CN115025188A - 调节炎症和/或纤维化相关信号通路的中药及其应用 - Google Patents
调节炎症和/或纤维化相关信号通路的中药及其应用 Download PDFInfo
- Publication number
- CN115025188A CN115025188A CN202210615395.0A CN202210615395A CN115025188A CN 115025188 A CN115025188 A CN 115025188A CN 202210615395 A CN202210615395 A CN 202210615395A CN 115025188 A CN115025188 A CN 115025188A
- Authority
- CN
- China
- Prior art keywords
- parts
- fibrosis
- inflammation
- traditional chinese
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 60
- 206010016654 Fibrosis Diseases 0.000 title claims abstract description 43
- 230000004761 fibrosis Effects 0.000 title claims abstract description 42
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 39
- 230000019491 signal transduction Effects 0.000 title claims abstract description 35
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 33
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 19
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 19
- 239000009636 Huang Qi Substances 0.000 claims abstract description 19
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 19
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 18
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 17
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 17
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 17
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 17
- 235000011477 liquorice Nutrition 0.000 claims abstract description 17
- 240000002505 Pogostemon cablin Species 0.000 claims abstract description 16
- 235000011751 Pogostemon cablin Nutrition 0.000 claims abstract description 16
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 13
- 230000009103 reabsorption Effects 0.000 claims description 39
- 239000000284 extract Substances 0.000 claims description 36
- 230000037361 pathway Effects 0.000 claims description 33
- 244000197580 Poria cocos Species 0.000 claims description 18
- 241000382455 Angelica sinensis Species 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims description 15
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 15
- 230000010799 Receptor Interactions Effects 0.000 claims description 15
- 239000011734 sodium Substances 0.000 claims description 15
- 229910052708 sodium Inorganic materials 0.000 claims description 15
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims description 14
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims description 14
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 14
- 229960002478 aldosterone Drugs 0.000 claims description 14
- 230000003993 interaction Effects 0.000 claims description 14
- 210000001578 tight junction Anatomy 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 10
- 102000002852 Vasopressins Human genes 0.000 claims description 8
- 108010004977 Vasopressins Proteins 0.000 claims description 8
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims description 8
- 229960003726 vasopressin Drugs 0.000 claims description 8
- 230000028956 calcium-mediated signaling Effects 0.000 claims description 7
- 230000003828 downregulation Effects 0.000 claims description 5
- 230000003827 upregulation Effects 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000012676 herbal extract Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 14
