CN115282075B

CN115282075B - Wrinkle-removing eye cream and preparation method thereof

Info

Publication number: CN115282075B
Application number: CN202211114703.8A
Authority: CN
Inventors: 吕根达
Original assignee: Xi'an Liuhe Shangpin Trading Co ltd
Current assignee: Xi'an Liuhe Shangpin Trading Co ltd
Priority date: 2022-09-14
Filing date: 2022-09-14
Publication date: 2023-10-10
Anticipated expiration: 2042-09-14
Also published as: CN115282075A

Abstract

The invention provides wrinkle-removing eye cream and a preparation method thereof, and belongs to the technical field of cosmetics. The composite material is prepared from the following raw materials in parts by weight: 10-15 parts of protein peptide probiotics fermentation composition, 1-2 parts of lecithin, 2-5 parts of macadimia nut oil, 1-4 parts of humectant, 0.5-2 parts of carbomer, 1-2 parts of natural antioxidant, 1-2 parts of transdermal absorption promoter, 0.5-1 part of carboxymethyl pachyman, 0.1-1 part of guar gum and 40-60 parts of water. The wrinkle-removing eye cream can inhibit muscle contraction, prevent wrinkles, promote cell proliferation and regeneration, increase skin elasticity, effectively improve antioxidant effect, inhibit decomposition of skin collagen, prevent wrinkles, and remove generated dynamic lines, static lines and dry lines, thereby radically solving the problem of skin wrinkles.

Description

Wrinkle-removing eye cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to wrinkle-removing eye cream and a preparation method thereof.

Background

The skin of the eyes is the weakest part of the skin of the human body. The sum of the thickness of the ocular epidermis and dermis is about 0.55mm, and only 1/4 of the thickness of facial skin, thus being more vulnerable to external injury. The loose connective tissue under the skin of the eyes is rich, soft and elastic, and in the fiber structure of the loose connective tissue, very rich capillaries and nerve endings are distributed, and the walls of the capillaries are very thin and have certain permeability. Loose connective tissue is prone to congestion, water accumulation, and formation of hematomas or oedema. There is little sebaceous or sweat gland distribution under the skin of the eye, and the thin skin around the eye is very dry and lacks moisture. Because the skin of the eyes lacks sebaceous glands and sweat glands, the skin around the eyes does not have natural moisturizing capability, and the supplied grease is relatively much less, so that the skin of the eyes is extremely easy to age. The skin around the eyes is sensitive and fragile, and the micro-blood vessels are very fine, so that wrinkles, dark circles and bags are easy to generate. The eye skin is heavy in work load and easy to fatigue, eyes are normally blinked for 2.4-2.8 ten thousands of times every day, and the eye muscles and the surrounding skin are subjected to great pressure by the actions.

The formation of eye lines is a chain reaction, and due to the increase of the age, the epidermis tissue of the eye skin is dried and thinned, collagen and elastin are gradually lost, and the fine screen net structure formed by interweaving collagen fibers and elastic fibers is damaged, so that wrinkles with different thicknesses can appear; the eye metabolism is slow, the blood circulation is not smooth, and the capillary vessel is blocked.

The eye products on the market are various, but the single efficacy is the main part; the absorption of the skin to the active ingredients in the eye cream products on the market is also unknown due to the special structure of the eye skin.

CN105943475a discloses an anti-wrinkle eye cream containing traditional Chinese medicine components, a preparation method and application thereof, wherein the anti-wrinkle eye cream comprises glycerin, methyl glucoside eicosyl oxide, stearic acid, siliceous smoothing agent, hyaluronic acid, isomerous saccharide, rose essential oil, astragalus extract, acanthopanax extract, rhodiola root extract, gynostemma pentaphylla extract and rhododendron extract. The anti-wrinkle eye cream provided by the invention is fresh, cool, soft and soft, is mild and has no stimulus, can maintain moisture of eye skin for a long time, promotes eye blood circulation, effectively reduces the generation of fine wrinkles on eyes, but cannot repair the generated fine wrinkles.

