CN1562079A - Broad spectrum bacteriostat and sterilizing of silver ion nano porous material - Google Patents
Broad spectrum bacteriostat and sterilizing of silver ion nano porous material Download PDFInfo
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Abstract
A broad-spectrum antibacterial Ag ion-nanoporous material for killing more than 11 bacteria including ringworm, fungus, candida, blue mold, etc is prepared from Ag ions and the nanoporous material chosen from A-type zeolite molecular sieve, X-type zeolite molecular sieve, mordenite molecular sieve, etc.
Description
Technical field
The invention belongs to the application of silver ion mano-porous material aspect antibacterial and sterilization, be specifically related to a kind of application of silver ion mano-porous material broad-spectrum antibacterial, sterilization and the antibiosis by mano-porous material and silver atoms, silver ion preparation.
Background technology
Antibacterial and virus are accompanied by development of human society all the time, but in a single day they morph and infect the mankind, will greatly influence human normal economic life order and health, as: Diplococcus gonorrhoeae (Neisseriagonorrhoeae), vibrio cholera (Vibrio cholerae), tubercule bacillus (Mycobacteriumtuberculosis), hepatitis B virus (HBV), HIV (human immunodeficiency virus) (HIV), SARS virus etc.Now confirm, helicobacter pylori (Helicobacter pylori) and peptic ulcer and gastric cancer pathogenic has substantial connection, HIV causes acquired immune deficiency syndrome (AIDS) (AIDS), cause entirely collapsing of body immune system, rate of propagation is fast, the mortality rate height does not still have satisfied treatment measure so far.Antibacterial and virus are all-pervasive, and especially volume has only the SARS virus of 50 nanometers, and human health is caused great harm.Therefore in the modern life, how all kinds of sources of infection are isolated, blocked to clean air, and human living and living environment are kept clean; How to handle patient especially highly infective, highly pathogenic patient's Excreta, stop virus and germ contamination air and, all be urgent problem to outside environmental dissemination.Concrete degerming virus killing as hospital air, waste liquid, the filtration of various antibacterials and virus in the ward air, the public environment sterilization, safe and sanitary or the like all is current extremely urgent significant problem at home.
Chinese patent ZL01112503.9: " mano-porous material ion exchange desalinizes seawater, salt water, misery " discloses a kind of silver ion mano-porous material of nano-silver ionic high degree of dispersion in mano-porous material of being made up of less than the silver atoms and the silver ion of 10 nanometers particle diameter, this material is by solion switching method preparation, have nontoxic, tasteless, do not have and smell and characteristics such as environmental friendliness.This patent also disclose simultaneously this silver ion mano-porous material be used to desalinize seawater, application aspect the misery, salt water.
Summary of the invention
The object of the invention provides Chinese patent ZL01112503.9: " mano-porous material ion exchange desalinizes seawater, salt water, misery " a kind of new broad-spectrum antibacterial of disclosed silver ion mano-porous material, the application of sterilization aspect.
As everyone knows, antibacterial and virus mainly are made up of protein, and antibacterial and virus mainly cause pathological changes by duplicating of DNA after invading organism.Nano level silver atoms and silver ion can form stable complex with the main matter protein of forming DNA, peptide, aminoacid, (oxygen atom COO-) combines by electrostatic interaction and coordinate bond with metal carboxyl, amido (NH during as aminoacid and silver ion coordination
2) in nitrogen-atoms provide the formation of lone pair electrons and metal to join key.Nano level in addition silver atoms and silver ion also can with hydroxyl (OH), sulfydryl (SH), thioether group (C-S-C-) form coordination, thus inhibition, killing bacteria and virus.
