CN115282111A - Body lotion with effects of relieving swelling, relieving itching and moisturizing and preparation method thereof - Google Patents
Body lotion with effects of relieving swelling, relieving itching and moisturizing and preparation method thereof Download PDFInfo
- Publication number
- CN115282111A CN115282111A CN202211128232.6A CN202211128232A CN115282111A CN 115282111 A CN115282111 A CN 115282111A CN 202211128232 A CN202211128232 A CN 202211128232A CN 115282111 A CN115282111 A CN 115282111A
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- CN
- China
- Prior art keywords
- extract
- parts
- hyaluronic acid
- body lotion
- effects
- Prior art date
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- 239000006210 lotion Substances 0.000 title claims abstract description 22
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- 230000008961 swelling Effects 0.000 title claims abstract description 14
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title abstract description 13
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 24
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Abstract
The invention discloses body lotion with the effects of diminishing swelling, relieving itching and moisturizing, which comprises the following components: water, beta-glucan, glycerol, propylene glycol, triglyceride, squalane, an emulsifier, a diaschisis yeast fermentation product filtrate, saccharide isomerate, total extracellular polysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, p-hydroxyacetophenone, ethylhexyl glycerol, small molecule hyaluronic acid, an astragalus extract, a cassia twig extract, a white paeony root extract, a Chinese date extract, a ginger extract and amino acids. The body lotion has the effects of resisting bacteria, relieving itching, eliminating lumps, preserving moisture and the like, and compared with the traditional Chinese medicine preparation, the body lotion has the advantages of good moisture preservation, no dry and astringent skin, high effect taking speed and longer maintenance time.
Description
Technical Field
The invention relates to the technical field of external body lotion, in particular to body lotion with swelling-diminishing, itching-relieving and moisture-preserving effects and a preparation method thereof.
Background
The skin is the organ with the largest area of the human body, and various diseases can cause the phenomena of pruritus and edema of the skin, for example, symptoms of pruritus or edema of large area of the body skin are accompanied at the positions of type 2 diabetes mellitus, eczema and the like, and the traditional detumescence and itching relieving ointment mostly adopts doxepin, corticosteroid preparations, menthol, camphor and other medicaments. Although hormone medicines can quickly relieve symptoms in a short time, the symptoms are not treated at the same time, hormone dependence and pruritus are caused after long-term use of the hormone medicines, local skin thinning, atrophy, telangiectasia, fungal infection, bacterial infection, hirsutism and the like can be caused, and in addition, when large-area body pruritus occurs due to diseases, the hormone-containing itching relieving ointment cannot be applied in a large area.
Although the lotion of the Chinese herbal medicine preparation does not contain hormone, the viscosity is low, the adhesiveness on the skin surface is poor, the medicine maintenance time is short, the lotion needs to be repeatedly used for a long time, and the long-term use can damage the microbial barrier of the skin, damage the skin regeneration mechanism, cause a large amount of loss of skin oil, cause the skin to be dry and astringent, and increase wrinkles. However, the body lotion which can be applied in a large area on the market generally only has a simple moisturizing effect and cannot realize the functions of relieving itching and diminishing swelling, so that the development of the body lotion with the effects of diminishing swelling, relieving itching and moisturizing and the preparation method thereof are urgently needed.
Disclosure of Invention
The invention aims to provide body lotion which can improve symptoms of skin edema and pruritus caused by type 2 diabetes and has the effects of relieving swelling, relieving itching and moisturizing and a preparation method thereof. The preparation method is simple to operate, and the prepared product is used for relieving skin problems caused by type 2 diabetes and other diseases, and has the effects of diminishing inflammation, diminishing swelling, relieving itching, moistening skin and improving skin darkness.
In order to achieve the purpose, the invention adopts the following technical scheme:
a body lotion with detumescence, itching relieving and moisturizing effects comprises the following components: water, beta-glucan, glycerol, propylene glycol, triglyceride, squalane, an emulsifier, a yeast fermentation product filtrate, saccharide isomerate, total extracellular polysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, p-hydroxyacetophenone, ethylhexylglycerol, small molecule hyaluronic acid, an astragalus extract, a cassia twig extract, a white paeony root extract, a jujube extract, a ginger extract and amino acids.
