CN115397387A - 身体清洁剂 - Google Patents
身体清洁剂 Download PDFInfo
- Publication number
- CN115397387A CN115397387A CN202180028720.7A CN202180028720A CN115397387A CN 115397387 A CN115397387 A CN 115397387A CN 202180028720 A CN202180028720 A CN 202180028720A CN 115397387 A CN115397387 A CN 115397387A
- Authority
- CN
- China
- Prior art keywords
- acid
- acyl
- body cleanser
- bacteria
- cleanser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
本发明为一种身体清洁剂,具有对与液状清洁剂的细菌污染相关的嗜碱性菌种的抗菌性,上述身体清洁剂包含液状组合物,上述液状组合物含有(A)阴离子性表面活性剂、0.10质量%以上的(B)螯合剂、以及水分,且制备成pH9.0以上。
Description
技术领域
本发明涉及一种在沐浴、洗脸等时用于身体清洁的身体清洁剂,更详细而言,涉及一种对嗜碱性菌种具有抗菌性的液状的身体清洁剂。
背景技术
通常,在对清洁剂、化妆品等制剂进行防腐设计的情况下,除了考虑制剂中通常包含的成分所具有的自身防腐性,也需要根据需要选定具有防腐效果的最佳成分,且配合适当的量。
特别是,洗发水、沐浴露等浴室、盥洗室等所使用的沐浴制品即身体清洁剂组合物由于是含有水分的液状,因此容易变质,近年来由于对环境的考虑,因此替换装等的需求也增加,由于使用时或重新灌装时受杂菌污染的机会也增加,因此对于洗手用液体清洁剂等,制剂上的防腐设计是必要的(非专利文献1)。
其中,认为碱性沐浴露由于通常所配合的成分自身的抗菌性而使自身防腐性强,另外,由于在碱性环境下生长的菌种少,因此碱性身体清洁剂中的防腐能力的设计基准尚不明确。
另外,由于还有嗜碱性的一部分革兰氏阴性杆菌所致的污染例,因此认为需要确保沐浴露等用于重新灌装的清洁剂中的对嗜碱性菌种的抗菌力。
例如,已知在市售的洗发水或护发素中,将以苯甲酸及其盐作为主体的酸型防腐剂、或异噻唑啉系防腐剂配合在清洁剂中,但这些防腐成分在碱性侧难以得到稳定的效果(非专利文献2)。
为了防止头皮或皮肤发痒,洗发水等清洁剂优选将pH调整在弱酸性一侧,例如,已知有一种在阴离子性表面活性剂中配合阳离子性表面活性剂等抗菌剂和螯合剂而成的清洁剂组合物(专利文献1)。
现有技术文献
专利文献
专利文献1:日本特开2001-131592号公报
非专利文献
非专利文献1:古田太郎,Fragrance Journal(Fragrance J.),1993年发行,9月号,p.59-64
非专利文献2:田中贤介,日本化妆品技术者会志,1997年发行,第31卷,第3号,p.245-253
发明内容
但是,如专利文献1所记载,添加螯合剂并配合阳离子性表面活性剂等并使抗菌剂的效力提高的清洁剂只是以头皮或身体的止痒、防臭、防头屑效果为目的而调整为弱酸性,并未设想与嗜碱性菌种所致的清洁剂的细菌污染相关的抗菌性作为技术课题。
上述嗜碱性菌种是在通常的细菌难以生长的pH9以上也可生长的细菌,例如,杆菌(Bacillus)属细菌是在接近中性的条件下也可生长的兼性嗜碱性微生物,另外,盐单胞菌(Halomonas)属细菌为仅可在pH9以上的条件下生长的绝对嗜碱性微生物,对于这些嗜碱性微生物的抗菌性充分的身体清洁剂的见解至今尚未得到。
