CN115141279B - 抗b7-h3的单克隆抗体及其在细胞治疗中的应用 - Google Patents
抗b7-h3的单克隆抗体及其在细胞治疗中的应用Info
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- CN115141279B CN115141279B CN202210708261.3A CN202210708261A CN115141279B CN 115141279 B CN115141279 B CN 115141279B CN 202210708261 A CN202210708261 A CN 202210708261A CN 115141279 B CN115141279 B CN 115141279B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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| WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
| CN113527487A (zh) * | 2020-04-22 | 2021-10-22 | 复星凯特生物科技有限公司 | 抗人b7-h3的单克隆抗体及其应用 |
| CN113754766A (zh) * | 2020-06-02 | 2021-12-07 | 明慧医药(上海)有限公司 | 抗b7-h3抗体及其制备和应用 |
| CN112877346B (zh) * | 2020-08-12 | 2023-01-03 | 山东兴瑞生物科技有限公司 | 抗b7-h3嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用 |
| CA3196549A1 (en) * | 2020-11-04 | 2022-05-12 | Bahram Valamehr | Engineered ipsc and immune effector cells for heterogenous tumor control |
| CN113667021B (zh) * | 2020-12-14 | 2022-03-29 | 广州百暨基因科技有限公司 | 靶向b7h3的嵌合抗原受体及其应用 |
| CN114763388B (zh) * | 2021-01-13 | 2024-12-17 | 博生吉医药科技(苏州)有限公司 | 靶向b7-h3的car-t细胞及其在急性髓系白血病治疗中的应用 |
| CN114763381B (zh) * | 2021-01-13 | 2025-01-28 | 博生吉医药科技(苏州)有限公司 | B7-h3嵌合抗原受体修饰的t细胞及其应用 |
| CN114763382B (zh) * | 2021-01-13 | 2024-12-17 | 博生吉医药科技(苏州)有限公司 | 靶向人cd276的单克隆抗体及其应用 |
| WO2023272924A1 (zh) * | 2021-06-30 | 2023-01-05 | 徐州医科大学 | 新型全人源抗人b7h3抗体和嵌合抗原受体及其用途 |
| CN113462651B (zh) * | 2021-06-30 | 2022-03-01 | 徐州医科大学 | 一种b7h3特异性抗性的car-nk细胞 |
| JP2024534661A (ja) * | 2021-09-30 | 2024-09-20 | バイオ-テラ ソリュ-ションズ,エルティーディー. | 抗b7-h3抗体及びその応用 |
| CN114081941A (zh) * | 2021-11-19 | 2022-02-25 | 上海奢旭企业管理中心(有限合伙) | B7-h4蛋白的制备方法及其制备抗过度免疫反应或抗细胞因子风暴的药品中的应用 |
| CN114380910B (zh) * | 2022-01-07 | 2023-04-28 | 苏州旭光科星抗体生物科技有限公司 | 靶向人b7-h3分子的人源化单克隆抗体及其应用 |
| CN114957484A (zh) * | 2022-04-30 | 2022-08-30 | 上海怡豪医疗科技有限公司 | 靶向实体肿瘤细胞b7-h3蛋白的car载体、car-t细胞及其构建方法和应用 |
| GB202209786D0 (en) * | 2022-07-04 | 2022-08-17 | Ucl Business Ltd | B7H3 Binders |
| CN119654342B (zh) * | 2022-07-28 | 2025-07-18 | 乐普创一生物科技(上海)有限公司 | 抗MerTK抗体及其用途 |
| CN116239699B (zh) * | 2022-11-10 | 2023-11-17 | 汕头普罗凯融生物医药科技有限公司 | 一种靶向cd276的嵌合抗原受体及其应用 |
| GB202217541D0 (en) * | 2022-11-24 | 2023-01-11 | Quell Therapeutics Ltd | Recombinant receptor |
| CN116284425B (zh) * | 2023-05-12 | 2023-07-21 | 北京纳百生物科技有限公司 | 一种抗壬基酚聚氧乙烯醚的单克隆抗体、试剂盒及应用 |
| CN117025541B (zh) * | 2023-08-15 | 2025-10-17 | 福建医科大学附属协和医院 | 一种靶向b7-h3并共表达细胞因子和趋化因子的car-t细胞及其用途 |
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| CN102892426A (zh) * | 2010-03-04 | 2013-01-23 | 宏观基因有限公司 | 与b7-h3反应性的抗体、其免疫学活性片段及其用途 |
| CN103687945A (zh) * | 2011-04-25 | 2014-03-26 | 第一三共株式会社 | 抗-b7-h3抗体 |
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| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| CN101578296A (zh) * | 2006-11-15 | 2009-11-11 | 梅达雷克斯公司 | 结合btla的人类单克隆抗体及使用方法 |
| CN101607985B (zh) * | 2008-12-24 | 2013-03-27 | 中国科学院生物物理研究所 | 抗人cea的单克隆抗体,包含其的组合物,及其用途 |
| RU2017102769A (ru) * | 2014-07-29 | 2018-08-28 | Пфайзер Инк. | EGFRvIII СПЕЦИФИЧЕСКИЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ ИММУНОТЕРАПИИ РАКА |
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| CN107034193B (zh) * | 2016-02-03 | 2020-06-05 | 北京马力喏生物科技有限公司 | 治疗b细胞白血病及b细胞淋巴瘤的治疗组合物 |
| JP6432121B2 (ja) * | 2016-03-04 | 2018-12-05 | シチュアン ケルン−バイオテック バイオファーマシューティカル カンパニー リミテッド | Pdl−1抗体、その医薬組成物及びその使用 |
| EP3442574A4 (en) * | 2016-04-15 | 2019-12-11 | MacroGenics, Inc. | Novel B7-H3 binding MOLECULES, ANTIBODY-ACTIVE CONJUGATES AND METHOD OF USE THEREOF |
| WO2017214339A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| CN109963870B (zh) * | 2016-06-08 | 2023-07-28 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
| CA3027044A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| IL271009B2 (en) * | 2017-06-05 | 2025-10-01 | Janssen Biotech Inc | Antibodies that specifically bind PD-1 and methods of use |
| CN107488230B (zh) * | 2017-09-01 | 2019-01-18 | 浙江大学 | 一种抗人CD79a胞外端蛋白的抗体、编码基因及应用 |
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| CN102892426A (zh) * | 2010-03-04 | 2013-01-23 | 宏观基因有限公司 | 与b7-h3反应性的抗体、其免疫学活性片段及其用途 |
| CN103687945A (zh) * | 2011-04-25 | 2014-03-26 | 第一三共株式会社 | 抗-b7-h3抗体 |
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