JP2002528502A - チプラナビルの薬物動態を改善する方法 - Google Patents
チプラナビルの薬物動態を改善する方法Info
- Publication number
- JP2002528502A JP2002528502A JP2000579225A JP2000579225A JP2002528502A JP 2002528502 A JP2002528502 A JP 2002528502A JP 2000579225 A JP2000579225 A JP 2000579225A JP 2000579225 A JP2000579225 A JP 2000579225A JP 2002528502 A JP2002528502 A JP 2002528502A
- Authority
- JP
- Japan
- Prior art keywords
- tipranavir
- ritonavir
- effective amount
- therapeutically effective
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229960000689 nevirapine Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
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- 235000019198 oils Nutrition 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 201000000317 pneumocystosis Diseases 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 108020003175 receptors Proteins 0.000 description 1
- 229940063627 rescriptor Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960000885 rifabutin Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
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- 230000002110 toxicologic effect Effects 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10696398P | 1998-11-04 | 1998-11-04 | |
| US60/106,963 | 1998-11-04 | ||
| PCT/US1999/021469 WO2000025784A1 (en) | 1998-11-04 | 1999-10-29 | Method for improving the pharmacokinetics of tipranavir |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002528502A true JP2002528502A (ja) | 2002-09-03 |
| JP2002528502A5 JP2002528502A5 (https=) | 2006-06-22 |
Family
ID=22314155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579225A Pending JP2002528502A (ja) | 1998-11-04 | 1999-10-29 | チプラナビルの薬物動態を改善する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6147095A (https=) |
| EP (1) | EP1126847A1 (https=) |
| JP (1) | JP2002528502A (https=) |
| CN (1) | CN1154491C (https=) |
| AU (1) | AU762349B2 (https=) |
| BR (1) | BR9914940A (https=) |
| CA (1) | CA2346131C (https=) |
| CO (1) | CO5160321A1 (https=) |
| HK (1) | HK1040625B (https=) |
| MY (1) | MY118526A (https=) |
| PE (1) | PE20001296A1 (https=) |
| TW (1) | TW580387B (https=) |
| WO (1) | WO2000025784A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006511538A (ja) * | 2002-12-16 | 2006-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ヌクレオシド系逆転写酵素阻害剤（ｎｎｒｔｉ）とプロテアーゼ阻害剤などのシトクロムｐ４５０の阻害剤とを含む組み合わせの使用 |
| JP2014518375A (ja) * | 2011-05-30 | 2014-07-28 | ストリング セラピューティックス インコーポレイテッド | ポイント・オブ・ケア薬物動態プロフィールによる治療薬モニタリングおよび用量投与のための方法および組成物 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
| DE60132103T2 (de) * | 2000-10-31 | 2008-04-17 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Perorale, selbst-emulgierende darreichungsformen von pyranon-proteaseinhibitoren |
| DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| US20040197321A1 (en) * | 2002-03-19 | 2004-10-07 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| US20030180279A1 (en) * | 2002-03-19 | 2003-09-25 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| AU2003295940A1 (en) * | 2002-12-16 | 2004-07-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Treatment of hiv infection through combined administration of tipranavir and capravirine |
| EP1610781A1 (en) * | 2003-03-27 | 2006-01-04 | Boehringer Ingelheim International GmbH | Antiviral combination of tipranavir and a further antiretroviral compound |
| AR045841A1 (es) * | 2004-09-28 | 2005-11-16 | Richmond Sa Com Ind Y Financie | Una composicion farmaceutica solida que comprende al tiazolil metil ester del acido [5s-(5r*, 8r*, 10r*,11r*)] -10- hidroxi-2- metil-5-(1-metiletil)-1-[2-(1-metiletil)-4-tiazolil]-3,6-dioxo-8,11-bis(fenilmetil)-2,4,7,12- tetraazatridecan-13-oico y un procedimiento para prepararla. |
| WO2006052373A2 (en) * | 2004-11-08 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and etravirine |
| JP2008520672A (ja) * | 2004-11-16 | 2008-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビルとダルナビルの共投与によるｈｉｖ感染症の治療方法 |
| WO2006055660A2 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
