p-aminobenzoic acid and amino acid.
The critical nutritional effects of folic acid in humans has been demonstrated as early as 1948, and the deficiency of folic acid in humans (or other animals) can cause megaloblastic anemia and leukopenia. In addition, folic acid has also been found to be particularly important in pregnant women. For example, the lack of folic acid in the first 3 months of pregnancy can lead to defects in fetal neural tube development, thereby increasing the incidence of split brain and no brain. Second, pregnant women are often supplemented with folic acid to prevent congenital malformations such as overweight and premature babies, cleft palate (rabbit lips) in infants, and the like.
Vitamin B12: the vitamin also called as cobalamin, which is used for resisting pernicious anemia, contains a metal element cobalt, and is the only one containing the metal element in the vitamin. Anti-fatty liver, promote the storage of vitamin A in the liver; promoting cell development and maturation and metabolism. Unlike other B vitamins, it is produced in a very small amount in general plants, and is produced only by some bacteria and soil bacteria. Liver, lean meat, fish, milk and eggs are sources from which vitamin B12 is obtained in humans. Commercial products may be obtained from the by-products of the manufacture of certain antibiotics or from special fermentations. Vitamin B12 is pink crystal, the aqueous solution is quite stable in weak acid, and is very easy to decompose in strong acid and strong alkali, and vitamin B12 is easily destroyed by sunlight, oxidant and reductant. When it is absorbed from the gastrointestinal tract, it must be absorbed by binding with a glycoprotein (also called intrinsic factor) secreted from the gastric pylorus. B12 deficiency due to lack of "intrinsic factor" should be treated by injection. Deoxyadenosylcobalamin is the predominant form of vitamin B12 found in the body. It is a coenzyme for enzymes that catalyze the interchange of hydrogen, alkyl, carbonyl, or amino groups on two adjacent carbon atoms. Another coenzyme in the body is methylcobalamin, which is involved in methyl transport and often correlates with folic acid action, and can increase folic acid utilization rate to influence nucleic acid and protein biosynthesis, thereby promoting erythrocyte development and maturation. Pernicious anemia can occur in the absence of vitamin B12, and the amount of B12 required in humans is very small, about 12 μ g (1/1000mg) per day being required in humans, which are not commonly lacking.
Vitamin E: can resist free radical invasion, and prevent cancer and myocardial infarction. Vitamin E is a strong antioxidant, and inadequate vitamin E supply can cause various intellectual or emotional disturbances. Wheat germ, cottonseed oil, soybean oil, sesame oil, corn oil, peas, sweet potatoes, poultry eggs, butter and the like are rich in vitamin E. Side effects: the intake of 200 mg vitamin E per day causes symptoms such as nausea, muscular atrophy, headache and fatigue. Ingestion of more than 300 mg of vitamin E per day can lead to hypertension, delayed wound healing and limited thyroid function.
Vitamin C, VC is a human body's role in recent studies showing that vitamin C is essential for human health, so VC deficiency, collagen cannot be normally synthesized, resulting in cell junction failure, human body is composed of cells, which are connected by intercellular substance, collagen is a key component of the intercellular substance, collagen occupies 1/3 of body protein, generates connective tissue, constitutes a body skeleton, such as bones, blood vessels, ligaments, etc., determines elasticity of skin, protects brain, and helps healing of human wound, ②, scurvy, vascular wall strength and VC have a great relationship, microvessels are the smallest of all blood vessels, wall thickness of only one cell may be determined, strength and elasticity are determined by collagen responsible for the cementous of connecting cells, VC deficiency in vivo, microvesses, blood flow to adjacent tissues, which results in blood stasis, purple stain, and purple stain, severe pain and joint pain in vivo, intestinal tract, nasal, and bone, and cartilage are important for preventing the development of cancer, calcium oxide, calcium chloride, calcium oxide, calcium chloride;
in the prior art, the traditional Chinese medicine composition is directly prepared from raw medicinal material powder or crude extracts, extractum and the like of medicinal materials, the extraction process is simple, the content of each effective component is low, the quality is difficult to control, and the stable curative effect cannot be ensured. In view of the above, there is a need in the art for a compound raw material extract powder suitable for low-temperature vacuum drying and a preparation process thereof, which can improve the content of active ingredients in the product and enhance the use effect. And then a proper amount of auxiliary materials are added to prepare a stable and medicinal injection preparation so as to achieve the effect of more effectively treating different symptoms.
