CN115317582B - 一种用于明目舒睛的眼贴 - Google Patents
一种用于明目舒睛的眼贴 Download PDFInfo
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- CN115317582B CN115317582B CN202210766409.9A CN202210766409A CN115317582B CN 115317582 B CN115317582 B CN 115317582B CN 202210766409 A CN202210766409 A CN 202210766409A CN 115317582 B CN115317582 B CN 115317582B
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Abstract
一种用于明目舒睛的眼贴,属于眼贴技术领域。本发明按重量计算其活性成分由珍珠6g、琥珀6g、麝香3g、冰片2g、黄芩10g、姜黄15g、白芷12g、细辛5g、生南星12g、薄荷脑3g、熊胆粉3g、硼砂10g、炉甘石20g、川黄连5g、红花6g、当归15g、生地黄15g、山栀子12g、川芎15g、龙胆15g、木贼15g、乳香12g、没药12g、牛黄3g、青黛5g、滑石粉15g、防风12g、蔓荆子12g、夏枯草15g、蝉蜕5g、海螵蛸15g、菊花10g、生大黄10g和连翘15g组成。本发明的眼贴可以抗疲劳、抗氧化、抗衰老,又可芳香开窍、清脑醒神,还可扩张血管、改善局部微循环,同时解热、镇痛、抗菌、抗炎,可有效防治视疲劳。
Description
技术领域
本发明涉及一种用于明目舒睛的眼贴,属于眼贴技术领域。
背景技术
视疲劳是目前眼科常见的一种疾病,患者的症状多种多样,常见的有近距离用眼不能持久,眼及眼眶周围疼痛、视物模糊、眼睛干涩、流泪、黑眼圈、眼袋、睑板腺功能障碍等,严重者头痛、眩晕。虽然市售的一些眼药水能缓解疲劳症状,但作用不够持久,疗效不够确切。
发明内容
本发明的目的是为了解决上述现有技术存在的问题,进而提供一种用于明目舒睛的眼贴。
本发明的目的是通过以下技术方案实现的:
一种用于明目舒睛的眼贴,按重量计算其活性成分由珍珠5~7g、琥珀5~7g、麝香2~4g、冰片1.5~2.5g、黄芩8~12g、姜黄12~18g、白芷10~14g、细辛6~7g、生南星10~14g、薄荷脑2.5~3.5g、熊胆粉2.5~3.5g、硼砂7~13g、炉甘石15~25g、川黄连4~6g、红花5~7g、当归12~18g、生地黄12~18g、山栀子10~14g、川芎13~17g、龙胆12~18g、木贼13~17g、乳香10~14g、没药9~13g、牛黄2.6~3.2g、青黛4~6g、滑石粉10~20g、防风9~13g、蔓荆子10~14g、夏枯草12~18g、蝉蜕4~6g、海螵蛸11~19g、菊花8~12g、生大黄8~12g和连翘13~17g组成。
制作方法:
采用“中药动态提取配合微乳化水凝胶工艺”的方法。
(1)中药动态提取得到高品质浓缩提取物:
①将药材锉或切成约2-3mm大小的粗粒;②使用下接较大体积的贮罐的带有搅拌器的提取罐,在搅拌下加热水并加热保温至90±5℃煮提;③三级固液分离:第一级采用外溢式离心机,第二级为振荡筛,第三级高速离心机(离心率设为16000r/min);④使用外循环真空浓缩器进行浓缩;⑤喷雾干燥:转速12000-13000r/min。
