CN115364011A - Spherical skin care matrix and preparation method and application thereof - Google Patents
Spherical skin care matrix and preparation method and application thereof Download PDFInfo
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- CN115364011A CN115364011A CN202211025506.9A CN202211025506A CN115364011A CN 115364011 A CN115364011 A CN 115364011A CN 202211025506 A CN202211025506 A CN 202211025506A CN 115364011 A CN115364011 A CN 115364011A
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- skin care
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention relates to a spherical skin care matrix and a preparation method and application thereof. Wherein the spherical skin care matrix contains 0.1-5 parts of agar or agarose. The daily chemical product prepared by the spherical skin-care matrix containing the agar or the agarose has beautiful appearance, stable active ingredients, safety and better effects of moisture retention, compactness, elasticity restoration and the like.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to a spherical skin care matrix as well as a preparation method and application thereof.
Background
The formulation of daily chemicals is becoming diversified. Especially, with the rapid development of new retail e-commerce modes such as social e-commerce, second-class e-commerce/self-media e-commerce, direct broadcast e-commerce and the like in recent years, the visual effect of cosmetics is more emphasized, and the requirements on the appearance aesthetic feeling of products as well as packaging materials are gradually improved. The development of cosmetic formulations has not been limited to general textures such as ordinary non-viscous liquids, low-viscosity liquids, high-viscosity liquids, and pastes, and special formulations such as multi-layer separation liquids and non-flowable solids have been developed, but it is difficult to satisfy safety, stability, and efficacy at the same time. At present, the agar (agarose) is utilized in the market to prepare daily chemical products with excellent skin feel, safety, stability and efficacy, and the beautiful appearance of spherical particles.
Therefore, the development of a spherical skin care matrix and a daily chemical product thereof, which have aesthetic appearance, skin feel, safety in use, stability and good skin care effect, is urgently needed.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the spherical skin-care matrix containing the agarose, which enables the active ingredients of daily chemicals to be stable, has safety and better moisturizing, tightening and elastic repairing effects.
The technical scheme of the invention is realized by the following technical scheme:
the invention relates to a spherical skin-care matrix, which comprises 0.1-5 parts of agar or agarose by weight.
Further, the formula of the spherical skin care matrix also comprises the following components: 1 to 99 parts of solvent, 0.01 to 50 parts of skin conditioner, 1 to 40 parts of humectant, 0.1 to 10 parts of emollient and 0.1 to 1 part of stabilizer.
Further, the skin conditioner of the present invention is one or more selected from the group consisting of an extract of cynanchum atratum, an extract of moringa oleifera, a concentrated solution of purslane, an extract of centella asiatica, a lysate of saccharomyces bifidus fermentation product, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate, allantoin, ceramide and hydroxyppinacolone retinoic acid ester. Preferably, the humectant is selected from one or more of glycerin, dipropylene glycol and butylene glycol; preferably, the stabilizer is selected from p-hydroxyacetophenone, and/or 1, 3-propanediol/octanohydroxamic acid/1, 2-hexanediol/glycerol octanoate (1, 3-propanediol, 1, 2-hexanediol, octanohydroxamic acid, glycerol octanoate in a weight ratio of 59; preferably, the emollient is selected from squalane.
Further, the formulation of the spherical skin care base of the present invention further comprises the following components: 0.01-3 parts of pH regulator and 0.01-20 parts of colorant; 0.01 to 5 portions of thickening agent, 0.001 to 1 portion of essence and 0.01 to 5 portions of emulsifier.
Further, the pH regulator of the present invention is selected from citric acid monohydrate and/or trisodium citrate; preferably, the colorant is selected from natural or synthetic pigments; preferably, the colorant is selected from titanium dioxide, zinc oxide, iron oxide, ultramarine, pearlescent, mica, or vegetable carbon black; preferably, the thickener is selected from hydroxyethylcellulose; preferably, the emulsifier is selected from hydrogenated castor oil.
Furthermore, the diameter of the spherical skin care substrate is 0.01-10 mm; preferably, the spherical skin care base is solid or hydrogel-like.
