NL2035186A - Chelerythrine wettable powder, preparation method and application thereof - Google Patents

Chelerythrine wettable powder, preparation method and application thereof Download PDF

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Publication number
NL2035186A
NL2035186A NL2035186A NL2035186A NL2035186A NL 2035186 A NL2035186 A NL 2035186A NL 2035186 A NL2035186 A NL 2035186A NL 2035186 A NL2035186 A NL 2035186A NL 2035186 A NL2035186 A NL 2035186A
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Netherlands
Prior art keywords
chelerythrine
wettable powder
preparation
rice
raw
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NL2035186A
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Dutch (nl)
Inventor
Jiao Zhanli
Pan Yaqing
Li Zhiyong
Song Weifeng
Wei Qinghui
Zhai Xihai
Shi Zhenghao
Li Baoying
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Institute Of Plant Prot Heilongjiang Academy Of Agricultural Sciences
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Application filed by Institute Of Plant Prot Heilongjiang Academy Of Agricultural Sciences filed Critical Institute Of Plant Prot Heilongjiang Academy Of Agricultural Sciences
Publication of NL2035186A publication Critical patent/NL2035186A/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A01N25/14—Powders or granules wettable
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A chelerythrine wettable powder, its preparation method and its application belong to the technical field of biological pesticides. In order to obtain a wettable powder which can be used for the prevention and treatment of rice false smut, the invention provides a wettable powder of chelerythrine, which takes chelerythrine as the original drug, TAMOL DN, Ultrazine NA and Atlox Metasperse as dispersants, GEROPON SDS as wetting agent, silica HL-200 and anhydrous glucose as fillers, and Aguique Soap L as defoaming agent. The preparation method of the chelerythrine wettable powder is simple, and the diluted chelerythrine wettable powder can be sprayed on rice to effectively prevent and control rice false smut.

