CN115279210A - 活力膳食补充剂 - Google Patents
活力膳食补充剂 Download PDFInfo
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- CN115279210A CN115279210A CN202180021926.7A CN202180021926A CN115279210A CN 115279210 A CN115279210 A CN 115279210A CN 202180021926 A CN202180021926 A CN 202180021926A CN 115279210 A CN115279210 A CN 115279210A
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Abstract
本发明涉及通过改善或增加免疫细胞的功能，促进充分的水合，并且提供免疫系统需要功能的必需营养物和氨基酸来改善免疫功能。本发明的补充剂组合物包含：胶原蛋白肽、l‑谷氨酰胺、l‑精氨酸、面包酵母β葡聚糖、l‑色氨酸、加热灭活的植物乳杆菌、维生素和矿物质。使用这种组分的组合改善免疫系统功能。
Description
技术领域
本发明涉及通过改善或增加免疫细胞的功能，促进充分的水合，并且提供免疫系统需要功能的必需营养物和氨基酸来改善免疫功能。本发明的补充剂组合物包含：胶原蛋白肽、l-谷氨酰胺、l-精氨酸、面包酵母β葡聚糖、l-色氨酸、加热灭活的植物乳杆菌、维生素和矿物质。使用这种组分的组合改善免疫系统功能。
背景技术
每天，数千人死于常见的感冒、流感或其它传染性疾病，诸如冠状病毒疾病(COVID)。许多人选择用功能性食品或膳食补充剂补充其饮食，以帮助加强他们的免疫系统，并将其自身放在更好的位置以防治这些疾病。胶囊、片剂、营养饮料或饮料粉末混合物的摄入是一种优选的方法，以帮助促进这些免疫支持功能，通过每天或在症状发作之前和期间即刻进行。
虽然适当的营养、睡眠和实践良好的卫生诸如洗涤手部或避免人流量高度拥挤的区域是支持免疫系统和避免传染性疾病的防御的前线，但某些可摄入膳食补充剂和成分具有增强和改善免疫系统功能的潜力，并且为身体提供抵抗疾病所需的支持。这些参数可以包括改善或增加免疫细胞的功能，促进充分的水合，并且供应免疫系统需要功能的必需营养物和氨基酸。
研究已表明，若干膳食补充剂成分具有支持这些免疫功能的固有特性，包括：钠、钾、镁、维生素C、维生素D、锌、胶原蛋白、l-谷氨酰胺、l-精氨酸、l-色氨酸、
面包酵母β葡聚糖、Immuno-
(加热灭活的植物乳杆菌L-137)。
仍然需要通过提供必需维生素和矿物质、氨基酸和免疫增强特异性成分来改善免疫功能。本发明解决了这种缺陷并增强这些成分的摄取并有助于支持免疫功能。
发明内容
本发明涉及一种膳食补充剂组合物，其包含胶原蛋白肽、l-谷氨酰胺、l-精氨酸、面包酵母β葡聚糖、l-色氨酸、加热灭活的植物乳杆菌、维生素和矿物质。
在一个实施方案中，胶原蛋白肽以组合物的约7重量％至69重量％的量存在，l-谷氨酰胺以组合物的约3重量％至约31重量％的量存在，l-精氨酸以组合物的约0.7重量％至约8重量％的量存在，面包酵母β葡聚糖以组合物的约0.3重量％至约4重量％的量存在，l-色氨酸以组合物的约0.1重量％至约0.8重量％的量存在，并且加热灭活的植物乳杆菌L-137以组合物的约0.1重量％至约0.8重量％的量存在。
本发明的组合物旨在支持和增强免疫系统功能。
具体实施方式
本发明涉及一种膳食补充剂组合物，其可以作为补充剂消耗以支持和增强免疫系统功能。
本发明的组合物包含胶原蛋白(优选地呈水解胶原蛋白肽的形式)与l-谷氨酰胺、l-精氨酸、面包酵母β葡聚糖、l-色氨酸、加热灭活的植物乳杆菌、任选地附加的维生素和矿物质的组合。
该组合物可以液体、溶液、悬浮液、粉末或凝胶的形式施用。如果为粉末形式，则粉末如所指导的那样在施用之前在可溶性液体中混合。
