CN115029362A - 核酸、包含其的工程免疫细胞及其生产方法和用途 - Google Patents

核酸、包含其的工程免疫细胞及其生产方法和用途 Download PDF

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CN115029362A
CN115029362A CN202210667502.4A CN202210667502A CN115029362A CN 115029362 A CN115029362 A CN 115029362A CN 202210667502 A CN202210667502 A CN 202210667502A CN 115029362 A CN115029362 A CN 115029362A
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cell
nucleic acid
cells
antibody
seq
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达里奥·康潘
贵广·神谷明
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National University of Singapore
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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CN202210667502.4A 2015-02-06 2016-02-05 核酸、包含其的工程免疫细胞及其生产方法和用途 Pending CN115029362A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562112765P 2015-02-06 2015-02-06
US62/112,765 2015-02-06
US201562130970P 2015-03-10 2015-03-10
US62/130,970 2015-03-10
CN201680018962.7A CN107709548B (zh) 2015-02-06 2016-02-05 用于增强治疗性免疫细胞的功效的方法
PCT/SG2016/050063 WO2016126213A1 (en) 2015-02-06 2016-02-05 Methods for enhancing efficacy of therapeutic immune cells

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CN202210667502.4A Pending CN115029362A (zh) 2015-02-06 2016-02-05 核酸、包含其的工程免疫细胞及其生产方法和用途
CN202210661143.1A Active CN114891816B (zh) 2015-02-06 2016-02-05 核酸、包含其的工程免疫细胞及其制备方法和用途
CN202111064400.5A Pending CN113713091A (zh) 2015-02-06 2016-02-05 工程免疫细胞及其用途和生产方法
CN201680018962.7A Active CN107709548B (zh) 2015-02-06 2016-02-05 用于增强治疗性免疫细胞的功效的方法

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CN202111064400.5A Pending CN113713091A (zh) 2015-02-06 2016-02-05 工程免疫细胞及其用途和生产方法
CN201680018962.7A Active CN107709548B (zh) 2015-02-06 2016-02-05 用于增强治疗性免疫细胞的功效的方法

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US (5) US10765699B2 (https=)
EP (2) EP4134430A1 (https=)
JP (5) JP6895380B2 (https=)
KR (2) KR102763121B1 (https=)
CN (4) CN115029362A (https=)
AU (3) AU2016216149B2 (https=)
CA (1) CA2975851A1 (https=)
CY (1) CY1125535T1 (https=)
DK (1) DK3253865T3 (https=)
ES (1) ES2926384T3 (https=)
HR (1) HRP20220890T1 (https=)
HU (1) HUE059662T2 (https=)
LT (1) LT3253865T (https=)
PL (1) PL3253865T3 (https=)
PT (1) PT3253865T (https=)
RS (1) RS63574B1 (https=)
SG (2) SG10201913124RA (https=)
SI (1) SI3253865T1 (https=)
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Cited By (2)

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US12404491B2 (en) 2015-02-06 2025-09-02 National University Of Singapore Methods for enhancing efficacy of therapeutic immune cells
US12479914B2 (en) 2017-08-10 2025-11-25 National University Of Singapore T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof

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CN109689693B (zh) * 2016-11-03 2022-06-28 深圳华大生命科学研究院 提高基因编辑效率的方法和系统
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US12023353B2 (en) * 2017-10-18 2024-07-02 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Methods and compounds for improved immune cell therapy
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