CN105010383A - Insecticidal composition containing dinotefuran and indoxacarb and preparation method thereof - Google Patents
Insecticidal composition containing dinotefuran and indoxacarb and preparation method thereof Download PDFInfo
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- CN105010383A CN105010383A CN201510467517.6A CN201510467517A CN105010383A CN 105010383 A CN105010383 A CN 105010383A CN 201510467517 A CN201510467517 A CN 201510467517A CN 105010383 A CN105010383 A CN 105010383A
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Abstract
The invention relates to an insecticidal composition containing dinotefuran and indoxacarb. The insecticidal composition comprises active ingredients, namely dinotefuran and indoxacarb at a weight ratio of (1:3.57)-(35:1). Due to different active mechanisms, different durable effects and fast-acting properties and different control objects, so that the dinotefuran and the indoxacarb have complementary advantages and are capable of overcoming the defect that resistance is easily generated by continuous selection pressure of single chemicals; experimental data indicates that the dinotefuran and the indoxacarb are relatively high in synergetic effect. The insecticidal composition containing dinotefuran and indoxacarb is capable of reducing the pesticide dosage, reducing the pesticide cost, alleviating the economic burden of farmers, reducing the environmental pollution caused by pesticides, reducing pesticide residues, improving the grain safety, delaying the pesticide resistance generation time of injurious insects, prolonging the service lives of the dinotefuran and the indoxacarb, and enlarging the control objects, and the dinotefuran and indoxacarb preparation has the advantages of safety, high efficiency and application amount reduction.
Description
Technical field
The invention belongs to a kind of insecticidal technology field containing pyridine compounds and their and anabasine compound, more specifically relate to a kind of Pesticidal combination containing MTI-446 and indoxacarb, also relate to a kind of preparation method containing MTI-446 and indoxacarb mixture preparation simultaneously, it is applicable to control thorn and inhales class pest brown planthopper, white-backed planthopper, small brown rice planthopper, long green plant hopper, aphid, Bemisia tabaci, Trialeurodes vaporariorum Westwood, leafhopper, the pest such as paddy rice thrips, can also to hold concurrently anti-snout moth's larva simultaneously, rice leaf roller, diamond-back moth, prodenia litura, beet armyworm, rice leaf beetles, oryza chinensis, a red-spotted lizard class, striped flea-beetle, stinkbug etc.
Background technology
Brown planthopper belongs to Homoptera, Delphacidae.Be the primary pest on China and Asia paddy rice, there is the habit of migrating at a distance.Brown planthopper is monophagy insect, mainly takes food on paddy rice and wild rice and raises up seed.Mainly to sting water suction rice juice, paddy rice " lice burning " is caused to the harm of paddy rice, can also rice disease be propagated: careless adornment bushy stunt and tingia dwarf wilt simultaneously.Brown planthopper mainly the Yangtze river basin and on the south the long-term population outbreak in area.Brown planthopper once great outburst for several times in 1987,1991,1997,2005 and 2006, bring serious loss to the country and people.For many years, to the control of brown planthopper mainly based on chemical control, due to long-term, a large amount of, the single use of chemical agent, brown planthopper is caused to create pesticide resistance in various degree to conventional medicament.Chemical agent uses in a large number and also causes certain influence to natural enemy simultaneously, and the natural contral power of brown planthopper is weakened.Therefore, must administer the resistance of brown planthopper.
MTI-446 is the insecticide of Mitsui Chemicals, Inc.'s exploitation.This insecticide has efficiently, the characteristic of wide spectrum, belongs to third generation anabasine insecticide.MTI-446 has good preventive effect to Semiptera, orthoptera, diptera, hymenopteran, has lower toxicity to mammal and environment simultaneously.MTI-446 can prevent brown planthopper, white-backed planthopper, small brown rice planthopper, long green plant hopper, leafhopper, striped rice borer, aphid, Bemisia tabaci, Trialeurodes vaporariorum Westwood, diamond-back moth, thrips, stinkbug etc.