胶原蛋白以组合物的约7重量％至69重量％、组合物的约20重量％至54重量％、或组合物的约27重量％至46重量％的量存在于组合物中。另选地，胶原蛋白可以以约1克/份至9克/份、约3克/份至7克/份或约4克/份至6克/份的量存在于组合物中。在一个优选的实施方案中，胶原蛋白可以约5克/份的量存在于组合物中。胶原蛋白是蛋白质并且可以任何可用的形式存在于组合物中。然而，本发明优选地使用胶原蛋白肽。胶原蛋白肽可源自任何已知的来源，包括但不限于牛肉、鸡肉、鱼肉、蛋壳膜和鸡蛋白。
L-谷氨酰胺以约0.5g/份至4.0g/份、约1g/份至3g/份、约1.5g/份至2.5g/份或约2g/份的量存在于组合物中。另选地，L-谷氨酰胺可以以约3重量％至31重量％、约7重量％至23重量％、或约10重量％至19重量％的量存在于组合物中。
L-精氨酸也以约0.1g/份至1g/份、约0.25g/份至0.75g/份、约0.4g/份至0.6g/份或约0.5g/份的量存在于组合物中。另选地，L-精氨酸可以以约0.7重量％至8重量％、约2重量％至6重量％、或约3重量％至5重量％的量存在于组合物中。
面包酵母β葡聚糖也以约0.05g/份至0.5g/份、约0.15g/份至0.4g/份、约0.2g/份至0.3g/份或约0.25g/份的量存在于组合物中。另选地，面包酵母β葡聚糖可以以约0.3重量％至4.0重量％、约1重量％至3.1重量％、或约1.3重量％至2重量％的量存在于组合物中。在一个优选的实施方案中，使用
面包酵母β葡聚糖。
L-色氨酸也以约0.01g/份至0.1g/份、约0.025g/份至0.075g/份、约0.04g/份至0.06g/份或约0.05g/份的量存在于组合物中。另选地，l-色氨酸可以以约0.1重量％至0.8重量％、约0.2重量％至0.6重量％、或约0.3重量％至0.5重量％的量存在于组合物中。
加热灭活的植物乳杆菌L-137也以约0.01g/份至0.1g/份、约0.025g/份至0.075g/份、约0.04g/份至0.06g/份或约0.05g/份的量存在于组合物中。另选地，加热灭活的植物乳杆菌L-137可以以约0.1重量％至0.8重量％、约0.2重量％至0.6重量％、或约0.3重量％至0.5重量％的量存在于组合物中。在一个优选的实施方案中，使用Immuno-
(加热灭活的植物乳杆菌L-137)。
组合物中可使用附加营养物质，包括电解质、维生素、矿物质和其他膳食补充剂。合适的电解质矿物质包括但不限于钙、钠、钾、镁、钙、碳酸氢盐、氯化物、锌和磷酸盐。电解质矿物质的总量可以组合物的约7重量％至39重量％、组合物的约10重量％至23重量％或约15重量％至21重量％的量添加到组合物中。另选地，总电解质可以以约1克/份至5克/份、约1.5克/份至3克/份或约2.25克/份至2.75克/份的范围存在。
钠可以以任何形式存在，诸如海盐、碘化盐、碳酸氢钠或喜马拉雅粉红海盐，其量为总组合物约0.2克/份至1克/份或0.3克/份至0.7克/份，或约1.3重量％至8重量％或约2重量％至6重量％。
钾可以任何合适的形式存在，诸如柠檬酸钾、氯化钾、山梨酸钾等。钾可以以总组合物的约0.1克/份至2克/份或约0.2克/份至1克/份，或约0.7重量％至15重量％或约1.3重量％至8重量％的量存在。
镁可以以任何合适的形式存在，诸如柠檬酸镁、氧化镁、赖氨酸-甘氨酸镁螯合物或苹果酸镁。镁可以以总组合物的约0.01克/份至0.2克/份或约0.02克/份至0.1克/份，或约0.1重量％至1.5重量％或约0.1重量％至0.8重量％的量存在。
锌可以任何合适的形式存在，诸如硫酸锌或柠檬酸锌。锌可以以总组合物的约0.01克/份至0.2克/份或约0.01克/份至0.1克/份，或约0.1重量％至1.5重量％或约0.1重量％至0.8重量％的量存在。
还可向组合物中添加维生素。适于以膳食补充剂摄取的任何维生素均是适用的。合适的维生素包括但不限于维生素B，包括维生素B1(例如，作为氯化硫胺素)、维生素B2(例如，作为核黄素)、维生素B3(例如，烟酰胺)、维生素B6(例如，作为盐酸吡哆醇)、维生素B5(例如，作为泛酸或D-泛酸钙)、维生素B12(氰钴胺)、叶酸盐(例如，作为叶酸)、维生素C(例如，作为抗坏血酸钠)、维生素D、维生素E等。在本发明的上下文中，所述维生素中的每一种维生素可以以总组合物的约0.01克/份至2克/份、约0.5克/份至1.5克/份、约0.75克/份至1.25克/份、或约0.001重量％至15.4重量％、约3重量％至12重量％、或约5重量％至10重量％的量独立地存在于组合物中。