因此,本发明的课题在于创造一种对嗜碱性菌种充分具有抗菌性,且具有对与液状清洁剂的细菌污染相关的嗜碱性菌种的抗菌性,并且防腐效果优异的液状的身体清洁剂,特别是制成一种在使用时和重新灌装时可防止嗜碱性菌种的二次污染的液状的身体清洁剂。
本申请发明人等基于阴离子性表面活性剂在pH为9.0以上的碱性侧防腐效果较弱、特别是几乎没有对嗜碱性菌种的抗菌力的方面不断进行深入研究,结果发现,通过配合规定量的螯合剂,从而在碱性侧也可使抗菌力提高,特别是可改善对嗜碱性菌种的抗菌力,另外,如果并用防腐效果剂,则抗菌力进一步提高,可以解决上述课题。
即,本发明为了解决上述课题,制成一种包含液状组合物的身体清洁剂,上述液状组合物含有(A)阴离子性表面活性剂和0.10质量%以上的(B)螯合剂,且制备成pH9.0以上。
上述包含液状组合物的本发明的身体清洁剂通过包含对皮肤等的清洁力优异的(A)阴离子性表面活性剂,且制备成pH9.0以上,从而可使(B)螯合剂更有效地发挥对嗜碱性菌种的抗菌作用。嗜碱性菌种由于具备在强碱性条件也不会改性的蛋白质、生物膜脂质而具备化学渗透压形成能力,因此在碱性条件下,螯合剂的金属封锁作用可容易地到达细胞膜内。
根据后述实施例的结果也可以认为,身体清洁剂所含的0.10质量%以上的螯合剂与嗜碱性菌种的细胞壁等所含的金属离子形成络合离子,以高添加效率起到金属封锁作用,可使上述菌种的栖息、增殖所需的酶的生成得到抑制,发挥优异的抗菌作用。
另外,上述液状组合物除上述螯合剂以外,还含有(C)防腐效果剂作为添加成分,由此,即便在包含嗜碱性菌种的更广泛的菌种或使用条件下,也可提高身体清洁剂的抗菌性、防腐性。
上述(A)阴离子性表面活性剂如果采用优选选自高级脂肪酸、N-酰基谷氨酸、N-酰基甘氨酸、N-酰基肌氨酸、N-酰基-β-丙氨酸、N-酰基-N-甲基-β-丙氨酸、N-酰基天冬氨酸、N-酰基-N-甲基牛磺酸、烷基硫酸、聚氧乙烯烷基硫酸、α-烯烃磺酸、烷基磷酸或这些的中和盐中的至少1种或2种以上,则可以得到发挥上述作用效果的品质稳定的身体清洁剂。
另外,为了能够稳定地发挥对嗜碱性菌种的金属封锁作用所得到的抗菌性,上述(B)螯合剂优选选自乙二胺四乙酸、二亚乙基三胺五乙酸、或这些的盐中的至少1种或2种以上。
进而,另外,为了提高身体清洁剂的抗菌性和防腐性,作为上述(C)防腐效果剂,优选采用选自苯氧基乙醇、乙基己基甘油、辛酸甘油酯、己基甘油、环己基甘油、丁基氨基甲酸碘代丙炔酯、氧化银中的至少1种或2种以上。
而且,上述液状组合物可以根据需要含有添加成分,例如也可以含有选自(D)两性表面活性剂、(E)非离子性表面活性剂和(F)纤维素系增粘剂中的1种以上。
本发明制成一种包含液状组合物的身体清洁剂,该液状组合物含有阴离子性表面活性剂和规定量的螯合剂,且制备成pH9.0以上,因此,其成为一种有效地使嗜碱性菌种受到螯合剂的作用而充分具有抗菌性,且防腐效果优异的身体清洁剂。另外,还存在如下优点:以在身体清洁剂的使用时和重新灌装时的使用环境下能够耐受二次污染的方式,实现其作为制剂的防腐设计。
具体实施方式
本发明的实施方式的身体清洁剂是一种液状组合物,其含有阴离子性表面活性剂、规定量的螯合剂和水分且调整各成分量而使得pH9.0以上。
pH的调整可依据常规方法进行,例如可添加如氢氧化钾的碱剂而调整至pH9.0以上。
作为上述(A)阴离子性表面活性剂的具体例,可例示如下,但也可根据所需的清洁力而采用除这些以外的阴离子性表面活性剂。
