CN115119847B - Chelidonine wettable powder and preparation method and application thereof - Google Patents
Chelidonine wettable powder and preparation method and application thereof Download PDFInfo
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- CN115119847B CN115119847B CN202210741435.6A CN202210741435A CN115119847B CN 115119847 B CN115119847 B CN 115119847B CN 202210741435 A CN202210741435 A CN 202210741435A CN 115119847 B CN115119847 B CN 115119847B
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- chelerythrine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A chelerythrine wettable powder and a preparation method and application thereof belong to the technical field of biological pesticides. In order to obtain wettable powder capable of being used for preventing and treating false smut of rice, the invention provides chelerythrine wettable powder, which takes chelerythrine as a raw material, TAMOLDN, ultrazineNA and AtloxMetasese 550S as dispersing agents, GERONONSSDS as wetting agents, white carbon black HL-200 and anhydrous glucose as fillers, and AguiqueSoapL as a defoaming agent. The preparation method of the chelerythrine wettable powder is simple, and the chelerythrine wettable powder can be diluted and then sprayed on rice to effectively prevent and treat false smut of the rice.
Description
Technical Field
The invention belongs to the technical field of biological pesticides, and particularly relates to chelerythrine wettable powder and a preparation method and application thereof.
Background
At present, the main method for controlling plant diseases is still chemical method control, but chemical pesticides have various problems of difficult degradation, easy drug resistance, environmental pollution and the like, which bring great threat to human health and ecological environment, and the problem of drug resistance also brings great difficulty to subsequent pest control. Chelerythrine has important biological activities such as anticancer, bacteriostasis, disinsection, antioxidation and the like, can effectively prevent and treat diseases such as fusarium wilt, anthracnose, gray mold pathogen and the like of crops in agricultural production, but is not applied to preventing and treating false smut. In recent years, false smut has become one of main fungal diseases of rice, not only affects the yield and the quality of the rice, but also causes toxins to pathogenic bacteria, and seriously affects the food safety. The disease is caused by the Rhizoctonia cerealis (Ustilaginoidea virens), and early researches show that chelerythrine (chelerythrine) has remarkable antibacterial effect on the fungus, the inhibition rate of spore germination of the fungus is up to 86.7%, and apoptosis of pathogenic bacteria cells is induced.
The formula of Wettable Powder (WP) contains raw materials, a carrier, various auxiliary agents (mainly wetting agents and dispersing agents) and the like, which are mixed in proportion, and the mixture is crushed into fine powder by a specific machine according to the particle size requirement. The suspension rate and wettability of wettable powder are important in the quality detection standard of the preparation. The medicine is dissolved in water for spraying, can be effectively adhered to plants, and improves the use efficiency of pesticides. In addition, various carriers and auxiliary agents required by the wettable powder have low cost, do not use organic solvents polluting the environment, can be packaged by paper bags or plastic bags as solid pesticides, and are economical, green and convenient to transport and store. Therefore, development of the wettable powder taking chelerythrine as a raw material has important significance for controlling plant diseases.
Disclosure of Invention
In order to obtain wettable powder capable of being used for preventing and treating rice false smut, the invention provides chelerythrine wettable powder, wherein the chelerythrine wettable powder contains 10% by weight of chelerythrine technical product, a dispersing agent is TAMOLDN, ultrazine NA and Atlox Metasese 550S, a wetting agent is GEROPON SDS, a filler is white carbon black HL-200 and anhydrous glucose, and a defoaming agent is Aguique Soap L.
The chelerythrine wettable powder is further limited by the following raw materials, by weight, 10% of a chelerythrine raw material, 16% of TAMOLDN, 8% of Ultrazine NA, 550S 8% of Atlox Metasese, 8% of GEROON SDS, 0.5% of Aguique Soap L, 0.10% of white carbon black HL-20010% and 39.5% of anhydrous glucose.