The silver ion mano-porous material is to be made by the solion switching method by mano-porous material and silver nitrate: get mano-porous material, add and fill in the reaction vessel of distilled water, add silver nitrate under stirring, lucifuge condition, the reactant mixture mass ratio is: mano-porous material: water: silver nitrate=1: 3～20: 0.05～0.5; In room temperature to 95 ℃ interval, constant temperature stirred 3～12 hours down then, and reaction finishes after-filtration, repeat above process, end product is at 35～170 ℃, generally at 80～100 ℃ of interval inner dryings, obtain the mano-porous material of Ag ion exchange, i.e. the silver ion mano-porous material.
Concrete preparation example is: get natural A type zeolite molecular sieve 2000g, add and fill in the reaction vessel of 10 liters of distilled water, stirring, lucifuge condition under add the 360g silver nitrate, be warming up to 85 ℃ then, constant temperature stirred 8 hours down, and reaction finishes after-filtration, repeat above process, end product gets natural silver ion mano-porous material, i.e. natural A g-A mano-porous material 100 ℃ of dryings.
Mano-porous material comprises: natural A type zeolite molecular sieve, natural X type zeolite molecular sieve, natural clinoptilolite molecular sieve, natural mordenite molecular sieve and synthetic Si-Al zeolite molecular sieve, as A type zeolite molecular sieve, X type zeolite molecular sieve, y-type zeolite molecular sieve, ZSM-5 type zeolite molecular sieve, with sial mesopore molecular sieve (mesoporous molecular sieves), as MCM-41 type sial mesopore molecular sieve, MCM-48 type sial mesopore molecular sieve, SBA-15 type sial mesopore molecular sieve.
This silver ion mano-porous material is white or gray solid powder, heat stability is fine, wherein the nanometer silver of being made up of silver atoms and silver ion (ultra micron silver) mass content is 5～37%, mano-porous material can be made the solid phase material of liquid phase or various sizes, shape according to the needs of practical application, have convenience, safety, zero pollution, recyclable, advantages such as unlimited repeated use.
Through evidence, this silver ion mano-porous material has the antibacterial and bactericidal action of broad-spectrum, and common various antibacterials are had very strong inhibition growth and the effect of killing.
Employed silver ion mano-porous material is a natural A g-A mano-porous material in the following examining report, is the field gray powder, and wherein the silver amount content of ultra micron is 22%.
Examining report one:
Measure the effect (measuring MIC and MBC) of the external anti-dermatophytosis of silicate angstrom Ag ion nano pore composite material (containing ultra micron silver).
Material and method:
1, detects bacterial strain: common 3 reference cultures that belong to 4 kinds of dermatophytosises that provide by China Committee for Culture Collection of Microorganisms medical mycology center, it is respectively trichophyton (Trichophyton): trichophyton (T.rubrum, bacterium number: CCCCM ID T.
1a), alpha fungus (T.mentagrophytes, bacterium number: CCCCM ID T.
5c); Microsporon (Microsporum): Sabouraudites lanosus (M.canis, bacterium number: CCCCM ID M.
3d); Epidermophyton (Epidermophyton): acrothesium floccosum (Epidermophyton floccosum, bacterium number: CCCCM ID E.
1c).
2, used culture medium: fungus is a basal medium not contain any antibiotic husky fort agar.
3, detection method: fungus, agar dilution (test tube method)
Accurately take by weighing silver ion mano-porous material 1.0g, add sterile purified water 20mL, 10mL silver ion mano-porous material suspension is drawn in ultrasonic concussion 30 minutes, adds the 10mL distilled water again, makes doubling dilution more successively, counts 11 gradient concentrations;
Under the ultrasonic concussion state, draw the medicinal liquid of each gradient of 8mL, join and be incubated in 65 ℃ husky fort agar the packing of ultrasonic again concussion mixing, every pipe 3mL after 72mL sterilizes.The actual concentration that contains ultra micron silver is respectively in the final messenger drug base;
(1)1.1mg/mL (2)0.55mg/mL (3)0.28mg/mL (4)0.14mg/mL
(5)0.07mg/mL (6)0.035mg/mL (7)0.018mg/mL (8)0.009mg/mL
(9)0.0045mg/mL (10)0.0023mg/mL (11)0.0012mg/mL
(12) basal medium matched group
Inoculation bacterium amount: 1.0～0.1 * 10
6Cfu/mL
Condition of culture: 26 ℃, 7d.