The insecticidal spectrum (Zhang Yibing, 2003) of table 1 MTI-446
Indoxacarb is a kind of insecticide researched and developed by E.I.Du Pont Company, it can prevent and treat the lepidoptera pest on cotton, fruit tree, vegetables, paddy rice, and indoxacarb plays a role by stoping insect nerve system sodium-ion channel, makes the coordination of target pest impaired, there is paralysis, finally lethal.This medicament without teratogenesis, carcinogenic, mutagenicity, and to birds and aquatile and non-target also fool proof, the Photolysis Half in water is 3 days.Different with traditional carbamate pesticide, indoxacarb is sodium channel inhibitor, and is not anticholinesterase, therefore without cross resistance.Also be the favourable agents that alternative organic phosphates and pyrethroid insecticides prevent and treat lepidoptera pest simultaneously.Beginning in 2013 is registered on rice grub snout moth's larva, rice leaf roller.Along with indoxacarb exceedes the protection period all in the patent protection of China and agriculture chemical registration information protection; production and the usage amount of indoxacarb probably significantly increase; very easily accelerate insect to the emergence and development of indoxacarb resistance; therefore; the mixture preparation with synergistic effect can delay the time that indenes worm produces resistance, extends the service life of indoxacarb.By showing the drug resistance mechanism research of diamond-back moth, prodenia litura and housefly: insect has indoxacarb and produces high-level drug-fast risk.Therefore, the mixture preparation of indoxacarb is the necessary means of indoxacarb being carried out to resistance management.
Summary of the invention
The object of the invention is to there are provided a kind of Pesticidal combination containing MTI-446 and indoxacarb, this formula, by the rational mixture between MTI-446 and indoxacarb, improves drug effect; Delay the time that brown planthopper, snout moth's larva and rice leaf roller and other insect develop immunity to drugs to MTI-446 and indoxacarb; Reduce the usage amount of agricultural chemicals, effectively alleviate the pollution to environment, reduce the harm to beneficial organism; With low cost, also reduce the financial burden of peasant simultaneously, meet the requirement of sustainable development; Resistance management can be carried out to rice fulgorid, to Imidacloprid, Diacloden, Buprofezin, pymetrozine produce high level drug-fast brown planthopper field population higher preventive effect; Reduce the toxic action to natural enemy, be conducive to alleviating the pollution to environment, improve quality, the safety of food; Extend controlling object; A kind of water baseization, safe, environmentally friendly, efficient formulation are provided.
Another object of the present invention is the preparation method that there are provided a kind of MTI-446 and indoxacarb mixture preparation, MTI-446 is different with the mechanism of action of indoxacarb, lasting effect and quick-acting are also different, them are made used in combinationly in field to have given full play to complementary advantage, can efficient kill pests brown planthopper, white-backed planthopper, small brown rice planthopper, long green plant hopper, aphid, aleyrodid, thrips, leafhopper, diaphorina citri, improve preventive effect, can also to hold concurrently anti-pink rice borer simultaneously, striped rice borer, paddy stem borer, oryza chinensis, rice leaf roller, diamond-back moth, beet armyworm, prodenia litura, the insects such as stinkbug,
Simultaneously the present invention is also in providing a kind of MTI-446 and indoxacarb bucket mixes technology (bucket mixture), the formulation that MTI-446 uses in the present invention is the one in water dispersible granules or suspending agent or wetting powder or effervescent tablet, the formulation that indoxacarb uses for wetting powder or microemulsion or suspending agent or this formulation of water dispersible granules environmentally friendly, simultaneously to operator safety; Due to be two kinds of single doses in field direct mixture, the complicated processes avoiding enterprise to register mixture preparation, has saved time and the cost of enterprise.
In order to realize above-mentioned object, the present invention adopts following technical measures:
Containing a Pesticidal combination for MTI-446 and indoxacarb, comprise active component MTI-446 and and active component indoxacarb, MTI-446 and indoxacarb weight ratio are 1:3.57 ~ 35:1.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, MTI-446 and indoxacarb weight ratio are 1:8.33 ~ 16:1.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, MTI-446 and indoxacarb weight ratio are 1:15 ~ 3.2:1.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, MTI-446 and indoxacarb weight ratio are 1:25 ~ 3.2:1.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, MTI-446 and indoxacarb weight ratio are 1:75 ~ 1:400.
The present invention contains the field synergistic formula of MTI-446 and indoxacarb, this formula is mixed by a certain percentage by MTI-446 and indoxacarb, after mixing, the weight of MTI-446 active component accounts for the ratio of Active principals weight is 0.25-97.20%, accounts for the 0.07-29.16% of total prescription quality; The ratio that indoxacarb active component weight accounts for Active principals weight is 2.80-99.75%, accounts for the 0.84-29.93% of total prescription quality, the weight sum that the weight of described Active principals is MTI-446 and indoxacarb.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, Gu composition makes missible oil, wetting powder, suspending agent, water dispersible granules, solid/bucket mixture, ultra low volume spraying agent, effervescent tablet.