Disclosure of Invention
In order to overcome the above problems in the prior art, the present inventors have conducted extensive studies and extensive experiments to provide the following technical solutions.
The compound low-temperature vacuum drying extraction powder comprises the following raw material components in parts by weight:
80-150 parts of compound main material, 3-8 parts of thickening agent, 5-15 parts of plasticizer, 1-5 parts of antioxidant, 3-8 parts of emulsifier, 120 parts of purified water, 8-15 parts of trace elements and 3-5 parts of vitamin.
The compound main material comprises the following raw materials in parts by weight: 8-15 parts of honeysuckle extract, 3-8 parts of salvia extract and 3-7 parts of ganoderma extract.
The thickening agent is one or a mixture of two or more than two of starch, cellulose, sodium alginate, carrageenan, agar, gellan gum, pullulan, locust bean gum, guar gum and xanthan gum in any proportion;
the plasticizer is one or a mixture of two or more of glycerol, propylene glycol, sorbitol and polyethylene glycol in any proportion;
the antioxidant is one or more of sodium sulfite, sodium bisulfite, sodium thiosulfate and sodium ascorbate;
the emulsifier is one or more of fish oil, egg yolk lecithin and soybean lecithin;
the microelements are one or a mixture of two or more of sodium selenite, magnesium lactate, zinc lactate and chromium trichloride;
the vitamins are one or more of vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B12, vitamin C, vitamin E, folic acid, vitamin D, nicotinamide and pantothenic acid.
Preferably, the composition comprises the following raw materials in parts by weight:
80 parts of compound main material, 5 parts of plasticizer, 3 parts of thickener, 1 part of antioxidant, 3 parts of emulsifier, 120 parts of purified water, 8 parts of trace elements and 3 parts of vitamin.
Preferably, the composition comprises the following raw materials in parts by weight:
150 parts of compound main material, 15 parts of plasticizer, 8 parts of thickener, 5 parts of antioxidant, 8 parts of emulsifier, 200 parts of purified water, 15 parts of trace elements and 5 parts of vitamin.
Preferably, 8 parts of honeysuckle extract, 3 parts of salvia extract and 3 parts of ganoderma extract.
Preferably, the compound main material comprises the following raw materials in parts by weight: 15 parts of honeysuckle extract, 8 parts of salvia extract and 7 parts of ganoderma extract.
An extraction method of the compound low-temperature vacuum drying extraction powder of claim 1, comprising the following steps:
step 1, preparing raw materials;
cleaning honeysuckle, salvia miltiorrhiza and lucid ganoderma, removing impurities, sterilizing for 20-30 seconds in a far infrared sterilizer, then grinding by a planetary ball mill respectively, grinding for 20-30 minutes under the condition that the rotating speed is 300-;
step 2, preparing a plant extract;
step 2-1, preparing a honeysuckle extract;
crushing the honeysuckle A to 400 meshes on an ultramicro wall-breaking crusher, adding ethanol with the weight of 1-2 times of the total weight of the honeysuckle powder into the crushed honeysuckle powder, wherein the concentration of the ethanol is 60-70%, stirring by ultrasonic oscillation, the ultrasonic frequency is 50-60KHz, and the power is 1000 plus 3000W to obtain a suspension A; adding the suspension A into a distillation retort, adding cellulase and water, wherein the weight of the cellulase is 1-2% of that of the suspension A, and soaking for 8-10h at normal temperature to obtain an extracting solution A; introducing water vapor into the distillation retort, heating the extracting solution A, and keeping the boiling time of the extracting solution for 1-2 hours to obtain mixed steam A; condensing the mixed steam A through a condenser to obtain an oil-water mixture A; carrying out oil-water separation on the oil-water mixture A through an oil-water separator to obtain a honeysuckle extract A;
