CN109464331A - A kind of the whitening and skin-protecting preparation and preparation method of containing water-soluble fullerene - Google Patents
A kind of the whitening and skin-protecting preparation and preparation method of containing water-soluble fullerene Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention belongs to skin care fields, it is related to the whitening and skin-protecting preparation and preparation method of a kind of containing water-soluble fullerene, using include water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber extract, lauric alcohol-caprylate/decylate, panthenol, by collocation emulsifier and natural plant preservative, skin care formulation is made in conjunction with simple technique, it, which has, removes free radical, inhibits melanin, antiultraviolet and other effects, it is a there is whitening, mild pro-skin, maintenance skin, and the salubrious non-greasy of quality, inirritative skin care formulation.
Description
Technical field
The invention belongs to the technical fields of skin care item, are related to whitening and skin-protecting preparation and preparation method, and in particular to Yi Zhonghan
The whitening and skin-protecting preparation and preparation method of water-soluble fullerene.
Background technique
Fullerene C60Spherical structure and good biocompatibility with high degree of symmetry, 1992, Dr.McEwen et al.
It was found that C60Fullerene has very strong free radical scavenging ability, and fullerene is visually known as to " free radical sponge "
(radical sponge).Since fullerene is not soluble in water；Nineteen ninety-five scientist discovery, some water-soluble C60Fullerene is derivative
Object has extremely superior free radical scavenging ability；2004, Dr.Ali et al. was pointed out, there is some C60Fullerene derivate is in life
The anti-radical action of object medically is stronger than super oxygen change disproportionation ferment (superoxide dimutase, SOD) ability to function；
Japan Takada in 2006 et al. is studies have shown that C60Fullerene can directly capture free radical molecule, and speed is obviously than β-calabash
Radish element (β-carotene) is fast very much.
Fullerene itself is a kind of nonpolar molecule, belongs to hydrophobicity, lipophilic molecule, in order to preferably apply it
Into biochemistry, many scientific research personnel have developed many water-soluble fullerenes.
In modern life environment, people increasingly focus on the maintenance to skin, especially women, due to operating pressure, life
Pressure living or as increases at age can all occur that the colour of skin is obscure, nigrescence, dark yellow problem, these are all the black by skin
Element precipitating accumulation, currently on the market there are many whitening skin-protection product, the mechanism of action of whitening be inhibit melanin formation,
Anti-oxidant, removing free radical etc., there are many mainly include dimension life by the cosmetics of this respect effect or the raw material of skin care item
Plain C and derivative, there are also niacinamide and some plant extracts.Though wherein vitamin C is that current safety coefficient is higher
Whitening spot-removing ingredient, but its unstable chemcial property, are easily oxidized, are not easy by percutaneous absorption, to be difficult to reach whitening
Effect is oxidized there are also other ingredients with white-skinned face function also Yin Qiyi and is difficult to long-term preservation.
And many skin care item with white-skinned face function contain the chemically synthesized of a large amount of being irritating to the skin property on the market
Preservative and emulsifier, therefore people are higher and higher to the quality requirement of makeup and skin-protection product, and it is soft, again to research and develop a pro-skin
Whitening effect can be reached, the skin care formulation that can stablize preservation it is urgently to be resolved.
Summary of the invention
In order to better solve problem above, the present invention develop it is a by water-soluble fullerene and original plant juice, it is natural
Plant extracts, arrange in pairs or groups emulsifier and natural plant preservative are made a with whitening, pro-skin in conjunction with simple technique
Skin care item preparation, and the salubrious non-greasy of quality, soft do not stimulate.
The purpose of the present invention is to provide a kind of whitening and skin-protecting preparation of containing water-soluble fullerene and preparation methods.
The technical solution of the present invention is as follows:
A kind of whitening and skin-protecting preparation of containing water-soluble fullerene, the skin care formulation include water-soluble fullerene, Ye Duguo
Stoste, Semen Armeniacae Amarum extract, green cucumber extract, lauric alcohol-caprylate/decylate, panthenol, emulsifier, plant antiseptic agent and
Deionized water；
In skin care formulation 7~10 parts of water-soluble fullerene, Ye Duguo stoste account for 5~9 parts, 4~6 parts of Semen Armeniacae Amarum extract,
10~12 parts of green cucumber extract, lauric alcohol -3~6 parts of caprylate/decylate, 3~5 parts of panthenol, 11~35 parts of emulsifier, plant
8~12 parts of preservative；
Group co-emulsifier includes 2~13 parts of soybean lecithin, 1~15 part of stearic acid sucrose ester and cetostearyl alcohol 2~15
Part；
Plant antiseptic agent includes 4~7 parts of bamboo extractive, 4~7 parts of ginkgo biloba p.e；
The dosage form of whitening and skin-protecting preparation is aqua, lotion or creme, the emulsifier content of water aqua type can it is lower, do not increase
Thickener, and the content for increaseing accordingly emulsifier and thickener of emulsion-type and creme type, the content of deionized water mostly with press less
Look after the dosage form addition of formulations for skin；
It further include 6~10 parts of thickener in the whitening and skin-protecting preparation of lotion or creme.