例如可举出选自辛酸、癸酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、油酸、亚油酸、山萮酸、椰油脂肪酸、棕榈仁油脂肪酸等高级脂肪酸;或N-月桂酰谷氨酸、N-椰油酰谷氨酸、N-月桂酰甘氨酸、N-椰油酰甘氨酸、N-月桂酰肌氨酸、N-椰油酰肌氨酸、N-月桂酰基-β-丙氨酸、N-椰油酰基-β-丙氨酸、N-月桂酰基-N-甲基-β-丙氨酸、N-椰油酰基-N-甲基-β-丙氨酸、N-月桂酰天冬氨酸、N-椰油酰天冬氨酸等N-酰基氨基酸;或N-月桂酰基-N-甲基牛磺酸、N-椰油酰基-N-甲基牛磺酸等N-酰基-N-甲基牛磺酸;或月桂基硫酸、聚氧乙烯月桂基硫酸、月桂基磷酸中的至少1种或2种以上。
另外,可举出选自上述阴离子性表面活性剂与中和剂的盐的至少1种或2种以上。上述中和盐为选自钠、钾、铵、三乙醇胺、2-氨基-2-甲基-1,3-丙二醇、2-氨基-2-乙基-1,3-丙二醇、2-氨基-2-羟甲基-1,3-丙二醇、精氨酸等中的至少1种或2种以上,但并不限定于此。
上述(B)螯合剂没有特别限定,如果举出具体例,则有选自乙二胺四乙酸二钠、乙二胺四乙酸三钠、乙二胺四乙酸四钠(EDTA-4Na)、乙二胺四乙酸二钾、乙二胺四乙酸四钾、羟乙基乙二胺三乙酸三钠、氮川三乙酸三钠、二亚乙基三胺五乙酸五钠(喷替酸五钠)、羟基乙烷二膦酸、羟基乙烷二膦酸二钠、3-羟基-2,2'-亚氨基二琥珀酸四钠、辛酰氧肟酸等中的至少1种或2种以上。
另外,通过将这些的配合量设为0.10质量%以上,从而可极力改善对嗜碱性菌种的抗菌力。应予说明,配合量的上限只要处在不损害液状组合物的品质稳定性和安全性的范围即可。例如为1.0质量%以下,在下述实施例中,配合0.4质量%以下而得到优选的结果。
上述(C)防腐效果剂没有特别限定,可采用具有防腐效果的公知的成分,如果举出具体例,则有选自苯氧基乙醇、乙基己基甘油、辛酸甘油酯、己基甘油、环己基甘油、异丙基甲基苯酚、丁基氨基甲酸碘代丙炔酯、氧化银等中的至少1种或2种以上。其配合量因所选择的成分而有所不同,为了充分发挥防腐效果,优选为0.001%以上,另外,可在考虑到刺激等安全性方面、质量稳定性的方面的范围内配合适当的量。
除上述(A)成分、(B)成分、(C)成分以外,为了提升身体清洁剂的使用感、使用性,除水分以外,还可配合(D)两性表面活性剂、(E)非离子性表面活性剂、(F)纤维素系增粘剂。
作为(D)两性表面活性剂,没有特别限定,如果举出具体例,则更优选为选自椰油酰两性基乙酸钠、月桂酰两性基乙酸钠、月桂基二甲氨基乙酸甜菜碱、肉豆蔻基二甲氨基乙酸甜菜碱、椰油烷基二甲氨基乙酸甜菜碱、月桂酰胺丙基二甲氨基乙酸甜菜碱、肉豆蔻酰胺丙基二甲氨基乙酸甜菜碱、椰油脂肪酰胺丙基二甲氨基乙酸甜菜碱、棕榈仁油脂肪酰胺丙基二甲氨基乙酸甜菜碱、月桂基二甲氨基羟基磺基甜菜碱、肉豆蔻基二甲氨基羟基磺基甜菜碱、椰油烷基二甲氨基羟基磺基甜菜碱、月桂酰胺丙基二甲氨基羟基磺基甜菜碱、肉豆蔻酰胺丙基二甲氨基羟基磺基甜菜碱、椰油脂肪酰胺丙基二甲氨基羟基磺基甜菜碱、棕榈仁油脂肪酰胺丙基二甲氨基羟基磺基甜菜碱、月桂基二甲基氧化胺、肉豆蔻基二甲基氧化胺、椰油烷基二甲基氧化胺、月桂酰胺丙基二甲基氧化胺、肉豆蔻酰胺丙基二甲基氧化胺、椰油脂肪酰胺丙基二甲基氧化胺、棕榈仁油脂肪酰胺丙基二甲基氧化胺等中的至少1种或2种以上。
作为上述(E)非离子性表面活性剂,没有特别限定,作为具体例,优选选自椰油脂肪酸单乙醇酰胺、月桂酸单乙醇酰胺、月桂酸二乙醇酰胺、肉豆蔻酸二乙醇酰胺、椰油脂肪酸二乙醇酰胺、棕榈仁油脂肪酸二乙醇酰胺、椰油脂肪酸N-甲基单乙醇酰胺、聚氧乙烯月桂酸单乙醇酰胺、聚氧乙烯椰油脂肪酸单乙醇酰胺、聚氧丙烯月桂酸单乙醇酰胺、聚氧丙烯椰油脂肪酸单乙醇酰胺、月桂基二醇羟基丙基醚、(月桂基/肉豆蔻基)二醇羟基丙基醚等中的至少1种或2种。
作为上述(F)纤维素系增粘剂,没有特别限定,具体例为选自羧甲基纤维素、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、纤维素胶、羧甲基羟乙基纤维素、羟丙基甲基纤维素硬脂氧基醚等中的至少1种或2种以上。