injecting the honeysuckle extract A into an air energy extraction device through a feeding device, closing a valve on the feeding device, and vacuumizing the extraction device; adding an extracting agent into the extraction device, and repeatedly extracting for 5h at 5-10 deg.C under 5-10 MPa; transferring the obtained extract to a separation device, and purifying after separating the solvent and the extract; the extraction is performed by supercritical CO2Performing supercritical extraction with fluid as extraction solvent and ethanol with volume concentration of 70-80% as entrainer to obtain flos Lonicerae extract A; the extraction time is 2h, the temperature is 5-10 ℃, and the pressure is 18-20 MPa; vacuum-drying the honeysuckle extract A at-5 deg.C for 40-50 min to obtain a honeysuckle extract B with water content of no more than 2%;
sealing the honeysuckle A, placing the honeysuckle A in a refrigerator with the temperature of between 15 ℃ below zero and 10 ℃ below zero for 1 to 2 hours at constant temperature, taking the honeysuckle A out, placing the honeysuckle A in a vacuum freeze dryer, freezing the honeysuckle A to between 40 ℃ below zero and 50 ℃ below zero at the cooling speed of 5 to 10 ℃/min, keeping the temperature for 2 to 4 hours, then placing the honeysuckle A in a freezer with the temperature of between 32 ℃ below zero and 36 ℃ below zero for 3 hours at constant temperature, and crushing the honeysuckle A to over 400 meshes in an ultramicro wall-breaking crusher.
The air energy extraction device comprises a heat pump unit; the device is provided with a cold water device for cold quantity exchange and a hot water device for heat quantity exchange; a condenser; the cold water device comprises a first refrigerant inlet pipe, a first refrigerant outlet pipe, a first water inlet pipe and a first water outlet pipe, wherein the first water inlet pipe and the first water outlet pipe are connected with a cold water device; a refrigerant storage tank; the cold water device comprises a cold medium second inlet pipe connected with a cold medium first outlet pipe, a cold medium second outlet pipe formed at the lower part of the cold medium storage tank, a second water inlet pipe connected with the cold water device and a second water outlet pipe; a reaction tank; the reaction tank is provided with a third refrigerant inlet pipe which is butted with a second refrigerant outlet pipe, and the third inlet pipe is connected with a shower head part arranged in the reaction tank; a third refrigerant outlet pipe is arranged below the reaction tank; a discharge tank; the device is provided with a refrigerant fourth inlet pipe connected with a refrigerant third outlet pipe, a refrigerant fourth outlet pipe arranged on one side of the discharge tank, a first hot water inlet pipe connected with a hot water device and a first hot water outlet pipe; a hot jacket sleeve; the hot water device is provided with a refrigerant fifth inlet pipe connected with a refrigerant fourth outlet pipe, a refrigerant fifth outlet pipe connected with a refrigerant first inlet pipe, a second hot water inlet pipe connected with the hot water device and a second hot water outlet pipe; the outer surfaces of the refrigerant storage tank, the reaction tank and the discharge tank are all coated with heat insulation materials; the discharge tank is provided with a manual ball valve, and an essential oil recovery tank is butted below the discharge tank; the reaction tank is provided with a cover body which can be opened or closed repeatedly; the outer surfaces of the condenser, the refrigerant storage tank, the reaction tank and the discharge tank are all provided with water tank bodies for water passages to circulate and exchange heat; the first water inlet pipe and the first water outlet pipe are arranged on a water tank body of the condenser; the second water inlet pipe and the second water outlet pipe are arranged on a water tank body of the refrigerant storage tank; the first hot water inlet pipe and the first hot water outlet pipe are arranged on the water tank body of the discharging tank; the second hot water inlet pipe and the second hot water outlet pipe are arranged on the water tank body of the hot jacket sleeve.