Another technical object of the present invention is to provide a method for preparing a spherical skin care base, comprising the steps of:
1) Preparing raw material components according to a formula: 0.01 to 5 portions of agar or agarose, 1 to 99 portions of solvent, 0.01 to 50 portions of skin conditioner, 1 to 40 portions of humectant, 0.1 to 10 portions of emollient, 0.1 to 1 portion of stabilizer, 0.01 to 3 portions of pH regulator and 0.01 to 20 portions of colorant; 0.01-5 parts of thickening agent, 0.001-1 part of essence and 0.01-5 parts of emulsifier;
2) Mixing agar or agarose, solvent, emulsifier, emollient, thickener, and essence, adding into dissolved skin conditioner, stabilizer, humectant, colorant, and pH regulator, and stirring to obtain mixed phase;
3) The mixed phase flows into the cooling phase under the stirring condition, and the product is obtained after stabilization and filtration; preferably, the mixed phase is flowed into the cooling phase using a pressure controlled jet.
Further, the skin conditioner, the stabilizer, the humectant, the colorant and the pH regulator are dissolved by heating at 85-95 ℃; preferably, the pressure value of the jet pipe is 0.1-0.5 mpa, and the diameter range of the jet pipe is 0.01-5 mm; preferably, the cooling phase is hydrophobic liquid, and the temperature of the cooling phase is 0-30 ℃; preferably, the cooling phase is selected from silicone oils, hydrocarbon based greases, squalane, cyclomethicones, mineral oils, vegetable oils, ester oils or liquid fluorine compounds; preferably, the liquid fluorine compound is selected from perfluoroisobutylethyl ether or methyl perfluoroisobutyl ether.
Further, the mixing speed is 20-150 rpm when the mixed phase is sprayed into the cooling phase; preferably, the mixed phase is stable in the cooling phase for 20 to 60min.
Another technical object of the present invention is to provide a use of the spherical skin care base in a daily chemical, wherein the daily chemical comprises lotion, essence, emulsion, cream, eye cream, mask, foundation, makeup base, makeup remover, cleansing cream, face cleanser, shampoo, body wash, body care oil, hand cream, foot cream, elbow cream, body lotion or body cream.
Compared with the prior art, the invention has the following beneficial effects:
(1) The spherical skin-care matrix prepared by the invention can wrap various effective components in the matrix of spherical particles, and the components are stabilized by reducing the mobility of solute, so that the potential efficacy of the active components is stabilized, and various efficacy cosmetics are more stable and effective.
(2) The agar (agarose) added into the spherical skin care matrix prepared by the invention is natural moisturizing factor polysaccharide, and has safe and reliable source and good safety.
(3) The spherical skin-care matrix prepared by the invention has better moisturizing, anti-wrinkle and elastic repairing effects by endowing a synergistic effect, and can improve the quality of cosmetics.
(4) The appearance of the spherical skin care matrix prepared by the invention is spherical particles, and the appearance is beautiful.
Drawings
FIG. 1 is a flow chart of a method of making the spherical skin care matrix of the present invention.
Fig. 2 is a sample of a spherical skin care matrix of the present invention.
Detailed Description
The present invention utilizes the heat stagnation effect of agar and the hydrophilic and hydrophobic characteristics of water matter and oil matter. In general, the melting temperature and the solidification temperature of a substance coincide with each other, but the melting temperature and the solidification temperature of agar (agarose) are different from each other. According to this feature, a method of melting agar (agarose) into a solution state and solidifying the solution into particles in a cooling process is adopted, and the melted phase of agar (agarose) is a hydrophilic phase, while the cooling phase utilizes a hydrophobic oil phase. When a molten phase of agar (agarose) is added to a hydrophobic oil phase, the relative surface tension increases, and dew drops close to the shape of a regular sphere are formed, and the temperature of the hydrophobic water phase is low, and a solidification phenomenon occurs, thereby forming spherical particles close to the shape of a regular sphere. The technology described in the present invention was named LTSS-TRF (Liquid to semi-solid transformation), and the product thereof, spherical particles of agar (agarose), was named LTSS-TRF spheres.
Technical features in the technical solutions provided by the present invention are further clearly and completely described below with reference to specific embodiments, and it is obvious that the described embodiments are only a part of embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The raw material components of the invention are not particularly specified and are all commercially available products. The unit of parts by weight in the present invention may be kg, etc.