进而,可在不损害本发明的效果的范围内,混合可在身体清洁剂中所添加的公知的基剂或载体而使用。
此外,例如还可配合:其他表面活性剂、油分、醇类、保湿剂、防腐剂、抗氧化剂、pH调整剂、稳定剂、分散剂、香料、着色剂、色素、珠光赋予剂、血液循环促进成分、紫外线吸收成分、紫外线散射成分、收敛成分、肽、氨基酸类、角质软化成分、细胞活化成分、助溶剂、水等。添加剂可使用1种或组合使用2种以上。
作为上述醇类,可使用选自乙醇、异丙醇、1,2-丙二醇、1,3-丙二醇、1,3-丁二醇、2-甲基-1,3-丁二醇、二丙二醇、聚丙二醇、聚乙二醇、1,2-戊二醇、1,2-己二醇、1,2-辛二醇、甘油、双甘油等中的1种或2种以上。
实施例
[实施例1-4、比较例1-19]
以下,示出实施例和比较例,对本发明进一步具体地进行说明。以下的例子和以下的表中所示的“%”均为“质量%”。
将在表1中示出组成的身体清洁剂中的规定成分的螯合剂和防腐效果剂的化合物名称和上述组成中的成分量(质量%)示于表2、表3、表4。
上述身体清洁剂是依照常规方法,以上述表中所示的配合比例搅拌混合原材料,以成为液状组合物的方式使成分的剩余部分为水,以达到100质量%的方式制备。
<防腐能力判定试验>
依据日本药典第17版的保存效力试验法,对以上述方式制备的实施例和比较例的组合物进行试验,此时,作为该试验法所记载的细菌的指定菌种,以使组合物中成为106CFU/g级的菌浓度的方式接种大肠杆菌(Echerichia coli)、绿脓杆菌(Pseudomonasaeruginosa)、金黄色葡萄球菌(Staphylococcus aureus)的混合菌(以下简称为“3种混合菌”)、和南方盐单胞菌(Halomonas meridiana)(以下简称为“HM菌”),研究接种14天后菌数的有无。
应予说明,将对于3种混合菌和HM菌的试验结果示于表2、表3、表4。
这些表中所示的缩写N.D.表示“未检测到菌”,记号+表示“检测到菌”,记号-表示“未配合”。另外,表中的椰油酰胺DEA表示椰油脂肪酸二乙醇酰胺,椰油酰胺MEA是椰油脂肪酸单乙醇酰胺的简称。
另外,表2中示出向表1的身体清洁剂中添加氢氧化钾而调整pH,由此将pH调整成pH7~10.5的HM菌的生长pH依赖性。
根据表2的结果可知,在比较例1、2的pH8.0以下,HM菌不会生长,在比较例3~5的pH9.0以上,HM菌会生长。
根据该试验结果,对于表3所示的比较例6~17、表4所示的实施例1~4和比较例18、19,在将pH调整至9.0以上的条件下进行。
[表1]
组成 | % |
肉豆蔻酸 | 4.0 |
月桂酸 | 4.0 |
棕榈酸 | 2.0 |
椰油酰胺丙基甜菜碱 | 4.0 |
月桂酰胺丙基甜菜碱 | 4.0 |
烯烃(C14-16)磺酸钠 | 2.5 |
椰油酰胺DEA | 1.0 |
椰油酰胺MEA | 1.0 |
香料 | 适量 |
氢氧化钾 | 适量 |
螯合剂 | ※1 |
防腐效果剂 | ※2 |
水 | 剩余部分 |
(表中的※1和※2配合了表2或表3所记载的量)
[表2]
[表3]
根据表3所示的结果可知,比较例6-17的清洁剂配合了0.08质量%的喷替酸五钠,且未配合防腐效果剂或配合了各种防腐效果剂,虽然表现出3种混合菌全部被杀灭的抗菌性,但HM菌并未被杀灭,因此未能得到充分的抗菌性。
[表4]
另外,根据表4所示的结果即可知,配合有0.08质量%的乙二胺四乙酸四钠的比较例18和比较例19与比较例6-17同样,虽然3种混合菌全部被杀灭,但HM菌未被杀灭。
另一方面,以超过0.08质量%配合喷替酸五钠或乙二胺四乙酸四钠的实施例1-4中,HM菌和3种混合菌均被杀灭,可认为具有对于耐碱性菌的充分的抗菌力。
