CN115484937A - 用于口服的包含氨基嘧啶衍生物或其药学上可接受的盐、水合物或溶剂化物的药物组合物 - Google Patents

用于口服的包含氨基嘧啶衍生物或其药学上可接受的盐、水合物或溶剂化物的药物组合物 Download PDF

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Publication number
CN115484937A
CN115484937A CN202180028642.0A CN202180028642A CN115484937A CN 115484937 A CN115484937 A CN 115484937A CN 202180028642 A CN202180028642 A CN 202180028642A CN 115484937 A CN115484937 A CN 115484937A
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China
Prior art keywords
weight
pharmaceutical composition
lazatinib
pharmaceutical formulation
pharmaceutical
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Pending
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CN202180028642.0A
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English (en)
Chinese (zh)
Inventor
J·马克西米利恩
G·拉詹
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Janssen Biotech Inc
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Janssen Biotech Inc
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Publication of CN115484937A publication Critical patent/CN115484937A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202180028642.0A 2020-04-14 2021-04-13 用于口服的包含氨基嘧啶衍生物或其药学上可接受的盐、水合物或溶剂化物的药物组合物 Pending CN115484937A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063009623P 2020-04-14 2020-04-14
US63/009623 2020-04-14
US202063014277P 2020-04-23 2020-04-23
US63/014277 2020-04-23
PCT/IB2021/053035 WO2021209893A1 (en) 2020-04-14 2021-04-13 Pharmaceutical composition for oral administration comprising amin op yrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof

Publications (1)

Publication Number Publication Date
CN115484937A true CN115484937A (zh) 2022-12-16

Family

ID=75562794

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180028642.0A Pending CN115484937A (zh) 2020-04-14 2021-04-13 用于口服的包含氨基嘧啶衍生物或其药学上可接受的盐、水合物或溶剂化物的药物组合物

Country Status (13)

Country Link
US (2) US12138351B2 (cg-RX-API-DMAC10.html)
EP (1) EP4135669A1 (cg-RX-API-DMAC10.html)
JP (2) JP7787824B2 (cg-RX-API-DMAC10.html)
KR (1) KR20230002656A (cg-RX-API-DMAC10.html)
CN (1) CN115484937A (cg-RX-API-DMAC10.html)
AU (2) AU2021257662B2 (cg-RX-API-DMAC10.html)
CA (1) CA3180184A1 (cg-RX-API-DMAC10.html)
IL (1) IL297240A (cg-RX-API-DMAC10.html)
MX (1) MX2022012898A (cg-RX-API-DMAC10.html)
PH (1) PH12022552454A1 (cg-RX-API-DMAC10.html)
TW (1) TWI923583B (cg-RX-API-DMAC10.html)
UY (1) UY39171A (cg-RX-API-DMAC10.html)
WO (1) WO2021209893A1 (cg-RX-API-DMAC10.html)

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KR20200043618A (ko) * 2018-10-18 2020-04-28 주식회사유한양행 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물
EP4349835A4 (en) * 2021-06-01 2025-06-25 Hangzhou Solipharma Co., Ltd. Hydrated crystal form of lazertinib methanesulfonate, process for its preparation and use thereof
WO2023138492A1 (zh) * 2022-01-19 2023-07-27 南京明德新药研发有限公司 一种包含嘧啶基团的三并环类化合物的组合物及其制备方法和应用
CA3228195A1 (en) 2023-05-23 2025-06-30 Janssen Biotech, Inc. Methods for treatment of non-small cell lung cancer (nsclc)
IL326946A (en) 2023-09-05 2026-05-01 Janssen Biotech Inc Methods of treating non-small cell lung cancer
WO2026042017A1 (en) 2024-08-19 2026-02-26 Janssen Biotech, Inc. Amivantamab in combination with lazertinib for the treatment of non-small cell lung cancer (nsclc)

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CN110520110A (zh) * 2017-03-08 2019-11-29 阿瑞雅德制药公司 包含5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的药物制剂

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CN110580014B (zh) * 2018-06-11 2021-03-30 北京京东尚科信息技术有限公司 用于控制自动导引运输车的方法、装置和系统
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CN110520110A (zh) * 2017-03-08 2019-11-29 阿瑞雅德制药公司 包含5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的药物制剂
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Publication number Publication date
TW202207940A (zh) 2022-03-01
JP2025179094A (ja) 2025-12-09
JP2023522634A (ja) 2023-05-31
UY39171A (es) 2021-10-29
BR112022020609A2 (pt) 2022-11-29
WO2021209893A1 (en) 2021-10-21
AU2021257662B2 (en) 2025-06-12
IL297240A (en) 2022-12-01
EP4135669A1 (en) 2023-02-22
TWI923583B (zh) 2026-05-01
US20250177311A1 (en) 2025-06-05
CA3180184A1 (en) 2021-10-21
MX2022012898A (es) 2023-01-24
US12138351B2 (en) 2024-11-12
KR20230002656A (ko) 2023-01-05
PH12022552454A1 (en) 2024-02-05
AU2025203347A1 (en) 2025-05-29
US20210322323A1 (en) 2021-10-21
WO2021209893A8 (en) 2022-10-13
AU2021257662A1 (en) 2022-12-15
JP7787824B2 (ja) 2025-12-17

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