AGAR or agarose was purchased from Ina Food Industry co., ltd, japan, model AGAR AX-100, and has the following structural formula:
wherein n =100-500.1, 3-propanediol/caprylhydroxamic acid/1, 2-hexanediol/glyceryl caprylate (1, 3-propanediol, 1, 2-hexanediol, caprylhydroxamic acid, glyceryl caprylate weight ratio 59; cynanchum atratum extract was purchased from Shanghai Ruidian Biotech, inc.; moringa extract was purchased from korea Biostandard inc; the lysate of the fermentation product of the yeast schizosaccharomyces was purchased from the biotechnology limited of the superior department of new areas of hezega; the herba Portulacae concentrated solution and herba Centellae extract are obtained from Shanghai Ruidian Biotech limited; mica (trade name: SUNMICA-AS-Korean SUNJIN BEAUTY SCIENCE CO., LTD.); ceramide is sold under the tradename SK-INFLUX, available from New daily chemical trade development (hong Kong) Co.Ltd; hydroxyppinacolone retinoic acid ester (trade name:
HPR-south kyo xiandao pharmaceutical technology ltd).
1. Formula and preparation method of spherical skin-care matrix
1. Formula of spherical skin-care matrix
TABLE 1 EXAMPLES 1 TO 5 AND COMPARATIVE EXAMPLE 1 (Unit: parts by weight)
2. Preparation method of spherical skin care matrix
The preparation method of the spherical skin care matrix is shown in figure 2 and specifically comprises the following steps:
1) Mixing the phase B with stirring (stirring speed about 500 rpm) according to the formula shown in Table 1, adding the mixture into the phase A which is heated and dissolved at 85-95 ℃, stirring and mixing for 3-15 min, and confirming complete dissolution to obtain a mixed phase.
2) Adjusting the temperature of the cooling phase (cyclopentadimethylsiloxane) to 0-30 ℃ for later use; the stirring speed is reduced to 150-200 rpm (IKA RW20 Digital display overhead mechanical stirrer), under the stirring condition of a cross paddle stirrer, a material body of a mixed phase (A + B phase) slowly flows into a cooling phase by adopting a pressure control injection pipe, is stabilized for 20-60 min, and is separated from the cooling phase by using a filter screen. Wherein the water flows into the reactor at a uniform speed of 0.1-10 kg/min and pressure: the pressure value range is 0.1-0.5 mpa, and the diameter range of the nozzle of the spray nozzle is 0.01-5 mm.
2. Effect test and evaluation
(1) Effect of different contents of agar (agarose) on spherical particle formation
The evaluation method comprises the following steps: skin feel was evaluated by sensory evaluation by 60 female evaluators aged 20 to 50 years. And respectively establishing scores of 1-5 points for evaluation, and taking an average value for measurement.
Evaluation criteria of molding effect: 1) The particles cannot be formed; 2) More broken particles and less spherical particles, and the sizes of the formed particles are not uniform; 3) The particles are less in broken particles and more in spherical particles, and the sizes of the formed particles are not uniform; 4) No broken particles, spherical particles and non-uniform particle size; 5) Spherical particles of uniform size are formed.
Skin feel evaluation criteria: 1) A difference; 2) Poor performance; 3) Generally; 4) Better is the result; 5) Is very good
TABLE 2 Molding Effect and sensory evaluation results
| Test sample | Effect of formation | Skin feel evaluation |
| Example 1 | 3.5 | 4.62 |
| Example 2 | 4.2 | 4.83 |
| Example 3 | 5 | 4.98 |
| Example 4 | 4.7 | 4.49 |
| Example 5 | 4.5 | 4.21 |
| Comparative example 1 | 1 | 3.42 |
According to the experimental results of table 2: examples 1 to 5 were significantly superior in both the forming effect and the skin feel evaluation to comparative example 1, and experimental example 3 was the most excellent in the spherical forming effect, and the feeling in use was significantly superior to examples 1,2, 4, 5 and comparative example 1.
