CA3032361C - TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY - Google Patents

TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY

Info

Publication number
CA3032361C
CA3032361C CA3032361A CA3032361A CA3032361C CA 3032361 C CA3032361 C CA 3032361C CA 3032361 A CA3032361 A CA 3032361A CA 3032361 A CA3032361 A CA 3032361A CA 3032361 C CA3032361 C CA 3032361C
Authority
CA
Canada
Prior art keywords
protein
concentration
salt
mixture
bioanalytical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3032361A
Other languages
English (en)
French (fr)
Other versions
CA3032361A1 (en
Inventor
Michael Marlow
Michael Sennett
Michael Schneider
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA3032361A1 publication Critical patent/CA3032361A1/en
Application granted granted Critical
Publication of CA3032361C publication Critical patent/CA3032361C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N2021/258—Surface plasmon spectroscopy, e.g. micro- or nanoparticles in suspension

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
CA3032361A 2016-08-18 2017-08-18 TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY Active CA3032361C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662376788P 2016-08-18 2016-08-18
US62/376,788 2016-08-18
PCT/US2017/047630 WO2018035470A1 (en) 2016-08-18 2017-08-18 Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA3254460A Division CA3254460A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3254461A Division CA3254461A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy

Publications (2)

Publication Number Publication Date
CA3032361A1 CA3032361A1 (en) 2018-02-22
CA3032361C true CA3032361C (en) 2025-07-08

Family

ID=59746357

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3032361A Active CA3032361C (en) 2016-08-18 2017-08-18 TEST TO DETERMINE THE SELF-ASSOCIATION POTENTIAL OF A PROTEIN BY MEANS OF CONCENTRATION-DEPENDENT SELF-INTERACTION NANOPARTICULAR SPECTROSCOPY
CA3254460A Pending CA3254460A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3254461A Pending CA3254461A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3254460A Pending CA3254460A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy
CA3254461A Pending CA3254461A1 (en) 2016-08-18 2017-08-18 Assay for Determining Potential to Self-Association of a Protein Using Concentration-Dependent Self-Interaction Nanoparticle Spectroscopy

Country Status (19)

Country Link
US (3) US11428695B2 (https=)
EP (2) EP3761035B1 (https=)
JP (3) JP6959327B2 (https=)
KR (3) KR102717462B1 (https=)
CN (2) CN115468919A (https=)
AU (2) AU2017313150B2 (https=)
BR (1) BR112019003175A2 (https=)
CA (3) CA3032361C (https=)
DK (2) DK3761035T3 (https=)
EA (1) EA201990316A1 (https=)
ES (2) ES2837093T3 (https=)
FI (1) FI3761035T3 (https=)
HU (2) HUE066064T2 (https=)
IL (2) IL307435A (https=)
MX (2) MX2019001930A (https=)
PL (2) PL3761035T3 (https=)
SG (1) SG11201900895QA (https=)
WO (1) WO2018035470A1 (https=)
ZA (1) ZA201901035B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018035470A1 (en) 2016-08-18 2018-02-22 Regeneron Pharmaceuticals, Inc. Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy
DK4364724T3 (da) 2018-05-10 2025-12-22 Regeneron Pharma Formuleringer med høj koncentration af VEGF-receptorfusionsprotein
CN113588582B (zh) * 2020-04-30 2024-05-14 上海药明生物技术有限公司 蛋白质样品浓度测定方式选择法及测定方法
WO2023095154A1 (en) * 2021-11-24 2023-06-01 Sensoville Biotech Pvt Ltd Method for determining changes in a protein's structure
AU2023208644A1 (en) * 2022-01-24 2024-07-04 Amgen Inc. Methods for detecting antibody self-association
CN119832975A (zh) * 2024-12-24 2025-04-15 上海药明生物技术有限公司 一种蛋白质共处方制剂的稳定性预测方法

Family Cites Families (25)