Determination methods as a result:
1, minimum inhibitory concentration (MIC): with the basal medium control tube is reference, and bacterium has been grown to the no bacteriostasis of "+" expression; Bacterium is not grown to "-" expression, and the concentration of the lowest concentration of drug pipe that bacteriostasis, bacterium do not grow is arranged is minimum inhibitory concentration (MIC), represents with mg/mL.
2, minimum bactericidal concentration (MBC): the bacterium of each pipe inoculation that will 7d does not grow on pharmaceutical culture medium, subcultivation does not contain on any antibiotic basal medium to fresh, and " Δ " expression only has bacteriostasis, and bacterium still is growth, "-" expression has bactericidal action, and bacterium does not grow; The concentration of the lowest concentration of drug pipe that bacterium grows not yet is minimum bactericidal concentration (MBC), represents with mg/mL.
Experimental result sees Table 1:
Table 1: natural A g-A type mano-porous material external anti-common 3 belongs to the result of the test (test tube method) of 4 kinds of dermatophytosises
Culture medium ultra micron silver concentration (mg/mL) MIC MBC
The bacterium name is right
1 2 3 4 5 6 7 8 9 10 11 (mg/mL)
According to
Trichophyton------Δ+++++0.018 0.035
Alpha fungus-----Δ++++++ 0.035 0.07
Sabouraudites lanosus----Δ Δ++++++ 0.035 0.14
Acrothesium floccosum------Δ+++++0.018 0.035
Conclusion:
Experimental result shows: Ag-A type mano-porous material has stronger antibacterial action to common 4 kinds of dermatosis tinea bacterium of 3 genus, and its MIC scope is at 0.018～0.035mg/mL, and the MBC scope is between 0.035～0.14mg/mL.
Examining report two:
Measure the external antifungal effect of silver ion mano-porous material (measuring MIC and MBC).
Material and method:
1, detects bacterial strain: common 7 reference cultures that belong to 12 kinds of pathomycetes and common conditioned pathogen that provide by China Committee for Culture Collection of Microorganisms medical mycology center, it is respectively Candida (Candida): Bai Nianse pearl bacterium (C..albicans, bacterium number: CCCCM ID C.
1a), Oidium tropicale (C..tropicalis, bacterium number: CCCCM ID C.
2b), Candida glabrata (C..glabrata, bacterium number: CCCCM ID Y.
10); Saccharomycodes (Saccharomyces): Rhodothece glutinis (Rhodotorula, bacterium number: CCCCM ID Y.
1), saccharomyces cerevisiae (Saccharomyces cerevisiae, bacterium number: CCCCM ID Y.
8); Penicillium (Penicillium): Aspergillus citrimum (Penicillium citrinum, bacterium number: CCCCM ID B.
7); Aspergillus (Aspergillus): fumigation color aspergillosis (A.fumigatus, bacterium number: CCCCM ID A.
1), aspergillus niger (A.niger, bacterium number: CCCCM ID A.
3), Aspergillus restrictus (A.restrictus, bacterium number: CCCCM IDA.
23); Alternaria (Altemaria): mutually every chain lattice spore (Altemaria altemata, bacterium number: CCCCMID B.
1); Fusarium (Fusarium): beading reaping hook is mould (to claim Fusarium moniliforme Fusariummonillforme again, bacterium number: CCCCM ID B.
36); The mould genus of broom (Scopulariopsis): scopulariopsis brevicaulis (Scopulariopsis brevicalus, bacterium number: CCCCM ID B.
4);
2, used culture medium: fungus: not contain any antibiotic husky fort agar is basal medium.