(2)微乳化水凝胶工艺,最大程度锁住提取液,使其亲润眼周皮肤。微乳化水凝胶工艺可达80%以上的锁液能力,眼贴的基材为无纺布。
①将步骤(1)中得到的中药与0.1g-30.0g油相(蓖麻油、中链甘油三酸酯、肉豆寇酸异丙酯、橄榄油、花生油和矿物油中的一种或其混合物)、0.3g-50.0g乳化剂(聚山梨酯、泊洛沙姆、卖泽、苄泽、卵磷脂、聚山梨坦、聚氧乙烯蓖麻油缩合物和聚氧乙烯氢化蓖麻油中的一种或其混合物)、5.0g-60.0g等渗调节剂(甘油、硼砂、葡萄糖、甘露糖醇、丙二醇和氯化钠中的一种或其混合物)混合均匀,加入适量纯化水,剪切乳化以得到初乳,进而用高压均质机均质,制得的乳剂用0.45um的微孔滤膜过滤;随后加入含0.1g-500.0g增稠剂(结冷胶、海藻酸钠、瓜儿胶、果胶质、玻璃酸钠、卡波姆、泊洛沙姆、羟丙甲纤维素、甲基纤维素、聚乙烯吡咯烷酮和聚乙烯醇中的一种或其混合物)的水溶液,再用pH调节剂(盐酸、氢氧化钠、磷酸盐、硼酸、硼酸盐、三羟甲基氨基甲烷、枸橼酸、枸橼酸盐和三乙醇胺中的一种或其混合物)调节pH值为5.0-9.0,最后加入0.1g-0.5g的抑菌剂(季铵盐、硫代水杨酸的烷基汞盐、三氯叔丁醇或对羟基苯甲酸酯类),用纯化水补至1000ml足量,并混合均匀后即得。②将上述所得中药微乳化水凝胶均匀分布于基材为无纺布的眼贴上即可。
诊断及治疗分析:
患者来源:由门诊或病房收入的诊断为“视疲劳、干眼、黑眼圈、眼袋、睑板腺功能障碍”的患者30人。
使用方法:外用,将眼贴撕去胶布后,贴于患者眼周。一次15分钟,每日2次,7天为一个疗程。
适应症:视疲劳、干眼、黑眼圈、眼袋、睑板腺功能障碍等眼病。
疗效评价标准:
治愈:视疲劳、干眼、黑眼圈等症状消失。
好转:视疲劳、干眼、黑眼圈等症状减轻。
未愈:视疲劳、干眼、黑眼圈等症状未有变化或加重。
(定义:治疗有效为治愈及好转;治疗无效为未愈。)
两个疗程后统计,治愈24人,占80%;好转4人,占13.33%;未愈2人,占6.67%。
方义解析:方中菊花疏风清热明目,夏枯草清肝泻火,明目,散结消肿,二者共为君药,共奏清肝明目之功。臣以黄芩、山栀子、生南星、川黄连、龙胆、生大黄清热利湿、平肝泻火、凉血解毒;蔓荆子、防风、木贼、白芷、连翘、细辛、蝉蜕辛香散达,清利头目,祛风止痒;珍珠、琥珀、麝香、熊胆粉、硼砂、炉甘石、牛黄、青黛、滑石粉、海螵蛸开窍醒神,退赤去翳,清热止痛,收湿敛疮,通诸窍,散郁火,去翳明目。佐以红花、当归、生地黄、川芎、乳香、没药、姜黄活血行气、消肿生肌。冰片、薄荷脑为使药增强药物渗透达到病所作用。诸药协同作用,共奏清热明目、开窍醒神、止痒去翳、活血行气止痛之功。
药理作用:单味药:
珍珠具有明显的中枢抑制、抗炎、延缓衰老、免疫促进、疏通微循环、保护神经元细胞等作用。实验研究表明,珍珠水解液能疏通微循环,增加血流速度。
琥珀于《本草纲目》中有载:琥珀气味甘平、无毒,能安五脏、定魂魄、消淤血、通五淋、壮心明目、止痛安神、破血生机,治疗心神不宁、失眠多梦、惊风癫痫、月经停闭、小便涩痛、瘀血等病。
麝香开窍醒神,对中枢神经系统有兴奋作用,对实验性缺血视神经元损伤有保护作用,可以增强中枢对缺氧的耐受力。此外还有抗炎、抗菌的作用。
冰片性味辛香走窜,可调节中枢神经的兴奋与抑制,可发挥提神醒脑的作用;还可促进其他药物透皮吸收,通过血脑屏障,提高其他药物的生物利用度。此外还有抗细菌、真菌,消炎止痛的作用。
黄芩为常用清热解毒中药,有效成分主要为黄酮类化合物,具有多方面的药理活性,包括抗炎、抗肿瘤、抗氧化、抗心律失常、肝保护、神经元保护、提升免疫等多种药理作用。