(2) Verification of safety and efficacy of spherical skin-care matrix of agar (agarose) prepared by the invention
In order to verify the excellent efficacy of the spherical skin care matrix, the human body efficacy tests on the safety, the moisturizing effect, the anti-wrinkle effect, the tightening effect, the repairing effect and the soothing effect are carried out on the formulas of the experimental examples 1 to 5.
a. Safety test (Patch test)
The spherical skin care bases prepared in examples 1 to 5 and a control group (deionized water) were subjected to a human body safety patch test according to the human body skin patch test in 2015 cosmetic safety technical specification.
Method of skin occlusion patch test: selecting 30 persons with age of 20-50 years, selecting the persons with area not more than 50mm 2 And a qualified spot test device with the depth of about 1mm, taking 0.020mL of the repairing and tightening composition prepared in the examples 1-5 and the control group, placing the repairing and tightening composition into a small chamber of a spot test device, placing a blank control hole (containing no substances), applying the spot test device with the repairing and tightening composition to the curved side of the forearm of a subject by using a hypoallergenic adhesive tape, and lightly pressing the patch with a palm to uniformly apply the patch to the skin for 24 hours. Skin reactions were observed according to the criteria of table 3 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque tester containing the repairing and tightening composition, respectively, and the observations were recorded.
TABLE 3 Patch test results
| Sample numbering | 30min | 24h | 48h | Total result |
| Example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
| Example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
| Control group | 0 | 0 | 0 | No positive reaction for 30 people |
TABLE 4 grading Standard of skin reaction in skin-closed Patch experiment
As can be seen from the test results in Table 4, the patch test results of examples 1 to 5 and the control group were negative, thereby indicating that the spherical skin care base prepared in examples 1 to 5 of the present invention did not irritate human skin.
b. Moisture test (moisture content of skin stratum corneum test)
The test method comprises the following steps: the moisture content of the facial skin of the subject before and after the product was applied was measured by a capacitance moisture tester CM825 (model: MPA580, CK, germany) and the moisture content of the skin before and after the product was applied was compared with the moisture content of the stratum corneum parameter (C.U.). Wherein the Δ c.u. = (c.u.2-c.u.1)/c.u.1 × 100%, the c.u.1 is a test value before a product is not used, and the c.u.2 is a test value after a product is used, and the larger the Δ c.u. Value is, the larger the increase of the moisture content of the skin stratum corneum after the product is used for testing the skin is, the better the moisturizing effect of the product is. The average values for each group were recorded and calculated as shown in table 5 below.
Table 5 moisture retention test experimental results
As can be seen from table 5, examples 1 to 5 all had very good moisturizing effects, and comparative example 1 had a poor moisturizing effect. In examples 1-5, the moisture content of the skin stratum corneum of the subjects after 1 month of use is increased by more than 35%, and in example 3, the moisture content of the skin stratum corneum of the subjects is increased by more than 50% to 51.31%, thus showing that example 3 is the best combination.
c. Anti-wrinkle test
The test method comprises the following steps: VISIA photographs were taken of the eye wrinkles before and after the subjects used the product, and then changes in the ratio of eye wrinkles before and after the use of the product were measured by professional IPP image analysis software on the photographs. Wherein Δ wrinkle = (wrinkle 1-wrinkle 2)/wrinkle 1 × 100%, wrinkle1 is a test value before a product is not used, wrinkle2 is a test value after the product is used, and the larger the Δ wrinkle value is, the larger the reduction range of the specific area occupied by the canthus wrinkles after the product is used for testing the skin is, and the better the anti-wrinkle effect of the product is. The average values for each group were recorded and calculated as shown in table 6 below.
TABLE 6 anti-wrinkle test results
| Test sample | wrinkle 1 | wrinkle 2 | △wrinkle(％) |
| Example 1 | 22.52 | 21.35 | 5.20 |
| Example 2 | 21.33 | 20.46 | 4.08 |
| Example 3 | 21.35 | 19.58 | 8.29 |
| Example 4 | 22.04 | 20.58 | 6.62 |
| Example 5 | 21.66 | 20.22 | 6.65 |
| Comparative example 1 | 21.57 | 21.00 | 2.64 |
As can be seen from table 6, examples 1 to 5 and comparative example 1 all had better anti-wrinkle effects, and examples 1 to 5 all had higher anti-wrinkle effects than comparative example 1, in which the reduction of the specific area of canthus wrinkles was the greatest in the subject of example 3, thus indicating that example 3 is the best combination.
d. Tightening test (increase skin elasticity test)
The test method comprises the following steps: similar to the skin moisturizing test, the skin elasticity values R2 before and after the application of the sample were measured using a skin elasticity tester (model: MPA580, CK, germany) and the degree of change in skin elasticity was evaluated based on the difference between the skin elasticity values before and after application, Δ R2= R2 (after application)
For R2 (before use), the greater the Δ R2 value, the more the elasticity is enhanced. The test results are recorded as an average for each group.