A kind of preparation method of the whitening and skin-protecting preparation of containing water-soluble fullerene, successively as follows:
1) each component is weighed by formulation dosage；2) heating deionized water；3) under stirring, emulsifier is added and plant is anti-
Rotten agent, is heated to 80-90 DEG C；4) the above mixed liquor is cooled to 50~60 DEG C, and water-soluble fullerene, Ye Duguo stoste, hardship is added
Apricot seed extract, green cucumber extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed and stir evenly；5) stop stirring, it is cold
But to 30~40 DEG C, 10~20min of constant temperature homogeneous is to get product；
Thickening is added in the preparation of the skin care formulation of emulsion-type or creme type after the mixture of step 4) stirs evenly
Agent, constant temperature stir.
Water-soluble fullerene is long-acting free radical scavenger, forms stable state after absorbing free radical, is had relatively strong
Antioxygenic property, therefore have the function of whitening, antiultraviolet, and because its stability can save for a long time in skin care item；
Ye Duguo stoste is a kind of high-purity the effect of property essence liquid for being derived from Ye Duguo, is captured for a kind of melanin
Device, DOPA (DOPA) the reaction formula that can destroy color spot formation, reach Whitening, spot, remove pigmented purpose；
Semen Armeniacae Amarum extract nature and flavor temperature is bitter, it contains the substances such as fat oil, amarogentin, emulsin, has moisturizing, shield
The effect of skin records its cosmetic result that " can reduce swelling, all general mood scar sores of head of dispelling " in Compendium of Material Medica；
Microelement rich in green cucumber extract, green cucumber enzyme material have stronger bioactivity, can promote
Into metabolism, there are the effect of moisturizing, whitening and the salubrious skin softening of its quality；
Lauric alcohol-caprylate/decylate be 100% natural origin, quality do not stick clearly it is greasy, can be provided for skin persistently
Brightness；
Panthenol is the compound of vitamin B, has stronger moistening effect, has enhancing skin histology, promotes cell again
The functions such as life, maintenance skin；
Soybean lecithin not only has emulsification in emulsifier, also has wetting and peptizaiton, has moisturizing, collaboration
The effect of effect, and do not stimulate naturally；
Contain Flavonoid substances in bamboo extractive in plant antiseptic agent, natural flavonoids has antibacterial, resists
The effects of oxidation, removing toxic substances, the free radical in skin can be removed, the metabolism of skin is promoted；
Contain a variety of active ingredients in ginkgo biloba p.e, as flavones, terpene, lactone, polypentenol, alkaloid, steroid,
Vitamin and microelement etc., wherein Flavonoid substances are the main active constituents of ginkgo, there is certain bacteriostasis, right
Fungi and bacterium have stronger bacteriostasis.
Bring of the present invention the utility model has the advantages that
Product produced by the present invention is in addition to having the whitening beauty function removed free radical, inhibit melanin, antiultraviolet etc.
Effect also has the function of mild pro-skin, maintenance skin, is a skin care item preparation with whitening, pro-skin, and quality is clearly not
Greasy, inirritative skin care formulation, by the way that by water-soluble fullerene and original plant juice, natural plant extracts etc., collocation is natural
Emulsifier and natural plant preservative are made in conjunction with simple technique, the skin care formulation more compared to other chemical synthesis contents,
It can not only achieve the effect that whitening effect, with pro-skin skin care, also reduce the irritation to skin.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, it should be understood that these embodiments are merely to illustrate this
It invents rather than limits the scope of the invention, after the present invention has been read, those skilled in the art are to of the invention
It is as defined in the appended claims that the modification of various equivalent forms falls within the application.