姜黄《唐本草》中列为中品,记载其“味辛,苦,温,归脾、肝经。有破血行气、通经止痛之功。药理研究表明,姜黄具有抗肿瘤、抗氧化、降血糖、抗炎抗菌抗病毒等作用。其抗炎作用主要是通过降低炎性细胞因子的表达和分泌,介导多种炎症信号通路,调节炎症相关的细胞功能(如巨噬细胞)等来实现的。
白芷对多种病原微生物有不同程度的抑制作用,川白芷镇痛抗炎的有效成分是脂溶性部分,滇白芷有镇痛作用;白芷酊外用对豚鼠二硝基氯苯变应性接触性皮炎有明显抑制作用,此外还有中枢兴奋的作用。
细辛主要成分含挥发油,油中含丁香油酚甲醚、优藏茴香酮、大黄樟醚、β-蒎烯、细辛醚、细辛酮。另含N-异丁基十二碳四烯胺及消旋去甲乌药碱等。现代药理学研究表明细辛具有解热镇痛、镇静、中枢抑制、局部麻醉等多种药理作用。临床实践和现代药理研究证明细辛有毒性,细辛所含的挥发油随着煎煮时间的延长而挥发,细辛水提取液在临床应用中安全、有效。因此,临床应用细辛,在正确辨别病症的前提下,应选择适当剂型。
生南星功效以清化热痰、息风定惊为主,其药理作用主要为清热、抗炎镇痛、抗惊厥、抗氧化等作用。
薄荷脑是薄荷原油精制得到的一种饱和环状醇。现代药理研究显示其有清凉止痒、促透、抗真菌、抗病毒的作用。对啮齿类动物的研究表明,薄荷油中所含的胡薄荷酮可能是导致肝毒性的成分。
熊胆粉具有解热、镇痛,抑制肝纤维化、保护肝脏、利胆退黄,抗病毒,预防胆结石及溶解胆石,降血脂,抑制血栓形成,对白血病细胞分化有分化诱导及抑制肿瘤,抗炎、抗菌,促进微循环等药理作用。临床应用不良反应少,毒副作用轻微。
硼砂有抑菌,抗惊厥、抗癫痫,防腐及保护皮肤黏膜的作用。
炉甘石消炎、清凉、止痒、收敛,其主要成分是碳酸锌及少量的钙、氧化镁、氧化铁,可抑制局部葡萄球菌生长,同时有收敛保护的作用,可以收泪止痛,吸收创面的渗液,有明目退翳的作用,在眼科发挥重要疗效。《原机启微》记载:“主治风热上攻,眼目昏暗,隐涩难开,痒痛多泪”。
川黄连味极苦、性寒,具有清热燥湿、泻火解毒之功,常用于治疗泄泻痢疾、消渴、痈疮肿毒等。具有抗炎以及改善消化系统、保护心脑血管、抗肿瘤、降血糖、抗病原微生物等药理作用。
红花可抗凝、扩张血管,还有良好的耐缺氧、镇静、镇痛、抗炎等效果。
当归有补血、活血功效,经现代药理学证实,其还具有抑制血小板凝集、增强心血管作用、镇痛等多种功效。
生地黄具有抗氧化、抗衰老,免疫兴奋,降血糖,抗癌,抗脑缺血等作用。可引起荨麻疹样皮疹。生地黄的不良反应可见头痛、头晕、乏力、面色苍白、口唇紫绀等。
山栀子有泻火除烦、清热利尿、凉血解毒之功。近几年报道的栀子通过抑制炎症通路和氧化应激反应发挥神经保护作用,抑制α-糖苷酶,激活胰高血糖素样肽-1受体信号通路降血糖,调节神经营养因子和单胺类神经递质水平抗抑郁,以及降低胆固醇、低密度脂蛋白水平,改善血管内皮功能紊乱,调节动脉粥样硬化等方面。
川芎嗪可改善微循环,川芎挥发油对延脑的血管运动中枢、呼吸中枢及脊髓反射有兴奋作用。
龙胆有明确的抗炎镇痛、抗病毒、抗肿瘤,及治疗心脑血管的作用。
木贼主治疏散风热、明目退翳。具有镇静,镇痛,降血糖,抗氧化,抗菌、抗病毒等作用。
乳香具有抗炎、抗肿瘤、抗哮喘、抗氧化等药理活性。
没药具有退热、抗炎、镇痛、神经保护等多方面的药理活性,无明显毒副作用。
牛黄具有熄风止痉,化痰开窍,清热解毒之功效。具有镇静,解热镇痛,抗炎,抗惊厥等作用。有研究显示其治疗细菌性角膜炎有效。
青黛具有抗炎、调节免疫、抗肿瘤等多种药理活性。
滑石粉具有抗菌、保护皮肤及粘膜等作用。
防风中色原酮类成分对酵母菌诱导的大鼠发热有明显的退热作用;对腹膜化学性刺激引起的疼痛及温度刺激引起的小鼠疼痛均有明显的抑制作用;同时具有明显的抗炎、抗菌作用。