The bactericidal composition of invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing, then adds surfactant as one or more in dispersant, wetting agent, binding agent, defoamer etc. by active component with liquid flux or solid carrier.According to different dosage form, in preparation, stabilizing agent known in those skilled in the art, antifreeze etc. can also be contained.
Described a kind of Pesticidal combination containing MTI-446 and indoxacarb, composition makes suspending agent, and suspending agent thing preparation method step is:
A, take raw material by component design:
MTI-446 and the former medicine of indoxacarb are put into container, then adds wetting agent, dispersant, antifreezing agent, thickener, stir;
B, at a high speed (1000 turns) stir pre-dispersed 25-35min (emulsifying), then stop stirring, and add sanding media, start sand milling;
Stop sand milling (to more than 98% suspended particulate particle diameter between 0.1-0.7 μm) after C, 1.8-2.2h, filter, go out bead, add other auxiliary agent (defoamer, stabilizing agent, preservative, solvent), obtain homogeneous phase formulation;
Described wetting agent is neopelex, lauryl sodium sulfate, Morwet EFW (composition is the mixture of alkyl naphthalene sulfonic acid sodium salt and anion wetting agent, Aksu Bel), Terspense4896 (alkyl phenol polyether class wetting dispersing agent), nekal, dioctyl sodium sulfosuccinate, tea are withered, one or more any combination in GY-W04 (polycarboxylate wetting agent);
Described dispersant is Morwet D-425 (sodium salt of alkylnaphthalene sulfonate formaldehyde condensation products), MorwetD-110 (alkylnaphthalene sulfonate formaldehyde condensation products+APE carboxylate), terspense 2425 (alkylnaphthalene sulfonate formaldehyde condensation products anionoid efficient general type dispersant), terspense 2700 (tailored version dispersant, UT product Co., Ltd), sodium lignin sulfonate, naphthalenesulfonate condensation compound, alkylnaphthalene sulfonate, sulphonyl succinate, alkylaryl sulfonates, lignosulfonates, CMC (CMC), PVA (polyvinyl alcohol), PVP (polyvinylpyrrolidone), one or more any combination in XG (xanthans),
Described antifreezing agent is any combination of a kind of in ethylene glycol, propane diols, glycerine, diethylene glycol (DEG), the third ethanol, glycerine-ether diglycol or two to six kinds;
Described defoamer is organosilicon ketone, C
8-10fatty alcohol, C
10-20one or more any combination in aliphatic saturated monocarboxylic acid and lipid thereof, polyglycerol, polyether silicone, ester-ether type compound;
Described thickener is one or more any combination in polyethylene glycol, xanthan gum, carboxymethyl cellulose, Sodium Polyacrylate, gaseous silicon oxide, bentonite, Magnesiumaluminumsilicate;
Described stabilizing agent is one or more any combination in bentonite, white carbon, lightweight sodium silicate;
Described preservative is one or more any combination in formaldehyde, paraformaldehyde, Sodium Benzoate, benzoic acid.
Described solvent is one or more any combination in water, dimethyl formamide, dimethyl sulfoxide (DMSO), dimethylbenzene, mineral oil, vegetable oil.
Contain a Pesticidal combination for MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
Insecticide comprises following component and content when being water dispersible granules: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93, dispersant 1-10%, wetting agent 1-5%, disintegrant 1-15%, binding agent 1-15%, filler surplus.
Insecticide comprises following component and content when being effervescent tablet: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93, dispersant 1-10%, wetting agent 2-3%, disintegrant 1-15%, binding agent 1-15%, filler surplus.
Insecticide comprises following component and content when being ultra low volume spraying agent: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93, emulsifier 5-10%, surplus is solvent and cosolvent.
Insecticide comprises following component and content when being missible oil: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93, emulsifier 5-10%, surplus is solvent and cosolvent.
Insecticide comprises following component and content when being wetting powder: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93, dispersant 3-6%, wetting agent 1-3%, other auxiliary agents (defoamer, anticaking agent, bleeding agent) 0-5%, filler surplus.
Gu insecticide for solid/bucket mixture time comprise following component and content: active component MTI-446 0.07-29.16, active component indoxacarb 0.84-29.93; MTI-446 can be 20% soluble granule, 25% wetting powder, 20% water dispersible granules, 40% water dispersible granules, 20% suspending agent; Indoxacarb can be 15% water dispersible granules, 30% suspending agent, 150g/L suspending agent, 30% water dispersible granules, 15% suspending agent, 20% missible oil.
