CN115414274A - Application of She Suanyin ionic material in preparation of scalp care composition, scalp care composition and preparation method - Google Patents
Application of She Suanyin ionic material in preparation of scalp care composition, scalp care composition and preparation method Download PDFInfo
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- CN115414274A CN115414274A CN202211199997.9A CN202211199997A CN115414274A CN 115414274 A CN115414274 A CN 115414274A CN 202211199997 A CN202211199997 A CN 202211199997A CN 115414274 A CN115414274 A CN 115414274A
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- suanyin
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- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 210000004761 scalp Anatomy 0.000 title claims abstract description 63
- 239000000463 material Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 38
- 239000004332 silver Substances 0.000 claims abstract description 29
- 229910052709 silver Inorganic materials 0.000 claims abstract description 29
- 235000019152 folic acid Nutrition 0.000 claims abstract description 22
- 239000011724 folic acid Substances 0.000 claims abstract description 22
- 208000001840 Dandruff Diseases 0.000 claims abstract description 21
- 239000011850 water-based material Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000002156 mixing Methods 0.000 claims description 19
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 17
- 229960000304 folic acid Drugs 0.000 claims description 17
- -1 silver ions Chemical class 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 4
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000665 guar gum Substances 0.000 claims description 4
- 229960002154 guar gum Drugs 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 2
- 230000001276 controlling effect Effects 0.000 claims 1
- 239000006254 rheological additive Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 210000004209 hair Anatomy 0.000 abstract description 16
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 12
- 238000012360 testing method Methods 0.000 abstract description 9
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 229940014144 folate Drugs 0.000 abstract description 5
- 230000007803 itching Effects 0.000 abstract description 5
- 239000002453 shampoo Substances 0.000 abstract description 5
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000032683 aging Effects 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000555676 Malassezia Species 0.000 abstract 1
- 238000005260 corrosion Methods 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 230000002147 killing effect Effects 0.000 abstract 1
- 230000008439 repair process Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 239000011550 stock solution Substances 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 206010019049 Hair texture abnormal Diseases 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 241000555688 Malassezia furfur Species 0.000 description 3
- 239000012062 aqueous buffer Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 3
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 description 2
- OTNXWHBAPNSDIA-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;boric acid Chemical compound OB(O)O.OCC(N)(CO)CO OTNXWHBAPNSDIA-UHFFFAOYSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 description 2
- 229940071536 silver acetate Drugs 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 description 2
- 229910000367 silver sulfate Inorganic materials 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 2
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- SXGZJKUKBWWHRA-UHFFFAOYSA-N 2-(N-morpholiniumyl)ethanesulfonate Chemical compound [O-]S(=O)(=O)CC[NH+]1CCOCC1 SXGZJKUKBWWHRA-UHFFFAOYSA-N 0.000 description 1
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical class NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses application of a silver folate ionic material in preparation of a scalp care composition, the scalp care composition and a preparation method. The She Suanyin ionic water-based material disclosed by the invention has a remarkable killing effect on bacteria and fungi, especially malassezia, is an excellent scalp bacteriostatic care agent, has antibacterial, bacteriostatic and repair care functions, and can replace the traditional anti-dandruff and anti-corrosion components, and the hair microenvironment is improved, and the damaged scalp cells are promoted to be repaired. Tests show that the scalp care shampoo prepared from She Suanyin ionic water-based material has good effects of removing dandruff, relieving itching, resisting aging, nourishing and repairing, and has better effect when being used with scalp massage cream containing silver folate ionic water-based material.
Description
Technical Field
The invention relates to the field of scalp care, in particular to application of a silver folate ionic material in preparing a scalp care composition, the scalp care composition and a preparation method.
Background
The surface layer of healthy hair is covered with a natural protective film consisting of a group of complete hair scales and naturally secreted grease, and the natural protective film is easily damaged by adverse factors such as excessive washing, sunlight solarization, and increasingly popular perm and hair dyeing, so that the water of the skin layer is lost, the hair is dried up, the elasticity and the softness of the hair are lost, and various scalp problems are caused by bacterial and fungal infections.
In the prior art, zinc pyrithione, piroctone olamine salt, climbazole, hydroxyphenylpropionamide benzoic acid and the like are mostly adopted as anti-dandruff components in the shampoo, but the effects are not ideal.
