CN115119847A - Chelerythrine wettable powder and preparation method and application thereof - Google Patents
Chelerythrine wettable powder and preparation method and application thereof Download PDFInfo
- Publication number
- CN115119847A CN115119847A CN202210741435.6A CN202210741435A CN115119847A CN 115119847 A CN115119847 A CN 115119847A CN 202210741435 A CN202210741435 A CN 202210741435A CN 115119847 A CN115119847 A CN 115119847A
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- CN
- China
- Prior art keywords
- chelerythrine
- wettable powder
- powder
- wettable
- rice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Chelerythrine wettable powder as well as a preparation method and application thereof, and belongs to the technical field of biological pesticides. In order to obtain wettable powder capable of being used for preventing and treating rice false smut, the invention provides chelerythrine wettable powder, which takes chelerythrine as a raw pesticide, TAMOLDN, UltrazineNA and AtloxMetaperse 550S as dispersing agents, GEROPONDS as wetting agents, white carbon black HL-200 and anhydrous glucose as fillers and Aguique Soap L as a defoaming agent. The chelerythrine wettable powder is simple in preparation method, and can be diluted and sprayed on rice to effectively prevent and treat false smut of rice.
Description
Technical Field
The invention belongs to the technical field of biological pesticides, and particularly relates to chelerythrine wettable powder as well as a preparation method and application thereof.
Background
At present, the main method for treating plant diseases still adopts a chemical method for preventing and treating, but various problems of difficult degradation, easy generation of drug resistance, environmental pollution and the like of chemical pesticides bring great threats to the health and ecological environment of human beings, and the problem of drug resistance also brings great difficulty to the prevention and treatment of subsequent pests. Chelerythrine has important biological activities of resisting cancer, inhibiting bacteria, killing insects, resisting oxidation and the like, can effectively prevent and treat diseases of crops such as fusarium wilt, anthracnose, botrytis cinerea and the like in agricultural production, but is not applied to prevention and treatment of false smut. In recent years, false smut becomes one of main fungal diseases of rice, which not only affects the rice yield and rice quality, but also causes toxin to be produced by pathogenic bacteria, thus seriously affecting food safety. The disease is caused by Rhizoctonia oryzae (Ustilaginoidea virens) of Deuteromycotina, and early researches find that chelerythrine (chelerythrine) has a remarkable bacteriostatic effect on the Rhizoctonia oryzae, has an inhibition rate of spore germination of the chelerythrine up to 86.7 percent, and induces apoptosis of pathogenic bacteria cells.
The Wettable Powder (WP) contains the raw pesticide, a carrier, various assistants (mainly wetting agent and dispersing agent) and other substances, is mixed in proportion, and is crushed by a specific machine according to the requirement of particle size to form fine powder. The suspension rate and wettability of wettable powder are the important factors of the quality detection standard of the preparation. The pesticide can be effectively adhered to plants by being dissolved in water for spraying, so that the use efficiency of the pesticide is improved. In addition, various carriers and auxiliary agents required by the wettable powder have low cost, and organic solvents polluting the environment are not used, so that the wettable powder can be packaged by paper bags or plastic bags as a solid pesticide, is economical and green, and is convenient to transport and store. Therefore, the development of the wettable powder taking chelerythrine as a raw pesticide for preventing and treating plant diseases has important significance.
Disclosure of Invention
In order to obtain wettable powder capable of being used for preventing and treating rice false smut, the invention provides celandine wettable powder which contains 10% by weight of celandine original drug, wherein a dispersing agent is selected from TAMOLDN, Ultrazine NA and Atlox Metasperse550S, a wetting agent is selected from GEROPON SDS, a filler is selected from white carbon black HL-200 and anhydrous glucose, and an antifoaming agent is selected from Aguique Soap L.
The chelerythrine wettable powder is further limited to comprise, by weight, 10% of chelerythrine technical product, 16% of TAMOLDN, 8% of Ultrazine NA, 550S 8% of Atlox Metasperse, 8% of GEROPON SDS, 0.5% of Aguique Soap L, HL-20010% of white carbon black and 39.5% of anhydrous glucose.