Step 2-2, preparing a salvia miltiorrhiza extract;
decocting Saviae Miltiorrhizae radix A with water at 30-40 deg.C with slow fire; decocting for 3-4 hr, standing for 1 hr, filtering with alumina-based bioceramic microfiltration membrane to obtain filtrate A and residue B, decocting residue B with water at 30-40 deg.C for 3-4 hr, standing for 1 hr, and filtering with alumina-based bioceramic microfiltration membrane to obtain filtrate B; mixing the filtrate A and B to obtain filtrate C, concentrating the filtrate C, adding ethanol, standing, passing the concentrated filtrate through macroporous adsorbent resin column, washing with water, eluting with ethanol, collecting ethanol eluate, concentrating to obtain soft extract, and drying to obtain Saviae Miltiorrhizae radix extract A;
the macroporous adsorption resin column filtration is specifically to adopt a wet method or a dry method to sample a macroporous adsorption resin column; washing the macroporous adsorbent resin column with acidic or neutral aqueous solution, and washing with 60-70 vol% organic solvent of acidic or neutral aqueous solution to remove impurities; collecting eluate, concentrating the collected eluate to remove organic solvent, adjusting pH to 6.5-7 with pH regulator, and extracting with ethanol to obtain ethanol solution containing Saviae Miltiorrhizae radix extract; removing ethanol from ethanol solution containing Saviae Miltiorrhizae radix extract to obtain extract product;
step 2-3, preparing the ganoderma lucidum extract;
adding ethanol with the weight 1.5 times that of the ganoderma lucidum A, wherein the concentration of the ethanol is 30-40%, and then passing through an ultrasonic continuous flow cell crusher, the ultrasonic frequency is 15-40KHz, the power is 1000-; vacuum adsorbing Ganoderma suspension A at 20-30 deg.C for 1-2 hr, using nonpolar macroporous resin as adsorbent, whose weight is 1-2 times of Ganoderma suspension A, extracting by hot reflux with 95% ethanol, enriching with macroporous resin, eluting with 60% ethanol-water to remove impurities, collecting 95% ethanol-water eluate, performing silica gel column chromatography, removing solvent to obtain Ganoderma extract crude product, and separating and purifying with high performance liquid chromatography to obtain Ganoderma extract A.
The high performance liquid preparative chromatography is to use ODS to prepare a chromatographic column; gradient eluting with 68-75% methanol-water for 0-60min, and adding 0.1-0.5% formic acid or trifluoroacetic acid into the eluate; detecting at 254nm, 280nm or 315nm, collecting chromatographic peak, and concentrating under reduced pressure to remove solvent to obtain Ganoderma extract A.
Step 3, mixing;
step 3-1, weighing corresponding raw materials according to the raw material proportion;
step 3-2, dissolving the main material in purified water under the protection of nitrogen, mixing and fully dissolving at 50-55 ℃, filling nitrogen for saturation, adding an emulsifier for full dissolution, then adding a plasticizer, an antioxidant, trace elements and vitamins, stirring at the rotation speed of 400-500r/min for 20-30 minutes, and forming a mixed oil phase A after complete dissolution;
step 3-3, mixing the purified water and the thickening agent at 30-40 ℃ to form a water phase B;
step 3-4, mixing the water phase B with the mixed oil phase A under the protection of nitrogen, mechanically stirring for 1-2h to prepare primary emulsion after high-speed dispersion at 1500-1800r/min at 30-40 ℃, adjusting the pH to 6.5-7, and homogenizing for 3-4 times under the pressure of 100-110MPa to obtain uniform emulsion solution;
step 3-5, decolorizing the emulsion, adding activated carbon for injection, stirring for 30-40min to remove pyrogen, decolorizing, carrying out sterile filtration, carrying out rough filtration and decarburization through a 1-2 micron microporous filter membrane, carrying out fine filtration through a 0.5 micron microporous filter membrane, subpackaging into a freeze-drying bottle, introducing nitrogen for hermetic sealing, carrying out sterilization treatment at 100-120 ℃ for 30-40min, and storing at below 25 ℃ to obtain a standby liquid A;
step 4, freezing and drying;
step 4-1, subpackaging the prepared standby liquid A into unit dosage for use in a container and placing in a freeze dryer;
step 4-2, starting a freeze dryer, pre-freezing for 2-3 hours at-10 ℃, simultaneously starting a vacuum pump, vacuumizing the freeze dryer to 50-100 Pa, carrying out sublimation drying, raising the temperature to 5 ℃ within 5-10 hours of programmed temperature rise, carrying out vacuum drying for 12 hours at 5 ℃, raising the temperature to 10 ℃ and drying for 3 hours to obtain dry powder A;
step 5, sterilizing and packaging;
and (3) performing sterile sealing on the dry powder A obtained in the step (4-2) after powder injection, storing at the temperature below 0 ℃ in a dark place, and packaging.