The invention also provides a preparation method of the chelerythrine wettable powder, which comprises the steps of weighing all raw materials according to parts by weight, adding the raw materials into a stirring cooking cup for preliminary mixing and crushing, and crushing and mixing the mixture by using an airflow crusher after crushing to obtain the chelerythrine wettable powder.
Further defined, the jet mill has a mill standard to obtain a powder having a particle size of D505.00-6.00 μm.
The invention also provides application of the chelerythrine wettable powder in preventing and treating false smut of rice.
Further limited, the chelerythrine wettable powder is utilized for spraying and twice when the rice grows to 3-5 days before and after the heading period.
Further limited, the interval time between the two spraying is 8-12 days.
Further defined as a dose of 2kg/hm chelerythrine wettable powder per administration 2 -8kg/hm 2 。
Further defined as the dosage of chelerythrine wettable powder used for each spraying is 8kg/hm 2 。
Further defined is that the diluted chelerythrine wettable powder prior to spraying uses 600 liters of water per hectare.
The invention has the beneficial effects that:
the chelerythrine wettable powder obtained by the invention can be diluted and sprayed on rice to effectively prevent and treat false smut of the rice, and the dosage of the chelerythrine wettable powder for each spraying is 2kg/hm 2 When the pesticide composition is used, the control effect is 70.97%; the dosage of chelerythrine wettable powder used in each spraying is 8kg/hm 2 When the control effect is 95.88%, compared with the control effect (56.18%) of 13% validamycin in the positive control group, the control effect is thatThe method is obviously improved. As can be seen, the chelerythrine wettable powder has good control effect on the false smut of rice, and the dosage for each spraying is 8kg/hm 2 The control effect is better.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents, methods and apparatus used, without any particular description, are those conventional in the art and are commercially available to those skilled in the art.
The raw materials related to the invention are as follows:
the raw materials are as follows: chelidonine original drug;
dispersing agent: greenperse 1506 (beijing lattice Lin Taim technologies, inc.), greenperse 1508 (beijing lattice Lin Taim technologies, inc.), MORWET D-425 (aku nobel, inc.), ultrazine NA (haligy industries, inc.), TAMOL DN (basf, inc.), atlas metaperse 550S (grass chemicals (Shanghai), TERSPERSE 2700 (hounsmei chemical trade (Shanghai), geran T36 (sorrow group);
wetting agent: geran SDS (sor-wei group), morwe EFW (acethunobel corporation), GEROPON L-WET/P (sor-wei group), TERWET 1004 (hounsmei chemical trade (shanghai) limited), K12 (national drug group);
and (3) filling: ammonium sulfate (national drug group), sodium sulfate (national drug group), corn starch (Yufeng group), light calcium carbonate (Suzhou middling), calcined kaolin (Suzhou middling), diatomaceous earth (Suzhou middling), bentonite (Suzhou middling), white carbon black HL-200 (Yichang Hui Fu Si Material Co., ltd.), and anhydrous glucose (national drug group);
defoaming agent: aguique Soap L (Basf Co.).
Experimental facilities: stirring cup (Beijing Rui Baili commercial trade), electronic balance (precision 0.01g,0.0001 g), agilent HPLC1220, pH meter (Ha Na), and superfine jet mill.
Example 1: screening of chelerythrine wettable powder formula
(1) Screening of dispersing agent:
the flow point of the dispersant was measured by the flow point method, and the measurement results are shown in Table 1, and the results show that Ultrazine NA, TAMOLDN and Atlox Metasperse550S are relatively good in effect, and the next screening was performed using the same.
TABLE 1 flow Point determination of dispersants
(2) Screening a wetting agent:
each formulation as shown in Table 2 was designed to screen for wetting agents, and the results indicated that GEROON SDS was best wetting, and the wetting agents were selected for further screening.
TABLE 2 screening of wetting agents and results
(3) Screening of the filler:
the prescreening experiment shows that after the fillers such as diatomite, bentonite, beta cyclodextrin and the like are added singly, the fillers have precipitation, and only the white carbon black HL-200 and the anhydrous glucose are slightly improved after being added, so that the formula is optimized by taking the white carbon black HL-200 and the anhydrous glucose as the fillers, the formula optimization results after the fillers are added are shown in a table 3, and the dispersibility of the formula 10 is better as compared with the results of the formulas.