Described disintegrant is any mixing of urea, ammonium sulfate, sodium cellulose glycolate, citric acid, sodium bicarbonate, sodium carbonate wherein a kind of or two to six kinds;
Described binding agent is water soluble polymer cellulose, polyethylene glycol, any mixing of polyvinyl alcohol wherein a kind of or two to three kinds;
Described filler is any mixing of diatomite, kaolin, bentonite, imvite, white carbon, precipitated calcium carbonate, potter's clay, concave convex rod, atlapulgite wherein a kind of or two to nine kinds.
Described emulsifier is agriculture breast 500, Nongru-700,1602# (triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), NP-10 (polyoxyethylene nonylphenol ether), 0201B (special nonionic and anion surfactant), 2201 (composite emulsifier, the compounds of anion and non-ionic surface active chaste tree and molten chaste tree), any of 0203B (special nonionic and anion surfactant) wherein a kind of or two to seven kinds mix.
During MTI-446 provided by the invention and indoxacarb mixture combine, the mass ratio of MTI-446 and indoxacarb is: 1:400,1:75,1:25,1:15,1:8.33,1:3.57,3.2:1,16:1,34.67:1, MTI-446 and the preferred mass ratio of indoxacarb mixture formula are: 1:25,1:15,1:8.33,1:3.57,3.2:1,16:1,34.67:1.
The present invention compared with prior art, has the following advantages and effect:
1. MTI-446 and indoxacarb composite after, improve drug effect, the time that delaying drug resistance produces, extend MTI-446 and indoxacarb service life.
2. MTI-446 mixed with indoxacarb after, the consumption of mixture reduces, and reduces production cost, decreases peasant burden.
3. two kinds of medicaments owing to selecting are all the insecticides of high-efficiency low-toxicity, can reduce the toxic action to natural enemy, be conducive to alleviating the pollution to environment, improve quality, the safety of food.
4. the agricultural chemicals single dose that two kinds can have been registered by this formula directly carries out mixture (namely have developed a barrel mix formulation) in field, avoid the re-registration process of Mixed Pharmacy, provide convenience for enterprise produces, saved enterprise's production cost, reduce peasant's drug cost.
5. administer the field population, particularly high-level drug-fast pest population that develop immunity to drugs to Imidacloprid, Buprofezin, Diacloden, after medicine, 14 days preventive effects are more than 90%, and after medicine, the preventive effect of 21 days reaches more than 83%.
6. extend controlling object, the insects such as sucking pest plant hopper, aphid, aleyrodid can be prevented and treated due to MTI-446, therefore, MTI-446 and the combination of indoxacarb mixture not only can prevent and treat the Hemipteran pest such as Bemisia tabaci, aphid, brown planthopper, white-backed planthopper, small brown rice planthopper, long green plant hopper, diaphorina citri, thrips, leafhopper and can to hold concurrently the insects such as lepidoptera pest and stinkbug such as the anti-snout moth's larva of rice, rice leaf roller, diamond-back moth, beet armyworm, prodenia litura, oryza chinensis.
7. the formulation Environmental Safety of the application, water baseization, safety, efficiently reduces pollution to environment.
Embodiment
Embodiment 1:(1:24.86)
Contain a Pesticidal combination for MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
The above-mentioned Pesticidal combination formulation preparation method containing MTI-446 and indoxacarb, the steps include:
A, by component design, take MTI-446 and the former medicine of indoxacarb, put into container, then add lauryl sodium sulfate, nekal, lignin sulfonic acid sodium salt and naphthalene sulphonate formaldehyde polymer, glycerine, AF9903, lightweight sodium silicate etc., stir;
B, at a high speed (1000 turns) stir pre-dispersed 25-35min, then stop stirring (complete homogeneous phase), add sanding media, start sand milling;
Stop sand milling (to more than 98% suspended particulate particle diameter between 0.1-0.7 μm) after C, 1.8-2.2h, filter, go out bead, add other auxiliary agent (Sodium Benzoate, polyethylene glycol and water), obtain homogeneous phase formulation.
Embodiment 2:(1:14.96)
Contain a Pesticidal combination for MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
Preparation method is with embodiment 1.
Embodiment 3:(1:8.32)
Contain a Pesticidal combination for MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
Preparation method is with embodiment 1.