CN108904414a discloses a fast wrinkle-removing eye cream, which comprises the following raw materials: dipropylene glycol, 26-cyclohexene glyceryl ether, hyaluronic acid, umarone, ammonium acryloyldimethyl taurate/VP copolymer, hydroxypropyl methylcellulose, coenzyme Q10, cyclopentadimethicone, BT-9268, isohexadecane, dimethicone/vinyl dimethicone cross polymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, olangmine, acetyl hexapeptide-8, SYN-COLL, BSASM, 1, 2-hexanediol, SYN-AKE, and essence. The quick wrinkle-removing eye cream disclosed by the invention has the advantages of good instant effect on wrinkle removal of eyes, long wrinkle-removing effect duration and good wrinkle-removing duration effect, but has larger irritation.

Disclosure of Invention

The invention aims to provide an anti-wrinkle eye cream and a preparation method thereof, which can inhibit muscle contraction, prevent wrinkles, promote cell proliferation and regeneration, increase skin elasticity, effectively improve antioxidation effect, inhibit decomposition of skin collagen, prevent wrinkles, remove generated dynamic lines, static lines and dry lines, and radically solve the problem of skin wrinkles.

The technical scheme of the invention is realized as follows:

the invention provides wrinkle-removing eye cream which is prepared from the following raw materials: protein peptide probiotics fermentation composition, lecithin, macadamia nut oil, humectant, carbomer, natural antioxidant, transdermal absorption promoter, carboxymethyl pachyman, guar gum and water; the structure of the transdermal absorption promoter is shown as a formula I:

as a further improvement of the invention, the invention is prepared from the following raw materials in parts by weight: 10-15 parts of protein peptide probiotics fermentation composition, 1-2 parts of lecithin, 2-5 parts of macadimia nut oil, 1-4 parts of humectant, 0.5-2 parts of carbomer, 1-2 parts of natural antioxidant, 1-2 parts of transdermal absorption promoter, 0.5-1 part of carboxymethyl pachyman, 0.1-1 part of guar gum and 40-60 parts of water.

As a further improvement of the invention, the humectant is at least one selected from butanediol, glycerol, hyaluronic acid, sodium hyaluronate and propylene glycol; the natural antioxidant is at least one selected from tea polysaccharide, vitamin C, vitamin E, tea polyphenols, catechin, anthocyanin and resveratrol.

As a further improvement of the present invention, the preparation method of the protein peptide probiotic fermented composition is as follows: uniformly mixing hexapeptide, octapeptide, oligopeptide and acetyl hexapeptide, inoculating activated bifidobacterium adolescentis and lactobacillus acidophilus strain seed liquid, fermenting, freeze-drying to obtain the protein peptide probiotic fermented composition.

As a further improvement of the invention, the mass ratio of the hexapeptide, the octapeptide, the oligopeptide and the acetyl hexapeptide is 3-5:1-2:2-4:5-7; the bacterial content in the seed liquid of the bifidobacterium adolescentis and the lactobacillus acidophilus is 10 ⁸ -10 ⁹ cfu/mL; the inoculum sizes of the bifidobacterium adolescentis and the lactobacillus acidophilus are respectively 2-3% and 1-2%; the fermentation temperature is 36-38 ℃ and the fermentation time is 24-36h.

As a further improvement of the present invention, the method for preparing the percutaneous absorption promoter comprises the following steps:

s1, mixing azepan-2-one, alkali and 3-bromo-1-propanol for reaction to obtain an intermediate A, wherein the structural formula is as follows:

s2, reacting the intermediate A with thionyl chloride to obtain an intermediate B, wherein the structural formula is as follows:

s3, reacting the intermediate B, alkali and diethylene glycol to obtain the transdermal absorption accelerator.

As a further improvement of the present invention, the ratio of the amounts of the substances azepan-2-one, base and 3-bromo-1-propanol in step S1 is 1:3-5:1.1-1.2; the alkali is at least one selected from NaOH, KOH, sodium carbonate, potassium carbonate, triethylamine and diethylamine; the ratio of the amount of the intermediate A to the amount of the thionyl chloride in the step S2 is 1:1.1-1.2; the reaction temperature is-5 to 0 ℃; the ratio of the amount of the intermediate B, the alkali and the diglycol in the step S3 is 2-2.1:5-7:1; the alkali is at least one selected from NaOH, KOH, sodium carbonate, potassium carbonate, triethylamine and diethylamine.