Further, the composition of each component in parts by weight is as follows: 70-80 parts of water, 3-5 parts of beta-glucan, 2-3 parts of glycerol, 1-2 parts of propylene glycol, 1-2 parts of triglyceride, 1-2 parts of squalane, 0.5-1 part of emulsifier, 0.5-1.5 parts of yeast fermentation product filtrate, 0.5-1 part of saccharide isomer, 0.3-0.5 part of total-effect extracellular polysaccharide, 0.3-0.5 part of lactobacillus, 0.2-0.4 part of retinol, 0.2-0.3 part of 3-o-ethyl ascorbic acid, 0.1-0.2 part of hyaluronic acid, 0.1-0.2 part of carnosine, 0.1-0.2 part of tocopherol, 0.1-0.2 part of p-hydroxyacetophenone, 0.05-0.2 part of ethylhexylglycerin, 0.02-0.05 part of micromolecular hyaluronic acid, 0.01-0.025 part of astragalus extract, 0.01-0.015 part of cassia twig extract, 0.01-0.015 part of radix paeoniae alba extract, 0.01-0.005 part of ginger extract and 0.01-0.005 part of amino acid extract.
Further, the emulsifier is composed of polyacrylamide and polyethylene glycol diacrylate.
A preparation method of body lotion with the effects of diminishing swelling, relieving itching and moisturizing comprises the following specific steps:
a. sequentially adding water, beta glucan, glycerol, propylene glycol, squalane and saccharide isomer into an emulsifying pot, and stirring for dispersing for 25-30 minutes;
b. setting the heating temperature to be 55-75 ℃, starting to heat the emulsifying pot, adding triglyceride into the emulsifying pot after the temperature reaches the set temperature, and stirring for 20-25 ℃; then naturally cooling to normal temperature;
c. adding the secondary fission yeast fermentation product filtrate, total-effect exopolysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, small molecular hyaluronic acid, astragalus extract, cassia twig extract, white paeony root extract, chinese date extract, ginger extract and amino acid into an emulsifying pot, and homogenizing for 20-30 minutes;
d. adding p-hydroxyacetophenone and ethylhexyl glycerol into an emulsifying pot for 20-30 minutes;
e. finally, adding polyacrylamide and polyethylene glycol diacrylate into an emulsifying pot, and finally standing for defoaming;
f. the material was transferred to a container storage tank and allowed to stand for 48 hours, and the product was canned after filtration of the non-emulsified particulate material therein.
The invention has the beneficial effects that: the body lotion prepared by the invention avoids using hormone medicines, has the effects of antibiosis, itching relieving, lump eliminating, moisture retention and the like, and compared with the traditional Chinese medicine preparation, the body lotion has good moisture retention, does not cause skin dryness, can improve the skin microenvironment, promotes the proliferation of fiber cells, and inhibits oxidation reaction; the radix astragali extract contains astragalus polysaccharides, and can promote interleukin 1 beta to decrease, and promote fibroblast proliferation and angiogenesis; the retinol can effectively prevent and reduce cell wrinkles and reduce the roughness of the skin; the radix Paeoniae alba extract contains radix Paeoniae alba polysaccharide, which has antioxidant and antiinflammatory effects in vitro; the cassia twig extract has certain antibacterial and anti-inflammatory effects; the beta glucan can improve the flatness of the wound surface and reduce inflammatory reaction; the secondary split yeast fermentation product filtrate is rich in various amino acids, active ingredients such as lipid, vitamin, adenosine and the like, and can moisten and nourish the skin, repair the skin barrier, improve the skin elasticity and resist the damage of the external environment and pressure to the skin; hyaluronic acid can permeate into skin, supplement water, nourish skin tissue, and regulate water and oil balance. The body lotion prepared by the invention has fast effect taking speed and longer maintenance time; finally, the preparation method is simple and convenient for large-scale production.