Therefore, the invention is especially provided.
Disclosure of Invention
The invention aims to provide an application of a silver folate ion material in preparing a scalp care composition, the scalp care composition and a preparation method, and the scalp care composition has good dandruff removing, itching relieving, anti-aging, nourishing and repairing effects.
In order to solve the above problems, embodiments of the present invention provide an application of a silver folate ionic material in preparing a scalp care composition.
Optionally, the application includes:
dissolving folic acid in water or an aqueous material to obtain a first component;
dissolving silver ions in water or an aqueous material to obtain a second component;
mixing the first component and the second component to obtain the She Suanyin ionic material;
preparing the scalp care composition using the She Suanyin ionic material as an active ingredient.
Embodiments of the present invention also provide a scalp care composition comprising:
she Suanyin ionic material as an antidandruff component;
an auxiliary material;
and (3) water.
Optionally, in the scalp care composition, the weight part of She Suanyin ionic material is 1-10 parts.
Optionally, the scalp care composition comprises, in parts by mass:
she Suanyin ion material 1-5 parts;
the auxiliary materials comprise:
15-25 parts of a main surfactant;
auxiliary active agent 2-5 parts;
2-6 parts of a conditioner;
0.1-1 part of rheological control agent;
1-4 parts of a humectant;
0.1-0.5 part of pH regulator;
0.5-2 parts of a chelating agent;
essence capable of adjusting the amount of fragrance;
an appropriate amount of water.
Optionally, the She Suanyin ionic material is prepared by the following steps:
dissolving folic acid in water or an aqueous material to obtain a first component;
dissolving silver ions in water or an aqueous material to obtain a second component;
mixing the first component and the second component to obtain the She Suanyin ionic material.
The embodiment of the invention also provides a preparation method of the scalp care composition, which comprises the following steps:
preparing She Suanyin ionic material, wherein the preparation of She Suanyin ionic material comprises the following steps:
dissolving folic acid in water or an aqueous material to obtain a first component;
dissolving silver ions in water or an aqueous material to obtain a second component;
mixing the first component and the second component to obtain the She Suanyin ionic material;
mixing the She Suanyin ionic material as an anti-dandruff component with an auxiliary material and water to obtain the scalp care composition.
Optionally, the She Suanyin ionic material is used as an anti-dandruff ingredient to be mixed with an auxiliary material and water to obtain the scalp care composition, and the scalp care composition comprises:
weighing the raw materials in proportion;
heating to 80-85 ℃ under the stirring of deionized water, adding guar gum hydroxypropyl trimethyl ammonium chloride, keeping the temperature to be completely dissolved, uniformly mixing, adding a main surfactant, uniformly stirring, and keeping the temperature to obtain a first mixture;
adding an auxiliary surfactant into the first mixture, cooling to 60-70 ℃ while stirring, and completely dissolving and uniformly mixing the added substances to obtain a second mixture;
adding She Suanyin ionic material as an anti-dandruff component into the second mixture, and completely dissolving and uniformly mixing the added substances to obtain a third mixture;
adding a pH regulator into the third mixture, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a fourth mixture;
adding the humectant, the conditioner and the thickener into the fourth mixture, and uniformly stirring until the humectant, the conditioner and the thickener are completely dissolved to obtain a fifth mixture;
and adding essence into the fifth mixture, and stirring to completely mix to obtain the scalp care composition.
The silver salt may be organic silver and/or inorganic silver. Organic silver such as silver acetate, silver EDTA, inorganic silver such as silver nitrate, silver sulfate, and the like.
When preparing the first component and the second component, the aqueous material can adopt an aqueous buffer solution, and the aqueous buffer solution is selected from one or more of acetic acid-sodium acetate, sodium bicarbonate-sodium carbonate, boric acid-borax, N- (2-hydroxyethyl) piperazine-N' -2-ethanesulfonic acid, 3-morpholine propanesulfonic acid, 2- (N-morpholine) ethanesulfonic acid, trimethylol methylamine-hydrochloric acid, trimethylol methylamine-boric acid and trimethylol methylamine-acetic acid.