3, detection method: fungus: agar dilution (test tube method)
Accurately take by weighing silicate angstrom Ag ion nano pore composite material 1.0g, add sterile purified water 20mL, 10mL silicate angstrom Ag ion nano pore composite material suspension was drawn in ultrasonic concussion in 30 minutes, added the 10mL distilled water again, make doubling dilution more successively, count 11 gradient concentrations;
Under the ultrasonic concussion state, draw the medicinal liquid of each gradient of 8mL, join and be incubated in 65 ℃ husky fort agar the packing of ultrasonic again concussion mixing, every pipe 3mL after 72mL sterilizes.The actual concentration that contains ultra micron silver is respectively in the final messenger drug base:
(1)1.1mg/mL (2)0.55mg/mL (3)0.28mg/mL (4)0.14mg/mL
(5)0.07mg/mL (6)0.035mg/mL (7)0.018mg/mL (8)0.009mg/mL
(9)0.0045mg/mL (10)0.0023mg/mL (11)0.0012mg/mL
(12) basal medium contrast
Inoculation bacterium amount: 1.0～0.1 * 10
6Cfu/mL
Condition of culture: fungus: 30 ℃ in candidiasis, yeast, 48h; 26 ℃ of other filamentous fungis, 7d.
Determination methods as a result:
1, minimum inhibitory concentration (MIC): with the basal medium control tube is reference, and bacterium has been grown to the no bacteriostasis of "+" expression; Bacterium is not grown to "-" expression, and the concentration of the lowest concentration of drug pipe that bacteriostasis, bacterium do not grow is arranged is minimum inhibitory concentration (MIC), represents with mg/mL.
2, minimum bactericidal concentration (MBC): the bacterium of each pipe inoculation that will 7d does not grow on pharmaceutical culture medium, subcultivation does not contain on any antibiotic basal medium to fresh, and " Δ " expression only has bacteriostasis, and bacterium still is growth, "-" expression has bactericidal action, and bacterium does not grow; The concentration of the lowest concentration of drug pipe that bacterium grows not yet is minimum bactericidal concentration (MBC), represents with mg/mL.
Experimental result sees Table 2:
Table 2:Ag-A type mano-porous material external anti-common 7 belongs to 12 kinds of mycologic test results (test tube method)
Culture medium ultra micron silver concentration (mg/mL) MIC MBC
The bacterium name
Right
1 2 3 4 5 6 7 8 9 10 11
(mg/mL)
According to
Candida albicans-------Δ Δ+++0.0045 0.018
Oidium tropicale--------Δ Δ++ 0.0023 0.009
Candida glabrata---------Δ++ 0.0015 0.009
Rhodothece glutinis---------Δ++ 0.0015 0.009
Saccharomyces cerevisiae--------Δ+++0.0023 0.009
Aspergillus citrimum---Δ Δ+++++++0.07 0.28
Fumigation color aspergillosis-----Δ Δ+++++0.018 0.07
Aspergillus niger---Δ Δ+++++++0.07 0.28
Aspergillus restrictus---Δ Δ++++++ 0.035 0.14
Mutually every chain lattice spore------Δ+++++0.018 0.035
Beading reaping hook is mould-----Δ Δ+++++0.018 0.07
Scopulariopsis brevicaulis-----Δ Δ+++++0.018 0.07
Conclusion:
Experimental result shows, Ag-A type mano-porous material has stronger antibacterial action to common 12 kinds of funguses of 7 genus, its MIC scope is at 0.0015～0.07mg/mL, the MBC scope is between 0.009～0.28mg/mL, especially strong to Candida, Rhodothece glutinis, saccharomyces cerevisiae antibacterial action, MIC scope: 0.0015～0.0045mg/mL, MBC scope: 0.009～0.018mg/mL.
Examining report three:
Measure the external antifungal effect of silver ion mano-porous material (measuring MIC and MBC).