Detailed description of the invention
The technical solution of the present invention will be further described in detail with reference to the following examples, so that those skilled in the art can more clearly understand the contents of the solution. The following examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
Example 1:
the body milk with the effects of diminishing swelling, relieving itching and moisturizing comprises the following components, by weight, 70 parts of water, 3 parts of beta-glucan, 2 parts of glycerol, 1 part of propylene glycol, 1 part of triglyceride, 1 part of squalane, 0.5 part of polyacrylamide and polyethylene glycol diacrylate, 0.5 part of a yeast fermentation product filtrate, 0.5 part of saccharide isomerate, 0.3 part of total-effect extracellular polysaccharide, 0.3 part of lactobacillus, 0.2 part of retinol, 0.2 part of 3-o-ethyl ascorbic acid, 0.1 part of hyaluronic acid, 0.1 part of carnosine, 0.1 part of tocopherol, 0.1 part of p-hydroxyacetophenone, 0.05 part of ethylhexylglycerin, 0.02 part of micromolecular hyaluronic acid, 0.01 part of astragalus extract, 0.01 part of cassia twig extract, 0.01 part of white paeony root extract, 0.005 part of jujube extract, 0.005 part of ginger extract and 0.005 part of amino acid.
Example two: the body milk with the functions of relieving swelling and itching and keeping efficacy in the embodiment comprises, by weight, 75 parts of water, 4 parts of beta-glucan, 2.5 parts of glycerol, 1.5 parts of propylene glycol, 1.5 parts of triglyceride, 1.5 parts of squalane, 0.75 part of polyacrylamide and polyethylene glycol diacrylate, 0.75 part of a yeast fermentation product filtrate, 0.75 part of saccharide isomerate, 0.4 part of total extracellular polysaccharide, 0.4 part of lactobacillus, 0.3 part of retinol, 0.25 part of 3-o-ethyl ascorbic acid, 0.15 part of hyaluronic acid, 0.15 part of carnosine, 0.15 part of tocopherol, 0.15 part of p-hydroxyacetophenone, 0.1 part of ethylhexylglycerol, 0.035 part of small molecular uric acid, 0.015 part of astragalus extract, 0.01 part of cassia twig extract, 0.01 part of white paeony root extract, 0.005 part of jujube extract, 0.005 part of ginger extract and 0.005 part of amino acid.
Example three: the body milk with the functions of relieving swelling and itching and keeping efficacy in the embodiment comprises, by weight, 80 parts of water, 5 parts of beta-glucan, 3 parts of glycerol, 2 parts of propylene glycol, 2 parts of triglyceride, 2 parts of squalane, 1.0 part of polyacrylamide and polyethylene glycol diacrylate, 1.5 parts of a fermentation product filtrate of saccharomyces cerevisiae, 1.0 part of saccharide isomerate, 0.5 part of total-effect extracellular polysaccharide, 0.5 part of lactobacillus, 0.4 part of retinol, 0.3 part of 3-o-ethyl ascorbic acid, 0.2 part of hyaluronic acid, 0.2 part of carnosine, 0.2 part of tocopherol, 0.2 part of p-hydroxyacetophenone, 0.2 part of ethylhexylglycerin, 0.05 part of micromolecular hyaluronic acid, 0.025 part of astragalus extract, 0.015 part of cassia twig extract, 0.015 part of white paeony root extract, 0.01 part of jujube extract, 0.01 part of ginger extract and 0.01 part of amino acid.
Example four: the body milk with the functions of relieving swelling and itching and keeping efficacy in the embodiment comprises, by weight, 73 parts of water, 5 parts of beta-glucan, 2 parts of glycerol, 1 part of propylene glycol, 2 parts of triglyceride, 1 part of squalane, 0.5 part of polyacrylamide and polyethylene glycol diacrylate, 1.5 parts of a yeast fermentation product filtrate, 0.5 part of saccharide isomerate, 0.35 part of total-effect extracellular polysaccharide, 0.5 part of lactobacillus, 0.2 part of retinol, 0.3 part of 3-o-ethyl ascorbic acid, 0.1 part of hyaluronic acid, 0.2 part of carnosine, 0.1 part of tocopherol, 0.15 part of p-hydroxyacetophenone, 0.1 part of ethylhexyl glycerol, 0.04 part of micromolecular hyaluronic acid, 0.02 part of astragalus extract, 0.01 part of cassia twig extract, 0.01 part of white paeony root extract, 0.01 part of jujube extract, 0.01 part of ginger extract and 0.01 part of amino acid.