The silver ion has good antibacterial effect, long-acting property and no drug resistance. Silver ions are often contained in the high-efficiency sterilization and antibiosis product, and the silver ions are easy to reduce to form black silver precipitates when contacting ultraviolet rays, so that the appearance is influenced, and the sterilization and antibiosis effects are further influenced.
Folic acid can help protein metabolism, relieve scalp tension, promote cell regeneration, make scalp healthier, and has effects of relieving inflammation, keeping moisture, repairing hair quality, nourishing hair, and maintaining hair and scalp health.
The invention adopts the technical scheme that the two materials are perfectly combined together in a monodispersed form. Due to the reducibility of folic acid, silver ions can be effectively protected, and the silver ions are prevented from being precipitated. Meanwhile, the solubility of folic acid is increased, so that folic acid can be more effectively absorbed by cells, she Suanyin ionic water-based materials are used as anti-dandruff agents to replace the anti-dandruff agents and preservatives in the original formula of shampoo and hair conditioner, and the prepared shampoo and hair conditioner have the effects of removing dandruff, relieving itching, resisting aging, nourishing and repairing.
Drawings
FIG. 1 is a schematic diagram of the chemical structure of folic acid after coordination with silver ions;
fig. 2 is a graph showing the effect of a first case of using a scalp care composition provided by an embodiment of the present invention;
fig. 3 is a graph showing the effect of a second example of using a scalp care composition provided by an embodiment of the present invention;
fig. 4 is a graph showing the effect of a third case using a scalp care composition provided by an embodiment of the present invention;
fig. 5 is a graph showing the effect of a fourth case using a scalp care composition provided by an embodiment of the present invention;
FIG. 6 is a graph of an evaluation of product texture using a scalp care composition provided by an embodiment of the present invention;
FIG. 7 is a statistical chart of a subject's scalp problem self-assessment provided using an embodiment of the present invention;
fig. 8 is a graph showing evaluation of the treatment effect of a subject using the scalp care composition provided by the present example;
FIG. 9 shows the results of a sterilization test using a She Suanyin stock solution of ionic material according to an embodiment of the present invention.
Detailed Description
The principles and spirit of the present invention will be described with reference to a number of exemplary embodiments shown in the drawings. It should be understood that these embodiments are described only to enable those skilled in the art to better understand and to implement the present invention, and are not intended to limit the scope of the present invention in any way.
The embodiment of the invention provides a preparation method of a scalp care composition, which comprises the steps of preparing stock solution as an effective anti-dandruff ingredient and mixing the stock solution and auxiliary materials to obtain the scalp care composition.
The step of preparing the stock solution can be divided into a step of preparing She Suanshui solution as the first component, a step of preparing silver ion water solution as the second component, and a step of mixing the first component and the second component.
In one embodiment, the first component is prepared by first taking folic acid solids and then adding the folic acid solids to water or an aqueous buffer solution to prepare She Suanshui solution, which yields a first component She Suanzhi in an amount of 1-2%. The buffer may be selected from one or more of acetic acid-sodium acetate, sodium bicarbonate-sodium carbonate, boric acid-borax, N- (2-hydroxyethyl) piperazine-N' -2-ethanesulfonic acid, 3-morpholinopropanesulfonic acid, 2- (N-morpholino) ethanesulfonic acid, trimethylolmethylamine-hydrochloric acid, trimethylolmethylamine-boric acid, trimethylolmethylamine-acetic acid.
In one embodiment, when preparing the second component, the raw material for providing silver ions, such as organic silver like silver acetate, silver EDTA and the like, or silver nitrate, silver sulfate and the like, is dissolved in water to obtain the second component, wherein the mass percentage of the silver ions is 0.1-1%.
And finally, uniformly mixing the first component and the second component (for example, slowly adding the first component into the second component), and standing to obtain She Suanyin ionic material, namely the stock solution. The mol ratio of folic acid to silver ion in the stock solution is 11:1.5-1:2, folic acid is coordinated and connected with silver ions to form a structural formula shown in figure 1.
The stock solution can be mixed with adjuvants and water to obtain scalp care composition. In one embodiment, the following ratios may be used:
examples and comparative examples
Wherein:
in the stock solutions of examples 1-3, the mass percentage of silver ions was 0.3%, the mass percentage of She Suanzhi was 0.6%, and the balance was 0.1M buffer solution (sodium bicarbonate-sodium carbonate).