The alumina-based biological ceramic microfiltration membrane is a zirconia-based nano inorganic film, the cut-off molecular weight is 2000-2500MW, and the microfiltration temperature is 20-25 ℃; the thickness of the nano inorganic film is 10-15 microns.
The extract obtained by the extract plant preparation method has high content of effective components and low loss, and the effective components are retained to the maximum extent.
The ceramic membrane used in the step is used for filtering, so that the extract product is free from pollution, impurities can be effectively filtered, and a solid foundation is laid for improving the purity of the extract.
Therefore, the technical problems of the invention are solved and the beneficial effects which cannot be achieved by the prior art are realized just by setting the specific process parameters and realizing the mutual synergistic effect.
Advantageous effects
According to the technical scheme, the extraction efficiency of the plant extract is improved, the content of effective components is improved, and the process is simple;
by using the ceramic film, the health and environmental protection in the production link are ensured.
Detailed Description
Example 1
The compound feed comprises 80 parts of compound main materials, 5 parts of plasticizer, 3 parts of thickener, 1 part of antioxidant, 3 parts of emulsifier, 120 parts of purified water, 8 parts of trace elements and 3 parts of vitamin, wherein the compound main materials comprise the following raw materials in parts by weight: 8 parts of honeysuckle extract, 3 parts of salvia extract and 3 parts of ganoderma extract.
The thickening agent is cellulose; the plasticizer is sorbitol; the antioxidant is sodium sulfite; the emulsifier is fish oil; the trace element is sodium selenite; the vitamins include vitamin A, vitamin B1 and vitamin D.
Example 2
The composition comprises the following raw material components in parts by weight: 150 parts of compound main material, 15 parts of plasticizer, 8 parts of thickener, 5 parts of antioxidant, 8 parts of emulsifier, 200 parts of purified water, 15 parts of trace elements and 5 parts of vitamin, wherein the compound main material comprises the following raw materials in parts by weight: 15 parts of honeysuckle extract, 8 parts of salvia extract and 7 parts of ganoderma extract.
The thickening agent is sodium alginate; the plasticizer is propylene glycol; the antioxidant is sodium bisulfite; the emulsifier is fish oil; the trace element is zinc lactate; the vitamins include vitamin B3, vitamin B12, vitamin C and vitamin E.
And (3) testing:
the determination method comprises the following steps: the following test results were obtained according to the specifications of the first part of the chinese pharmacopoeia 2005 edition by performing pilot production in a pilot plant base according to the raw material ratios in examples 1 and 2:
1. taking the extraction powder in the example 1 as a test object, the yield of the honeysuckle extract is 3-4%, the yield of the salvia miltiorrhiza extract is 5-6%, and the yield of the ganoderma lucidum extract is 5-6%;
therefore, the yield and the quality of the pilot plant products are stable, the process and the operation are simpler, the recovery utilization rate of the raw materials is high, the impurity removal effect is good, and the method is more suitable for industrial production. The preparation process of the compound raw material extract disclosed by the invention has certain difficulty; the invention discloses a preparation method and an optimization process of a compound raw material extract through a series of experiments, wherein the compounding proportion of raw material components, the selection of raw material types, the stability during component compounding and how to optimize the preparation process to obtain stable compound freeze-dried powder are all technical problems to be overcome by the patent of the invention
Finally, it should be noted that: it should be understood that the above examples are only for clearly illustrating the present application and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of this type are intended to be covered by the present invention.
Claims (9)
1. The compound low-temperature vacuum drying extraction powder is characterized by comprising the following raw material components in parts by weight:
80-150 parts of compound main material, 3-8 parts of thickening agent, 5-15 parts of plasticizer, 1-5 parts of antioxidant, 3-8 parts of emulsifier, 120 parts of purified water, 8-15 parts of trace elements and 3-5 parts of vitamin.