According to the preparation method of the body lotion with the effects of relieving swelling, itching and moisturizing in the embodiment, a, weighing the components according to the amount of the components in the embodiment, sequentially adding water, beta glucan, glycerol, propylene glycol, squalane and saccharide isomerate into an emulsifying pot, and stirring and dispersing for 25-30 minutes;
b. setting the heating temperature to be 55-75 ℃, starting to heat the emulsifying pot, adding triglyceride into the emulsifying pot when the temperature reaches the set temperature, and stirring for 20-25 ℃; then naturally cooling to normal temperature;
c. adding the secondary fission yeast fermentation product filtrate, total extracellular polysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, small molecule hyaluronic acid, radix astragali extract, cassia twig extract, radix paeoniae alba extract, chinese date extract, ginger extract and amino acid into an emulsifying pot, and homogenizing for 20-30 minutes;
d. adding p-hydroxyacetophenone and ethylhexyl glycerol into an emulsifying pot for 20-30 minutes;
e. finally, adding polyacrylamide and polyethylene glycol diacrylate into an emulsifying pot, and finally standing for defoaming;
f. the material was transferred to a container tank and allowed to stand for 48 hours, and the product was canned after filtration of the non-emulsified particulate material therein.
(1) Skin irritation and allergy tests:
60 small guinea pigs weighing about 300g were selected, randomly divided into six groups of 10 animals each for testing the products of the control group and the working group, and the backs of the small guinea pigs were shaved off with 3 × 3cm of hair, after 24 hours, the six groups of products were applied to the surfaces, washed with warm water 30 minutes later, and the small guinea pigs were observed for the presence of erythema, edema, etc. 1 hour and 24 hours after washing, and for the presence of skin allergy.
The control and examples one to four are non-irritating and allergic to small guinea pigs.
(2) Non-traumatic human body efficacy evaluation
Trial detection results are carried out on the products of the first to the fourth examples, and the control group A is a commercial itching relieving ointment; the control group B is a Chinese medicinal composition (prepared by soaking and boiling, and washing at 45 deg.C for 20 min); each experimental group had 10 patients with type ii diabetes complications between 55 and 65 years of age, test area: skin of limbs and trunk, dose and period 2 times a day for 4 weeks, test items: detumescence, moisture retention and itching.
Observation results of efficacy evaluation
The experimental results show that: the formula adopted by the invention has good performance, and the effect is superior to that of products sold in the market.
(3) Non-traumatic human body efficacy time evaluation
Trial detection results are carried out on the products of the first to the fourth examples, and the control group A is a commercial itching relieving ointment; the control group B is prepared from Chinese medicinal materials by soaking, boiling, and washing at 45 deg.C for 20 min; each experimental group had 10 patients with type ii diabetes complications between 55 and 65 years of age, test area: skin of limbs and trunk, dose and period 2 times per day for 4 weeks, test items: onset time and maintenance time.
Observation results of efficacy evaluation
| Time | Control group A | Control group B | Example one | Example two | EXAMPLE III | Example four |
| Onset time | 5min | 2h | 3min | 4min | 3min | 2min |
| Maintenance time | 1h | 7d | 27d | 25d | 27d | 28d |
The experimental results show that: the formula adopted by the invention has good performance and the effect is superior to that of the product sold in the market.
In summary, the following steps:
the invention is processed by preparing a plurality of traditional Chinese medicine extracts and a plurality of polysaccharide mixtures in proportion, and has the advantages of resisting bacteria, relieving itching, eliminating lumps, improving skin microenvironment, promoting fibroblast proliferation and angiogenesis, inhibiting oxidation reaction and the like. Improves the skin symptoms of users, restores the biological environment of the skin and fundamentally solves the skin problems of pruritus, edema, dryness and the like.
Claims (4)
1. A body lotion with the effects of detumescence, itching relieving and moisture retention is characterized in that: comprises the following components: water, beta-glucan, glycerol, propylene glycol, triglyceride, squalane, an emulsifier, a yeast fermentation product filtrate, saccharide isomerate, total extracellular polysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, p-hydroxyacetophenone, ethylhexylglycerol, small molecule hyaluronic acid, an astragalus extract, a cassia twig extract, a white paeony root extract, a jujube extract, a ginger extract and amino acids.
