CN115068379A

CN115068379A - Long-acting oil control composition and preparation method thereof

Info

Publication number: CN115068379A
Application number: CN202210424171.1A
Authority: CN
Inventors: 舒俊超; 刘礼刚
Original assignee: Xinbozhuang Guangzhou Technology R & D Center Co ltd
Current assignee: Xinbozhuang Guangzhou Technology R & D Center Co ltd
Priority date: 2022-04-21
Filing date: 2022-04-21
Publication date: 2022-09-20

Abstract

The invention discloses a long-acting oil control composition and a preparation method thereof, belonging to the technical field of cosmetics and comprising the following raw materials in percentage by mass: 6603 oil control powder 0.1-3%, Hamamelis virginiana extract 0.1-50%, caprylyl glycine 0.1-1%, zinc salt 0.1-2%, pore cleaning factor 0.11-2%, schizophyllan 0.1-3%, extract of Picea japonica 0.1-50%, and water in balance, and the long-acting oil control composition prepared by the method acts on different approaches for controlling skin oil secretion to achieve synergistic effect and effectively functions from inside to outside; the preparation method of the long-acting oil control composition provided by the invention is simple and convenient in steps, is suitable for industrial large-scale preparation, can keep the activity of the product, and is low in production cost.

Description

Long-acting oil control composition and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a long-acting oil control composition and a preparation method thereof.

Background

Along with the acceleration of work and life rhythm of people, various pressures are increased, and in addition, the situation that multiple external factors such as air pollution, screen radiation, ultraviolet rays and the like destroy the skin all the year round, more and more people are troubled by the problems of dry, rough, dark, fine lines and the like of the skin, along with the improvement of the living standard, the consciousness of people on skin protection and repair is gradually improved, and the demand of repair cosmetics such as anti-aging and anti-inflammation is also continuously improved. However, the existing cosmetics for controlling skin oil secretion comprise an oil absorption type, a skin astringing type and an oil secretion inhibiting type, wherein the oil absorption type such as silica, starch, PMMA and the like is weak in oil absorption capability of materials, oil control is difficult to realize for a long time, and long-term oil control is required to be achieved and the use feeling is influenced; astringent skin type such as plant extract containing tannins (tannins); the lipid secretion inhibiting type such as Vb6, Vb3 (nicotinamide, such as olay), VA, salvia miltiorrhiza, rhizoma anemarrhenae, dalbergia odorifera and the like can inhibit the activity of 5 alpha-reductase and reduce the generation of DHT, so that the lipid secretion is reduced, but in actual application, the acting concentration can be reduced only by improving the acting efficiency; cleaning grease and keratotic plug, dredging capillary hole, inhibiting microorganism growth, diminishing inflammation and resisting bacteria. The three types of cosmetics can play a certain role, but have single efficacy and are difficult to play a role in controlling oil from inside to outside.

The final composition contains 1% of schizophyllan, 50% of Norway spruce (Picea EXCELSA) leaf extract, and 45% of Hamamelis virginiana (HAMAMELIS VIRGINIANA) extract.

The yield after final treatment is 75%, the content of caprylyl glycine in the composition is 13.3%, the content of caprylyl salicylic acid is 13.3%, and the content of hydroxy pinacolone retinoic acid ester is 6.7%.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide a long-acting oil control composition which effectively plays a role in controlling oil from inside to outside through acting on different approaches for controlling skin oil secretion and synergistic action.

The second purpose of the invention is to provide a preparation method of the long-acting oil-control composition, which has simple steps, is suitable for industrial large-scale preparation and can keep the activity.

One of the purposes of the invention is realized by adopting the following technical scheme:

the long-acting oil control composition comprises the following raw materials in percentage by mass:

6603 oil control powder: the lauryl alcohol methacrylate/ethylene glycol dimethacrylate crosslinked polymer has a sponge-like structure and super-strong adsorption performance, can adsorb active substances in a body, and releases the active substances according to osmotic concentration difference when the environment is changed.

Witch hazel extract: contains various tannins, such as Ellagtannin and Hamamelanin, and has effects of regulating sebum secretion, keeping moisture, whitening skin, relieving, astringing, resisting bacteria, and resisting aging, and has remarkable therapeutic effects of astringing, controlling oil, and killing bacteria. For adolescents or skin with severe oil production, the hamamelis virginiana can help to adjust the water-oil balance of the skin, effectively improve the water content of the skin, balance the pH value and shrink pores.