Embodiment 1
A kind of preparation method of the whitening water aqua type of containing water-soluble fullerene:
1) 7 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 6 parts, Semen Armeniacae Amarum extract accounts for 5 parts, green cucumber mentions
Take object account for 10 parts, lauric alcohol-caprylate/decylate account for 4 parts, panthenol account for 5 parts, 5 parts of soybean lecithin, 2 parts of stearic acid sucrose ester, with
And 4 parts of cetostearyl alcohol, 4 parts of bamboo extractive, 5 parts of ginkgo biloba p.e, 65 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 80 DEG C；
4) the above mixed liquor is cooled to 50 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly；
5) stop stirring, be cooled to 30 DEG C, constant temperature homogeneous 10min is to get water aqua type skin care item.
Embodiment 2
A kind of preparation method of the whitening water aqua type of containing water-soluble fullerene:
1) 10 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 5 parts, Semen Armeniacae Amarum extract accounts for 4 parts, green cucumber mentions
Take object account for 11 parts, lauric alcohol-caprylate/decylate account for 6 parts, panthenol account for 3 parts, 2 parts of soybean lecithin, 5 parts of stearic acid sucrose ester, with
And 3 parts of cetostearyl alcohol, 5 parts of bamboo extractive, 4 parts of ginkgo biloba p.e, 75 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 85 DEG C；
4) the above mixed liquor is cooled to 55 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly；
5) stop stirring, be cooled to 35 DEG C, constant temperature homogeneous 15min is to get water aqua type skin care item.
Embodiment 3
A kind of preparation method of the whitening water aqua type of containing water-soluble fullerene:
1) 7 parts of water-soluble fullerene, Ye Duguo stoste account for 9 parts, Semen Armeniacae Amarum extract account for 6 parts, green cucumber extract account for 12 parts,
Lauric alcohol-caprylate/decylate account for 6 parts, panthenol account for 3 parts, 4 parts of soybean lecithin, 3 parts of stearic acid sucrose ester and cetearyl alcohol
4 parts of alcohol, 7 parts of bamboo extractive, 4 parts of ginkgo biloba p.e, 85 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 90 DEG C；
4) the above mixed liquor is cooled to 60 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly；
5) stop stirring, be cooled to 40 DEG C, constant temperature homogeneous 20min is to get water aqua type skin care item.
Embodiment 4
A kind of preparation method of the whitening emulsion type of containing water-soluble fullerene:
1) 7 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 9 parts, Semen Armeniacae Amarum extract accounts for 4 parts, green cucumber mentions
Take object account for 12 parts, lauric alcohol-caprylate/decylate account for 5 parts, panthenol account for 5 parts, 8 parts of soybean lecithin, 8 parts of stearic acid sucrose ester, with
And 8 parts of cetostearyl alcohol, 4 parts of bamboo extractive, 7 parts of ginkgo biloba p.e, 8 parts of thickener xanthan gum, 50 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 80 DEG C；
4) the above mixed liquor is cooled to 50 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；
5) stop stirring, be cooled to 30 DEG C, constant temperature homogeneous 10min is to get emulsion-type skin care item.
Embodiment 5
A kind of preparation method of the whitening emulsion type of containing water-soluble fullerene:
1) 8 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 8 parts, Semen Armeniacae Amarum extract accounts for 5 parts, green cucumber mentions
Take object account for 10 parts, lauric alcohol-caprylate/decylate account for 3 parts, panthenol account for 5 parts, 7 parts of soybean lecithin, 9 parts of stearic acid sucrose ester, with
And 8 parts of cetostearyl alcohol, 6 parts of bamboo extractive, 6 parts of ginkgo biloba p.e, 10 parts of thickener xanthan gum, 65 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 85 DEG C；
4) the above mixed liquor is cooled to 55 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；；
5) stop stirring, be cooled to 35 DEG C, constant temperature homogeneous 15min is to get emulsion-type skin care item.
Embodiment 6
A kind of preparation method of the whitening emulsion type of containing water-soluble fullerene:
1) 10 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 5 parts, Semen Armeniacae Amarum extract accounts for 6 parts, green cucumber mentions
Take object account for 10 parts, lauric alcohol-caprylate/decylate account for 6 parts, panthenol account for 3 parts, 7 parts of soybean lecithin, 9 parts of stearic acid sucrose ester, with
And 8 parts of cetostearyl alcohol, 7 parts of bamboo extractive, 4 parts of ginkgo biloba p.e, 6 parts of thickener xanthan gum, 70 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 90 DEG C；
4) the above mixed liquor is cooled to 60 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；
5) stop stirring, be cooled to 40 DEG C, constant temperature homogeneous 20min is to get emulsion-type skin care item.