根据以上结果可知,配合小于0.1质量%的螯合剂时,确认到对于耐碱性菌(南方盐单胞菌(Halomonas meridiana))的抗菌力较为缺乏,配合0.1质量%以上的螯合剂时,确认到有充分的防腐能力。
以下示出本发明的身体清洁剂的制剂处方例。应予说明,表中的DPG是二丙二醇的简称,PPG是丙二醇的简称,BG是丁二醇的简称,PCA是吡咯烷酮羧酸的简称。
(制剂处方例1)沐浴露(全身用清洁剂)
[表5]
对制剂处方例1进行上述防腐能力试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例2)沐浴露(全身用清洁剂)
[表6]
对制剂处方例2进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例3)沐浴露(全身用清洁剂)
[表7]
对制剂处方例3进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例4)沐浴露(全身用清洁剂)
[表8]
对制剂处方例4进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例5)沐浴露(全身用清洁剂)
[表9]
对制剂处方例5进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例6)沐浴露(全身用清洁剂)
[表10]
对制剂处方例6进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例7)沐浴露(全身用清洁剂)
[表11]
对制剂处方例7进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例8)沐浴露(全身用清洁剂)
[表12]
对制剂处方例8进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例9)沐浴露(全身用清洁剂)
[表13]
对制剂处方例9进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例10)沐浴露(全身用清洁剂)
[表14]
对制剂处方例10进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例11)沐浴露(全身用清洁剂)
[表15]
对制剂处方例11进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例12)沐浴露(全身用清洁剂)
[表16]
对制剂处方例12进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
(制剂处方例13)沐浴露(全身用清洁剂)
[表17]
对制剂处方例13进行上述防腐能力判定试验,结果确认到对于HM菌和3种混合菌均有充分的防腐能力。
产业上的可利用性
本发明涉及一种含有表面活性剂的用于身体清洁的身体清洁剂,例如作为沐浴露(全身用清洁剂)、洗手液(洗手用清洁剂)、洗发水(毛发用清洁剂)、和其他液状的制剂形态,可以用于有助于与化妆品相关的其他美容领域或生活、健康、医疗领域等各种产业的具有通用性的身体清洁剂。
Claims (6)
1.一种身体清洁剂,其包含液状组合物,所述液状组合物含有(A)阴离子性表面活性剂和0.10质量%以上的(B)螯合剂,且制备成pH9.0以上。
2.根据权利要求1所述的身体清洁剂,其中,所述(A)阴离子性表面活性剂为选自高级脂肪酸、N-酰基谷氨酸、N-酰基甘氨酸、N-酰基肌氨酸、N-酰基-β-丙氨酸、N-酰基-N-甲基-β-丙氨酸、N-酰基天冬氨酸、N-酰基-N-甲基牛磺酸、烷基硫酸、聚氧乙烯烷基硫酸、α-烯烃磺酸、烷基磷酸或这些的中和盐中的至少1种或2种以上。