TABLE 3 optimization of formulation results after filler addition
(4) And (3) formula determination:
a small amount of the defoamer Aguique Soap L was added on the basis of formulation 10, and the final formulation was as shown in Table 4.
Table 4 formula of finally screened chelerythrine wettable powder
Example 2: preparation method of chelerythrine wettable powder
Weighing the raw materials according to the table 4, adding the raw materials into a stirring cooking cup for preliminary mixing and crushing, and further crushing and mixing the mixture by using an airflow crusher after crushing to obtain chelerythrine wettable powder. The standard of jet mill is to obtain powder with particle size of D505.00-6.00 μm.
Example 3: application of chelerythrine wettable powder in preventing and treating false smut of rice
In order to verify the effect of the chelerythrine wettable powder prepared in example 2 in preventing and treating false smut of rice, the invention adopts a chelerythrine wettable powder experimental group and a 13% validamycin positive control group to prevent and treat false smut of rice. The experimental group and the positive control group are respectively used for spraying rice for 3-5 days before and after the heading period, the spraying is carried out twice, the interval time between the spraying and the spraying is 8-10 days, the spraying dose is the same each time, the water consumption per hectare is 600L, and the dosage of chelerythrine wettable powder used in each spraying in the experimental group 1 is 2kg/hm 2 Experimental group 2 the dose of chelerythrine wettable powder used for each spraying is 8kg/hm 2 The dose of each spraying of the positive control group is 69mL/hm of effective concentration 2 The rice growth conditions of all groups of experiments are guaranteed to be the same, and the spraying time is the same.
As a result, it was found that the amount of chelerythrine wettable powder used per spray was 2kg/hm 2 When the prevention and treatment effect is 7097%; the dosage of chelerythrine wettable powder used in each spraying is 8kg/hm 2 When the control effect is 95.88%, the control effect of the positive control group is 56.18%. As can be seen, the chelerythrine wettable powder has good control effect on the false smut of rice, and the dosage for each spraying is 8kg/hm 2 The effect is better.
While the invention has been described with reference to the preferred embodiments, it is not limited thereto, and various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (8)
1. The application of the chelerythrine wettable powder in preventing and treating rice false smut is characterized in that the raw materials of the chelerythrine wettable powder comprise, by weight, 10% of a chelerythrine raw material, 16% of TAMOLDN, 8% of Ultrazine NA, 8% of atlax Metasee 5508%, 8% of GERON SDS, 0.5% of Aguique Soap L, HL-200% of white carbon black and 39.5% of anhydrous glucose.
2. The use according to claim 1, wherein the preparation method of the chelerythrine wettable powder is characterized in that the preparation method comprises the steps of weighing all raw materials according to parts by weight, adding the raw materials into a stirring cup for preliminary mixing and crushing, and crushing and mixing the mixture by using a jet mill after crushing to obtain the chelerythrine wettable powder.
3. The use according to claim 2, wherein the jet mill has a mill standard of obtaining a powder with a particle size D505.00-6.00 μm.
4. The use according to claim 1, wherein said chelerythrine wettable powder is applied by spraying twice a total of 3-5 days before and after the heading stage of rice.