Table 7 results of the compact testing experiment
As can be seen from Table 7 above, examples 1 to 5 all had skin elasticity increasing values of more than 0.23 as compared with comparative example 1, whereas comparative example 1 had substantially no change in skin elasticity before and after use. Comparing examples 1-5, example 3 showed the greatest increase in skin elasticity, thus indicating that example 3 is the best combination partner.
e. Repair test (percutaneous moisture loss test)
The test method comprises the following steps: the water loss of the facial skin before and after the product was used by the subject was measured by a percutaneous water loss meter Tewameter TM300 (model: MPA580, germany CK corporation), and the TEWL parameter was compared with the water loss of the facial skin before and after the product was used. Wherein the Delta TEWL = (TEWL 1-TEWL 2)/TEWL 1 x 100%, the TEWL1 is a test value before a product is not used, the TEWL2 is a test value after the product is used, and the larger the value of the Delta TEWL of the obtained result is, the larger the reduction amplitude of the percutaneous water loss after the product is used for testing the skin is, and the better the barrier repair effect of the product is. The average values for each group were recorded and calculated as shown in table 8 below.
TABLE 8 results of repair test experiments
| Test sample | TEWL 1 | TEWL 2 | △TEWL(％) |
| Example 1 | 16.36 | 12.86 | 21.39 |
| Example 2 | 16.05 | 12.95 | 19.31 |
| Example 3 | 15.25 | 11.25 | 26.23 |
| Example 4 | 15.56 | 11.76 | 24.42 |
| Example 5 | 15.65 | 11.84 | 24.35 |
| Comparative example 1 | 16.23 | 15.33 | 5.55 |
As can be seen from the above table, examples 1 to 5 all had very good barrier repair effect, the repair effect reached more than 19%, and comparative example 1 also had a certain barrier repair effect, about 5%. In examples 1-5, the water loss of the skin through the skin is reduced after the subject takes the composition for 1 month, wherein the reduction range of the subject in example 3 is the largest and reaches 26.23%, thereby indicating that the best combination and collocation is realized in example 3.
f. Comfort test
The test method comprises the following steps: the facial skin erythema index a before and after the product was used by the subject was measured by using a skin color measuring probe CL400 (model: MPA580, CK, germany), and the change of the erythema index before and after the product was used was compared by the a value parameter. Wherein Δ a = (a × 1-a × 2)/a × 1 × 100%, a × 1 is a test value before the product is not used, a × 2 is a test value after the product is used, and a larger value of Δ a =indicatesa larger reduction range of the erythema index after the product is used on the test skin, and the better the soothing effect of the product is. The average values were recorded and calculated for each group, and the results are shown in the table below.
TABLE 9 relaxation test results for spherical matrices of agar (agarose)
| Test sample | a* 1 | a* 2 | △a*(％) |
| Example 1 | 12.24 | 11.85 | 3.19 |
| Example 2 | 12.33 | 11.62 | 5.85 |
| Example 3 | 12.41 | 10.10 | 18.61 |
| Example 4 | 12.08 | 11.03 | 8.69 |
| Example 5 | 12.55 | 11.36 | 9.48 |
| Comparative example 1 | 12.59 | 12.57 | 0.16 |
As can be seen from table 9 above, examples 1 to 5 and comparative example 1 all have a certain soothing effect, and examples 1 to 5 all have a higher soothing effect than comparative example 1, wherein the skin erythema index of the subject in example 3 is reduced to 18.61% to the maximum, thereby indicating that example 3 is the best combination.