As a further improvement of the present invention, the preparation method of the percutaneous absorption promoter specifically comprises the following steps:

s1, adding 1mol of azepan-2-one and 3-5mol of alkali into 100mL of dichloromethane, stirring and mixing for 15-20min, then adding 1.1-1.2mol of 3-bromo-1 propanol, carrying out reflux stirring and reacting for 1-3h, filtering, washing and drying to obtain an intermediate A;

s2, dissolving 1mol of the intermediate A in 50mL of dichloromethane, cooling the system to-5 to 0 ℃, adding 1.1 to 1.2mol of thionyl chloride, stirring and reacting for 15 to 30min, filtering, washing and drying to obtain an intermediate B;

s3, adding 2-2.1mol of the intermediate B and 5-7mol of alkali into 150mL of dichloromethane, stirring and mixing for 15-30min, then adding 1mol of diethylene glycol, carrying out reflux reaction for 1-3h, filtering, washing, and recrystallizing to obtain the transdermal absorption accelerator.

The invention further provides a preparation method of the wrinkle-removing eye cream, which comprises the following steps:

(1) Dissolving the protein peptide probiotic fermented composition, a humectant and carboxymethyl pachyman in water to obtain a phase A;

(2) Mixing lecithin, macadamia nut oil, natural antioxidant, guar gum and transdermal absorption promoter, heating to 50-70deg.C, stirring and reacting for 30-50min to obtain phase B;

(3) Cooling phase B to room temperature, adding phase A and carbomer, emulsifying, stirring for 10-15min, and discharging to obtain the eye cream.

As a further improvement of the invention, the emulsifying condition is 12000-15000r/min for 3-5min; the stirring speed is 500-700r/min.

The invention has the following beneficial effects: the composition obtained by mixing and fermenting various protein peptides (including hexapeptide, octapeptide, oligopeptide and acetyl hexapeptide) in the protein peptide probiotic fermented composition not only generates a large amount of micromolecular amino acids, short peptides, lactic acid, short chain fatty acids and the like, but also can inhibit muscle contraction, prevent wrinkles from generating, promote cell proliferation regeneration and increase skin elasticity, effectively improve antioxidant effect, inhibit decomposition of skin collagen, prevent wrinkles from generating, remove generated dynamic lines, static lines and dry lines and radically solve the problem of skin wrinkles;

the invention prepares the efficient transdermal absorption promoter, combines two molecules of azone into one molecule of transdermal absorption promoter, and further, uses ether chains to connect two molecules of azone, thereby not only further improving the solubility of the transdermal absorption promoter and enabling the transdermal absorption promoter to better play the effect of transdermal absorption promotion, but also obviously enhancing the effect of the transdermal absorption promoter.

Detailed Description

The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Preparation example 1 preparation of transdermal absorption enhancer

The synthetic route is as follows:

the method comprises the following steps:

s1, adding 1mol of azepan-2-one and 3mol of KOH into 100mL of dichloromethane, stirring and mixing for 15min, then adding 1.1mol of 3-bromo-1 propanol, carrying out reflux stirring and reacting for 1h, filtering, washing and drying to obtain an intermediate A;

s2, dissolving 1mol of the intermediate A in 50mL of dichloromethane, cooling the system to-5 ℃, adding 1.1mol of thionyl chloride, stirring and reacting for 15min, filtering, washing and drying to obtain an intermediate B;

s3, adding 2mol of the intermediate B and 5mol of KOH into 150mL of dichloromethane, stirring and mixing for 15min, then adding 1mol of diethylene glycol, carrying out reflux reaction for 1-3h, filtering, washing, and recrystallizing to obtain the transdermal absorption accelerator.

Preparation example 2 preparation of transdermal absorption enhancer

The method comprises the following steps:

s1, adding 1mol of azepan-2-one and 5mol of triethylamine into 100mL of dichloromethane, stirring and mixing for 20min, then adding 1.2mol of 3-bromo-1 propanol, carrying out reflux stirring and reacting for 3h, filtering, washing and drying to obtain an intermediate A;

s2, dissolving 1mol of the intermediate A in 50mL of dichloromethane, cooling the system to 0 ℃, adding 1.2mol of thionyl chloride, stirring and reacting for 30min, filtering, washing and drying to obtain an intermediate B;

s3, adding 2.1mol of the intermediate B and 7mol of triethylamine into 150mL of dichloromethane, stirring and mixing for 30min, then adding 1mol of diethylene glycol, carrying out reflux reaction for 3h, filtering, washing and recrystallizing to obtain the transdermal absorption accelerator.

