CN1154491C - 用于改善替普拉那维的药物动力学的方法 - Google Patents

用于改善替普拉那维的药物动力学的方法 Download PDF

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Publication number
CN1154491C
CN1154491C CNB998123587A CN99812358A CN1154491C CN 1154491 C CN1154491 C CN 1154491C CN B998123587 A CNB998123587 A CN B998123587A CN 99812358 A CN99812358 A CN 99812358A CN 1154491 C CN1154491 C CN 1154491C
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China
Prior art keywords
tipranavir
ritonavir
bid
therapeutically effective
effective amount
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Expired - Lifetime
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CNB998123587A
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English (en)
Chinese (zh)
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CN1324237A (zh
Inventor
J・J・菲瑞
J·J·菲瑞
鲍德温
J·R·鲍德温
柏林
M·T·柏林
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Pharmacia and Upjohn Co
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Pharmacia and Upjohn Co
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Publication of CN1324237A publication Critical patent/CN1324237A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB998123587A 1998-11-04 1999-10-29 用于改善替普拉那维的药物动力学的方法 Expired - Lifetime CN1154491C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10696398P 1998-11-04 1998-11-04
US60/106,963 1998-11-04

Publications (2)

Publication Number Publication Date
CN1324237A CN1324237A (zh) 2001-11-28
CN1154491C true CN1154491C (zh) 2004-06-23

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ID=22314155

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CNB998123587A Expired - Lifetime CN1154491C (zh) 1998-11-04 1999-10-29 用于改善替普拉那维的药物动力学的方法

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Country Link
US (1) US6147095A (https=)
EP (1) EP1126847A1 (https=)
JP (1) JP2002528502A (https=)
CN (1) CN1154491C (https=)
AU (1) AU762349B2 (https=)
BR (1) BR9914940A (https=)
CA (1) CA2346131C (https=)
CO (1) CO5160321A1 (https=)
HK (1) HK1040625B (https=)
MY (1) MY118526A (https=)
PE (1) PE20001296A1 (https=)
TW (1) TW580387B (https=)
WO (1) WO2000025784A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
DE60132103T2 (de) * 2000-10-31 2008-04-17 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Perorale, selbst-emulgierende darreichungsformen von pyranon-proteaseinhibitoren
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
US20040197321A1 (en) * 2002-03-19 2004-10-07 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
US20030180279A1 (en) * 2002-03-19 2003-09-25 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
AU2003295940A1 (en) * 2002-12-16 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. Treatment of hiv infection through combined administration of tipranavir and capravirine
WO2004054586A1 (en) * 2002-12-16 2004-07-01 Boehringer Ingelheim International Gmbh Use of a combination containing a non-nucleoside reverse transcriptase inhibitor (nnrti) with an inhibitor of cytochrome p450, such as protease inhibitors
EP1610781A1 (en) * 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antiviral combination of tipranavir and a further antiretroviral compound
AR045841A1 (es) * 2004-09-28 2005-11-16 Richmond Sa Com Ind Y Financie Una composicion farmaceutica solida que comprende al tiazolil metil ester del acido [5s-(5r*, 8r*, 10r*,11r*)] -10- hidroxi-2- metil-5-(1-metiletil)-1-[2-(1-metiletil)-4-tiazolil]-3,6-dioxo-8,11-bis(fenilmetil)-2,4,7,12- tetraazatridecan-13-oico y un procedimiento para prepararla.
WO2006052373A2 (en) * 2004-11-08 2006-05-18 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and etravirine
JP2008520672A (ja) * 2004-11-16 2008-06-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チプラナビルとダルナビルの共投与によるｈｉｖ感染症の治療方法
WO2006055660A2 (en) * 2004-11-19 2006-05-26 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and uk-427, 857
WO2006055754A1 (en) * 2004-11-19 2006-05-26 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and reverset
CA2585663A1 (en) * 2004-12-01 2006-06-08 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and sch-417690
US20060142344A1 (en) * 2004-12-01 2006-06-29 Boehringer Ingelheim International Gmbh Method for treating HIV infection through co-administration of tipranavir and GW695634
EP1819333A1 (en) * 2004-12-01 2007-08-22 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gw873140
CN101631568B (zh) 2007-03-12 2012-08-22 尼克塔治疗公司 低聚物-蛋白酶抑制剂偶联物
US9095620B2 (en) * 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
US20100021505A1 (en) * 2008-07-28 2010-01-28 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
JP2012530069A (ja) 2009-06-12 2012-11-29 ネクター セラピューティックス プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体
MA34215B1 (fr) * 2010-04-02 2013-05-02 Phivco 1 Llc Traitement d'association comprenant un antagoniste du récepteur ccr5, un inhibiteur de la protéase du vih-1 et un accélérateur pharmacocinétique
AU2012262322B2 (en) * 2011-05-30 2016-11-03 Autotelic Llc Methods and compositions for therapeutic drug monitoring and dosing by point-of-care pharmacokinetic profiling

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5608085A (en) * 1995-02-27 1997-03-04 The University Of Tennessee Research Corporation Synthesis of optically active calanolides A and B and enantiomers and related compounds
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.

Also Published As

Publication number Publication date
TW580387B (en) 2004-03-21
AU1440400A (en) 2000-05-22
CA2346131C (en) 2013-01-15
CA2346131A1 (en) 2000-05-11
HK1040625A1 (en) 2002-06-21
PE20001296A1 (es) 2000-11-23
BR9914940A (pt) 2001-07-10
MY118526A (en) 2004-11-30
HK1040625B (zh) 2005-04-01
US6147095A (en) 2000-11-14
CN1324237A (zh) 2001-11-28
CO5160321A1 (es) 2002-05-30
WO2000025784A1 (en) 2000-05-11
AU762349B2 (en) 2003-06-26
EP1126847A1 (en) 2001-08-29
JP2002528502A (ja) 2002-09-03

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