The invention also provides a preparation method of the chelerythrine wettable powder, which comprises the steps of weighing the raw materials in parts by weight, adding the raw materials into a stirring cooking cup for preliminary mixing and crushing, and crushing and mixing the mixture by using an airflow crusher to obtain the chelerythrine wettable powder.
Further defined, the pulverization criteria of the jet mill are to obtain a powder having a particle size of D505.00-6.00. mu.m.
The invention also provides application of the chelerythrine wettable powder in preventing and treating rice false smut.
Further limiting, when the rice grows to 3-5 days before and after the heading stage, spraying the chelerythrine wettable powder twice.
Further limiting, the interval time of spraying twice is 8-12 days.
Further limiting, the dosage of the chelerythrine wettable powder used in each spraying is 2kg/hm 2 -8kg/hm 2 。
Further limiting, the dosage of the chelerythrine wettable powder used in each spraying is 8kg/hm 2 。
Further, the water consumption of the diluted chelerythrine wettable powder before spraying is 600L per hectare.
The invention has the beneficial effects that:
the celandine obtained by the invention is used for preparing the celandineThe alkali wettable powder can effectively prevent and treat rice false smut when being sprayed on rice after being diluted, and the dosage of the chelerythrine wettable powder used when being sprayed each time is 2kg/hm 2 When the composition is used, the control effect is 70.97%; when the chelerythrine wettable powder is sprayed every time, the dosage of the chelerythrine wettable powder is 8kg/hm 2 In the case of the validamycin A, the control effect is 95.88%, and is obviously improved compared with the control effect (56.18%) of 13% of validamycin A of a positive control group. As can be seen, the chelerythrine wettable powder has good prevention and treatment effect on rice false smut, and the dosage of spraying each time is 8kg/hm 2 The prevention and treatment effect is better.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
The experimental procedures used in the following examples are conventional unless otherwise specified. The materials, reagents, methods and apparatus used, unless otherwise specified, are conventional in the art and are commercially available to those skilled in the art.
The invention relates to the following raw materials:
raw materials: chelerythrine raw drug;
dispersing agent: greensperse 1506 (beijing greentam technologies, inc.), Greensperse 1508 (beijing greentam technologies, inc.), MORWET D-425 (aksonobel, inc.), Ultrazine NA (pall industries, inc.), TAMOL DN (basf, inc.), Atlox Metasperse550S (procheim, inc.), TERSPERSE 2700 (heng chemical trade, shanghai, inc.), GEROPON T36 (solvelykup, inc.);
wetting agent: GEROPON SDS (Solvay group), Morewet EFW (Acksonobel), Geropon L-WET/P (Solvay group), TERWET 1004 (Hensmei chemical trade (Shanghai) Co., Ltd.), K12 (national drug group);
filling: ammonium sulfate (national medicine group), sodium sulfate (national medicine group), corn starch (Yufeng group), light calcium carbonate (Suzhou middle wood), calcined kaolin (Suzhou middle wood), diatomite (Suzhou middle wood), bentonite (Suzhou middle wood), white carbon HL-200 (Yichanghui silicon-rich materials Co., Ltd.), and anhydrous glucose (national medicine group);
defoaming agent: aguique Soap L (BASF corporation).
Experimental equipment: stirring cup (Beijing Ruibeili commercial), electronic balance (precision 0.01g, 0.0001g), Agilent HPLC1220, pH meter (Hana), ultramicro jet mill.
Example 1: screening of chelerythrine wettable powder formula
(1) Screening of the dispersant:
the flow point of the dispersant is determined by adopting a flow point method, the determination results are shown in table 1, the results show that Ultrazine NA, TAMOLDN and Atlox Metaperse 550S have relatively good effects, and the ultra-trazine NA, TAMOLDN and Atlox Metaperse 550S are used for carrying out next-step screening.
TABLE 1 flow point measurement of dispersants
(2) Screening of wetting agents:
the formulations as shown in table 2 were designed for screening of wetting agents, and the results showed that the wetting effect of GEROPON SDS was the best, and the wetting agent was selected for the next screening.
TABLE 2 screening of wetting agents and results
(3) Screening of the filler:
the pre-screening experiment shows that after the filler such as diatomite, bentonite, beta cyclodextrin and the like is added independently, precipitates exist, and only the white carbon black HL-200 and the anhydrous glucose are slightly improved after the filler is added, so that the formula is optimized by taking the white carbon black HL-200 and the anhydrous glucose as the filler, the optimization result of the formula after the filler is added is shown in a table 3, and the better dispersibility of the formula 10 is found by comparing the results of all the formulas.