Description

CHELERYTHRINE WETTABLE POWDER, PREPARATION
METHOD AND APPLICATION THEREOF
TECHNICAL FIELD
The invention belongs to the technical field of biological pesticides, and in particular to a chelerythrine wettable powder, its preparation method and its application.
BACKGROUND
At present, the main method to control plant diseases is still chemical methods, but chemical pesticides are difficult to degrade, easy to produce drug resistance, environmental pollution and other problems, which pose a great threat to human health and ecological environment, and the problem of drug resistance will also bring great difficulties to the subsequent pest control. Chelerythrine has important biological activities such as anti-cancer, bacteriostasis, insecticidal, antioxidant, etc. It can effectively control crop diseases such as Fusarium oxysporum, Colletotrichum nigrum and Botrytis cinerea in agricultural production, but it has not been applied to the control of false smut. In recent years, false smut has become one of the main fungal diseases in rice, which not only affects rice yield and quality, but also produces toxins, seriously affecting food safety. The disease is caused by Ustilaginoidea virens. Previous studies found that chelerythrine had a significant antifungal effect on this fungus, and the inhibition rate of its spore germination is as high as 86.7%, and it also induces the apoptosis of pathogenic cells.
The formula of wettable powder (WP) contains raw materials, carriers, various auxiliaries (mainly wetting agents and dispersing agents) and other substances, which are mixed in proportion and crushed by a special machine according to the particle size requirements to form fine powder. The suspension rate and wettability of wettable powder are the most important in the quality inspection standard of preparation. The medicine is dissolved in water and sprayed for use, which can effectively adhere to plants and improve the use efficiency of pesticides. In addition, the cost of all kinds of carriers and additives needed by the wettable powder is low, and organic solvents that pollute the environment are not used. As a solid pesticide, it can be packaged in paper bags or plastic bags, which is economical and green, and convenient to transport and store.
Therefore, it is of great significance to develop wettable powder based on chelerythrine for plant disease control.
SUMMARY
In order to obtain a wettable powder which can be used for the prevention and treatment of rice false smut, the invention provides a chelerythrine wettable powder, which contains 10% by weight of chelerythrine raw material, the dispersant is TAMOL
DN, Ultrazine NA and Atlox Metasperse, the wetting agent is GEROPON SDS, the filler is silica HL-200 and anhydrous glucose, and the defoamer is Aguique SOAP L.
It is further defined that the raw materials of the chelerythrine wettable powder are, in parts by weight, chelerythrine 10%, TAMOL DN 16%, Ultrazine NA 8%, Atlox
Metasperse 5508 8%, GEROPON SDS 8%, Aguique Soap L 0.5%, silica HL-200 10% and anhydrous glucose 39.5%.
The invention also provides a preparation method of the chelerythrine wettable powder, which comprises the following steps: weighing the raw materials according to parts by weight, adding the raw materials into a stirring cooking cup for preliminary mixing and crushing, and then crushing and mixing the mixture by using an airflow pulverizer to obtain the chelerythrine wettable powder.
It is further defined that the crushing standard of the jet mill is to obtain powder with a particle size of D50 5.00-6.00 um.
The invention also provides an application of the chelerythrine wettable powder in preventing and treating rice false smut.
It is further defined that when the rice grows to 3-5 days before and after the heading date, it is sprayed with the chelerythrine wettable powder concentrate for two times.
Further, the interval between spraying twice is 8-12 days.
Further, the dosage of chelerythrine wettable powder used for each spraying is 2-8 kg/hm?
Preferably, the dosage of chelerythrine wettable powder used for each spraying is 8 kg/hm?,
The invention has the following beneficial effects:
After being diluted and sprayed on rice, the chelerythrine wettable powder obtained by the invention can effectively prevent and control rice false smut, and compared with the existing 13% validamycin used for preventing and controlling rice false smut, the chelerythrine wettable powder can effectively improve the prevention and control effect of rice false smut.
DESCRIPTION OF THE INVENTION
In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention will be further described in detail with specific examples. It should be understood that the specific embodiments described here are only used to explain the invention, and are not used to limit the invention.
The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents, methods, and instruments used, without special instructions, are conventional materials, reagents, methods, and instruments in the art and are commercially available to those skilled in the art.
The raw materials involved in the invention are as follows:
Original drug: chelerythrine original drug;
Dispersants: Greensperse 1506 (Beijing Green-times Technology Co., Ltd.),
Greensperse 1508 (Beijing Green-times Technology Co, Ltd), MORWET D-425 (AkzoNobel Company), Ultrazine NA (Borregaard Industry Co., Ltd.), TAMOL DN (BASF Co, Ltd.), Atlox Metasperse 550S (Croda Chemicals (Shanghai) Co, Ltd.),
TERSPERSE 2700 (Huntsman Chemical Trading (Shanghai) Co., Ltd.), GEROPON