Zinc salt: for example, zinc gluconate and zinc pyrrolidone carboxylate are essential micronutrients for human, and the importance of the zinc gluconate and zinc pyrrolidone carboxylate is measured by the main components, more than 300 metalloenzymes are involved in regulating lipid, protein and nucleic acid metabolism, and transcription factors necessary for gene transcription and the like, and all levels of gene transcription can be involved by the factors involved in histone deacetylation reaction and possessed by zinc finger structures. Zinc also plays an important role in maintaining proper reproductive function, immune status and wound repair by regulating DNA and RNA polymerases, thymidine kinases and ribonucleases. It can maintain macrophage and neutrophil functions, natural killer cells and complement activity. Zinc utilization by keratinocytes inhibits integrin expression, regulates TNF and IL-6 synthesis, and slows the production of inflammatory mediators such as nitric oxide. Zinc also has antioxidant properties and can prevent ultraviolet rays which induce damage. It has also been shown to have antiandrogenic properties, modulating the activity of 5-reductase type 1 and type 2.

The black spruce contains monoterpene with high proportion, mainly terpineol, has the effects of cortisone-like, relieving pain, diminishing inflammation, tranquilizing, strengthening and toughening skin, decomposing sebum, resisting bacteria, softening and tendering skin, effectively removing dirt in pores, improving blackhead acne and enabling oily skin easy to block to be fresh and bright.

Octanoyl salicylic acid: is a lipidated derivative of salicylic acid, is an exfoliating, anti-inflammatory, anti-infective drug, and is used to treat the appearance of dry damaged skin, reduce dry plaques/scaling, and restore skin flexibility. This means that it can not only peel off the surface layer of the skin but also penetrate into the epidermis to peel off dead skin cells and excess oil accumulated in pores, and thus caprylyl salicylic acid is frequently used for the treatment of blackheads, whiteheads and pimples, and is used in various cosmetics because it requires a very low concentration to remove dead skin cells, remove deposits in pores, condition the skin, and calm inflamed skin.

The caprylyl glycine has good antibacterial effect, has strong inhibiting effect on staphylococcus aureus, propionibacterium acnes and the like, can inhibit excessive sebum secretion, and has obvious effect on preventing and treating acne.

Retinol and derivatives: is helpful for relieving inflammation, protecting epidermal mucosa from bacteria, improving pore wall morphology, and recovering pore function.

Schizophyllan: is dextran secreted by Schizophyllum commune (Schizophyllum commune) culture, and has effects in activating Tc cell, NK cell, and macrophage activity, promoting secretion of various lymphokines such as IL-1, IL-2, IL-3, and IFN, and enhancing immunity. Schizophyllan promotes the production of interleukin IL-12, shows an immune function, and is useful as an anti-inflammatory agent. Schizophyllan is a water-soluble mushroom polysaccharide capable of improving human immunity, and the schizophyllan can form a stable three-spiral rigid rod-shaped structure in an aqueous solution, can be recognized and combined by receptors on immune cells of a human body, activates biological expression of the immune cells of the human body, regulates and improves immunity of a tissue system, and enhances resistance to various adverse factors of the internal and external world. It is now used in a large number of skin care cosmetics, because it rapidly penetrates into the skin at the skin surface and binds to skin tissue cells and receptors on immune cells. When the schizophyllan is used in skin care cosmetics, the schizophyllan can rapidly permeate into the skin, molecules are recognized and combined by immune cells in the skin and receptors on epidermal and dermal tissue cells, the activity of the skin immune cells and other tissue cells is activated, and the resistance and the repair capacity of the whole skin tissue are improved. The schizophyllan is used in the hair washing and caring product formula, can act on hair follicle cells and immune cells, and integrally regulates and enhances the health level of the hair follicle cells and the whole tissue cells, so that the immunity of the hair follicle cells and various tissue cells is enhanced, the nutrition of the scalp and the hair is fully supplied, the health level of the hair and the scalp is also improved, the repaired hair follicle can grow hair again, and the problems of dryness, pruritus and scurf of the scalp can be thoroughly improved.

Further, the zinc salt is one or two of zinc gluconate and zinc pyrrolidone carboxylate.