此外，可使用任何已知的天然风味剂对组合物进行调味，以增强组合物的风味。另选地，适用于膳食补充剂的其它添加剂，包括但不限于僧侣果提取物、喜马拉雅粉红海盐、果蔬汁粉、β-胡萝卜素、柠檬酸和苹果酸。
根据本发明，合适的组合物包括但不限于表1中所述的那些。
表1
**每日值未建立
在本发明的一个实施方案中，补充剂的热量摄取为每份小于约100卡路里、小于约75卡路里、或约30卡路里。另外，组合物中碳水化合物和总糖的量有利地较低。例如，碳水化合物可以以小于10克/份、小于7克/份、小于5克/份、约2克/份或约1克/份的量存在。类似地，总糖有利地保持较少，例如小于6克/份、小于5克/份、或约0克/份。如上所述，呈胶原蛋白或胶原蛋白肽的形式的蛋白质的含量较高，优选地高于2克/份，高于4克/份，或约5克/份。
实施例1
制备表1中描绘的配方的组合物。
Claims (20)
1.膳食补充剂组合物，所述膳食补充剂组合物包含：所述组合物的约7重量％至69重量％的量的胶原蛋白，所述组合物的约3重量％至31重量％的量的l-谷氨酰胺，所述组合物的约0.7重量％至8重量％的量的l-精氨酸，所述组合物的约0.3重量％至4.0重量％的量的面包酵母β葡聚糖，所述组合物的约0.1重量％至0.8重量％的量的l-色氨酸，以及所述组合物的约0.1重量％至0.8重量％的量的加热灭活的植物乳杆菌L-137。
2.根据权利要求1所述的膳食补充剂组合物，其中所述胶原蛋白以水解的胶原蛋白肽的形式存在。
3.根据权利要求1或2所述的膳食补充剂组合物，其中所述组合物还包含电解质矿物质，并且其中电解质矿物质的总量以总组合物的约7重量％至39重量％的量存在。
4.根据权利要求1或2所述的膳食补充剂组合物，其中所述组合物还包含适合在膳食补充剂中摄取的维生素，并且其中每种此类维生素以所述总组合物的约0.001重量％至15.4重量％的量存在。
5.根据权利要求1至4中任一项所述的膳食补充剂组合物，其中所述组合物是粉末。
6.根据权利要求1至4中任一项所述的膳食补充剂组合物，其中所述组合物是液体。
7.根据权利要求1所述的膳食补充剂组合物，其中胶原蛋白以所述组合物的约20重量％至54重量％的量存在，l-谷氨酰胺以所述组合物的约7重量％至23重量％的量存在，l-精氨酸以所述组合物的约2重量％至6重量％的量存在，面包酵母β葡聚糖以所述组合物的约1重量％至3.1重量％的量存在，l-色氨酸以所述组合物的约0.2重量％至0.6重量％的量存在，并且加热灭活的植物乳杆菌L-137以所述组合物的约0.2重量％至0.6重量％的量存在。
8.根据权利要求7所述的膳食补充剂组合物，其中所述胶原蛋白以水解的胶原蛋白肽的形式存在。
9.根据权利要求7或8所述的膳食补充剂组合物，其中所述组合物还包含电解质矿物质，并且其中电解质矿物质的总量以所述总组合物的约10重量％至23重量％的量存在。
10.根据权利要求7或8所述的膳食补充剂组合物，其中所述组合物还包含适合在膳食补充剂中摄取的维生素，并且其中每种此类维生素以所述总组合物的约3重量％至12重量％的量存在。
11.根据权利要求7至10中任一项所述的膳食补充剂组合物，其中所述组合物是粉末。
12.根据权利要求7至10中任一项所述的膳食补充剂组合物，其中所述组合物是液体。
13.根据权利要求1所述的膳食补充剂组合物，其中胶原蛋白以所述组合物的约27重量％至46重量％的量存在，l-谷氨酰胺以所述组合物的约10重量％至19重量％的量存在，l-精氨酸以所述组合物的约3重量％至5重量％的量存在，面包酵母β葡聚糖以所述组合物的约1.3重量％至2重量％的量存在，l-色氨酸以所述组合物的约0.3重量％至0.5重量％的量存在，并且(加热灭活的植物乳杆菌L-137)以所述组合物的约0.3重量％至0.5重量％的量存在。
14.根据权利要求13所述的膳食补充剂组合物，其中所述胶原蛋白以水解的胶原蛋白肽的形式存在。
15.根据权利要求13或14所述的膳食补充剂组合物，其中所述组合物还包含电解质矿物质，并且其中电解质矿物质的总量以所述总组合物的约15重量％至21重量％的量存在。