T36 (Solway Group);
Wetting agents: GEROPON SDS (Solway Group), Morewet EFW (AkzoNobel
Company), Geropon L-WET/P (Solway Group), TERWET 1004 (Huntsman Chemical
Trading (Shanghai) Co., Ltd.) and K12 (Sinopharm Group);
Fillers: ammonium sulfate (Sinopharm Group), sodium sulfate (Sinopharm Group),
corn starch (Yufeng Group), light calcium carbonate (Suzhou Sinoma), calcined kaolin (Suzhou Sinoma), diatomite (Suzhou Sinoma), bentonite (Suzhou Sinoma), silica HL- 200 (Yichang Huifu Silicon Material Co., Ltd.) and anhydrous glucose (Sinoma Group);
Defoamer: Aguique Soap L (BASF Co, Ltd.).
Experimental equipment: stirring cooking cup (Beijing Ruibaili Business), electronic balance (accuracy 0.01g, 0.0001g), Agilent HPLC1220, pH meter (HANNA) and ultra-micro jet mill.
Example 1: Selection of chelerythrine wettable powder formula (1) Screening of dispersant:
The flow point of dispersant is determined by the flow point method, and the results are shown in Table 1. The results show that Ultrazine NA, TAMOL DN and Atlox
Metasperse 5508 have relatively good effects, so they are used for the next screening.
Table 1 Determination results of flow point of dispersant
Auxiliary chemical Flow point
Greensperse 1506 7.25
Greensperse 1508 7.86
MORWET D-425 6.65
Ultrazine NA 4.24
TAMOL DN 3.61
Atlox Metasperse 5508 3.53
TERSPERSE 2700 6.85
GEROPON T36 7.19 (2) Screening of wetting agent:
Each formula as shown in Table 2 is designed to screen wetting agent, and the results show that GEROPON SDS has the best wetting effect, so this wetting agent is selected for the next screening.
Table 2 Screening and results of wetting agents
Raw materials/g Formula 1 Formula 2 Formula3 Formula4 Formula 5
Chelerythrine 10 10 10 10 10 es original drug
Ultrazine NA 10 10 10 10 10
TAMOL DN 20 15 10 5 0
Atlox 5 5 5 5 5
Metasperse 5505
GEROPON SDS 10
Geropon L- 10
WET/P
K12 10
Morewet EFW 10
TERWET 1004 10 distilled water 45 50 55 60 65
Phenomenon The wetting The wetting Difficult to Difficult to Difficult to after entering time is about time is about wet wet wet water 110s. 130s. (3) Screening of fillers:
Through the pre-screening experiment, it is found that diatomite, bentonite, B- cyclodextrin and other fillers are precipitated after being added separately, and only silica HL-200 and anhydrous glucose are slightly improved after being added. Therefore, silica HL-200 and anhydrous glucose are used as fillers to optimize the formula, and the formula optimization results after adding fillers are shown in Table 3. By comparing the results of each formula, it is found that the dispersion of formula 10 is better.
Table 3 Formula optimization results after adding fillers
Raw Formula6 Formula7 Formula8 Formula9 Formula 10 materials /g
Chelerythri 10 10 10 10 10 ne original drug
Ultrazine 10 5 5 10 8
—_—
NA
TAMOL 20 10 10 10 16
DN
Atlox 10 5 5 10 8
Metasperse 5508
GEROPON 10 5 5 10 8
SDS
Silica HL- 10 20 5 10 10 200
Anhydrous 30 45 60 40 40 dextrose
Phenomeno It can be More More There are It can be n after dispersed precipitatio precipitatio floating dispersed entering by shaking, ns at the ns at the objectsonit by shaking, water with less bottom bottom and more with less precipitatio precipitatio precipitatio ns ns on the ns bottom (4) Determination of formula:
On the basis of Formula 10, a small amount of defoamer Aguique Soap L is added, and the final formula is shown in Table 4.
Table 4 The finally screened formula of chelerythrine wettable powder
Raw materials /g Dosage /g
Chelerythrine original drug 10
Ultrazine NA 8
TAMOL DN 16
Atlox Metasperse 550S 8
GEROPON SDS 8
Aguique Soap L 0.5
Silica HL-200 10 anhydrous dextrose 39.5
Embodiment 2: Preparation Method of Chelerythrine Wettable Powder
Weighing the raw materials according to Table 4, adding them into a stirring cooking cup for preliminary mixing and crushing, and then further crushing and mixing the mixture with an airflow crusher to obtain chelerythrine wettable powder. The crushing standard of jet mill is to obtain powder with a particle size of D50 5.00-6.00um.
Embodiment 3: Application of chelerythrine wettable powder in controlling rice false smut
In order to verify the effect of chelerythrine wettable powder prepared in
Embodiment 2 in the prevention and treatment of rice false smut, the experimental group of chelerythrine wettable powder and the positive control group of 13% validamycin are used to prevent and treat rice false smut. Both the experimental group and the positive control group sprayed the rice 3-5 days before and after the heading stage, with an interval of 8-10 days. The dosage of each spray is the same, and the water consumption per hectare is GOOL. The dosage of the experimental group 1 is 2 kg/hm? the dosage of the experimental group 2 is 8 kg/hm?, and the dosage of the positive control group is 69 mL/hm?, which ensure the same growth conditions of the experimental rice in each group are the same and the spray time is the same.
The results show that when the dosage of chelerythrine wettable powder is 2 kg/hm?, the control effect 1s 70.97%. When the dosage of chelerythrine wettable powder is 8 kg/hm? the control effect is 95.88%, and that of the positive control group is 56.18%. It can be seen that chelerythrine wettable powder has a good control effect on rice false smut.
Although the present invention has been disclosed in terms of preferred embodiments, it is not intended to limit the present invention. Anyone familiar with this technology can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be determined by the claims.