Further, the pore cleaning factor is one or a combination of more than two of a black spruce extract, caprylyl salicylic acid, retinol and derivatives thereof.

Further, the long-acting oil control composition also comprises 0.1-1% of preservative, 0.1-4% of thickening agent, 0.05-5.2% of pH regulator, 0.01-0.1% of chelating agent and 0.1-2% of humectant.

Further, the preservative is phenoxyethanol, the thickener is carbomer 981, the PH modifier is arginine, the chelating agent is disodium EDTA, and the humectant is 1, 2-hexanediol.

The second purpose of the invention is realized by adopting the following technical scheme:

the invention provides a preparation method of a long-acting oil control composition, wherein the long-acting oil control composition comprises a component A and a component B, and the long-acting oil control composition is prepared by uniformly mixing the component A and the component B according to the weight ratio of 0.2-3: 5-80;

the preparation method of the component A comprises the following steps:

s1, dissolving the caprylyl glycine and the pore-cleaning factor by ethanol in a micro-heating manner until the caprylyl glycine and the pore-cleaning factor are completely transparent, and respectively obtaining a caprylyl glycine solution and a pore-cleaning factor solution for later use;

s2, spraying the caprylyl glycine solution and the pore cleaning factor solution into the 6603 oil control powder, and stirring in the spraying process to obtain a sprayed mixture;

s3, removing residual ethanol in the sprayed mixture at low temperature by using a dryer to obtain a dried mixture;

s4, grinding the dried mixture at a high speed for 2-3 min to be uniform and fine to obtain the component A;

the preparation method of the component B comprises the following steps:

s1, freeze-drying the schizophyllan into powder schizophyllan at-50 to-70 ℃ under vacuum condition;

s2, dispersing the schizophyllan powder with butanediol to obtain a dispersed schizophyllan solution;

s3, homogenizing and heating the hamamelis virginiana extract, then adding the dispersed schizophyllan solution, and stirring and dissolving to obtain the component B.

Further, in the preparation method of the component A, residual ethanol in the sprayed mixture is removed at a low temperature by a dryer at 50-60 ℃ in the S3, so as to obtain a dried mixture.

Further, in the preparation method of the component B, in the step S3, the hamamelis virginiana extract is homogenized, the temperature is raised to 40-45 ℃, and then the dispersed schizophyllan solution is added and stirred for dissolution.

Further, in the preparation method of the component B, in the step S3, the spruce extract and the hamamelis virginiana extract are homogenized and heated, and then the dispersed schizophyllan solution is added and stirred for dissolution.

Further, in the preparation method of the component B, the step of adding the p-hydroxyacetophenone and the 1, 2-hexanediol to the solution in the S3 is further included after the step of S3, so that the component B is obtained.

Compared with the prior art, the invention has the beneficial effects that:

(1) the long-acting oil control composition provided by the invention inhibits the activity of 5-reductase through zinc salt, reduces the generation of DHT, thereby reducing the secretion of grease, and caprylyl glycine assists zinc salt to inhibit the excessive secretion of sebum, further reduces the secretion of grease, the Hamamelis virginiana extract further regulates the secretion of sebum, regulates the water-oil balance of skin, controls the secretion of sebum, effectively improves the water content of skin, balances the pH value and shrinks pores, when endocrine dyscrasia occurs, a pore cleaning factor can improve the form of pore walls, effectively removes dirt in the pores, enables grease to be smoothly secreted, improves blackheads, and absorbs excessive sebum in vivo to achieve the effect of oil control when excessive sebum is secreted, schizophyllan can rapidly permeate into the skin, is recognized and combined by immune cells in the skin and receptors on epidermal and dermal tissue cells, activates the activity of the skin immune cells and other tissue cells, is supplemented with caprylyl glycine, improves the immunity of the cells, enhances the resistance to various adverse factors of the internal and external world, plays a role in resisting bacteria and diminishing inflammation, effectively improves the resistance and the repair capacity of the whole skin tissue, enhances the health level of hair follicle cells and the whole tissue cells, and effectively improves the secretion of grease in the skin.

(2) The preparation method of the long-acting oil control composition provided by the invention is simple and convenient in steps, is suitable for industrial large-scale preparation, and can keep activity.

Detailed Description

The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.

The sources of raw materials required for preparing the long-acting oil control composition are shown in table 1, and the sources of the raw materials are not limited to manufacturers in the table and do not limit the protection scope of the invention.