Table 3 formula optimization results after filler addition
(4) Determining a formula:
a small amount of defoamer Aguique Soap L was added based on formulation 10, and the final formulation is shown in Table 4.
TABLE 4 Final screening chelerythrine wettable powder formulation
Example 2: preparation method of chelerythrine wettable powder
Weighing the raw materials according to the table 4, adding the raw materials into a stirring cooking cup for preliminary mixing and crushing, and further crushing and mixing the mixture by using an airflow crusher to obtain the chelerythrine wettable powder. The pulverization standard of the jet mill is to obtain a powder having a particle size of D505.00-6.00. mu.m.
Example 3: application of chelerythrine wettable powder in prevention and treatment of rice false smut
In order to verify the effect of the chelerythrine wettable powder prepared in the example 2 in preventing and treating the false smut of rice, the invention adopts a chelerythrine wettable powder experimental group and a 13% validamycin positive control group to prevent and treat the false smut of rice. The experimental group and the positive control group are used for spraying the paddy rice 3-5 days before and after the heading stage for two times, the time interval between the two spraying is 8-10 days, the spraying dosage is the same, the water consumption per hectare is 600L, and the dosage of the chelerythrine wettable powder used for spraying each time of the experimental group 1 is 2kg/hm 2 Experiment group 2 Each sprayThe dosage of the chelerythrine wettable powder applied is 8kg/hm 2 The effective concentration of the positive control group is 69mL/hm 2 The growth conditions of the experimental rice in each group are ensured to be the same, and the spraying time is the same.
The result shows that the dosage of the chelerythrine wettable powder used in each spraying is 2kg/hm 2 When the composition is used, the control effect is 70.97%; when the chelerythrine wettable powder is sprayed every time, the dosage of the chelerythrine wettable powder is 8kg/hm 2 The control effect is 95.88%, and the control effect of the positive control group is 56.18%. As can be seen, the chelerythrine wettable powder has good prevention and treatment effect on rice false smut, and the dosage of spraying each time is 8kg/hm 2 The effect is better.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. The chelerythrine wettable powder is characterized in that the chelerythrine wettable powder contains 10% of chelerythrine raw drug by weight, a dispersing agent is TAMOLDN, Ultrazine NA and AtloxMetaperse 550S, a wetting agent is GEROPON SDS, a filler is white carbon black HL-200 and anhydrous glucose, and an antifoaming agent is Aguique Soap L.
2. The chelerythrine wettable powder according to claim 1, wherein the chelerythrine wettable powder comprises, by weight, 10% of chelerythrine raw pesticide, 16% of TAMOLDN, 8% of UltrazineNA, 550S 8% of Atlox Metaperse, 8% of GEROPON SDS, 0.5% of Aguique Soap L, HL-20010% of white carbon black, and 39.5% of anhydrous glucose.
3. The preparation method of the chelerythrine wettable powder as claimed in claim 1 or claim 2, characterized in that the chelerythrine wettable powder is prepared by weighing the raw materials according to the parts by weight, adding the raw materials into a stirring cup for preliminary mixing and crushing, crushing the mixture by using an airflow crusher, and crushing and mixing the crushed mixture.
4. The method according to claim 3, wherein the jet mill is subjected to a pulverization standard to obtain a powder having a particle size of D505.00-6.00. mu.m.
5. Use of the chelerythrine wettable powder of claim 1 for preventing and treating rice false smut.
6. The application of claim 5, wherein the chelerythrine wettable powder is sprayed twice when rice grows to 3-5 days before and after a heading stage.