16.根据权利要求13或14所述的膳食补充剂组合物，其中所述组合物还包含适合在膳食补充剂中摄取的维生素，并且其中每种此类维生素以所述总组合物的约5重量％至10重量％的量存在。
17.根据权利要求13至16中任一项所述的膳食补充剂组合物，其中所述组合物是粉末。
18.根据权利要求13至16中任一项所述的膳食补充剂组合物，其中所述组合物是液体。
19.膳食补充剂组合物，所述膳食补充剂组合物包含以下成分：
**每日值未建立
20.改善免疫系统功能的方法，所述方法包括向对其有需要的患者施用根据权利要求1至19中任一项所述的组合物。
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| CN101720935A (zh) * | 2008-10-16 | 2010-06-09 | 好侍健康食品株式会社 | 包含乳酸菌的免疫刺激组合物 |
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| CN109221864A (zh) * | 2018-08-28 | 2019-01-18 | 杭州千岛湖标普健康食品有限公司 | 一种增强人体免疫力的多成分复合的功能性固体饮料及其制备方法 |
| CN110468175A (zh) * | 2019-08-22 | 2019-11-19 | 赵秋萍 | 一种复合植物肽粉及其制备方法和用途 |
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| JP3287842B2 (ja) * | 1989-12-29 | 2002-06-04 | ビー ブラウン メディカル インコーポレイテッド | 免疫刺激剤としてのアルギニンの用途 |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10221403A1 (de) * | 2002-05-14 | 2003-12-04 | Kyberg Pharma Vertriebs Gmbh & | Diätetische und pharmazeutische Zusammensetzungen, ihre Herstellung und ihre Verwendung |
| CN101720935A (zh) * | 2008-10-16 | 2010-06-09 | 好侍健康食品株式会社 | 包含乳酸菌的免疫刺激组合物 |
| CN102228176A (zh) * | 2011-05-19 | 2011-11-02 | 北京康比特体育科技股份有限公司 | 一种用于增强免疫力的组合物及其制备方法 |
| CN108853486A (zh) * | 2018-05-04 | 2018-11-23 | 湖北和格复合骨胶原生物科技有限公司 | 一种具有增强免疫力功能的配方产品 |
| CN108785660A (zh) * | 2018-06-21 | 2018-11-13 | 石丰 | 一种具有提高免疫力作用的牛骨胶原蛋白肽及其制备方法 |
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| CN110468175A (zh) * | 2019-08-22 | 2019-11-19 | 赵秋萍 | 一种复合植物肽粉及其制备方法和用途 |
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| AU2021253451A1 (en) | 2022-09-08 |
| US20230157344A1 (en) | 2023-05-25 |
| BR112022017285A2 (pt) | 2022-11-29 |
| JP2023519530A (ja) | 2023-05-11 |
| WO2021204644A1 (en) | 2021-10-14 |
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| EP4132299A1 (en) | 2023-02-15 |
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