(7) Stability test
TABLE 10 stability of agar (agarose) ball-type matrix skin care products prepared according to the invention
Evaluation criteria:
(2) instability: the spherical appearance is completely broken;
(2) and (3) relatively stable: the spherical particles are broken, and most of the spherical particles keep the original shape;
(3) and (3) stabilizing: the spherical appearance is kept, and the difference of the hardness and the softness is not large;
and (4) conclusion: the agar (agarose) spherical matrix skin care products prepared in the embodiments 1-5 of the invention show excellent stability in various stability tests.
3. The product of the invention was applied as follows and compared to a common cosmetic formulation for appearance, skin feel, efficacy
Mixing the filtered spherical skin care matrix with common cosmetic preparations (such as common skin care water, cleanser, emulsion, cream, etc.) at any ratio by simple stirring. Depending on the viscosity and hardness of the preparation, a particle suspension type cosmetic or a particle immersion type cosmetic can be prepared. The product has beautiful appearance, as shown in figure 1.
1) The spherical skin care base prepared in example 3 was added to a common skin lotion, a common essence, a common lotion, and a common cream in an amount of 5% by weight, and the respective examples were designated as reference example 1, reference example 2, reference example 3, and reference example 4.
2) The spherical skin care base prepared in the experimental example 3 was added to a common skin care lotion, a common essence, a common emulsion and a common cream in an amount of 10% by weight, and the mixture was respectively labeled as reference example 5, reference example 6, reference example 7 and reference example 8.
(1) Sensory evaluation
Evaluation method and criteria: the appearance and skin feel were evaluated by sensory evaluation on 60 female evaluators aged 20 to 50 years. And respectively establishing scores of 1-5 points for evaluation, and taking an average value for measurement. The evaluation of the appearance of the material body and the evaluation of the skin feeling belong to subjective evaluation, and the satisfaction degree of using the skin feeling is scored according to the preference degree of individuals to the appearance of the material body. A larger value indicates a higher appeal to the appearance, and a higher satisfaction.
TABLE 10 evaluation results of appearance and skin feeling
The sensory evaluation results of reference examples 1 to 8 and the ordinary cosmetic formulations show that the daily chemical products (reference examples 1 to 8) to which the agar (agarose) spherical skin care base prepared by the present invention was added were superior to the daily chemical products of the ordinary formulations in appearance and feeling of use.
(2) Validation of efficacy of spherical particle cosmetic formulations of agar (agarose) prepared in accordance with the invention
In order to further verify that the spherical particle cosmetic formulation can generate synergistic effect on the effect in various formulations and compare the effect with the work effect of common formulation cosmetics, the efficacy tests of a human body are performed on the moisturizing effect, the anti-wrinkle effect, the tightening effect, the repairing effect and the relieving effect of the reference example and the common cosmetic formulation. The test method is the same as the method for carrying out each efficacy test.
g. Moisture test (moisture content of skin stratum corneum test)
TABLE 11 moisturizing test results
| Test sample | C.U. 1 | C.U. 2 | △C.U.(％) |
| Reference example 1 | 30.74 | 42.97 | 39.79％ |
| Reference example 2 | 30.17 | 42.05 | 39.38％ |
| Reference example 3 | 31.11 | 44.23 | 42.17％ |
| Reference example 4 | 30.88 | 45.05 | 45.89％ |
| Reference example 5 | 30.02 | 44.08 | 46.84％ |
| Reference example 6 | 30.79 | 45.27 | 47.03％ |
| Reference example 7 | 30.07 | 44.71 | 48.69％ |
| Reference example 8 | 30.56 | 44.88 | 46.86％ |
| Common skin lotion | 31.25 | 35.08 | 12.26％ |
| Common essence | 31.08 | 37.83 | 21.72％ |
| Ordinary emulsion | 30.74 | 37.97 | 23.52％ |
| Common face cream | 30.88 | 42.01 | 36.04％ |
As can be seen from the above table, reference examples 1 to 8 all had very good moisturizing effects and were superior to the moisturizing effects of the conventional cosmetic formulations. It is clear that the moisture content of the horny layer of reference examples 5 to 8 was increased more than that of reference examples 1 to 4. This shows that the agar (agarose) spherical particle cosmetic formulation prepared according to the present invention has an excellent moisturizing effect, and the moisturizing effect is better as the content of spherical particles of agar (agarose) is larger.