PREPARATION EXAMPLE 3 preparation of transdermal absorption enhancer

The method comprises the following steps:

s1, adding 1mol of azepan-2-one and 4mol of NaOH into 100mL of dichloromethane, stirring and mixing for 17min, then adding 1.15mol of 3-bromo-1 propanol, carrying out reflux stirring and reacting for 2h, filtering, washing and drying to obtain an intermediate A;

s2, dissolving 1mol of the intermediate A in 50mL of dichloromethane, cooling the system to-2 ℃, adding 1.15mol of thionyl chloride, stirring and reacting for 20min, filtering, washing and drying to obtain an intermediate B;

s3, adding 2.05mol of the intermediate B and 6mol of NaOH into 150mL of dichloromethane, stirring and mixing for 20min, then adding 1mol of diethylene glycol, carrying out reflux reaction for 2h, filtering, washing, and recrystallizing to obtain the transdermal absorption accelerator.

Preparation example 4 preparation of protein peptide probiotic fermented composition

The method comprises the following steps: uniformly mixing 3 parts by weight of hexapeptide, 1 part by weight of octapeptide, 2 parts by weight of oligopeptide and 5 parts by weight of acetyl hexapeptide, inoculating activated bifidobacterium adolescentis and lactobacillus acidophilus strain seed liquid, wherein the bacterial content is 10 ⁸ cfu/mL, inoculum size is 2% and 1% respectively, fermenting at 36 ℃ for 24 hours, and freeze drying to obtain the protein peptide probiotic fermented composition.

Preparation example 5 preparation of protein peptide probiotic fermented composition

The method comprises the following steps: uniformly mixing 5 parts by weight of hexapeptide, 2 parts by weight of octapeptide, 4 parts by weight of oligopeptide and 7 parts by weight of acetyl hexapeptide, inoculating activated bifidobacterium adolescentis and lactobacillus acidophilus strain seed liquid, wherein the bacterial content is 10 ⁹ cfu/mL, inoculum size is 3% and 2% respectively, fermenting at 38deg.C for 36h, and freeze drying to obtain protein peptide probiotic fermented composition.

Preparation example 6 preparation of protein peptide probiotic fermented composition

The method comprises the following steps: uniformly mixing 4 parts by weight of hexapeptide, 1.5 parts by weight of octapeptide, 3 parts by weight of oligopeptide and 6 parts by weight of acetyl hexapeptide, inoculating activated bifidobacterium adolescentis and lactobacillus acidophilus strain seed liquid, wherein the bacterial content is 10 ⁸ cfu/mL, inoculum size is 2.5% and 1.5% respectively, fermenting at 37deg.C for 30h, and freeze drying to obtain protein peptide probiotic fermented composition.

Example 1

The raw materials comprise the following components in parts by weight: 10 parts of the protein peptide probiotic fermented composition prepared in preparation example 4, 1 part of lecithin, 2 parts of macadamia nut oil, 1 part of butanediol, 0.5 part of carbomer, 1 part of anthocyanin, 1 part of transdermal absorption promoter prepared in preparation example 1, 0.5 part of carboxymethyl pachyman, 0.1 part of guar gum and 40 parts of water.

The method comprises the following steps:

(1) Dissolving a protein peptide probiotic fermented composition, butanediol and carboxymethyl pachymaran in water to obtain a phase A;

(2) Mixing lecithin, macadamia nut oil, anthocyanin, guar gum and a percutaneous absorption promoter, heating to 50 ℃, and stirring and reacting for 30min at 500r/min to obtain a phase B;

(3) Cooling phase B to room temperature, adding phase A and carbomer, emulsifying for 3min at 12000r/min, stirring for 10-15min at 500r/min, and discharging to obtain wrinkle removing eye cream.

Example 2

The raw materials comprise the following components in parts by weight: 15 parts of the protein peptide probiotic fermented composition prepared in preparation example 5, 2 parts of lecithin, 5 parts of macadamia nut oil, 4 parts of propylene glycol, 2 parts of carbomer, 2 parts of resveratrol, 2 parts of the transdermal absorption promoter prepared in preparation example 2, 1 part of carboxymethyl pachyman, 1 part of guar gum and 60 parts of water.