Example 1

The long-acting oil control composition provided by the embodiment comprises the following raw materials in percentage by mass:

example 2

example 3

comparative example 1

The long-acting oil control composition provided by the comparative example comprises the following raw materials in percentage by mass:

comparative example 2

comparative example 3

comparative example 4

comparative example 5

comparative example 6

comparative example 7

Example 4

The preparation method of the long-acting oil control composition provided by the embodiment comprises the following steps:

the long-acting oil control composition comprises a component A and a component B, and is prepared by uniformly mixing the component A and the component B according to the weight ratio of 0.2: 5;

the preparation method of the component A comprises the following steps:

s1, dissolving caprylyl glycine and caprylyl salicylic acid with 5 times of ethanol by weight under slight heating until the solution is completely transparent, and respectively obtaining a caprylyl glycine solution and a caprylyl salicylic acid solution for later use;

s2, dissolving the hydroxy pinacolone retinoic acid ester with 10 times of ethanol by weight in a micro-heating manner until the solution is completely transparent, so as to obtain a hydroxy pinacolone retinoic acid ester solution for later use;

s3, putting the lauryl alcohol methacrylate/ethylene glycol dimethacrylate cross-linked polymer into a powder premixer, respectively spraying caprylyl glycine solution, caprylyl salicylic acid solution and hydroxy pinacolone retinoic acid ester solution into the lauryl alcohol methacrylate/ethylene glycol dimethacrylate cross-linked polymer, and stirring in the spraying process to obtain a sprayed mixture;

s4, removing residual ethanol in the sprayed mixture at low temperature by using a dryer at 50-60 ℃ to obtain a dried mixture;

s5, grinding the dried mixture at a high speed for 2-3 min to be uniform and fine to obtain a component A;

the preparation method of the component B comprises the following steps:

s1, freeze-drying schizophyllan into powder schizophyllan at-50 to-70 ℃ under vacuum condition;

s3, putting the black spruce extract and the hamamelis virginiana extract into a homogenizing emulsifying pot for homogenizing, heating to 40 ℃, then adding the dispersed schizophyllan solution, and stirring for dissolving;

s4, adding p-hydroxyacetophenone and 1, 2-hexanediol into the solution in the S3, and uniformly stirring to obtain the component B.

Example 5

the long-acting oil control composition comprises a component A and a component B, and is prepared by uniformly mixing the component A and the component B according to the weight ratio of 3: 80;

the preparation method of the component A comprises the following steps:

s1, dissolving caprylyl glycine and caprylyl salicylic acid with 5 times of ethanol by weight in a slightly heating manner until the solution is completely transparent, and respectively obtaining a caprylyl glycine solution and a caprylyl salicylic acid solution for later use;

the preparation method of the component B comprises the following steps:

s3, putting the black spruce extract and the hamamelis virginiana extract into a homogenizing emulsifying pot for homogenizing, heating to 45 ℃, then adding the dispersed schizophyllan solution, and stirring for dissolving;

Example 6

the long-acting oil control composition comprises a component A and a component B, and is prepared by uniformly mixing the component A and the component B according to the weight ratio of 2: 50;

the preparation method of the component A comprises the following steps:

the preparation method of the component B comprises the following steps:

Experimental example 1: testing of oil control effect of human body

The experimental principle is as follows: based on the principle of a photometer, a special adhesive tape absorbs grease on the skin of a human body and then becomes a semitransparent adhesive tape, the light transmittance of the semitransparent adhesive tape changes, and therefore the grease content on the surface of the skin is measured. The greater the transparency of the tape, the more oil is absorbed on the skin surface.

An experimental instrument: sebumeter SM815(CK, germany).

Measuring parameters: sebum index T (μ g/cm) ² )。

Subject: oily skin (sebum index is more than or equal to 150 mu g/cm) ² ) Volunteers, age 18-50 years, with 100 people in each group of 10 people and 10 groups in total.

The parameter testing method comprises the following steps: room temperature below 20 + -2 deg.C, Relative Humidity (RH) below 50 + -5%; the testees first cleaned their faces 1 hour before the test using the specified cleaning product, then entered the test environment to wait for one hour quietly, the tape was applied to the forehead of the volunteer and allowed to contact the skin for one minute, and then the frontal sebum index T was measured with SM 815.