Embodiment 4:(1:3.57)
Contain a Pesticidal combination for MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
Preparation method is with embodiment 1.
The auxiliary agents such as described lauryl sodium sulfate can use that Morwet EFW (composition is the mixture of alkyl naphthalene sulfonic acid sodium salt and anion wetting agent, Aksu Bel), Terspense4896 (alkyl phenol polyether class wetting dispersing agent), dioctyl sodium sulfosuccinate, tea are withered, a kind of or two to six kinds any combination in GY-W04 (polycarboxylate wetting agent) etc. replaces.
Embodiment 5:(3.2:1)
Contain a water dispersible granules for the Pesticidal combination of MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
The above-mentioned Pesticidal combination formulation preparation method containing MTI-446 and indoxacarb, the steps include:
A, by MTI-446, indoxacarb, dispersant (lauryl sodium sulfate and nekal (1:1)), wetting agent (lignin sulfonic acid sodium salt and naphthalene sulphonate formaldehyde polymer (1:5)), filler (diatomite), disintegrant (sodium cellulose glycolate), the samples such as binding agent (starch) weigh up by component design, then by MTI-446, indoxacarb, dispersant (lauryl sodium sulfate and nekal (1:1)), wetting agent (lignin sulfonic acid sodium salt and naphthalene sulphonate formaldehyde polymer (1:5)), filler (diatomite), disintegrant (sodium cellulose glycolate) mixes, high speed disintegrator is pulverized,
Sample after B, pulverizing is placed in beaker, adds the water (water containing 10-20% binding agent) containing binding agent while stirring, tentatively can pinch into mud, then add extruder grain in comminutor;
Finally the particle squeezed out is placed in 30-40 DEG C of baking oven, dry, moisture is that 0.5-1.0% is advisable.
Embodiment 6:(15.67:1)
Contain a ultra low volume spraying agent for the Pesticidal combination of MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
The above-mentioned Pesticidal combination formulation preparation method containing MTI-446 and indoxacarb, the steps include:
A, by component design, take MTI-446 and the former medicine of indoxacarb, add dimethyl sulfoxide (DMSO), dissolve former medicine;
B and then add dense newborn 500 and dense newborn 700, stir (100-200 rev/min), stirs the liquid preparation that 30-40min obtains transparent and homogeneous.
Ultra low volume spraying agent performance indications reference table 10, storage-stable is good without precipitation.
Embodiment 7:(34.71:1)
Contain an effervescent tablet for the Pesticidal combination of MTI-446 and indoxacarb, it is made up of the raw material of following mass fraction:
The above-mentioned Pesticidal combination formulation preparation method containing MTI-446 and indoxacarb, the steps include:
A, by component design, take MTI-446 and the former medicine of indoxacarb, put into container, then lauryl sodium sulfate and nekal, lignin sulfonic acid sodium salt and naphthalene sulphonate formaldehyde polymer, citric acid and starch, white carbon and diatomaceous earth sample is added, mix, obtain a kind of mixture;
B, mixture is placed on high-energy crushing machine and pulverizes 8-12min (200 order), then in airslide disintegrating mill, pulverize (200 order), make the pulvis of 40%;
C, pulvis is added binding agent (20% aqueous solution) aqueous solution, stir, dry, compressing tablet.
Embodiment 8:(4.8:1)
Contain a Pesticidal combination bucket mix formulation preparation method for MTI-446 and indoxacarb,
Above-mentioned Pesticidal combination bucket mixture preparation method and the mixed method containing MTI-446 and indoxacarb, the steps include:
A, experimentally to design respectively, MTI-446 is made the one in water dispersible granules, suspending agent, soluble granule, effervescent tablet or wetting powder.Indoxacarb is made the one in water dispersible granules, microemulsion, suspending agent, wetting powder, missible oil, effervescent tablet.
B, by calculating indoxacarb water dispersible granule, microemulsion, suspending agent, wetting powder, missible oil, the one in effervescent tablet that consumption takes 30%, adding water 1000-2000ml, stirring, dissolving;
C, after 30% indoxacarb formulation dissolution, add the one in 20% MTI-446 water dispersible granules, suspending agent, soluble granule, effervescent tablet or wetting powder, stir, mix;
D, the mother liquor prepared will carry out secondary dilution, carry out secondary dilution within 14-16min.