2. The body lotion with the effects of detumescence, itching relieving and moisturizing as claimed in claim 1, which is characterized in that: the composition of each component in parts by weight is as follows: 70-80 parts of water, 3-5 parts of beta-glucan, 2-3 parts of glycerol, 1-2 parts of propylene glycol, 1-2 parts of triglyceride, 1-2 parts of squalane, 0.5-1 part of emulsifier, 0.5-1.5 parts of schizosaccharomyces cerevisiae fermentation product filtrate, 0.5-1 part of saccharide isomer, 0.3-0.5 part of total-effect exopolysaccharide, 0.3-0.5 part of lactobacillus, 0.2-0.4 part of retinol, 0.2-0.3 part of 3-o-ethyl ascorbic acid, 0.1-0.2 part of hyaluronic acid, 0.1-0.2 part of carnosine, 0.1-0.2 part of tocopherol, 0.1-0.2 part of p-hydroxyacetophenone, 0.05-0.2 part of ethylhexyl glycerol, 0.02-0.05 part of micromolecular hyaluronic acid, 0.01-0.025 part of astragalus extract, 0.01-0.015 part of cassia twig extract, 0.01-0.015 part of white peony root extract, 0.01-0.015 part of ginger extract and 0.01-0.1-0.3 part of amino acid extract.
3. The body lotion with the effects of diminishing swelling, relieving itching and preserving moisture as claimed in claim 2, which is characterized in that: the emulsifier is composed of polyacrylamide and polyethylene glycol diacrylate.
4. A method for preparing the body lotion with the effects of detumescence, itching relieving and moisturizing as claimed in claim 3, which is characterized in that: the method comprises the following specific steps:
a. sequentially adding water, beta glucan, glycerol, propylene glycol, squalane and saccharide isomerate into an emulsifying pot, and stirring for dispersing for 25-30 minutes;
b. setting the heating temperature to be 55-75 ℃, starting to heat the emulsifying pot, adding triglyceride into the emulsifying pot when the temperature reaches the set temperature, and stirring for 20-25 ℃; then naturally cooling to normal temperature;
c. adding the secondary fission yeast fermentation product filtrate, total-effect exopolysaccharide, lactobacillus, retinol, 3-o-ethyl ascorbic acid, hyaluronic acid, carnosine, tocopherol, small molecular hyaluronic acid, astragalus extract, cassia twig extract, white paeony root extract, chinese date extract, ginger extract and amino acid into an emulsifying pot, and homogenizing for 20-30 minutes;
d. adding p-hydroxyacetophenone and ethylhexyl glycerol into an emulsifying pot for 20-30 minutes;
e. finally, adding polyacrylamide and polyethylene glycol diacrylate into an emulsifying pot, and finally standing for defoaming;
f. the material was transferred to a container tank and allowed to stand for 48 hours, and the product was canned after filtration of the non-emulsified particulate material therein.
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| CN113197836A (en) * | 2021-05-19 | 2021-08-03 | 广东添乐化妆品有限公司 | Moisturizing, relieving, itching-relieving and skin-protecting cream and preparation method thereof |
| CN114246818A (en) * | 2021-03-08 | 2022-03-29 | 山东祥隆医药研究院有限公司 | Essence milk with allergy preventing, moisturizing and repairing effects and preparation method thereof |
| CN114869827A (en) * | 2022-04-12 | 2022-08-09 | 贵州山茶产业综合开发有限公司 | Itching-relieving swelling-reducing moisturizing composition and preparation method and application thereof |
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| CN114246818A (en) * | 2021-03-08 | 2022-03-29 | 山东祥隆医药研究院有限公司 | Essence milk with allergy preventing, moisturizing and repairing effects and preparation method thereof |
| CN113197836A (en) * | 2021-05-19 | 2021-08-03 | 广东添乐化妆品有限公司 | Moisturizing, relieving, itching-relieving and skin-protecting cream and preparation method thereof |
| CN114869827A (en) * | 2022-04-12 | 2022-08-09 | 贵州山茶产业综合开发有限公司 | Itching-relieving swelling-reducing moisturizing composition and preparation method and application thereof |
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| 成都蓝风(集团)股份有限公司: "春娟黄芪止痒保湿润体乳", vol. 1, pages 171 - 172, Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=1064936669959946240&gb=G> * |
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