The test method comprises the following steps: volunteers used the long-acting oil-controlling compositions provided in examples 1 to 3 and comparative examples 1 to 7 as test samples on the face for 4 consecutive weeks in the morning and evening, the volunteers' initial sebum index (T0) was measured before starting the test, and the corresponding sebum indexes T7, T21, T28 were measured on days 7, 21, and 28 after starting the test, respectively.

Sebum suppression ratio r: r ═ T0-T)/T0 × 100%

Average sebum suppression ratio R: r ═ R (R1+ R2+ R3+ R4+ R5+ R6+ R7+ R8+ R9+ R10)/10

The test results are shown in Table 3

TABLE 3 average sebum suppression

As can be seen from the table, compared with comparative examples 1 to 7, the long-acting oil control compositions provided in examples 1 to 3 have a significant sebum secretion inhibiting effect and can achieve an effective oil control effect.

Experimental example 1: subjective evaluation of volunteers

The volunteers participating in the test were questionnaire on day 28, and the average score of the volunteer scores of the test group of the long-acting oil-control compositions provided in examples 1 to 3 and comparative examples 1 to 7 was taken as the average score of the group, and the results are shown in table 2.

Grading standard:

0-no improvement in skin condition, even more greasy

1-No improvement in skin oiliness, but no exacerbation

2-slight improvement of the degree of greasiness of the skin, but no apparent effect

3-improvement of the degree of greasiness of the skin

4-the degree of greasiness of the skin is obviously improved

TABLE 2 subjective evaluation of volunteers

As can be seen from the table, subjective evaluation of volunteers shows that compared with comparative examples 1 to 7, the long-acting oil control compositions provided in examples 1 to 3 show good oil control effect, and satisfaction of the volunteers is achieved.

The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims

1. The long-acting oil control composition is characterized by comprising the following raw materials in percentage by mass:

2. the long acting oil control composition of claim 1, wherein the zinc salt is one or both of zinc gluconate and zinc pyrrolidone carboxylate.

3. The long-acting oil-control composition of claim 1, wherein the pore-cleaning factor is one or a combination of two or more of a spruce extract, caprylyl salicylic acid, retinol and derivatives thereof.

4. The long-acting oil control composition of claim 1, further comprising the following raw materials in percentage by mass: 0.1-1% of preservative, 0.1-4% of thickening agent, 0.05-5.2% of pH regulator, 0.01-0.1% of chelating agent and 0.1-2% of humectant.

5. The long acting oil control composition of claim 4, wherein the preservative is phenoxyethanol, the thickener is carbomer 981, the pH adjusting agent is arginine, the chelating agent is disodium EDTA, and the humectant is 1, 2-hexanediol.

6. The preparation method of the long-acting oil control composition according to any one of claims 1 to 5, characterized in that the long-acting oil control composition is divided into a component A and a component B, and the long-acting oil control composition is prepared by uniformly mixing the component A and the component B according to the weight ratio of 0.2-3: 5-80;

the preparation method of the component A comprises the following steps:

s4, grinding the dried mixture at a high speed to be uniform and fine to obtain the component A;

the preparation method of the component B comprises the following steps:

s1, freeze-drying the schizophyllan into powder schizophyllan at the temperature of between 50 ℃ below zero and 70 ℃ below zero under the vacuum condition;

7. The method for preparing the long-acting oil-control composition according to claim 6, wherein in the method for preparing the component A, residual ethanol in the sprayed mixture is removed by a dryer at a low temperature of 50-60 ℃ in S3 to obtain a dried mixture.

8. The method for preparing the long-acting oil control composition according to claim 6, wherein in the method for preparing the component B, in the step S3, the hamamelis virginiana extract is homogenized, heated to 40-45 ℃, and then the dispersed schizophyllan solution is added and stirred for dissolution.

9. The method for preparing the long-acting oil control composition as claimed in claim 6, wherein the component B is prepared by homogenizing the extract of Picea nigra and the extract of Hamamelis virginiana at an elevated temperature in S3, adding the dispersed schizophyllan solution, and dissolving with stirring.

10. The method for preparing the long-acting oil-control composition according to claim 6, wherein the method for preparing the component B further comprises the step of adding the p-hydroxyacetophenone and the 1, 2-hexanediol to the solution in the S3 after the step of S3 to obtain the component B.