The method comprises the following steps:

(1) Dissolving a protein peptide probiotic fermented composition, propylene glycol and carboxymethyl pachyman in water to obtain a phase A;

(2) Mixing lecithin, macadamia nut oil, resveratrol, guar gum and a percutaneous absorption promoter, heating to 70 ℃, and stirring and reacting for 50min at 700r/min to obtain a phase B;

(3) Cooling the phase B to room temperature, adding the phase A and carbomer, emulsifying for 5min at 15000r/min, stirring for 15min at 700r/min, and discharging to obtain the wrinkle-removing eye cream.

Example 3

The raw materials comprise the following components in parts by weight: 12 parts of the protein peptide probiotic fermented composition prepared in preparation example 6, 1.5 parts of lecithin, 3.5 parts of macadamia nut oil, 2 parts of sodium hyaluronate, 1 part of carbomer, 1.5 parts of vitamin E, 1.5 parts of the transdermal absorption enhancer prepared in preparation example 3, 0.7 part of carboxymethyl pachyman, 0.5 part of guar gum and 50 parts of water.

The method comprises the following steps:

(1) Dissolving the protein peptide probiotic fermented composition, sodium hyaluronate and carboxymethyl pachyman in water to obtain phase A;

(2) Mixing lecithin, macadamia nut oil, vitamin E, guar gum and a percutaneous absorption promoter, heating to 60 ℃, and stirring and reacting for 40min at 600r/min to obtain a phase B;

(3) Cooling phase B to room temperature, adding phase A and carbomer, emulsifying for 4min at 13500r/min, stirring for 12min at 600r/min, and discharging to obtain wrinkle removing eye cream.

Comparative example 1

In comparison with example 3, the transdermal absorption enhancer prepared in preparation 3 was replaced with laurocapram, and the other conditions were not changed.

Comparative example 2

Compared with example 3, the protein peptide probiotic fermented composition prepared in preparation example 6 was replaced by the same amount of hexapeptide, and the other conditions were not changed.

Test example 1 human skin patch test

Test article: wrinkle-removing eye creams prepared in examples 1 to 3 and comparative examples 1 to 2.

Negative control: deionized water.

The subject: 30 people, 0 man and 30 woman, with ages of 35-42, meet the volunteer selection standard of the subjects.

The patch method comprises the following steps: selecting a qualified patch tester, dripping about 0.020mL-0.025mL (semi-fluid) of a test object and a negative control into the patch tester by a closed patch test method, applying a special adhesive tape for external use on the back of a subject, taking 6 pieces of skin, 1 piece of skin coated with the negative control, the remaining 5 pieces of skin coated with the wrinkle-removing eye cream prepared in examples 1-3 and comparative examples 1-2 respectively, removing the test object after 24 hours, observing skin reaction after 0.5, 24 and 48 hours respectively, and recording the results according to the skin reaction grading standard in cosmetic health Specification (2007 edition).

The skin patch test results show that skin adverse reactions occur in 0 cases of all people; the wrinkle-removing eye cream prepared by the invention is safe to use.

Test example 2 type iii collagen synthesis acceleration rate:

the content of terminal peptide (P III P) of type III collagen secreted in the supernatant was determined by using "RIA-gnost P III P (P III P) assay kit". These samples were evaluated for the anti-wrinkle effect by the rate of promotion of III-type collagen synthesis.

Human fibroblasts cultured in DMEM medium containing 10% fbs were inoculated into 24-well plates, respectively, and after cell attachment, medium exchange was performed with DMEM medium containing 0.3% fbs and 250 μmol magnesium ascorbyl phosphate, and 2 μg of wrinkle-removing eye creams prepared in examples 1 to 3 and comparative examples 1 to 2 were added, respectively. After three days of culture, the culture was centrifuged, and the supernatant was collected, and the content of type III collagen in the supernatant was measured to calculate the acceleration rate.

The calculation formula is as follows:

promotion rate= (W) ₁ -W ₀ )/W ₀ *100％

W ₁ III type collagen production amount after test sample addition

W ₀ III type collagen production amount without test sample added

The results are shown in Table 1.

TABLE 1

As can be seen from the above table, the wrinkle-removing eye cream prepared in the embodiments 1-3 of the present invention can promote secretion of III type collagen by cells, can obviously increase III type collagen production, thicken extracellular matrix, and further realize anti-wrinkle effect.