h. Anti-wrinkle test
TABLE 12 wrinkle resistance test results
As can be seen from table 12 above, the cosmetics containing the spherical skin care base according to the present invention have significant anti-wrinkle effects, which are higher than those of the conventional cosmetic formulations, and the more the spherical agar (agarose) particles prepared according to the present invention are, the better the anti-wrinkle effect is (reference examples 5 to 8 are better than reference examples 1 to 4).
i. Tightening test (increase skin elasticity test)
Table 13 results of the compact testing experiment
| Test sample | △R2 |
| Reference example 1 | 0.245 |
| Reference example 2 | 0.247 |
| Reference example 3 | 0.271 |
| Reference example 4 | 0.278 |
| Reference example 5 | 0.274 |
| Reference example 6 | 0.279 |
| Reference example 7 | 0.283 |
| Reference example 8 | 0.289 |
| Common skin lotion | 0.120 |
| Common essence | 0.151 |
| Ordinary emulsion | 0.175 |
| Common face cream | 0.167 |
As is clear from Table 13 above, reference examples 1 to 8, which contained spherical particles of agar (agarose), all had a higher increase in skin elasticity than those using conventional cosmetic formulations; the skin elasticity increase values of reference examples 5 to 8 (containing 10% of the spherical skin care matrix of agar (agarose)) were larger than those of reference examples 1 to 4 (containing 5% of the spherical skin care matrix of agar (agarose)), further showing that the higher the content of the spherical skin care matrix of agar (agarose), the larger the elasticity increase value.
j. Repair test (percutaneous moisture loss test)
TABLE 14 results of repair test experiments
| Test sample | TEWL 1 | TEWL 2 | △TEWL(％) |
| Reference example 1 | 16.45 | 12.83 | 22.01％ |
| Reference example 2 | 16.31 | 12.85 | 21.21％ |
| Reference example 3 | 15.15 | 11.81 | 22.05％ |
| Reference example 4 | 17.18 | 13.01 | 24.27％ |
| Reference example 5 | 17.62 | 13.01 | 26.16％ |
| Reference example 6 | 16.82 | 12.11 | 28.00％ |
| Reference example 7 | 16.83 | 12.02 | 28.58％ |
| Reference example 8 | 16.11 | 11.36 | 29.48％ |
| Common skin lotion | 16.30 | 14.23 | 12.70％ |
| Common essence | 17.42 | 14.16 | 18.71％ |
| Ordinary emulsion | 16.91 | 14.78 | 12.60％ |
| Common face cream | 17.21 | 14.41 | 16.27％ |
As can be seen from table 14 above, the cosmetics containing the spherical skin care base of agar (agarose) all had superior barrier repair effects than the ordinary cosmetics; the skin moisture loss through the skin was more greatly reduced in reference examples 5 to 6 (containing 10% of the spherical skin care base of agar (agarose)) than in reference examples 1 to 2 (containing 5% of the spherical skin care base of agar (agarose)), further indicating that the higher the content of the spherical skin care base of agar (agarose), the better the barrier repair effect.
k. Comfort test
TABLE 15 results of the comfort test
As can be seen from Table 15 above, the soothing effects of reference examples 7-8 and reference examples 3-4 are superior to those of the conventional dosage forms. Reference examples 7-8 are higher than reference examples 3-4, thus demonstrating that the greater the content of agar (agarose) spherical particles, the better the soothing effect.
By combining all the experimental tests, the daily chemical product containing the agar (agarose) spherical skin-care matrix prepared by the invention has the effect of improving all the effects, and particularly has very excellent effects on the aspects of moisture preservation, compactness and restoration. Synergistic effects in efficacy can be produced in a variety of dosage forms.
Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art will appreciate that various modifications and substitutions can be made without departing from the scope of the present invention.
Claims (10)
1. The spherical skin care matrix is characterized in that the formula comprises 0.1-5 parts of agar or agarose by weight.
2. The spherical skin care matrix of claim 1, wherein the formulation further comprises the following components: 1 to 99 parts of solvent, 0.01 to 50 parts of skin conditioner, 1 to 40 parts of humectant, 0.1 to 10 parts of emollient and 0.1 to 1 part of stabilizer.