The preparation method comprises the following steps:
(1) Weighing the raw materials in proportion (see the above examples 1-3 and comparative examples 1-2);
(2) Stirring deionized water, heating to 80-85 ℃, adding guar gum hydroxypropyl trimethyl ammonium chloride, keeping the temperature until the guar gum hydroxypropyl trimethyl ammonium chloride is completely dissolved and uniformly mixed, adding a surfactant, uniformly stirring, and keeping the temperature at 80 ℃ for 30 minutes to obtain a mixture I;
(3) Adding an auxiliary surfactant into the first mixture, cooling to 60-70 ℃ while stirring, and completely dissolving and uniformly mixing the added substances to obtain a second mixture;
(4) Adding the anti-dandruff agent into the mixture II until the added substances are completely dissolved and uniformly mixed to obtain a mixture III;
(5) Adding a pH regulator into the mixture III, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a mixture IV;
(6) Adding panthenol, a hair care conditioner and a thickening agent into the mixture IV, and uniformly stirring until the panthenol, the hair care conditioner and the thickening agent are completely dissolved to obtain a mixture V;
(7) And adding essence into the mixture five, and stirring until the essence is completely mixed to obtain the anti-dandruff shampoo.
Effect test 1:
the test method comprises the following steps: 4 men and women in the middle and young ages of 20-40 are selected, and the problems of much oil, dandruff, dry hair and the like are observed by eyes. Product example 1 was used 3 times a week (once every 2 days), and VISIA was used to observe the maintenance effect on the scalp before and one week after use, and questionnaires were used to investigate the effect of the subjects on the product. The application method comprises washing hair, pouring the product into scalp hair follicle root, massaging for about 10min, standing for about 10min, cleaning, and normally caring hair. Wherein, in order to obtain more accurate results, the number of days without washing hair before the VISIA test is firstly received is consistent with the number of days without washing hair after the product is used.
With reference to fig. 2-5, the results of the tests show that:
a) Except from the 4 th case, the remaining 3 cases showed a decrease in oil secretion.
b) A small reduction in dandruff was observed.
c) In case 1, the improvement of the whiteness of the scalp was clearly observed.
Questionnaires:
a) The texture, color and smell of the product can be evaluated in terms of auxiliary massage, and the general evaluation and the evaluation of the above accounts for 100 percent, and the satisfactory evaluation and the evaluation of the above are respectively 50 percent, 75 percent and 25 percent. The values are shown in FIG. 6.
b) Self scalp problems assessed the dandruff problem was at most (4.5, followed by scalp itching (3.75), dry hair (3.5), scalp laxity (2.5). The full scale score was divided into 5 points and the numerical line graph is shown in figure 7.
c) The treatment effect is evaluated, namely the dandruff problem is improved to the greatest extent (3.75), and then scalp pruritus (3), dry hair (3), excessive grease secretion (2.5) and scalp looseness (2.25) are carried out. The scale score was scored to be 5 points and the numerical broken line is shown in figure 8.
From the above results, it can be seen that the scalp care composition provided by the embodiment of the present invention has good oil control and alleviates the problem of dandruff, can improve dry hair and itching of the scalp, and does not cause skin staining.
Effect test 2:
the stock solution described in She Suanyin aqueous materials examples 1-3 was tested for malassezia furfur kill by:
test strains: malassezia furfur (ATCC 44344) supplied by Ji Taiyi Corsai, shanghai, was cultured for the 3 rd passage.
Culture medium: pityrosporum media/20220718
The instrument equipment comprises: electric heating constant temperature incubator LRH-250F (WPE-RH 0253), biological safety cabinet BSC-1604IIA2 (WPE-RH 0310), water bath DC0510 (WPE-RH 0327)
The inspection basis is as follows: QB/T2738-2012 evaluation method for antibacterial and bacteriostatic effects of daily chemical products 7.3
Detecting the environment: temperature: 24 ℃, humidity: 48% RH
The bacteriostatic effect is as follows: the test substance acts for 1min, 3min and 10min, and the test is repeated for 3 times.
