CN115468919A - 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定 - Google Patents

使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定 Download PDF

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Publication number
CN115468919A
CN115468919A CN202211108451.8A CN202211108451A CN115468919A CN 115468919 A CN115468919 A CN 115468919A CN 202211108451 A CN202211108451 A CN 202211108451A CN 115468919 A CN115468919 A CN 115468919A
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protein
salt
concentration
buffer
sample
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Chinese (zh)
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M·马洛
M·森尼特
M·施耐德
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N2021/258—Surface plasmon spectroscopy, e.g. micro- or nanoparticles in suspension

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
CN202211108451.8A 2016-08-18 2017-08-18 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定 Pending CN115468919A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662376788P 2016-08-18 2016-08-18
US62/376,788 2016-08-18
PCT/US2017/047630 WO2018035470A1 (en) 2016-08-18 2017-08-18 Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy
CN201780050825.6A CN109661577B (zh) 2016-08-18 2017-08-18 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定

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CN201780050825.6A Active CN109661577B (zh) 2016-08-18 2017-08-18 使用浓度相关的自相互作用纳米粒子光谱法确定蛋白质自缔合的可能性的测定

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US (3) US11428695B2 (https=)
EP (2) EP3500856B1 (https=)
JP (3) JP6959327B2 (https=)
KR (3) KR102717462B1 (https=)
CN (2) CN115468919A (https=)
AU (2) AU2017313150B2 (https=)
BR (1) BR112019003175A2 (https=)
CA (3) CA3254461A1 (https=)
DK (2) DK3500856T3 (https=)
EA (1) EA201990316A1 (https=)
ES (2) ES2837093T3 (https=)
FI (1) FI3761035T3 (https=)
HU (2) HUE052805T2 (https=)
IL (2) IL264640B2 (https=)
MX (2) MX2019001930A (https=)
PL (2) PL3500856T3 (https=)
SG (1) SG11201900895QA (https=)
WO (1) WO2018035470A1 (https=)
ZA (1) ZA201901035B (https=)

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DK3500856T3 (da) 2016-08-18 2020-12-14 Regeneron Pharma Assay til bestemmelse af et proteins potentiale for at selvassociere ved hjælp af koncentrationsafhængig selvinteraktionsnanopartikelspektroskopi
US11103552B2 (en) 2018-05-10 2021-08-31 Regeneron Pharmaceuticals, Inc. High concentration VEGF receptor fusion protein containing formulations
CN113588582B (zh) * 2020-04-30 2024-05-14 上海药明生物技术有限公司 蛋白质样品浓度测定方式选择法及测定方法
WO2023095154A1 (en) * 2021-11-24 2023-06-01 Sensoville Biotech Pvt Ltd Method for determining changes in a protein's structure
WO2023141319A1 (en) * 2022-01-24 2023-07-27 Amgen Inc. Methods for detecting antibody self-association
CN119832975A (zh) * 2024-12-24 2025-04-15 上海药明生物技术有限公司 一种蛋白质共处方制剂的稳定性预测方法

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US20100035359A1 (en) * 2006-10-23 2010-02-11 Peter Cormack Functionalised polymers for binding metal surfaces
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CN1930475A (zh) * 2004-03-30 2007-03-14 英特尔公司 通过表面增强拉曼光谱检测分子结合的方法
CN101238141A (zh) * 2005-05-02 2008-08-06 巴斯福股份公司 灵敏检测分析物的新标记策略
US20100035359A1 (en) * 2006-10-23 2010-02-11 Peter Cormack Functionalised polymers for binding metal surfaces
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US20240280582A1 (en) 2024-08-22
SG11201900895QA (en) 2019-02-27
DK3761035T3 (da) 2024-03-11
JP2019532267A (ja) 2019-11-07
EP3761035A1 (en) 2021-01-06
IL264640B1 (en) 2023-11-01
AU2017313150B2 (en) 2023-09-14
US11428695B2 (en) 2022-08-30
JP6959327B2 (ja) 2021-11-02
MX2023013583A (es) 2023-11-30
IL307435A (en) 2023-12-01
CA3254460A1 (en) 2025-07-03
ZA201901035B (en) 2024-06-26
US20190187149A1 (en) 2019-06-20
EA201990316A1 (ru) 2019-07-31
KR20190039185A (ko) 2019-04-10
WO2018035470A9 (en) 2018-07-05
EP3500856A1 (en) 2019-06-26
JP2023139189A (ja) 2023-10-03
ES2837093T3 (es) 2021-06-29
CA3254461A1 (en) 2025-07-03
EP3761035B1 (en) 2024-02-14
JP2022008959A (ja) 2022-01-14
DK3500856T3 (da) 2020-12-14
WO2018035470A1 (en) 2018-02-22
CA3032361C (en) 2025-07-08
HUE066064T2 (hu) 2024-07-28
MX2019001930A (es) 2019-07-04
JP7321227B2 (ja) 2023-08-04
CA3032361A1 (en) 2018-02-22
AU2017313150A1 (en) 2019-02-21
US11988668B2 (en) 2024-05-21
IL264640B2 (en) 2024-03-01
CN109661577B (zh) 2022-09-27
KR102534506B1 (ko) 2023-05-30
CN109661577A (zh) 2019-04-19
PL3761035T3 (pl) 2024-06-24
KR20220126801A (ko) 2022-09-16
ES2974961T3 (es) 2024-07-02
PL3500856T3 (pl) 2021-04-19
KR102717462B1 (ko) 2024-10-16
KR20230074614A (ko) 2023-05-30
BR112019003175A2 (pt) 2019-06-18
HUE052805T2 (hu) 2021-05-28
AU2023274236A1 (en) 2023-12-21
EP3500856B1 (en) 2020-10-07
FI3761035T3 (fi) 2024-03-18
US20220357335A1 (en) 2022-11-10
IL264640A (https=) 2019-04-30
KR102441221B1 (ko) 2022-09-07

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Application publication date: 20221213