3. The spherical skin care base according to claim 2, wherein the skin conditioning agent is selected from one or more of banaba extract, moringa extract, purslane concentrate, centella asiatica extract, schizosaccharomyces cerevisiae fermentation product lysate, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate, allantoin, ceramide, and hydroxyppinacolone retinoic acid ester; preferably, the humectant is selected from one or more of glycerin, dipropylene glycol and butylene glycol; preferably, the stabilizer is selected from p-hydroxyacetophenone, and/or 1, 3-propanediol/octanohydroxamic acid/1, 2-hexanediol/glycerol octanoate; preferably, the emollient is selected from squalane.
4. The topical skin care base according to claim 2, wherein the formulation further comprises the following components: 0.01-3 parts of pH regulator and 0.01-20 parts of colorant; 0.01 to 5 portions of thickening agent, 0.001 to 1 portion of essence and 0.01 to 5 portions of emulsifying agent.
5. The topical skin care base according to claim 4, wherein the pH adjusting agent is selected from citric acid monohydrate and/or trisodium citrate; preferably, the colorant is selected from natural or synthetic pigments; preferably, the colorant is selected from titanium dioxide, zinc oxide, iron oxide, ultramarine, pearlescent, mica, or vegetable carbon black; preferably, the thickener is selected from hydroxyethylcellulose; preferably, the emulsifier is selected from hydrogenated castor oil.
6. The spherical skin care base according to claim 1, wherein the spherical skin care base has a diameter of 0.01 to 10mm; preferably, the spherical skin care base is solid or hydrogel-like.
7. A method of making a spherical skin care matrix comprising the steps of:
1) Preparing the following raw material components according to a formula: 0.01 to 5 portions of agar or agarose, 1 to 99 portions of solvent, 0.01 to 50 portions of skin conditioner, 1 to 40 portions of humectant, 0.1 to 10 portions of emollient, 0.1 to 1 portion of stabilizer, 0.01 to 3 portions of pH regulator and 0.01 to 20 portions of colorant; 0.01-5 parts of thickening agent, 0.001-1 part of essence and 0.01-5 parts of emulsifier;
2) Mixing agar or agarose, solvent, emulsifier, emollient, thickener, and essence, adding into dissolved skin conditioner, stabilizer, humectant, colorant, and pH regulator, and stirring to obtain mixed phase;
3) The mixed phase flows into the cooling phase under the stirring condition, and the product is obtained after stabilization and filtration; preferably, the mixed phase is flowed into the cooling phase using a pressure controlled jet.
8. The preparation method of claim 7, wherein the skin conditioner, the stabilizer, the humectant, the colorant and the pH regulator are dissolved by heating at 85-95 ℃; preferably, the pressure value of the injection pipe is 0.1-0.5 mpa, and the diameter range of the injection pipe is 0.01-5 mm; preferably, the cooling phase is hydrophobic liquid, and the temperature of the cooling phase is 0-30 ℃; preferably, the cooling phase is selected from silicone oils, hydrocarbon based greases, squalane, cyclomethicone, mineral oils, vegetable oils, ester oils or liquid fluorine compounds; preferably, the liquid fluorine compound is selected from perfluoroisobutylethyl ether or methyl perfluoroisobutyl ether.
9. The production method according to claim 7, wherein the mixing speed of the mixed phase sprayed into the cooling phase is 20 to 150rpm; preferably, the mixed phase has a stabilization time in the cooling phase of 20 to 60min.
10. Use of the spherical skin care base according to claim 1 in a daily chemical, wherein the daily chemical comprises a lotion, essence, emulsion, cream, eye cream, mask, foundation, makeup base, makeup remover, cleansing cream, face cleanser, face toilet, shampoo, body wash, body care oil, hand cream, foot cream, elbow cream, body lotion, or body cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115869216A (en) * | 2022-12-21 | 2023-03-31 | 娇时日化（杭州）股份有限公司 | Sweat-resistant foundation liquid and preparation method thereof |
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| CN104001205A (en) * | 2014-05-26 | 2014-08-27 | 广州创尔生物技术股份有限公司 | Fluid dressing and preparation method thereof |
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