蔓荆子具有解热镇痛抗炎、平喘祛痰、抗肿瘤、抗衰老等药理作用。
夏枯草具有清肝火、明目、消肿、散结等功效。具有降血糖、降血压、调节免疫系统、抗肿瘤、抗炎抗菌及抗病毒等药理作用。
蝉蜕具有抗炎、镇咳祛痰平喘、镇静止痛解痉、抗惊厥、抗凝等作用。
海螵蛸抗溃疡,抗肿瘤,抗放射及接骨的作用。
菊花解热、抗炎,其提取物可以缓解视疲劳,对眼痛、眼胀、畏光、视物模糊、眼干涩等视疲劳症状有改善作用,此外还有广泛的抑菌作用。
生大黄性寒、苦,具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效。大黄的药理作用为抗炎、清除自由基、降脂、免疫调控、抗肿瘤、致泻等。
连翘具有清热解毒、消肿散结、疏散风热等功效。化学成分主要包括苯乙醇苷类、木脂素类、酚酸类、黄酮类、萜类及挥发油、C6-C2天然醇及其苷类等。现代药理研究表明,连翘具有抗炎、抑菌、抗病毒、抗氧化、保肝、抗肿瘤、免疫调节等活性。
以上药物不仅可以改善微循环、刺激冷觉感受器、促进药物透皮吸收的作用,此外,多数药物均具有解热、镇痛、抗炎、抗菌、抗氧化、抗疲劳、免疫调节等功能,对局部组织有刺激作用。
本发明的眼贴可以抗疲劳、抗氧化、抗衰老,又可芳香开窍、清脑醒神,还可扩张血管、改善局部微循环,同时解热、镇痛、抗菌、抗炎,可有效防治视疲劳。
具体实施方式
下面将对本发明做进一步的详细说明:本实施例在以本发明技术方案为前提下进行实施,给出了详细的实施方式,但本发明的保护范围不限于下述实施例。
实施例1
一种用于明目舒睛的眼贴,按重量计算其活性成分由珍珠5~7g、琥珀5~7g、麝香2~4g、冰片1.5~2.5g、黄芩8~12g、姜黄12~18g、白芷10~14g、细辛6~7g、生南星10~14g、薄荷脑2.5~3.5g、熊胆粉2.5~3.5g、硼砂7~13g、炉甘石15~25g、川黄连4~6g、红花5~7g、当归12~18g、生地黄12~18g、山栀子10~14g、川芎13~17g、龙胆12~18g、木贼13~17g、乳香10~14g、没药9~13g、牛黄2.6~3.2g、青黛4~6g、滑石粉10~20g、防风9~13g、蔓荆子10~14g、夏枯草12~18g、蝉蜕4~6g、海螵蛸11~19g、菊花8~12g、生大黄8~12g和连翘13~17g组成。
制作方法:
采用“中药动态提取配合微乳化水凝胶工艺”的方法。
(1)中药动态提取得到高品质浓缩提取物:
①将药材锉或切成约2-3mm大小的粗粒;②使用下接较大体积的贮罐的带有搅拌器的提取罐,在搅拌下加热水并加热保温至90±5℃煮提;③三级固液分离:第一级采用外溢式离心机,第二级为振荡筛,第三级高速离心机(离心率设为16000r/min);④使用外循环真空浓缩器进行浓缩;⑤喷雾干燥:转速12000-13000r/min。
(2)微乳化水凝胶工艺,最大程度锁住提取液,使其亲润眼周皮肤。微乳化水凝胶工艺可达80%以上的锁液能力,眼贴的基材为无纺布。