- 235000001188 Peltandra virginica Nutrition 0.000 abstract description 7
- 244000046146 Pueraria lobata Species 0.000 abstract description 5
- 235000010575 Pueraria lobata Nutrition 0.000 abstract description 5
- 235000007716 Citrus aurantium Nutrition 0.000 abstract description 4
- 244000183685 Citrus aurantium Species 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 4
- 241001127714 Amomum Species 0.000 abstract description 3
- 244000061520 Angelica archangelica Species 0.000 abstract description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract description 3
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 21
- 230000000694 effects Effects 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 238000005303 weighing Methods 0.000 description 14
- 229940079593 drug Drugs 0.000 description 11
- 241000405414 Rehmannia Species 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical group [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- 229910001424 calcium ion Inorganic materials 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 239000012452 mother liquor Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 241000756943 Codonopsis Species 0.000 description 7
- 241000700605 Viruses Species 0.000 description 7
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000008176 lyophilized powder Substances 0.000 description 7
- 208000005069 pulmonary fibrosis Diseases 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 201000002793 renal fibrosis Diseases 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 206010019668 Hepatic fibrosis Diseases 0.000 description 6
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 206010028594 Myocardial fibrosis Diseases 0.000 description 5
- 102000000591 Tight Junction Proteins Human genes 0.000 description 5
- 108010002321 Tight Junction Proteins Proteins 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 210000005036 nerve Anatomy 0.000 description 5
- 239000006187 pill Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 210000000582 semen Anatomy 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 241000588653 Neisseria Species 0.000 description 4
- 241000589516 Pseudomonas Species 0.000 description 4
- 208000001647 Renal Insufficiency Diseases 0.000 description 4
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 4
- 241000191940 Staphylococcus Species 0.000 description 4
- 241000194017 Streptococcus Species 0.000 description 4
- 241001148134 Veillonella Species 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 201000006370 kidney failure Diseases 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000010413 mother solution Substances 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 201000004193 respiratory failure Diseases 0.000 description 4
- 210000004926 tubular epithelial cell Anatomy 0.000 description 4
- 241001529821 Agastache Species 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 3
- 241000628997 Flos Species 0.000 description 3
- 241000555712 Forsythia Species 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 208000033679 diabetic kidney disease Diseases 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 244000000010 microbial pathogen Species 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 208000001889 Acid-Base Imbalance Diseases 0.000 description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