Material and method:
1, detect bacterial strain: Malassezia (Malassezia): the type strain of Malassezia furfur (Malassezia furfur), sympodium chlosma (Malassezia sympodialis), spherical chlosma (Malassezia globosa) is by the special institute present of French Bath.Propionibacterium acnes 1 strain (Propionibacteriumacnes) is separated by the outpatient service acne patient of Inst. of Dermatology, Chinese Academy of Medical Sciences.
2, used culture medium: chlosma: not contain any antibiotic, the husky fort agar that contains 4% olive oil is basal medium; Propionibacterium acnes: not contain any antibiotic anaerobism meat soup is basal medium.
3, detection method: fungus: agar dilution (test tube method)
Propionibacterium acnes: liquid broth dilution method (test tube method)
Accurately take by weighing silicate angstrom Ag ion nano pore composite material 1.0g, add sterile purified water 20mL, the 10mL suspension is drawn in ultrasonic concussion 30 minutes, adds the 10mL distilled water again, makes doubling dilution more successively, counts 11 gradient concentrations;
Under the ultrasonic concussion state, the medicinal liquid of drawing each gradient of 8mL joins and is incubated in 65 ℃ husky fort agar the packing of ultrasonic again concussion mixing, every pipe 3mL after 72mL sterilizes.The actual concentration that contains ultra micron silver is respectively in the final messenger drug base:
(1)1.1mg/mL (2)0.55mg/mL (3)0.28mg/mL (4)0.14mg/mL
(5)0.07mg/mL (6)0.035mg/mL (7)0.018mg/mL (8)0.009mg/mL
(9)0.0045mg/mL (10)0.0023mg/mL (11)0.0012mg/mL
(12) basal medium contrast
Inoculation bacterium amount: 1.0～0.1 * 10
6Cfu/mL
Condition of culture: fungus: 30 ℃, 48～72h;
Propionibacterium acnes: 37 ℃, 48～72h.
Determination methods as a result:
1, low Mlc (MIC): with the basal medium control tube is reference, and bacterium has been grown to the no bacteriostasis of "+" expression; Bacterium is not grown to "-" expression, and the concentration of the lowest concentration of drug pipe that bacteriostasis, bacterium do not grow is arranged is minimum inhibitory concentration (MIC), represents with mg/mL.
2, minimum bactericidal concentration (MBC): the bacterium of each pipe inoculation that will 7d does not grow on pharmaceutical culture medium, subcultivation does not contain on any antibiotic basal medium to fresh, and " Δ " expression only has bacteriostasis, and bacterium still is growth, "-" expression has bactericidal action, and bacterium does not grow; The concentration of the lowest concentration of drug pipe that bacterium grows not yet is minimum bactericidal concentration (MBC), represents with mg/mL.
Experimental result sees Table 3:
External anti-common fungus of table 3:Ag-A type mano-porous material and propionibacterium result of the test (test tube method)
Culture medium ultra micron silver concentration (mg/mL) MIC MBC
The bacterium name
Right
1 2 3 4 5 6 7 8 9 10 11
(mg/mL)
According to
Malassezia furfur----Δ+++++++0.07 0.14
The sympodium chlosma---Δ++++++++ 0.14 0.28
Spherical chlosma----Δ+++++++0.07 0.14
Propionibacterium acnes---Δ++++++++ 0.14 0.28
Conclusion:
Experimental result shows: Ag-A type mano-porous material has stronger antibacterial action to 3 kinds of common chlosmas, its MIC scope is at 0.07～0.14mg/mL, the MBC scope is 0.14mg/mL to the MIC of propionibacterium acnes between 0.14～0.28mg/mL, and MBC is 0.28mg/mL.