①将步骤(1)中得到的中药与0.1g-30.0g油相(蓖麻油、中链甘油三酸酯、肉豆寇酸异丙酯、橄榄油、花生油和矿物油中的一种或其混合物)、0.3g-50.0g乳化剂(聚山梨酯、泊洛沙姆、卖泽、苄泽、卵磷脂、聚山梨坦、聚氧乙烯蓖麻油缩合物和聚氧乙烯氢化蓖麻油中的一种或其混合物)、5.0g-60.0g等渗调节剂(甘油、硼砂、葡萄糖、甘露糖醇、丙二醇和氯化钠中的一种或其混合物)混合均匀,加入适量纯化水,剪切乳化以得到初乳,进而用高压均质机均质,制得的乳剂用0.45um的微孔滤膜过滤;随后加入含0.1g-500.0g增稠剂(结冷胶、海藻酸钠、瓜儿胶、果胶质、玻璃酸钠、卡波姆、泊洛沙姆、羟丙甲纤维素、甲基纤维素、聚乙烯吡咯烷酮和聚乙烯醇中的一种或其混合物)的水溶液,再用pH调节剂(盐酸、氢氧化钠、磷酸盐、硼酸、硼酸盐、三羟甲基氨基甲烷、枸橼酸、枸橼酸盐和三乙醇胺中的一种或其混合物)调节pH值为5.0-9.0,最后加入0.1g-0.5g的抑菌剂(季铵盐、硫代水杨酸的烷基汞盐、三氯叔丁醇或对羟基苯甲酸酯类),用纯化水补至1000ml足量,并混合均匀后即得。②将上述所得中药微乳化水凝胶均匀分布于基材为无纺布的眼贴上即可。
实施例2
一种用于明目舒睛的眼贴,按重量计算其活性成分由珍珠6g、琥珀6g、麝香3g、冰片2g、黄芩10g、姜黄15g、白芷12g、细辛5g、生南星12g、薄荷脑3g、熊胆粉3g、硼砂10g、炉甘石20g、川黄连5g、红花6g、当归15g、生地黄15g、山栀子12g、川芎15g、龙胆15g、木贼15g、乳香12g、没药12g、牛黄3g、青黛5g、滑石粉15g、防风12g、蔓荆子12g、夏枯草15g、蝉蜕5g、海螵蛸15g、菊花10g、生大黄10g和连翘15g组成。制作方法与实施例1相同。
以上所述,仅为本发明较佳的具体实施方式,这些具体实施方式都是基于本发明整体构思下的不同实现方式,而且本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到的变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应该以权利要求书的保护范围为准。
Claims (2)
1.一种用于明目舒睛的眼贴,其特征在于,按重量计算其活性成分由珍珠5~7g、琥珀5~7g、麝香2~4g、冰片1.5~2.5g、黄芩8~12g、姜黄12~18g、白芷10~14g、细辛6~7g、生南星10~14g、薄荷脑2.5~3.5g、熊胆粉2.5~3.5g、硼砂7~13g、炉甘石15~25g、川黄连4~6g、红花5~7g、当归12~18g、生地黄12~18g、山栀子10~14g、川芎13~17g、龙胆12~18g、木贼13~17g、乳香10~14g、没药9~13g、牛黄2.6~3.2g、青黛4~6g、滑石粉10~20g、防风9~13g、蔓荆子10~14g、夏枯草12~18g、蝉蜕4~6g、海螵蛸11~19g、菊花8~12g、生大黄8~12g和连翘13~17g组成;
制作方法:
采用中药动态提取配合微乳化水凝胶工艺的方法;
(1)中药动态提取得到高品质浓缩提取物:
①将药材锉或切成2~3mm大小的粗粒;②使用下接较大体积的贮罐的带有搅拌器的提取罐,在搅拌下加热水并加热保温至90±5℃煮提;③三级固液分离:第一级采用外溢式离心机,第二级为振荡筛,第三级高速离心机,离心率设为16000r/min;④使用外循环真空浓缩器进行浓缩;⑤喷雾干燥:转速12000~13000r/min;
(2)微乳化水凝胶工艺,最大程度锁住提取液,使其亲润眼周皮肤;微乳化水凝胶
工艺可达80%以上的锁液能力,眼贴的基材为无纺布;
①将步骤(1)中得到的中药与0.1g~30.0g油相、0.3g~50.0g乳化剂、5.0g~60.0g等渗调节剂混合均匀,加入纯化水,剪切乳化以得到初乳,进而用高压均质机均质,制得的乳剂用0.45um的微孔滤膜过滤;随后加入含0.1g~500.0g增稠剂的水溶液,再用pH调节剂调节pH值为5.0~9.0,最后加入0.1g~0.5g的抑菌剂,用纯化水补至1000ml足量,并混合均匀后即得;②将上述所得中药微乳化水凝胶均匀分布于基材为无纺布的眼贴上即可;