The method preparing mixture liquid when agricultural chemicals single dose is used with is generally the liquid first preparing a kind of single dose with enough water, then dilutes another kind of single dose with this liquid; And first can not mix two kinds of single doses, then dilute with water, to avoid bad reaction, comprise the destruction of active ingredient and the deterioration of physical behavior.First time carries out two kinds of single dose tentative existing mixed existing used times, first can test a small amount of admixing medical solutions in transparent glass container, observe whether have the abnormalities such as oil slick, flocculation, precipitation or variable color, heating, generation bubble.All liquids demonstrate and create chemical change or liquid physical behavior worsens to some extent, and this mixture is just inadvisable.The performance of suspending agent, water dispersant and effervescent agent energy index reference table 7, table 8 and table 9.
When table 1 is barrel mixed, pesticidal preparations uses stability with
When table 1 is barrel mixed, pesticidal preparations uses stability (Continued) with
MTI-446 and indoxacarb mixture combine brown planthopper indoor virulence test
The best compatibility of A and B mixture is determined in this experiment according to being total to malicious factorization method, again according to summation action line in equivalent line ten Along ents setting A and B proportioning be 1:9,2:8,3:7,4:6,5:5,6:4,7:3,8:2,9:1 (volume ratio), then calculate co-toxicity coefficient by toxicity test result.Malicious factor >20 altogether, representing that two single doses are mixed has synergistic effect; ≤-20 indicate antagonism, and-20 ~ 20 represent summation action.Co-toxicity coefficient >=120 are synergistic effect, and co-toxicity coefficient≤80 are antagonism, and 80 ~ 120 is summation action.
For examination insect: within 2006, picking up from experimental field, Hunan academy of agricultural sciences, raising so far when not contacting any medicament.
Sod cultivation: rice-stem dipping method, grub out and get the rice strain of healthy and strong consistent tillering regularity to the booting initial stage, clean, be cut into company's root rice stem that about 10cm is long, 3 strains 1 group, dry in the air in the cool to surface without washmarking, take out after rice stem is soaked 30s in liquid and dry, encase root with the absorbent cotton of dipping and put into disposal plastic cup, support from field label taking the paddy rice of worm net accurate consistent 3 mid-term in age nymph, the disposal plastic cup that the level of putting into is sidelong, 20 every glass, it is vertical more all to climb up after rice stem or wall of cup until nymph, reject the individuality of mechanical damage, and supply 20, each concentration repeats 3 times, take clear water as contrast.Putting into temperature after connecing worm is 27 ± 1 DEG C, and the photoperiod is cultivate in the constant temperature climatic cabinate of L:D=16:8h.Note the absorbent cotton moisturizing of rice stem root after process, anti-rice stem is withered.Review time: check result after pesticide treatments 96h.
MTI-446 and indoxacarb different ratio make same one dosage type low temperature (suspending agent, auxiliary agent ratio adopts proportioning in embodiment 1)
Table 2 MTI-446 and indoxacarb different ratio to 3 age brown planthopper nymph the common malicious factor
| Group | Concentration (MTI-446+indoxacarb) mg/L | Active ingredient mass ratio | The malicious factor altogether |
| 1 | 0.05+45 | 1:900 | 19.59 |
| 2 | 0.1+40 | 1:400 | 20.00 |
| 3 | 0.2+35 | 1:175 | 17.82 |
| 4 | 0.4+30 | 1:75 | 20.67 |
| 5 | 0.6+25 | 1:41.67 | 15.28 |
| 6 | 0.8+20 | 1:25 | 37.82 |
| 7 | 1+15 | 1:15 | 23.45 |
| 8 | 1.2+10 | 1:8.33 | 27.82 |
| 9 | 1.4+5 | 1:3.57 | 20.15 |
| 10 | 1.6+2.5 | 1:1.56 | 13.38 |
| 11 | 1.8+1.25 | 1.44:1 | 20.33 |
| 12 | 2+0.625 | 3.2:1 | 26.99 |
| 13 | 2.2+0.3 | 7.33:1 | 39.88 |
| 14 | 2.4+0.15 | 16:1 | 22.22 |
| 15 | 2.6+0.075 | 34.67:1 | 40.11 |
Table 3 MTI-446 indoxacarb different ratio to 3 age brown planthopper nymph co-toxicity coefficient
| Group | Active ingredient mass ratio | Co-toxicity coefficient |
| 1 | 1:400 | 123.77 |
| 2 | 1:75 | 121.50 |
| 3 | 1:25 | 119.62 |
| 4 | 1:15 | 168.71 |
| 5 | 1:8.33 | 203.45 |
| 6 | 1:3.57 | 289.11 |
| 7 | 1.44:1 | 104.21 |
| 8 | 3.2:1 | 199.10 |
| 9 | 7.33:1 | 108.99 |
| 10 | 16:1 | 296.89 |
| 11 | 34.67:1 | 245.36 |
As can be seen from table 2,3, in each ratio of MTI-446 and indoxacarb mixture, the common malicious factor of group 2,4,6,7,8,9,11,12,13,14,15 is greater than 20 (see table 2), the co-toxicity coefficient of group 1,2,4,5,6,8,10,11 is all greater than 120 (see table 3), all have obvious synergistic effect, 1:400,1:75,1:25,1:15,1:8.33,1:3.57,3.2:1,16:1,34.67:1 nine ratios of wherein choosing do field trial.