Examining report four:
The bacteriostatic experiment of silver ion mano-porous material
Test strain:
Staphylococcus aureus ATCC6538 (Staphylococcus aureus), bacillus coli (Escherichia coli), bacillus pyocyaneus (Pseudomonas aeruginosa), cured sample bacillus (Bacilluscereus), bacillus subtilis ATCC6633 (Bacillus subtilis), staphylococcus epidermidis (Staphylococcus epidermidis), Candida albicans ATCC10231 (C..albicans), Aspergillus niger (A.niger), bacillus acidophilus (Lactobacillus acidophilus), streptococcus acidi lactici (Streptococcuslactis) and Neisseria gonorrhoeae (Neisseria gonorrhoeae).
Culture medium:
Bacillus acidophilus's culture medium: malt process 5Be ', yeast extract powder 0.5%, CaCO
30.6%, agar 2%.The streptococcus acidi lactici culture medium: beef leaches cream 0.5%, yeast extract powder 0.5%, and peptone 1%, glucose 1%, lactose 0.5%, NaCl 0.5%, agar 2%, pH6.8.The Neisseria gonorrhoeae culture medium: beef leaches cream 0.3%, peptone 1%, and NaCl 0.5%, agar 2%, defat Sanguis caprae seu ovis 8%～9%, pH7.2～7.4.All the other culture of strains bases all are nutrient broth medium and nutrient agar.
Experimental technique:
The outer minimum inhibitory concentration (MIC) of Neisseria gonorrhoeae alms bowl: adopt the solid doubling dilution to measure, test organisms liquid is for containing 10
9The liquid medium of individual cell/ml; Selecting the highest drug level is 256mg/L, and minimum mensuration concentration is 0.5mg/L; Drawing 10 μ l test organisms liquid with micro sample adding appliance is inoculated on the solid medium that contains the variable concentrations testing drug, cultivated 20 hours, observed result, the external Mlc of judgement testing drug (the inoculation position pairing lowest concentration of drug of culture of long bacterium is the MIC value).
The external minimum bactericidal concentration of Neisseria gonorrhoeae (MBC): the experimental result with external minimum inhibitory concentration MIC is that carry out on the basis.At first measure MIC in the test, the solid culture of general 〉=MIC drug level continues to cultivate 20 hours again, observed result, the external minimum bactericidal concentration of judgement testing drug (the inoculation position pairing lowest concentration of drug of culture of long bacterium is the MBC value).
The external minimum inhibitory concentration (MIC) of all the other strains: adopt the liquid doubling dilution to measure, test organisms liquid is for containing 10
9The liquid medium of individual cell/ml; Selecting the highest drug level is 256mg/L, and minimum mensuration concentration is 0.5mg/L; Contain at 1ml and to add 10 μ l test organisms liquid in the fluid medium of variable concentrations testing drug, cultivated observed result, the external Mlc (MIC) of judgement testing drug 20 hours.
The external minimum bactericidal concentration (MBC) of all the other strains: the experimental result with external minimum inhibitory concentration MIC is that carry out on the basis, at first measure MIC in the test, the liquid culture of general 〉=MIC drug level (0.1ml) is coated on the plate that contains agar culture medium again, cultivate the counting of the bacterium colony of surviving after 20 hours, judge MBC value (clump count is the MBC value less than the pairing lowest concentration of drug of 5 culture).
Experimental result sees Table 4, table 5:
Table 4:Ag-A type mano-porous material in-vitro antibacterial result of the test
Positive
Concentration (mg/L)
256 128 64 32 16 8421 0.5 contrasts
Staphylococcus aureus--
1.----
2.+++++
Bacillus coli------
1. 2.+++++
Bacillus pyocyaneus-----
1.-
2.+++++
Cured sample bacillus--
1.----
2.+++++
Bacillus subtilis--
1.---
2.++++++
Staphylococcus epidermidis----
1.--
2.+++++
Candida albicans-----
1.-
2.+++++
Aspergillus niger----
1.--
2.+++++
The bacillus acidophilus-----
1.---
2.+++
Streptococcus acidi lactici--
1.---
2.++++++
Neisseria gonorrhoeae-----
1.----
2.++
The long bacterium of+test pipe range bacterium-developmental tube is 2. minimum inhibitory concentration of minimum bactericidal concentration 1..