- 241001672694 Citrus reticulata Species 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- 235000002722 Dioscorea batatas Nutrition 0.000 description 2
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 2
- 240000001811 Dioscorea oppositifolia Species 0.000 description 2
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 241000606790 Haemophilus Species 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 241000712079 Measles morbillivirus Species 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 240000004371 Panax ginseng Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 208000000389 T-cell leukemia Diseases 0.000 description 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 2
- 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 1
- 244000141331 Amomum villosum Species 0.000 description 1
- 102000005862 Angiotensin II Human genes 0.000 description 1
- 101800000733 Angiotensin-2 Proteins 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000000018 Chemokine CCL2 Human genes 0.000 description 1
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 description 1
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 1
- 240000006766 Cornus mas Species 0.000 description 1
- 241000759833 Cornus officinalis Species 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 101710158332 Diuretic hormone Proteins 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 description 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 206010023421 Kidney fibrosis Diseases 0.000 description 1
- 208000004852 Lung Injury Diseases 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 description 1
- 108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 240000005001 Paeonia suffruticosa Species 0.000 description 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 206010069363 Traumatic lung injury Diseases 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 229950006323 angiotensin ii Drugs 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009693 chronic damage Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 238000010201 enrichment analysis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000012165 high-throughput sequencing Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- BFBPISPWJZMWJN-UHFFFAOYSA-N methyl 2-[(7-hydroxy-3,7-dimethyloctylidene)amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1N=CCC(C)CCCC(C)(C)O BFBPISPWJZMWJN-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000009874 shenqi Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及中药技术领域，尤其涉及调节炎症和/或纤维化相关信号通路的中药及其应用。本发明提供了连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁中至少一种在制备调节炎症和/或纤维化相关信号通路的药物中的应用；其中任意一种单一药材都能够作用于调节炎症和/或纤维化相关信号通路中的至少一条。以上述15种药材组成的组合物，能够作用于8条与炎症和/或纤维化相关的信号通路，各组分缺一不可，相互配合产生了增效协同作用。
Description
本申请是申请日为2020年06月24日、发明名称为“调节炎症和/或纤维化相关信号通路的中药及其应用”、申请号为202010588510.0的发明的分案申请。
技术领域
本发明涉及中药技术领域，尤其涉及调节炎症和/或纤维化相关信号通路的中药及其应用。
背景技术
炎症与组织纤维化与多种疾病密切相关，例如：炎症细胞在糖尿病肾病的发生、发展中发挥着重要的作用。肾间质的主要炎症细胞巨噬细胞及T淋巴细胞，同样参与糖尿病肾病肾组织的慢性炎症及间质纤维化。同时，中性粒细胞可能也参与糖尿病肾病肾间质纤维化的发生。
炎症细胞的浸润、活化所致细胞因子的反常表达及细胞因子分泌的不平衡，在间质性肺炎的发生和发展过程中发挥着重要作用。例如，肺损伤中起重要作用的细胞因子有TFG-β、TNF-α、IFN-γ、IL及单核细胞趋化蛋白I、MCP-1等。
心肌纤维化在冠心病、高血压、肥厚性心肌病、心力衰竭等多种心血管疾病中普遍存在，现认为其与心律失常、心功能障碍甚至心脏猝死密切相关，众多炎症因子在心肌纤维化的进展过程汇总起到重要作用，例如：血管紧张素II与醛固酮、转化生长因子β、结缔组织生长因子、单核细胞趋化蛋白-1、肿瘤坏死因子-α、白介素-1、基质金属蛋白酶、一氧化氮和内皮素。