2. field trial
The test of pesticide effectiveness is carried out at Hubei Province's Wuxue City, and paddy rice is semilate rice, kind Yue You 9113, and carry out rice fulgorid control experiment on August 28th, 2013, adopt WBD-16 type knapsack sprayer, spray after being diluted on request by liquid, each plot area is 25m
2, every mu of water consumption is 45L, each process 4 repetition, and once, after dispenser, 3d, 7d, 14d, 21d investigate its control efficiency to spray medicine, and 5 points are investigated in each community, and often some investigation 5 pockets, record data, analytic statistics result of the test also carries out significance of difference analysis.
Table 4 MTI-446 and indoxacarb different ratio are to the control efficiency of field Population of Rice Brown Planthopper
Table 5 Wuxue City Brown Planthopper in 2012 is to the pesticide resistance of Imidacloprid, Buprofezin and Diacloden
Fold resistance's classification: RR≤3, responsive; 3≤RR<5, susceptibility declines; 5≤RR<10, low-level pesticide resistance; 10≤RR<40, medium level pesticide resistance; 40≤RR<160, high-level pesticide resistance; RR >=160, high horizontal pesticide resistance.
From upper table (table 5), Wuxue City brown planthopper field population creates extremely high-caliber pesticide resistance to Imidacloprid, Buprofezin, creates high-caliber pesticide resistance to Diacloden.From table 4, table 5, MTI-446 and indoxacarb mixture still have higher preventive effect to brown planthopper Imidacloprid, Buprofezin, Diacloden having been produced to high-level resistance.MTI-446 and the synergistic effect possible cause 1. of indoxacarb to brown planthopper suppress the main detoxification enzyme activity in body; 2. reduce surface tension after two kinds of medicine mixing; 3. after two kinds of medicine mixing, improve the penetration capacity to blade and insect body wall; 4. may create new target.
Table 6 Nitenpyram and indoxacarb mixture are to the insecticidal effect of field rice leaf roller population
Table 7 MTI-446 indoxacarb suspending agent performance indications
| Formulation | Suspension % |
| 30% MTI-446 indoxacarb suspending agent | 76.56 |
Table 8 MTI-446 indoxacarb water dispersible granule performance indications
Table 9 MTI-446 indoxacarb effervescent tablet performance indications
Table 10 MTI-446 indoxacarb ultra low volume spraying agent performance indications
Table 11 MTI-446 and indoxacarb different ratio resist the co-toxicity coefficient of Imidacloprid and Buprofezin 3 brown planthopper in age nymph
Under 1:25,1:15,1:8.33,1:3.57 tetra-ratios, spend coefficient together and be all greater than 120, show that the Population of Rice Brown Planthopper that MTI-446 and indoxacarb mixture resist Imidacloprid and Buprofezin still has synergistic effect, can be used for the control of field rice fulgorid.
Claims (8)
1., containing a Pesticidal combination for MTI-446 and indoxacarb, it is characterized in that: comprise active component MTI-446 and and active component indoxacarb, MTI-446 and indoxacarb weight ratio are 1:3.57 ~ 35:1.
2. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to claim 1, is characterized in that: MTI-446 and indoxacarb weight ratio are 1:8.33 ~ 16:1.
3. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to claim 1, is characterized in that: MTI-446 and indoxacarb weight ratio are 1:15 ~ 3.2:1.
4. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to claim 1, is characterized in that: MTI-446 and indoxacarb weight ratio are 1:25 ~ 3.2:1.
5. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to claim 1, is characterized in that: MTI-446 and indoxacarb weight ratio are 1:75 ~ 1:400.
6. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to any one of claim 1-5, is characterized in that: Gu composition makes missible oil, wetting powder, suspending agent, water dispersible granules, solid/bucket mixture, ultra low volume spraying agent, effervescent tablet.
7. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to any one of claim 1-5, it is characterized in that: composition makes suspending agent, suspending agent thing preparation method step is:
A, take raw material by component design:
Material quality mark %
The former medicine 30 of the former medicine+indoxacarb of MTI-446
Wetting agent 0.2-5
Dispersant 0.3-10
Antifreezing agent 5-10
Defoamer 0.1-5
Thickener 0.2-5
Stabilizing agent 0.1-10
Preservative 0.1-0.5
Solvent 33-64,
MTI-446 and the former medicine of indoxacarb are put into container, then adds wetting agent, dispersant, antifreezing agent, thickener, stir;
The pre-dispersed 25-35min of B, high-speed stirred, then stops stirring, adds sanding media, start sand milling;
C, between 0.1-0.7 μm, stop sand milling to more than 98% suspended particulate particle diameter, filter, go out bead, add defoamer, stabilizing agent, preservative and solvent, obtain homogeneous phase formulation;
Described wetting agent is that neopelex, lauryl sodium sulfate, Morwet EFW, Terspense4896, nekal, dioctyl sodium sulfosuccinate, tea are withered, one or more any combination in GY-W04;
Described dispersant is one or more any combination in Morwet D-425, Morwet D-110, terspense 2425, terspense 2700, sodium lignin sulfonate, naphthalenesulfonate condensation compound, alkylnaphthalene sulfonate, sulphonyl succinate, alkylaryl sulfonates, lignosulfonates, CMC, PVA, PVP, XG;
Described antifreezing agent is any combination of a kind of in ethylene glycol, propane diols, glycerine, diethylene glycol (DEG), the third ethanol, glycerine-ether diglycol or two to six kinds;
Described defoamer is organosilicon ketone, C
8-10fatty alcohol, C
10-20one or more any combination in aliphatic saturated monocarboxylic acid and lipid thereof, polyglycerol, polyether silicone, ester-ether type compound;
Described thickener is one or more any combination in polyethylene glycol, xanthan gum, carboxymethyl cellulose, Sodium Polyacrylate, gaseous silicon oxide, bentonite, Magnesiumaluminumsilicate;
Described stabilizing agent is one or more any combination in bentonite, white carbon, lightweight sodium silicate;
Described preservative is one or more any combination in formaldehyde, paraformaldehyde, Sodium Benzoate, benzoic acid;
Described solvent is one or more any combination in water, dimethyl formamide, dimethyl sulfoxide (DMSO), dimethylbenzene, mineral oil, vegetable oil.
8. a kind of Pesticidal combination containing MTI-446 and indoxacarb according to any one of claim 1-5, it is characterized in that: composition makes water dispersible granules, water dispersible granules preparation method step is:
A, take raw material by component design:
Raw material
mass fraction%
The former medicine 30 of the former medicine+indoxacarb of MTI-446
Wetting agent 0.2-5
Dispersant 0.3-10
Filler 30-68
Disintegrant 0.2-15
Binding agent 0.3-10
Former for pymetrozine medicine, the former medicine of MTI-446, dispersant, wetting agent, filler, disintegrant, binding agent sample are weighed up by component design, mixing, high speed disintegrator is pulverized;
Sample after B, pulverizing is placed in beaker, adds the water containing 10-20% binding agent while stirring, tentatively pinches into mud, then add extruder grain in comminutor;
C, finally the particle squeezed out is placed in 30-40 DEG C of baking oven, dry, moisture is 0.5-1.0%;
Described disintegrant is any mixing of urea, ammonium sulfate, sodium cellulose glycolate, citric acid, sodium bicarbonate, sodium carbonate wherein a kind of or two to six kinds;
Described binding agent is water soluble polymer cellulose, polyethylene glycol, any mixing of polyvinyl alcohol wherein a kind of or two to three kinds;
Described filler is any mixing of diatomite, kaolin, bentonite, imvite, white carbon, precipitated calcium carbonate, potter's clay, concave convex rod, atlapulgite wherein a kind of or two to nine kinds.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112335671A (en) * | 2020-10-22 | 2021-02-09 | 湖南顺新龙辰生物工程有限公司 | Insecticidal composition |
| CN114615889A (en) * | 2019-10-28 | 2022-06-10 | 组合化学工业株式会社 | Pesticide composition and method for producing same |
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