As shown in FIG. 9, it is clear that the inhibition rate of malassezia furfur is greater than or equal to 90%, and the product has strong inhibition effect.
The inventive concept is explained in detail herein using specific examples, which are only provided to help understanding the core idea of the present invention. It should be understood that any obvious modifications, equivalents and other improvements made by those skilled in the art without departing from the spirit of the present invention are included in the scope of the present invention.
Claims (8)
1. Use of She Suanyin ionic material in the preparation of a scalp care composition.
2. The use according to claim 1, comprising:
dissolving folic acid in water or water-based material, and controlling pH at 8-9 to obtain a first component with folic acid content of 0.01-1%;
dissolving silver salt in water or water-based material to obtain a second component, wherein the content of silver ions is 0.01-1%;
mixing the first component and the second component to obtain the She Suanyin ionic material, preferably with a folic acid to silver ion molar ratio of 1:1.5-1:2, the preferred concentration of silver ions is 0.1% -0.3%;
preparing the scalp care composition using the She Suanyin ionic material as an active ingredient.
3. A scalp care composition characterized by comprising:
she Suanyin ionic material as a scalp care ingredient;
an auxiliary material;
and (3) water.
4. A scalp care composition according to claim 3 wherein the scalp care composition has a mass fraction of She Suanyin ionic material of 1 to 10 parts.
5. The scalp care composition according to claim 4, comprising, in parts by mass:
she Suanyin ion material 1-5 parts;
the auxiliary materials comprise:
15-25 parts of a main surfactant;
auxiliary active agent 2-5 parts;
2-6 parts of a conditioner;
0.1-1 part of rheology modifier;
1-4 parts of a humectant;
0.1-0.5 part of pH regulator;
0.5-2 parts of a chelating agent;
essence capable of adjusting the amount of fragrance;
an appropriate amount of water.
6. A scalp care composition according to any of claims 3-5 characterized in that the She Suanyin ionic material is prepared by the steps of:
dissolving folic acid in water or an aqueous material to obtain a first component;
dissolving silver ions in water or an aqueous material to obtain a second component;
mixing the first component and the second component to obtain the She Suanyin ionic material.
7. A method of preparing a scalp care composition comprising:
preparing She Suanyin ionic material, wherein the preparation of She Suanyin ionic material comprises the following steps:
dissolving folic acid in water or an aqueous material to obtain a first component;
dissolving silver ions in water or an aqueous material to obtain a second component;
mixing the first component and the second component to obtain the She Suanyin ionic material;
mixing the She Suanyin ionic material as an anti-dandruff component with an auxiliary material and water to obtain the scalp care composition.
8. A method of preparing a scalp care composition according to claim 7 wherein said mixing of said She Suanyin ionic material as an anti-dandruff ingredient with an adjuvant, water, to provide said scalp care composition comprises:
weighing the raw materials in proportion;
heating to 80-85 ℃ under the stirring of deionized water, adding guar gum hydroxypropyl trimethyl ammonium chloride, keeping the temperature to be completely dissolved, uniformly mixing, adding a main surfactant, uniformly stirring, and keeping the temperature to obtain a first mixture;
adding an auxiliary surfactant into the first mixture, cooling to 60-70 ℃ while stirring, and completely dissolving and uniformly mixing the added substances to obtain a second mixture;
adding She Suanyin ionic material as an anti-dandruff component into the second mixture, and completely dissolving and uniformly mixing the added substances to obtain a third mixture;
adding a pH regulator into the third mixture, regulating the pH value to 6.0-6.5, and cooling to 40-50 ℃ to obtain a fourth mixture;
adding the humectant, the conditioner and the thickener into the fourth mixture, and uniformly stirring until the humectant, the conditioner and the thickener are completely dissolved to obtain a fifth mixture;
and adding essence into the fifth mixture, and stirring to completely mix to obtain the scalp care composition.
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Inventor after: Wu Wenfeng Inventor after: Shen Dongdong Inventor after: Xu Dachuang Inventor after: Dai Jun Inventor after: Gu Kuiqing Inventor before: Shen Dongdong Inventor before: Xu Dachuang Inventor before: Wu Wenfeng Inventor before: Dai Jun Inventor before: Gu Kuiqing |