Embodiment 7
A kind of preparation method of the skin whitener dosage form of containing water-soluble fullerene:
1) 7 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 9 parts, Semen Armeniacae Amarum extract accounts for 6 parts, green cucumber mentions
Take object account for 10 parts, lauric alcohol-caprylate/decylate account for 6 parts, panthenol account for 3 parts, 13 parts of soybean lecithin, 10 parts of stearic acid sucrose ester,
And 10 parts of cetostearyl alcohol, 7 parts of bamboo extractive, 4 parts of ginkgo biloba p.e, 10 parts of thickener, 50 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 80 DEG C；
4) the above mixed liquor is cooled to 50 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；
5) stop stirring, be cooled to 30 DEG C, constant temperature homogeneous 10min is to get creme type skin care item.
Embodiment 8
A kind of preparation method of the skin whitener dosage form of containing water-soluble fullerene:
1) 9 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 5 parts, Semen Armeniacae Amarum extract accounts for 6 parts, green cucumber mentions
Take object account for 12 parts, lauric alcohol-caprylate/decylate account for 5 parts, panthenol account for 5 parts, 10 parts of soybean lecithin, 15 parts of stearic acid sucrose ester,
And 8 parts of cetostearyl alcohol, 4 parts of bamboo extractive, 7 parts of ginkgo biloba p.e, 10 parts of thickener, 50 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and plant antiseptic agent is added, is heated to 85 DEG C；
4) the above mixed liquor is cooled to 55 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；
5) stop stirring, be cooled to 35 DEG C, constant temperature homogeneous 15min is to get creme type skin care item.
Embodiment 9
A kind of preparation method of the skin whitener dosage form of containing water-soluble fullerene:
1) 10 parts of water-soluble fullerene is weighed by formula, Ye Duguo stoste accounts for 5 parts, Semen Armeniacae Amarum extract accounts for 5 parts, green cucumber mentions
Take object account for 12 parts, lauric alcohol-caprylate/decylate account for 5 parts, panthenol account for 4 parts, 10 parts of soybean lecithin, 10 parts of stearic acid sucrose ester,
And 15 parts of cetostearyl alcohol, 6 parts of bamboo extractive, 6 parts of ginkgo biloba p.e, 9 parts of thickener, 50 parts of deionized water；
2) heating deionized water；
3) under stirring, emulsifier and thickener is added, is heated to 90 DEG C；
4) the above mixed liquor is cooled to 60 DEG C, and water-soluble fullerene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber is added
Extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed uniformly, are eventually adding thickener and are stirred；
5) stop stirring, be cooled to 40 DEG C, constant temperature homogeneous 20min is to get creme type skin care item.
The product of above 9 embodiments is subjected to experimental test:
45 female volunteers are chosen, the age, trial volunteer existed due to solarization, life pressure between 20~35 years old
The problems such as colour of skin is more black, the colour of skin is uneven caused by power, irregular or operating pressure of working and resting etc., obscure or jaundice, subject
Meet subject's selection principle in " cosmetics safety technical specification " (2015 editions).
1. human skin patch
45 female volunteers are divided into 9 groups, according to human body skin in " cosmetics safety technical specification " (2015 editions)
The product of above 9 embodiments is carried out human skin spot to 9 groups of female volunteers respectively by the test method in skin patch test
Patch test, the experiment including arm and back, the dermoreaction degree of 45 female volunteers is that "-" is as the result is shown
Negative reaction shows that product of the invention has no stimulation to human skin.
2. human efficiency uses test
By above 9 groups of female volunteers, respectively use Examples 1 to 9 product, that is, have 3 groups of women using water aqua type,
3 groups using emulsion-type, 3 groups using creme type.
Application method: having cleaned after face, dries face with cotton towel, appropriate product is taken uniformly to be applied to face, sooner or later
Each to use once, test period is 3 months.
During test, the skin of user is visited and investigated, the result is as follows:
1 water aqua type skin care formulation service condition of table
2 emulsion-type skin care formulation service condition of table
3 creme type skin care formulation service condition of table
By result above, adhere to reaching 85% or more using the whitening curative effect of the volunteer of this experimental products, and show
Product of the invention has whitening effect and non-stimulated to skin.
It above are only part specific embodiment of the invention, but design concept of the invention is not limited to this, all utilizations
This design makes a non-material change to the present invention, and should all belong to behavior that violates the scope of protection of the present invention.As long as without departing from
The content of technical solution of the present invention, it is to the above embodiments according to the technical essence of the invention any type of simply to repair
Change, equivalent variations and remodeling, still falls within the protection scope of technical solution of the present invention.