7. The use of claim 6, wherein the two spraying operations are carried out at intervals of 8-12 days.
8. The use as claimed in claim 7, characterized in that the dosage of the wettable chelerythrine powder used per spray application is 2kg/hm 2 -8 kg/hm 2 。
9. The use as claimed in claim 8, characterized in that the dosage of the wettable chelerythrine powder used per spray application is 8kg/hm 2 。
10. The use according to any one of claims 8 or 9, wherein the amount of water used to dilute the wettable chelerythrine powder prior to spraying is 600L per hectare.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210741435.6A CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
| NL2035186A NL2035186A (en) | 2022-06-28 | 2023-06-27 | Chelerythrine wettable powder, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210741435.6A CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115119847A true CN115119847A (en) | 2022-09-30 |
| CN115119847B CN115119847B (en) | 2023-09-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210741435.6A Active CN115119847B (en) | 2022-06-28 | 2022-06-28 | Chelidonine wettable powder and preparation method and application thereof |
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| Country | Link |
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| CN (1) | CN115119847B (en) |
| NL (1) | NL2035186A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256873A (en) * | 1998-12-15 | 2000-06-21 | 安庆市茁壮农药有限公司 | Application of macleaya cordata in pesticide preparation |
| CN102657192A (en) * | 2012-05-22 | 2012-09-12 | 芜湖市多威农化有限责任公司 | Biological bactericide chelerythrine suspending agent and preparation method thereof |
| CN105123777A (en) * | 2015-08-26 | 2015-12-09 | 青岛文创科技有限公司 | Botanical insecticide |
| CN110278970A (en) * | 2019-07-31 | 2019-09-27 | 黑龙江省农业科学院植物保护研究所 | A kind of Chinese herbal medicine type seed coat agent and preparation method thereof |
| CN110679612A (en) * | 2019-10-29 | 2020-01-14 | 宁波市鄞州赛弗兑食品科技有限公司 | Agricultural insecticidal composition for preventing and treating corn borers |
| CN112079846A (en) * | 2020-08-17 | 2020-12-15 | 贵州梵净山生态农业股份有限公司 | Sanguinarine derivative and chelerythrine derivative and application thereof |
| CN112457322A (en) * | 2020-12-02 | 2021-03-09 | 铜仁职业技术学院 | Insecticidal and antibacterial 5-imino substituted derivative and preparation method and application thereof |
| CN113875763A (en) * | 2021-10-29 | 2022-01-04 | 黑龙江省农业科学院植物保护研究所 | Chelerythrine suspending agent and preparation method and application thereof |
-
2022
- 2022-06-28 CN CN202210741435.6A patent/CN115119847B/en active Active
-
2023
- 2023-06-27 NL NL2035186A patent/NL2035186A/en unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256873A (en) * | 1998-12-15 | 2000-06-21 | 安庆市茁壮农药有限公司 | Application of macleaya cordata in pesticide preparation |
| CN102657192A (en) * | 2012-05-22 | 2012-09-12 | 芜湖市多威农化有限责任公司 | Biological bactericide chelerythrine suspending agent and preparation method thereof |
| CN105123777A (en) * | 2015-08-26 | 2015-12-09 | 青岛文创科技有限公司 | Botanical insecticide |
| CN110278970A (en) * | 2019-07-31 | 2019-09-27 | 黑龙江省农业科学院植物保护研究所 | A kind of Chinese herbal medicine type seed coat agent and preparation method thereof |
| CN110679612A (en) * | 2019-10-29 | 2020-01-14 | 宁波市鄞州赛弗兑食品科技有限公司 | Agricultural insecticidal composition for preventing and treating corn borers |
| CN112079846A (en) * | 2020-08-17 | 2020-12-15 | 贵州梵净山生态农业股份有限公司 | Sanguinarine derivative and chelerythrine derivative and application thereof |
| CN112457322A (en) * | 2020-12-02 | 2021-03-09 | 铜仁职业技术学院 | Insecticidal and antibacterial 5-imino substituted derivative and preparation method and application thereof |
| CN113875763A (en) * | 2021-10-29 | 2022-01-04 | 黑龙江省农业科学院植物保护研究所 | Chelerythrine suspending agent and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| QING-HUI WEI. ET AL: "In vitro antifungal activity and possible mechanisms of action of chelerythrine", 《PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY》, pages 140 - 148 * |
| 范海延;薛广厚;吕春茂;崔娜;: "白屈菜中白屈菜红碱的提取及抑菌活性", 食品科学, no. 24, pages 120 - 129 * |
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| Publication number | Publication date |
|---|---|
| NL2035186A (en) | 2023-08-01 |
| CN115119847B (en) | 2023-09-19 |
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