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US771997A (en) 1903-11-21 1904-10-11 Alfred Palm Lathe attachment.
US4254102A (en) * 1975-09-08 1981-03-03 Plough, Inc. Substantive PABA compositions
US4080264A (en) 1976-03-01 1978-03-21 Massachusetts Institute Of Technology Immunoassay by light scattering spectroscopy
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US20050214356A1 (en) * 2004-03-24 2005-09-29 Joyce Timothy H Self assembling activation agents targeted using active drug release
US20050221507A1 (en) * 2004-03-30 2005-10-06 Intel Corporation Method to detect molecular binding by surface-enhanced Raman spectroscopy
US7514938B2 (en) 2004-05-11 2009-04-07 Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno Dielectric relaxation spectroscopy apparatus and methods of use
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
CN101238141B (zh) * 2005-05-02 2016-10-12 巴斯福股份公司 灵敏检测分析物的新标记策略
US20070291265A1 (en) 2006-04-13 2007-12-20 Mississippi State University Optical apparatus for simultaneously measuring the scattering and concentration of signals of macromolecules in a flow cell
EP2076287A2 (en) 2006-10-12 2009-07-08 Wyeth Methods and compositions with reduced opalescence
GB0621050D0 (en) * 2006-10-23 2006-11-29 Univ Strathclyde Functionalised polymers for labelling metal surfaces
EP2150617B1 (en) 2007-06-04 2014-10-22 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
KR20100123674A (ko) * 2007-09-21 2010-11-24 싸이티뮨 사이언스, 인크. 나노치료제 콜로이드성 금속 조성물 및 방법
US20110305765A1 (en) * 2008-11-21 2011-12-15 Board Of Regents, The University Of Texas System Preparation and methodology of silk fibroin nanoparticles
US20140024024A1 (en) * 2012-07-17 2014-01-23 General Electric Company Methods of detecting dna, rna and protein in biological samples
WO2014192937A1 (ja) 2013-05-30 2014-12-04 公立大学法人大阪府立大学 被検出物質の検出装置および方法
IL312865B2 (en) * 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
EP2902503A1 (en) * 2014-01-31 2015-08-05 Fundación Imdea Nanociencia Functionalized metal nanoparticles and uses thereof for detecting nucleic acids
WO2015196091A1 (en) * 2014-06-20 2015-12-23 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
CN104062287B (zh) 2014-07-01 2017-08-08 福建工程学院 一种基于纳米金催化的化学发光分析检测铁蛋白的方法
MA40861A (fr) * 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
WO2016115475A1 (en) * 2015-01-18 2016-07-21 Biogen Ma Inc. Anti-cd40 antibody formulations
WO2018035470A1 (en) 2016-08-18 2018-02-22 Regeneron Pharmaceuticals, Inc. Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy

Also Published As

Publication number Publication date
MX2023013583A (es) 2023-11-30
KR102441221B1 (ko) 2022-09-07
MX2019001930A (es) 2019-07-04
US20190187149A1 (en) 2019-06-20
BR112019003175A2 (pt) 2019-06-18
FI3761035T3 (fi) 2024-03-18
EP3761035A1 (en) 2021-01-06
JP6959327B2 (ja) 2021-11-02
ES2974961T3 (es) 2024-07-02
EP3500856B1 (en) 2020-10-07
JP7321227B2 (ja) 2023-08-04
IL264640B2 (en) 2024-03-01
JP2022008959A (ja) 2022-01-14
US11988668B2 (en) 2024-05-21
CA3254460A1 (en) 2025-07-03
ZA201901035B (en) 2024-06-26
IL264640A (https=) 2019-04-30
JP2019532267A (ja) 2019-11-07
CN115468919A (zh) 2022-12-13
AU2023274236A1 (en) 2023-12-21
HUE066064T2 (hu) 2024-07-28
EA201990316A1 (ru) 2019-07-31
AU2017313150B2 (en) 2023-09-14
KR102534506B1 (ko) 2023-05-30
CA3032361A1 (en) 2018-02-22
CN109661577A (zh) 2019-04-19
DK3500856T3 (da) 2020-12-14
HUE052805T2 (hu) 2021-05-28
EP3500856A1 (en) 2019-06-26
IL264640B1 (en) 2023-11-01
KR20220126801A (ko) 2022-09-16
CN109661577B (zh) 2022-09-27
JP2023139189A (ja) 2023-10-03
WO2018035470A9 (en) 2018-07-05
EP3761035B1 (en) 2024-02-14
KR20230074614A (ko) 2023-05-30
WO2018035470A1 (en) 2018-02-22
US11428695B2 (en) 2022-08-30
CA3254461A1 (en) 2025-07-03
PL3500856T3 (pl) 2021-04-19
IL307435A (en) 2023-12-01
KR102717462B1 (ko) 2024-10-16
ES2837093T3 (es) 2021-06-29
US20220357335A1 (en) 2022-11-10
US20240280582A1 (en) 2024-08-22
AU2017313150A1 (en) 2019-02-21
SG11201900895QA (en) 2019-02-27
DK3761035T3 (da) 2024-03-11
KR20190039185A (ko) 2019-04-10
PL3761035T3 (pl) 2024-06-24

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