Claims (8)
1. a kind of whitening and skin-protecting preparation of containing water-soluble fullerene, which is characterized in that the skin care formulation includes water-soluble fowler
Alkene, Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber extract, lauric alcohol-caprylate/decylate, panthenol, emulsifier, plant are anti-
Rotten agent and deionized water.
2. by the whitening and skin-protecting preparation of containing water-soluble fullerene described in claim 1, which is characterized in that the skin care formulation packet
Include 7 ~ 10 parts of water-soluble fullerene, 5 ~ 9 parts of Ye Duguo stoste, 4 ~ 6 parts of Semen Armeniacae Amarum extract, 10 ~ 12 parts of green cucumber extract, cocounut oil
Alcohol -3 ~ 6 parts of caprylate/decylate, 3 ~ 5 parts of panthenol, 11 ~ 35 parts of emulsifier, 9 ~ 12 parts of plant antiseptic agent.
3. by the whitening and skin-protecting preparation of containing water-soluble fullerene of any of claims 1 or 2, which is characterized in that the emulsifier
Including 2 ~ 13 parts of soybean lecithin, 1 ~ 15 part of stearic acid sucrose ester and 2 ~ 15 parts of cetostearyl alcohol.
4. by the whitening and skin-protecting preparation of containing water-soluble fullerene of any of claims 1 or 2, which is characterized in that the plant is anti-
Rotten agent includes 4 ~ 7 parts of bamboo extractive, 4 ~ 7 parts of ginkgo biloba p.e.
5. by the whitening and skin-protecting preparation of containing water-soluble fullerene of any of claims 1 or 2, which is characterized in that the whitening shield
The dosage form of formulations for skin is aqua, lotion or creme.
6. the whitening and skin-protecting preparation of the containing water-soluble fullerene as described in claim 5, which is characterized in that lotion or creme
It further include 6 ~ 10 parts of thickener in whitening and skin-protecting preparation.
7. a kind of preparation method of the whitening and skin-protecting preparation of containing water-soluble fullerene as claimed in any one of claims 1 to 6, special
Sign is, successively as follows: 1) weighing each component by formulation dosage；2) heating deionized water；3) it under stirring, is added
Emulsifier and plant antiseptic agent, are heated to 80-90 DEG C；4) the above mixed liquor is cooled to 50 ~ 60 DEG C, be added water-soluble fullerene,
Ye Duguo stoste, Semen Armeniacae Amarum extract, green cucumber extract, lauric alcohol-caprylate/decylate, panthenol are sufficiently mixed and stir evenly；
5) stop stirring, be cooled to 30 ~ 40 DEG C, 10 ~ 20min of constant temperature homogeneous is to get product.
8. the preparation method of the whitening and skin-protecting preparation by containing water-soluble fullerene as claimed in claim 7, which is characterized in that lotion
Thickener is added after the mixture of step 4) stirs evenly in the preparation of the skin care formulation of type or creme type, and constant temperature sufficiently stirs
It mixes uniformly.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109806184A (en) * | 2019-04-08 | 2019-05-28 | 安徽复本生物科技有限公司 | A kind of skin base solution enabling skin whitening |
| CN109966158A (en) * | 2019-04-08 | 2019-07-05 | 安徽复本生物科技有限公司 | A kind of freeze-dried powder enabling skin whitening |
| CN113520888A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | Anti-aging composition containing fullerene and preparation method and application thereof |
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| CN104323948A (en) * | 2014-11-12 | 2015-02-04 | 福建春辉生物工程有限公司 | Freckle-removing compound essential oil |
| CN108714126A (en) * | 2018-08-21 | 2018-10-30 | 宁波越尚优品贸易有限公司 | Skin care compositions and the preparation method and application thereof with moisturizing and anti-oxidation efficacy |
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| CN104323948A (en) * | 2014-11-12 | 2015-02-04 | 福建春辉生物工程有限公司 | Freckle-removing compound essential oil |
| CN108714126A (en) * | 2018-08-21 | 2018-10-30 | 宁波越尚优品贸易有限公司 | Skin care compositions and the preparation method and application thereof with moisturizing and anti-oxidation efficacy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109806184A (en) * | 2019-04-08 | 2019-05-28 | 安徽复本生物科技有限公司 | A kind of skin base solution enabling skin whitening |
| CN109966158A (en) * | 2019-04-08 | 2019-07-05 | 安徽复本生物科技有限公司 | A kind of freeze-dried powder enabling skin whitening |
| CN113520888A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | Anti-aging composition containing fullerene and preparation method and application thereof |
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