2. The compound low-temperature vacuum drying extraction powder as claimed in claim 1, wherein the compound main material comprises the following raw materials in parts by weight: 8-15 parts of honeysuckle extract, 3-8 parts of salvia extract and 3-7 parts of ganoderma extract.
3. The compound low-temperature vacuum drying extraction powder as claimed in claim 1, wherein the thickener is one or a mixture of two or more of starch, cellulose, sodium alginate, carrageenan, agar, gellan gum, pullulan, locust bean gum, guar gum and xanthan gum in any proportion;
the plasticizer is one or a mixture of two or more of glycerol, propylene glycol, sorbitol and polyethylene glycol in any proportion;
the antioxidant is one or more of sodium sulfite, sodium bisulfite, sodium thiosulfate and sodium ascorbate;
the emulsifier is one or more of fish oil, egg yolk lecithin and soybean lecithin;
the microelements are one or a mixture of two or more of sodium selenite, magnesium lactate, zinc lactate and chromium trichloride;
the vitamins are one or more of vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B12, vitamin C, vitamin E, folic acid, vitamin D, nicotinamide and pantothenic acid.
4. The compound low-temperature vacuum drying extraction powder as claimed in claim 1, wherein the composition comprises the following raw materials in parts by weight:
80 parts of compound main material, 5 parts of plasticizer, 3 parts of thickener, 1 part of antioxidant, 3 parts of emulsifier, 120 parts of purified water, 8 parts of trace elements and 3 parts of vitamin.
5. The compound low-temperature vacuum drying extraction powder as claimed in claim 1, wherein the composition comprises the following raw materials in parts by weight:
150 parts of compound main material, 15 parts of plasticizer, 8 parts of thickener, 5 parts of antioxidant, 8 parts of emulsifier, 200 parts of purified water, 15 parts of trace elements and 5 parts of vitamin.
6. The compound low-temperature vacuum drying extraction powder as claimed in claim 2, wherein the honeysuckle extract is 8 parts, the salvia miltiorrhiza extract is 3 parts, and the ganoderma lucidum extract is 3 parts.
7. The compound low-temperature vacuum drying extraction powder as claimed in claim 2, wherein the compound main material comprises the following raw materials in parts by weight: 15 parts of honeysuckle extract, 8 parts of salvia extract and 7 parts of ganoderma extract.
8. The extraction method of the compound low-temperature vacuum drying extraction powder of claim 1, which is characterized by comprising the following steps:
step 1, preparing raw materials;
cleaning honeysuckle, salvia miltiorrhiza and lucid ganoderma, removing impurities, sterilizing for 20-30 seconds in a far infrared sterilizer, then grinding by a planetary ball mill respectively, grinding for 20-30 minutes under the condition that the rotating speed is 300-;
step 2, preparing a plant extract;
step 2-1, preparing a honeysuckle extract;
crushing the honeysuckle A to 400 meshes on an ultramicro wall-breaking crusher, adding ethanol with the weight of 1-2 times of the total weight of the honeysuckle powder into the crushed honeysuckle powder, wherein the concentration of the ethanol is 60-70%, stirring by ultrasonic oscillation, the ultrasonic frequency is 50-60KHz, and the power is 1000 plus 3000W to obtain a suspension A; adding the suspension A into a distillation retort, adding cellulase and water, wherein the weight of the cellulase is 1-2% of that of the suspension A, and soaking for 8-10h at normal temperature to obtain an extracting solution A; introducing water vapor into the distillation retort, heating the extracting solution A, and keeping the boiling time of the extracting solution for 1-2 hours to obtain mixed steam A; condensing the mixed steam A through a condenser to obtain an oil-water mixture A; carrying out oil-water separation on the oil-water mixture A through an oil-water separator to obtain a honeysuckle extract A;