3.根据权利要求1或2所述的身体清洁剂,其中,所述(B)螯合剂为选自乙二胺四乙酸、二亚乙基三胺五乙酸、或这些的盐中的至少1种或2种以上。
4.根据权利要求1~3中任一项所述的身体清洁剂,其中,所述液状组合物含有(C)防腐效果剂作为添加成分,所述(C)防腐效果剂不包括螯合剂。
5.根据权利要求4所述的身体清洁剂,其中,所述(C)防腐效果剂是选自苯氧基乙醇、乙基己基甘油、辛酸甘油酯、己基甘油、环己基甘油、丁基氨基甲酸碘代丙炔酯、氧化银中的至少1种或2种以上。
6.根据权利要求1~4中任一项所述的身体清洁剂,其中,所述液状组合物含有选自(D)两性表面活性剂、(E)非离子性表面活性剂和(F)纤维素系增粘剂中的1种以上作为添加成分。
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- 2020-04-14 JP JP2020072095A patent/JP2021169413A/ja active Pending
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2021
- 2021-04-05 WO PCT/JP2021/014498 patent/WO2021210438A1/ja active Application Filing
- 2021-04-05 CN CN202180028720.7A patent/CN115397387A/zh active Pending
- 2021-04-07 TW TW110112514A patent/TW202203890A/zh unknown
Patent Citations (8)
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CN1158633A (zh) * | 1994-08-31 | 1997-09-03 | 埃科莱布有限公司 | 改进的蛋白酶清洁剂 |
JP2001172686A (ja) * | 1999-12-14 | 2001-06-26 | Lion Corp | 洗浄剤組成物 |
JP2012126805A (ja) * | 2010-12-15 | 2012-07-05 | Kao Corp | 皮膚洗浄剤組成物 |
WO2012117828A1 (ja) * | 2011-02-28 | 2012-09-07 | ライオン株式会社 | 洗浄剤組成物 |
WO2014047428A1 (en) * | 2012-09-21 | 2014-03-27 | Segetis, Inc. | Cleaning, surfactant, and personal care compositions |
JP2017025005A (ja) * | 2015-07-17 | 2017-02-02 | ソー・ジャパン株式会社 | アンマロク抽出物を含む防腐剤 |
WO2017208541A1 (ja) * | 2016-05-31 | 2017-12-07 | ライオン株式会社 | 液体皮膚洗浄剤組成物 |
CN108342258A (zh) * | 2017-01-25 | 2018-07-31 | 花王株式会社 | 液体清洁剂组合物 |
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TW202203890A (zh) | 2022-02-01 |
JP2021169413A (ja) | 2021-10-28 |
WO2021210438A1 (ja) | 2021-10-21 |
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