Remarks: above result of the test is the flat value of three result of the tests.
Table 5: experiment conclusion
Pathogen numbering MIC (mg/L) MBC (mg/L)
Staphylococcus aureus ATCC6538 8 128
Bacillus coli 88
Bacillus pyocyaneus 8 16
Cured sample bacillus 8 128
Bacillus subtilis ATCC6633 16 128
Staphylococcus epidermidis 8 32
Candida albicans ATCC10231 8 16
Aspergillus niger 8 32
Bacillus acidophilus DM104 2 16
Streptococcus acidi lactici 16 128
Neisseria gonorrhoeae 1 16
This test shows that the Ag-A mano-porous material has certain killing action to 11 kinds of common bacterium, and the minimal inhibitory concentration scope is at 1～16mg/L, and the minimal bactericidal concentration scope is at 16～128mg/L.
By further tests showed that, by the described method of Chinese patent ZL01112503.9, adopt silicate silver ion mano-porous material (the natural A g-X mano-porous material of other type of different mano-porous material preparations, natural A g-mercerising mano-porous material, natural A g-tiltedly sends out mano-porous material, synthetic Ag-A mano-porous material, synthetic Ag-X mano-porous material, synthetic Ag-mercerising mano-porous material, the Ag-ZSM-5 mano-porous material, the Ag-MCM-41 mano-porous material, the Ag-MCM-48 mano-porous material, Ag-SBA-15 mano-porous material etc.) the same with Ag-A type silicate silver ion mano-porous material, have identical or close broad-spectrum sterilization, the effect of antibacterial and antibiotic (virus).
This silver ion mano-porous material can be scattered in various organic solvents, inorganic solvent and water, can be mixed with the antibacterial of various uses.Can select according to the difference of occupation modes such as aqueous, pasty state, spray, mousse agent, or suit to select according to the difference of usings method such as spraying, dipping, coating, wiping.When for example this antibacterial uses as spray, can be in the restaurant, public places such as hotel, school, station, cinema, hospital use, also can use in the family.
Because broad-spectrum sterilization and bacteriostasis antibiosis effect that this silver ion mano-porous material has, also can be widely used in industries such as food, medicine, health protection product, cosmetics, prepare various products, as packaging material, various vessel, skin care item, widely use and the various forms of pharmaceutical products accepted etc. now with sterilization, antibacterial and antibacterial action.Also can be used, also can be used with the composition more than 2 kinds with compositions such as the various compositions of normal application such as acidity regulator, stabilizing agent, surfactant, antioxidants.In addition, in order to strengthen bactericidal effect, also can and use with other antibacterial.
This silver ion mano-porous material can also with material mixes such as plastics, chemical fibre, resin, utilize existing processing technique and equipment, be prepared in have sterilization, construction material of antibacterial and antibacterial action, sanitary ware, decoration ornament materials etc., can be widely used in building field and field such as at home civilian even military, neither influence raw-material physical and chemical performance, do not influence the raw-material technology that adds again, and can expand raw-material range of application again.
Claims (10)
1, the broad-spectrum antibacterial of silver ion mano-porous material, germicidal applications.
2, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-dermatophytosis.
3, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-pathomycete.
4, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-Malassezia (Malassezia) antibacterial.
5, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-acne propionibacterium (Propionibacterium acnes).
6, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-staphylococcus aureus (Staphylococcus aureus), bacillus coli (Escherichia coli), bacillus pyocyaneus (Pseudomonas aeruginosa), cured sample bacillus (Bacillus cereus), bacillus subtilis (Bacillus subtilis), staphylococcus epidermidis (Staphylococcus epidermidis), Candida albicans (C..albicans), Aspergillus niger (A.niger), bacillus acidophilus (Lactobacillus acidophilus), streptococcus acidi lactici (Streptococcus lactis) and Neisseria gonorrhoeae (Neisseria gonorrhoeae).
7, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 2, germicidal applications is characterized in that:
Be used for anti-trichophyton (Trichophyton), Microsporon (Microsporum) or Epidermophyton antibacterial (Epidermophyton).
8, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 7, germicidal applications is characterized in that:
Be used for anti-trichophyton (T.rubrum), alpha fungus (T.mentagrophytes), Sabouraudites lanosus (M.canis) or acrothesium floccosum (Epidermophyton floccosum).
9, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 1, germicidal applications is characterized in that:
Be used for anti-candida and belong to (Candida) antibacterial, Saccharomycodes (Saccharomyces) antibacterial, Penicillium (Penicillium) antibacterial, aspergillus (Aspergillus) antibacterial, Alternaria (Altemaria) antibacterial, fusarium (Fusarium) antibacterial or the mould genus of broom (Scopulariopsis) antibacterial.
10, the broad-spectrum antibacterial of silver ion mano-porous material as claimed in claim 9, germicidal applications is characterized in that:
Be used for anti-Bai Nianse pearl bacterium (C..albicans), Oidium tropicale (C..tropicalis), Candida glabrata (C..glabrata), Rhodothece glutinis (Rhodotorula), saccharomyces cerevisiae (Saccharomycescerevisiae), Aspergillus citrimum (Penicillium citrinum), fumigation color aspergillosis (A.fumigatus), aspergillus niger (A.niger), Aspergillus restrictus (A.restrictus), mutually every chain lattice spore (Altemaria altemata), beading reaping hook mould (Fusarium monillforme) or scopulariopsis brevicaulis (Scopulariopsis brevicalus).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410010746 CN1562079A (en) | 2004-03-24 | 2004-03-24 | Broad spectrum bacteriostat and sterilizing of silver ion nano porous material |
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|---|---|---|---|
| CN 200410010746 CN1562079A (en) | 2004-03-24 | 2004-03-24 | Broad spectrum bacteriostat and sterilizing of silver ion nano porous material |
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| CN1562079A true CN1562079A (en) | 2005-01-12 |
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| CN 200410010746 Pending CN1562079A (en) | 2004-03-24 | 2004-03-24 | Broad spectrum bacteriostat and sterilizing of silver ion nano porous material |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499255A (en) * | 2011-09-26 | 2012-06-20 | 宋树芹 | Method for preparing novel silver ion molecular sieve as antiseptic |
| CN103435801B (en) * | 2013-07-19 | 2016-03-30 | 苏州纳埃净化科技有限公司 | A kind of silver chloride/porous fragrance frame composite material and preparation method thereof |
| CN109758474A (en) * | 2019-03-06 | 2019-05-17 | 大连民族大学 | A kind of Ag/ZIF-8 antibacterial agent and preparation method thereof |
| CN115414274A (en) * | 2022-09-29 | 2022-12-02 | 宁波博雅格致健康科技有限公司 | Application of She Suanyin ionic material in preparation of scalp care composition, scalp care composition and preparation method |
-
2004
- 2004-03-24 CN CN 200410010746 patent/CN1562079A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499255A (en) * | 2011-09-26 | 2012-06-20 | 宋树芹 | Method for preparing novel silver ion molecular sieve as antiseptic |
| CN103435801B (en) * | 2013-07-19 | 2016-03-30 | 苏州纳埃净化科技有限公司 | A kind of silver chloride/porous fragrance frame composite material and preparation method thereof |
| CN109758474A (en) * | 2019-03-06 | 2019-05-17 | 大连民族大学 | A kind of Ag/ZIF-8 antibacterial agent and preparation method thereof |
| CN115414274A (en) * | 2022-09-29 | 2022-12-02 | 宁波博雅格致健康科技有限公司 | Application of She Suanyin ionic material in preparation of scalp care composition, scalp care composition and preparation method |
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