injecting the honeysuckle extract A into an air energy extraction device through a feeding device, closing a valve on the feeding device, and vacuumizing the extraction device; adding an extracting agent into the extraction device, and repeatedly extracting for 5h at 5-10 deg.C under 5-10 MPa; transferring the obtained extract to a separation device, and purifying after separating the solvent and the extract; the extraction is performed by supercritical CO2Performing supercritical extraction with fluid as extraction solvent and ethanol with volume concentration of 70-80% as entrainer to obtain flos Lonicerae extract A; the extraction time is 2h, the temperature is 5-10 ℃, and the pressure is 18-20 MPa; vacuum-drying the honeysuckle extract A at-5 deg.C for 40-50 min to obtain a honeysuckle extract B with water content of no more than 2%;
step 2-2, preparing a salvia miltiorrhiza extract;
decocting Saviae Miltiorrhizae radix A with water at 30-40 deg.C with slow fire; decocting for 3-4 hr, standing for 1 hr, filtering with alumina-based bioceramic microfiltration membrane to obtain filtrate A and residue B, decocting residue B with water at 30-40 deg.C for 3-4 hr, standing for 1 hr, and filtering with alumina-based bioceramic microfiltration membrane to obtain filtrate B; mixing the filtrate A and B to obtain filtrate C, concentrating the filtrate C, adding ethanol, standing, passing the concentrated filtrate through macroporous adsorbent resin column, washing with water, eluting with ethanol, collecting ethanol eluate, concentrating to obtain soft extract, and drying to obtain Saviae Miltiorrhizae radix extract A;
step 2-3, preparing the ganoderma lucidum extract;
adding ethanol with the weight 1.5 times that of the ganoderma lucidum A, wherein the concentration of the ethanol is 30-40%, and then passing through an ultrasonic continuous flow cell crusher, the ultrasonic frequency is 15-40KHz, the power is 1000-; vacuum adsorbing Ganoderma suspension A at 20-30 deg.C for 1-2 hr, with adsorbent of nonpolar macroporous resin 1-2 times of Ganoderma suspension A, extracting with 95% ethanol under reflux, enriching with macroporous resin, eluting with 60% ethanol-water to remove impurities, collecting 95% ethanol-water eluate, performing silica gel column chromatography, removing solvent to obtain Ganoderma extract crude product, and separating and purifying with high performance liquid chromatography to obtain Ganoderma extract A;
step 3, mixing;
step 3-1, weighing corresponding raw materials according to the raw material proportion;
3-2, dissolving the compound main material in purified water under the protection of nitrogen, mixing and fully dissolving at 50-55 ℃, filling nitrogen for saturation, adding an emulsifier for full dissolution, then adding a plasticizer, an antioxidant, trace elements and vitamins, stirring at the stirring speed of 400-500r/min for 20-30 minutes, and forming a mixed oil phase A after complete dissolution;
step 3-3, mixing the purified water and the thickening agent at 30-40 ℃ to form a water phase B;
step 3-4, mixing the water phase B with the mixed oil phase A under the protection of nitrogen, mechanically stirring for 1-2h to prepare primary emulsion after high-speed dispersion at 1500-1800r/min at 30-40 ℃, adjusting the pH to 6.5-7, and homogenizing for 3-4 times under the pressure of 100-110MPa to obtain uniform emulsion solution;
step 3-5, decolorizing the emulsion, adding activated carbon for injection, stirring for 30-40min to remove pyrogen, decolorizing, carrying out sterile filtration, carrying out rough filtration and decarburization through a 1-2 micron microporous filter membrane, carrying out fine filtration through a 0.5 micron microporous filter membrane, subpackaging into a freeze-drying bottle, introducing nitrogen for hermetic sealing, carrying out sterilization treatment at 100-120 ℃ for 30-40min, and storing at below 25 ℃ to obtain a standby liquid A;
step 4, freezing and drying;
step 4-1, subpackaging the prepared standby liquid A into unit dosage for use in a container and placing in a freeze dryer;
step 4-2, starting a freeze dryer, pre-freezing for 2-3 hours at-10 ℃, simultaneously starting a vacuum pump, vacuumizing the freeze dryer to 50-100 Pa, carrying out sublimation drying, raising the temperature to 5 ℃ within 5-10 hours of programmed temperature rise, carrying out vacuum drying for 12 hours at 5 ℃, raising the temperature to 10 ℃ and drying for 3 hours to obtain dry powder A;
step 5, sterilizing and packaging;
and (3) performing sterile sealing on the dry powder A obtained in the step (4-2) after powder injection, storing at the temperature below 0 ℃ in a dark place, and packaging.