所述的油相为蓖麻油、中链甘油三酸酯、肉豆寇酸异丙酯、橄榄油、花生油和矿物油中的一种或其混合物;
所述的乳化剂为聚山梨酯、泊洛沙姆、卖泽、苄泽、卵磷脂、聚山梨坦、聚氧乙烯蓖麻油缩合物和聚氧乙烯氢化蓖麻油中的一种或其混合物;
所述的等渗调节剂为甘油、硼砂、葡萄糖、甘露糖醇、丙二醇和氯化钠中的一种或其混合物;
所述的增稠剂为结冷胶、海藻酸钠、瓜儿胶、果胶质、玻璃酸钠、卡波姆、泊洛沙姆、羟丙甲纤维素、甲基纤维素、聚乙烯吡咯烷酮和聚乙烯醇中的一种或其混合物;
所述的pH调节剂为盐酸、氢氧化钠、磷酸盐、硼酸、硼酸盐、三羟甲基氨基甲烷、枸橼酸、枸橼酸盐和三乙醇胺中的一种或其混合物;
所述的抑菌剂为季铵盐、硫代水杨酸的烷基汞盐、三氯叔丁醇或对羟基苯甲酸酯类。
2.根据权利要求1所述的用于明目舒睛的眼贴,其特征在于,按重量计算其活性成分由珍珠6g、琥珀6g、麝香3g、冰片2g、黄芩10g、姜黄15g、白芷12g、细辛5g、生南星12g、薄荷脑3g、熊胆粉3g、硼砂10g、炉甘石20g、川黄连5g、红花6g、当归15g、生地黄15g、山栀子12g、川芎15g、龙胆15g、木贼15g、乳香12g、没药12g、牛黄3g、青黛5g、滑石粉15g、防风12g、蔓荆子12g、夏枯草15g、蝉蜕5g、海螵蛸15g、菊花10g、生大黄10g和连翘15g组成。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1205209A (zh) * | 1997-07-14 | 1999-01-20 | 沈阳王朝医药保健品公司 | 置于眼袋中的明目中药及制备方法 |
CN101028240A (zh) * | 2007-03-29 | 2007-09-05 | 中国科学院上海药物研究所 | 眼用微乳/亚微乳原位凝胶制剂及其制备方法 |
CN101579363A (zh) * | 2008-05-14 | 2009-11-18 | 北京和润创新医药科技发展有限公司 | 一种中药眼用制剂及其制备方法 |
-
2022
- 2022-06-30 CN CN202210766409.9A patent/CN115317582B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1205209A (zh) * | 1997-07-14 | 1999-01-20 | 沈阳王朝医药保健品公司 | 置于眼袋中的明目中药及制备方法 |
CN101028240A (zh) * | 2007-03-29 | 2007-09-05 | 中国科学院上海药物研究所 | 眼用微乳/亚微乳原位凝胶制剂及其制备方法 |
CN101579363A (zh) * | 2008-05-14 | 2009-11-18 | 北京和润创新医药科技发展有限公司 | 一种中药眼用制剂及其制备方法 |
Non-Patent Citations (3)
Title |
---|
眼干燥症八例治疗总结;郭升科等;山东中医药大学学报;-;第09卷(第02期);第45-47页 * |
程乐卿.祛病有方.青岛出版社,2019,(第1版),第241页第2段. * |
马应龙痔疮膏联合胰岛素治疗糖尿病足疗效观察;秀梅等;蚌埠医学院学报;-;第40卷(第04期);第540-541页 * |
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