Test example 3

100 testers, 35-56 years old, were randomly selected and divided into 5 groups of 20. Five measurements were averaged using a dermal elastometer mpa580 host with the probe being a reviscemeter RV600 elasto-fibrous tissue test probe. The test area is the periocular skin. Blank values were measured 30min after cleaning of the test area, and subjects were then prescribed to adhere to the wrinkle-removing eye cream prepared in examples 1 to 3 or comparative examples 1 to 2 at 8 early and 8 late daily, and the skin elasticity index R values (negative pressure constant 450mbar during the test) were measured for the test areas for 0 week and 4 weeks, respectively, with R approaching 1 and skin elasticity being better.

R＝U ₁ /U ₂

U ₁ To cancel the negative pressure for 0.1 seconds, the recovery value and the viscoelasticity fraction value, or the plasticity fraction value, of the skin;

U ₂ the stretching amount of the elastic portion was positioned at the stretching amount of the skin at 0.1 seconds after the constant negative pressure was applied to the skin.

The results are shown in Table 2.

TABLE 2

From the above table, the R value of the wrinkle-removing eye cream prepared in the embodiments 1 to 3 of the present invention can reach 0.7279 after the subject uses the eye cream for 4 weeks, and the skin elasticity index of the subject is greatly improved, so that the wrinkle-removing eye cream of the present invention has the effects of increasing skin elasticity and resisting aging.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.

Claims

1. The wrinkle-removing eye cream is characterized by being prepared from the following raw materials in parts by weight: 10-15 parts of protein peptide probiotics fermentation composition, 1-2 parts of lecithin, 2-5 parts of macadimia nut oil, 1-4 parts of humectant, 0.5-2 parts of carbomer, 1-2 parts of natural antioxidant, 1-2 parts of transdermal absorption promoter, 0.5-1 part of carboxymethyl pachyman, 0.1-1 part of guar gum and 40-60 parts of water; the structure of the transdermal absorption promoter is shown as a formula I:

2. the wrinkle-removing eye cream according to claim 1, wherein the humectant is at least one selected from the group consisting of butylene glycol, glycerin, hyaluronic acid, sodium hyaluronate, propylene glycol; the natural antioxidant is at least one selected from tea polysaccharide, vitamin C, vitamin E, tea polyphenols, catechin, anthocyanin and resveratrol.

3. The wrinkle-removing eye cream according to claim 1, wherein the preparation method of the protein peptide probiotic fermented composition is as follows: uniformly mixing hexapeptide, octapeptide, oligopeptide and acetyl hexapeptide, inoculating activated bifidobacterium adolescentis and lactobacillus acidophilus strain seed liquid, fermenting, freeze-drying to obtain the protein peptide probiotic fermented composition.

4. The wrinkle-removing eye cream according to claim 3, wherein the mass ratio of the hexapeptide, the octapeptide, the oligopeptide and the acetyl hexapeptide is 3-5:1-2:2-4:5-7; the bacterial content in the seed liquid of the bifidobacterium adolescentis and the lactobacillus acidophilus is 10 ⁸ -10 ⁹ cfu/mL; the inoculum sizes of the bifidobacterium adolescentis and the lactobacillus acidophilus are respectively 2-3% and 1-2%; the fermentation temperature is 36-38 ℃ and the fermentation time is 24-36h.

5. The wrinkle-removing eye cream according to claim 1, wherein the transdermal absorption enhancer is prepared by the following method:

6. The wrinkle-removing eye cream according to claim 5, wherein the ratio of the amounts of the azepan-2-one, the base and the 3-bromo-1-propanol in step S1 is 1:3-5:1.1-1.2; the alkali is at least one selected from NaOH, KOH, sodium carbonate, potassium carbonate, triethylamine and diethylamine; the ratio of the amount of the intermediate A to the amount of the thionyl chloride in the step S2 is 1:1.1-1.2; the reaction temperature is-5 to 0 ℃; the ratio of the amount of the intermediate B, the alkali and the diglycol in the step S3 is 2-2.1:5-7:1; the alkali is at least one selected from NaOH, KOH, sodium carbonate, potassium carbonate, triethylamine and diethylamine.

7. The wrinkle-removing eye cream according to claim 5, wherein the transdermal absorption promoter is prepared by the following steps:

8. A method of preparing a wrinkle-removing eye cream according to any one of claims 1-7, comprising the steps of:

9. The method according to claim 8, wherein the conditions for emulsification are 12000-15000r/min for 3-5min; the stirring speed is 500-700r/min.