| WO2006055754A1 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and reverset |
| CA2585663A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and sch-417690 |
| US20060142344A1 (en) * | 2004-12-01 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW695634 |
| EP1819333A1 (en) * | 2004-12-01 | 2007-08-22 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and gw873140 |
| CN101631568B (zh) | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
| US9095620B2 (en) * | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
| US20100021505A1 (en) * | 2008-07-28 | 2010-01-28 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| JP2012530069A (ja) | 2009-06-12 | 2012-11-29 | ネクター セラピューティックス | プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体 |
| MA34215B1 (fr) * | 2010-04-02 | 2013-05-02 | Phivco 1 Llc | Traitement d'association comprenant un antagoniste du récepteur ccr5, un inhibiteur de la protéase du vih-1 et un accélérateur pharmacocinétique |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5608085A (en) * | 1995-02-27 | 1997-03-04 | The University Of Tennessee Research Corporation | Synthesis of optically active calanolides A and B and enantiomers and related compounds |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5932570A (en) * | 1996-11-08 | 1999-08-03 | Dupont Pharmaceuticals Company | 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors |
| ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
-
1999
- 1999-10-29 AU AU14404/00A patent/AU762349B2/en not_active Expired
- 1999-10-29 CN CNB998123587A patent/CN1154491C/zh not_active Expired - Lifetime
- 1999-10-29 US US09/430,742 patent/US6147095A/en not_active Expired - Lifetime
- 1999-10-29 EP EP99971319A patent/EP1126847A1/en active Pending
- 1999-10-29 HK HK02102194.8A patent/HK1040625B/zh not_active IP Right Cessation
- 1999-10-29 BR BR9914940-0A patent/BR9914940A/pt not_active Application Discontinuation
- 1999-10-29 JP JP2000579225A patent/JP2002528502A/ja active Pending
- 1999-10-29 WO PCT/US1999/021469 patent/WO2000025784A1/en not_active Ceased
- 1999-10-29 CA CA2346131A patent/CA2346131C/en not_active Expired - Lifetime
- 1999-11-03 PE PE1999001100A patent/PE20001296A1/es not_active Application Discontinuation
- 1999-11-04 TW TW088119229A patent/TW580387B/zh not_active IP Right Cessation
- 1999-11-04 MY MYPI99004794A patent/MY118526A/en unknown
- 1999-11-04 CO CO99069669A patent/CO5160321A1/es unknown
Non-Patent Citations (3)
| Title |
|---|
| JPN6009059951, ＣＨＯＮＧ， Ｋ．Ｔ． ｅｔ ａｌ．, ＡＮＴＩＭＩＣＲＯＢＩＡＬ ＡＧＥＮＴＳ ＡＮＤ ＣＨＥＭＯＴＨＥＲＡＰＹ, 1997, Ｖｏｌ．４１， Ｎｏ．１１, ｐ．２３６７−２３７３ * |
| JPN6009059952, ＢＯＲＩＮ， Ｍ．Ｔ． ｅｔ ａｌ．, ＡＢＳＴＲＡＣＳＴ ＯＦ ＴＨＥ ＩＮＴＥＲＳＣＩＥＮＣＥ ＣＯＮＦＥＲＥＮＣＥ ＯＮ ＡＮＴＩＭＩＣＲＯＢＩＡＬ ＡＧＥＮＴＳ ＡＮＤ ＣＨＥＭＯＴＨＥＲＡＰＹ, 1997, Ｖｏｌ．３７, ｐ．２７９ * |
| JPN6009059953, ＭＡＲＫＯＷＩＴＺ， Ｍ． ｅｔ ａｌ．, ＴＨＥ ＮＥＷ ＥＮＧＬＡＮＤ ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＥ, 1995, Ｖｏｌ．３３３， Ｎｏ．２３, ｐ．１５３４−１５３９ * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006511538A (ja) * | 2002-12-16 | 2006-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非ヌクレオシド系逆転写酵素阻害剤（ｎｎｒｔｉ）とプロテアーゼ阻害剤などのシトクロムｐ４５０の阻害剤とを含む組み合わせの使用 |
| JP2014518375A (ja) * | 2011-05-30 | 2014-07-28 | ストリング セラピューティックス インコーポレイテッド | ポイント・オブ・ケア薬物動態プロフィールによる治療薬モニタリングおよび用量投与のための方法および組成物 |
| JP2017207508A (ja) * | 2011-05-30 | 2017-11-24 | オートテリック エルエルシー | ポイント・オブ・ケア薬物動態プロフィールによる治療薬モニタリングおよび用量投与のための方法および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW580387B (en) | 2004-03-21 |
| AU1440400A (en) | 2000-05-22 |
| CA2346131C (en) | 2013-01-15 |
| CA2346131A1 (en) | 2000-05-11 |
| HK1040625A1 (en) | 2002-06-21 |
| PE20001296A1 (es) | 2000-11-23 |
| BR9914940A (pt) | 2001-07-10 |
| MY118526A (en) | 2004-11-30 |
| HK1040625B (zh) | 2005-04-01 |
| US6147095A (en) | 2000-11-14 |
| CN1324237A (zh) | 2001-11-28 |
| CO5160321A1 (es) | 2002-05-30 |
| CN1154491C (zh) | 2004-06-23 |
| WO2000025784A1 (en) | 2000-05-11 |
| AU762349B2 (en) | 2003-06-26 |
| EP1126847A1 (en) | 2001-08-29 |
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