9. The extraction method according to claim 8, wherein the honeysuckle A is crushed by an ultramicro wall-breaking crusher, specifically, the honeysuckle A is sealed and placed in a refrigerator with the temperature of-15 to-10 ℃ and is kept at the constant temperature for 1 to 2 hours, then the honeysuckle A is taken out and placed in a vacuum freeze dryer, the honeysuckle A is frozen to-40 to-50 ℃ at the cooling speed of 5 to 10 ℃/min, is kept for 2 to 4 hours, then the honeysuckle A is placed in a freezer with the freezer temperature of-32 to-36 ℃ and is frozen at the constant temperature for 3 hours, and the honeysuckle A is crushed by the ultramicro wall-breaking crusher to 400 meshes or more;
the macroporous adsorption resin column filtration is specifically to adopt a wet method or a dry method to sample a macroporous adsorption resin column; washing the macroporous adsorbent resin column with acidic or neutral aqueous solution, and washing with 60-70 vol% organic solvent of acidic or neutral aqueous solution to remove impurities; collecting eluate, concentrating the collected eluate to remove organic solvent, adjusting pH to 6.5-7 with pH regulator, and extracting with ethanol to obtain ethanol solution containing Saviae Miltiorrhizae radix extract; removing ethanol from ethanol solution containing Saviae Miltiorrhizae radix extract to obtain extract product; the alumina-based biological ceramic microfiltration membrane is a zirconia-based nano inorganic film, the cut-off molecular weight is 2000-2500MW, and the microfiltration temperature is 20-25 ℃; the thickness of the nano inorganic film is 10-15 microns.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288993A (en) * | 2021-02-18 | 2021-08-24 | 北京本草方源药业集团有限公司 | Compound low-temperature vacuum drying extraction powder and extraction method thereof |
| CN113303472A (en) * | 2021-06-08 | 2021-08-27 | 广西壮族自治区农业科学院 | Functional beverage produced by using litsea cubeba and preparation process thereof |
| CN113317506A (en) * | 2021-06-08 | 2021-08-31 | 广西壮族自治区农业科学院 | Solid beverage for reducing uric acid and preparation method thereof |
| CN116585434A (en) * | 2023-05-24 | 2023-08-15 | 广州恒健大健康产业有限公司 | Medicine and food homologous nanometer extract for treating asthma lung nodule chronic obstructive pulmonary disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102451184A (en) * | 2010-11-02 | 2012-05-16 | 天津瑞普生物技术股份有限公司 | Long-acting compound doxycycline injection |
| CN104739925A (en) * | 2015-04-17 | 2015-07-01 | 史建平 | Composition for treating acnes and preparation method for composition |
| CN109645476A (en) * | 2019-02-14 | 2019-04-19 | 王书敏 | A kind of cordyceps sinensis calcium Tableted compositions and preparation method thereof |
-
2019
- 2019-11-05 CN CN201911069977.8A patent/CN110755389A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102451184A (en) * | 2010-11-02 | 2012-05-16 | 天津瑞普生物技术股份有限公司 | Long-acting compound doxycycline injection |
| CN104739925A (en) * | 2015-04-17 | 2015-07-01 | 史建平 | Composition for treating acnes and preparation method for composition |
| CN109645476A (en) * | 2019-02-14 | 2019-04-19 | 王书敏 | A kind of cordyceps sinensis calcium Tableted compositions and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288993A (en) * | 2021-02-18 | 2021-08-24 | 北京本草方源药业集团有限公司 | Compound low-temperature vacuum drying extraction powder and extraction method thereof |
| CN113303472A (en) * | 2021-06-08 | 2021-08-27 | 广西壮族自治区农业科学院 | Functional beverage produced by using litsea cubeba and preparation process thereof |
| CN113317506A (en) * | 2021-06-08 | 2021-08-31 | 广西壮族自治区农业科学院 | Solid beverage for reducing uric acid and preparation method thereof |
| CN116585434A (en) * | 2023-05-24 | 2023-08-15 | 广州恒健大健康产业有限公司 | Medicine and food homologous nanometer extract for treating asthma lung nodule chronic obstructive pulmonary disease |
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