Claims (9)

ConclusiesConclusions 1. Chelerythrine bevochtigbaar poeder, met het kenmerk dat het chelerythrine bevochtigbare poeder 10 gew.% chelerythrine onbewerkte grondstof bevat, waarbij het dispergeermiddel TAMOL DN, Ultrazine NA en Atlox Metasperse is, het bevochtigingsmiddel GEROPON SDS is, het vulmiddel silica HL-200 en watervrije glucose is, en de ontschuimer Aguipe SOAP L is.1. Chelerythrine wettable powder, characterized in that the chelerythrine wettable powder contains 10 wt% chelerythrine raw raw material, the dispersant is TAMOL DN, Ultrazine NA and Atlox Metasperse, the wetting agent is GEROPON SDS, the filler is silica HL-200 and anhydrous is glucose, and the defoamer is Aguipe SOAP L. 2. Chelerythrine bevochtigbaar poeder volgens conclusie 1, met het kenmerk dat de onbewerkte grondstoffen van het chelerythrine bevochtigbare poeder de volgende zijn; chelerythrine 10 gew.%, TAMOL DN 16 gew.%, Ultrazine NA 8 gew.%, Atlox Metasperse 5508S 8 gew.%, GEROPON SDS 8 gew.%, Aguique Soap L 0,5 gew.%, silica HL-200 10 gew.% en watervrije glucose 39,5 gew.%.The chelerythrine wettable powder according to claim 1, characterized in that the raw raw materials of the chelerythrine wettable powder are as follows; chelerythrine 10 wt%, TAMOL DN 16 wt%, Ultrazine NA 8 wt%, Atlox Metasperse 5508S 8 wt%, GEROPON SDS 8 wt%, Aguique Soap L 0.5 wt%, Silica HL-200 10 wt% and anhydrous glucose 39.5 wt%. 3. Bereidingswerkwijze voor het chelerythrine bevochtigbare poeder volgens conclusie 1 of conclusie 2, gekenmerkt door het wegen van de onbewerkte grondstoffen volgens gewichtsdelen, het toevoegen van de onbewerkte grondstoffen aan een roerende kookbeker voor voorbereidend mengen en malen, en vervolgens het malen en mengen van het mengsel door het gebruiken van een luchtstroomvergruizer om het chelerythrine bevochtigbare poeder te verkrijgen.The preparation method for the chelerythrine wettable powder according to claim 1 or claim 2, characterized by weighing the raw raw materials by parts by weight, adding the raw raw materials to a stirring cooking cup for preliminary mixing and grinding, and then grinding and mixing the mixture using an airflow pulverizer to obtain the chelerythrine wettable powder. 4. Bereidingswerkwijze volgens conclusie 3, met het kenmerk dat de maalstandaard van de straalmolen het verkrijgen van een poeder met een deeltjesgrootte van D50 5,00-6,00 um is.The preparation method according to claim 3, characterized in that the grinding standard of the jet mill to obtain a powder having a particle size of D 50 is 5.00-6.00 µm. 5. Toepassing van het chelerythrine bevochtigbare poeder volgens conclusie 1 in het voorkomen en behandelen van valse brandschimmel in rijst.Use of the chelerythrine wettable powder according to claim 1 in the prevention and treatment of false scorch fungus in rice. 6. Toepassing volgens conclusie 5, met het kenmerk dat wanneer de rijst groeit tot 3-5 dagen voor en na de kopdatum, het met de chelerythrine suspensie voor twee keer besproeid wordt.Use according to claim 5, characterized in that when the rice grows to 3-5 days before and after the top date, it is sprayed with the chelerythrine suspension for two times. 7. Toepassing volgens conclusie 6, met het kenmerk dat het interval tussen het twee keer besproeien 8-12 dagen is.Use according to claim 6, characterized in that the interval between spraying twice is 8-12 days. 8. Toepassing volgens conclusie 7, met het kenmerk dat de dosering van het chelerythrine bevochtigbare poeder voor elke besproeiing 2-8 kg/hm? is.Use according to claim 7, characterized in that the dosage of the chelerythrine wettable powder for each spraying is 2-8 kg/hm? is. 9. Toepassing volgens conclusie 8, met het kenmerk dat de dosering van het chelerythrine bevochtigbare poeder voor elke besproeiing 8 kg/hm? is.Use according to claim 8, characterized in that the dosage of the chelerythrine wettable powder for each spraying is 8 kg/hm? is.
NL2035186A 2022-06-28 2023-06-27 Chelerythrine wettable powder, preparation method and application thereof NL2035186A (en)

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CN1127899C (en) * 1998-12-15 2003-11-19 安庆市茁壮农药有限公司 Application of macleaya cordata in pesticide preparation
CN102657192B (en) * 2012-05-22 2014-04-16 芜湖市多威农化有限责任公司 Biological bactericide chelerythrine suspending agent and preparation method thereof
CN105123777A (en) * 2015-08-26 2015-12-09 青岛文创科技有限公司 Botanical insecticide
CN110278970B (en) * 2019-07-31 2020-12-22 黑龙江省农业科学院植物保护研究所 Chinese herbal medicine type seed coating agent and preparation method thereof
CN110679612A (en) * 2019-10-29 2020-01-14 宁波市鄞州赛弗兑食品科技有限公司 Agricultural insecticidal composition for preventing and treating corn borers
CN112079846A (en) * 2020-08-17 2020-12-15 贵州梵净山生态农业股份有限公司 Sanguinarine derivative and chelerythrine derivative and application thereof
CN112457322B (en) * 2020-12-02 2022-06-17 铜仁职业技术学院 Insecticidal and antibacterial 5-imino substituted derivative, and preparation method and application thereof
CN113875763B (en) * 2021-10-29 2022-07-22 黑龙江省农业科学院植物保护研究所 Chelerythrine suspending agent and preparation method and application thereof

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