5. The use according to claim 4, wherein the two sprays are applied at an interval of 8-12 days.
6. The use according to claim 5, wherein the dosage of chelerythrine wettable powder per spray is 2kg/hm 2 -8 kg/hm 2 。
7. The use according to claim 6, wherein the dosage of chelerythrine wettable powder per spray is 8kg/hm 2 。
8. The use according to any one of claims 6 or 7, wherein the diluted chelerythrine wettable powder is applied in an amount of 600L per hectare prior to spraying.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210741435.6A CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
| NL2035186A NL2035186A (en) | 2022-06-28 | 2023-06-27 | Chelerythrine wettable powder, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210741435.6A CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115119847A CN115119847A (en) | 2022-09-30 |
| CN115119847B true CN115119847B (en) | 2023-09-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210741435.6A Active CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
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| NL (1) | NL2035186A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256873A (en) * | 1998-12-15 | 2000-06-21 | 安庆市茁壮农药有限公司 | Application of macleaya cordata in pesticide preparation |
| CN102657192A (en) * | 2012-05-22 | 2012-09-12 | 芜湖市多威农化有限责任公司 | Biological bactericide chelerythrine suspending agent and preparation method thereof |
| CN105123777A (en) * | 2015-08-26 | 2015-12-09 | 青岛文创科技有限公司 | Botanical insecticide |
| CN110278970A (en) * | 2019-07-31 | 2019-09-27 | 黑龙江省农业科学院植物保护研究所 | A kind of Chinese herbal medicine type seed coat agent and preparation method thereof |
| CN110679612A (en) * | 2019-10-29 | 2020-01-14 | 宁波市鄞州赛弗兑食品科技有限公司 | Agricultural insecticidal composition for preventing and treating corn borers |
| CN112079846A (en) * | 2020-08-17 | 2020-12-15 | 贵州梵净山生态农业股份有限公司 | Sanguinarine derivative and chelerythrine derivative and application thereof |
| CN112457322A (en) * | 2020-12-02 | 2021-03-09 | 铜仁职业技术学院 | Insecticidal and antibacterial 5-imino substituted derivative and preparation method and application thereof |
| CN113875763A (en) * | 2021-10-29 | 2022-01-04 | 黑龙江省农业科学院植物保护研究所 | Chelerythrine suspending agent and preparation method and application thereof |
-
2022
- 2022-06-28 CN CN202210741435.6A patent/CN115119847B/en active Active
-
2023
- 2023-06-27 NL NL2035186A patent/NL2035186A/en unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256873A (en) * | 1998-12-15 | 2000-06-21 | 安庆市茁壮农药有限公司 | Application of macleaya cordata in pesticide preparation |
| CN102657192A (en) * | 2012-05-22 | 2012-09-12 | 芜湖市多威农化有限责任公司 | Biological bactericide chelerythrine suspending agent and preparation method thereof |
| CN105123777A (en) * | 2015-08-26 | 2015-12-09 | 青岛文创科技有限公司 | Botanical insecticide |
| CN110278970A (en) * | 2019-07-31 | 2019-09-27 | 黑龙江省农业科学院植物保护研究所 | A kind of Chinese herbal medicine type seed coat agent and preparation method thereof |
| CN110679612A (en) * | 2019-10-29 | 2020-01-14 | 宁波市鄞州赛弗兑食品科技有限公司 | Agricultural insecticidal composition for preventing and treating corn borers |
| CN112079846A (en) * | 2020-08-17 | 2020-12-15 | 贵州梵净山生态农业股份有限公司 | Sanguinarine derivative and chelerythrine derivative and application thereof |
| CN112457322A (en) * | 2020-12-02 | 2021-03-09 | 铜仁职业技术学院 | Insecticidal and antibacterial 5-imino substituted derivative and preparation method and application thereof |
| CN113875763A (en) * | 2021-10-29 | 2022-01-04 | 黑龙江省农业科学院植物保护研究所 | Chelerythrine suspending agent and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| In vitro antifungal activity and possible mechanisms of action of chelerythrine;Qing-hui Wei. et al;《Pesticide Biochemistry and Physiology》;第140-148页 * |
| 白屈菜中白屈菜红碱的提取及抑菌活性;范海延;薛广厚;吕春茂;崔娜;;食品科学(第24期);第126-129页 * |
| 范海延 ; 薛广厚 ; 吕春茂 ; 崔娜 ; .白屈菜中白屈菜红碱的提取及抑菌活性.食品科学.2009,(第24期),第126-129页. * |
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| Publication number | Publication date |
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| CN115119847A (en) | 2022-09-30 |
| NL2035186A (en) | 2023-08-01 |
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