肝纤维化是多种慢性肝病进展过程中的重要病理阶段，其本质是肝脏对各种慢性损伤后持续进行伤口愈合反应的结果，主要表现为细胞外基质异常增生与沉积，伴随肝实质细胞的坏死和凋亡。肝纤维化持续发展会形成肝硬化，甚至进展为肝癌和肝衰竭。
炎症和/或纤维化的发生、发展与多条信号通路密切相关，在药物的研发过程中，针对这些信号通路进行有针对性的研究有利于药物的筛选。但目前对于中药材对炎症和/或纤维化的治疗作用的研究仍不足。
发明内容
有鉴于此，本发明要解决的技术问题在于提供调节炎症和/或纤维化相关信号通路的中药及其应用。
本发明提供了中药在制备调节炎症和/或纤维化相关信号通路的药物中的应用；
所述中药选自连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁中至少一种。
所述炎症和/或纤维化相关信号通路包括：
细胞因子-细胞因子受体相互作用、紧密连接、抗利尿激素调节的水重吸收、醛固酮调节的钠重吸收、近曲小管碳酸氢盐重吸收、HIF-1信号通路、钙离子信号通路、神经活性物质和受体的相互作用通路。
本发明中，所述炎症为由细菌、病毒等病原微生物感染导致的炎症；所述纤维化为感染导致的纤维化；所述纤维化为肾纤维化、肝纤维化肺纤维化或心肌纤维化。
所述病毒包括：冠状病毒、腺病毒、疱疹病毒、肠道病毒、麻疹病毒、乙型肝炎病毒、丙型肝炎病毒、人乳头瘤病毒、甲型H1N1流感病毒、人类T细胞白血病病毒。
所述细菌包括：嗜血杆菌(Hemophilus)、假单胞菌(Pseudomxonas)、链球菌(Streptococcus)、葡萄球菌(Staphylococcus)、奈瑟菌(Neisseria)、韦荣球菌(Veillonella)等。
传统中医理论认为：陈皮，理气健脾，燥湿化痰；甘草，补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药，用于脾胃虚弱；党参，健脾益肺，养血生津，可用于脾肺气虚。砂仁，化湿开胃，温脾理气；枳壳，理气宽中，行滞消胀；炙黄芪，益气补中，用于气虚乏力。生地黄，清热凉血，养阴生津；法半夏，燥湿化痰，用于痰多咳喘；广藿香，芳香化浊，和中止呕，发表解暑。连翘，清热解毒，消肿散结，疏散风热；桃仁，活血祛瘀，润肠通便，止咳平喘。葛根，解肌退热，生津止渴，透疹，升阳止泻，通经活络，可解酒毒；当归，补血活血，调经止痛，润肠通便；茯苓，利水渗湿，健脾，宁心。
本发明通过对8个信号通路中，3000余个基因的表达情况，分析8个信号通路受中药材的影响，其中，细胞因子-细胞因子受体相互作用、紧密连接与炎症及纤维化改变相关，抗利尿激素调节的水重吸收、醛固酮调节的钠重吸收参与调控水钠的重吸收，近曲小管碳酸氢盐重吸收调控酸碱平衡，HIF-1信号通路参与氧化应激保护过程，钙离子信号通路影响心肌收缩力，神经活性配体-受体相互作用决定了神经活性物质和受体的相互作用。对这些信号通路的调控可以改善病毒感染合并纤维化的各种病理过程，阻止病情的发展。
具体的，本发明实验表明：
红花能够上调钙离子信号通路、神经活性配体-受体相互作用；
砂仁能够上调近曲小管碳酸氢盐重吸收、钙离子信号通路、神经活性配体-受体相互作用，而对紧密连接、抗利尿激素调节的水重吸收存在抑制作用；
甘草能够上调钙离子信号通路、神经活性配体-受体相互作用，而对紧密连接、醛固酮调节的钠重吸收、抗利尿激素调节的水重吸收存在抑制作用；
法半夏能够上调HIF-1信号通路，而对紧密连接存在抑制作用；
广藿香能够上调近曲小管碳酸氢盐重吸收；
当归能够上调HIF-1信号通路、钙离子信号通路，而对细胞因子-细胞因子受体相互作用、紧密连接存在抑制作用；
炙黄芪能够上调HIF-1信号通路，而对细胞因子-细胞因子受体相互作用存在抑制作用；
桃仁能够上调HIF-1信号通路，而对细胞因子-细胞因子受体相互作用存在抑制作用；
陈皮能够上调钙离子信号通路，而对细胞因子-细胞因子受体相互作用存在抑制作用；
连翘能够上调钙离子信号通路，而对细胞因子-细胞因子受体相互作用存在抑制作用；
地黄对细胞因子-细胞因子受体相互作用、紧密连接、醛固酮调节的钠重吸收存在抑制作用；
枳壳、茯苓、党参、葛根对细胞因子-细胞因子受体相互作用存在抑制作用；
本发明还提供了一种中药组合物，其由连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁组成
本发明所述的中药组合物由如下质量份的组分组成：连翘5～30份、葛根6～30份、当归6～15份、生地黄10～20份、桃仁5～24份、红花3～15份、枳壳3～15份、甘草2～15份、法半夏3～15份、陈皮2～15份、党参9～24份、炙黄芪9～30份、茯苓6～30份、广藿香3～20份、砂仁3～6份组成。
一些具体实施例中，所述中药组合物由如下质量份的组分组成：连翘10份、葛根10份、当归10份、生地黄10份、桃仁10份、红花10份、枳壳10份、甘草10份、法半夏10份、陈皮10份、党参10份、炙黄芪10份、茯苓10份、广藿香10份、砂仁10份。
一些具体实施例中，所述中药组合物由如下质量份的组分组成：连翘5份、葛根6份、当归6份、生地黄10份、桃仁5份、红花3份、枳壳3份、甘草2份、法半夏3份、陈皮2份、党参9份、炙黄芪9份、茯苓6份、广藿香3份、砂仁3份。
一些具体实施例中，所述中药组合物由如下质量份的组分组成：连翘30份、葛根30份、当归15份、生地黄20份、桃仁24份、红花15份、枳壳15份、甘草15份、法半夏15份、陈皮15份、党参30份、炙黄芪30份、茯苓30份、广藿香20份、砂仁6份。
一些具体实施例中，所述中药组合物由如下质量份的组分组成：连翘9份、葛根12份、当归9份、生地黄12份、桃仁6份、红花6份、枳壳6份、甘草9份、法半夏6份、陈皮6份、党参15份、炙黄芪15份、茯苓12份、广藿香9份、砂仁6份。
本发明还提供了一种中药提取物，其由本发明所述的中药组合物提取获得。
所述中药提取物的制备方法包括：将连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁以90vol％乙醇水溶液进行标准索氏回流提取，所得提取液干燥，制得提取物。
所述90vol％乙醇水溶液的标准索氏回流提取的时间为3h，每10g药材以150mL90vol％乙醇水溶液提取。所述水的标准索氏回流提取的时间为2h，每10g药材以150mL水提取。
本发明所述中药提取物的制备方法中，各组分可混合提取物也可先后分别提取后混合，本发明对此不做限定。
本发明所述的中药组合物、中药提取物或所述制备方法制得的提取物，在制备治疗炎症和/或纤维化的药物中的应用。
所述防治包括：调节炎症和/或纤维化相关信号通路；
所述炎症和/或纤维化相关信号通路包括：
细胞因子-细胞因子受体相互作用、紧密连接、抗利尿激素调节的水重吸收、醛固酮调节的钠重吸收、近曲小管碳酸氢盐重吸收、HIF-1信号通路、钙离子信号通路、神经活性物质和受体的相互作用通路。
所述调节包括上调HIF-1信号通路、神经活性配体-受体相互作用、钙离子信号通路、近曲小管碳酸氢盐重吸收；下调细胞因子-细胞因子受体相互作用、醛固酮调节的钠重吸收、紧密连接、抗利尿激素调节的水重吸收。
本发明中，所述炎症为由细菌、病毒等病原微生物感染导致的炎症；所述纤维化为感染导致的纤维化；所述纤维化为肾纤维化、肝纤维化、肺纤维化或心肌纤维化。肺纤维化的发生会影响呼吸，引起呼吸困难，严重时出现呼吸衰竭，所述治疗还包括对肺纤维化导致的呼吸衰竭的治疗。肾纤维化的发生会影响机体对水、电解质和酸碱的调节，严重时出现肾功能衰竭，所述治疗还包括对肾纤维化导致的肾功能衰竭的治疗。
所述病毒包括：冠状病毒、腺病毒、疱疹病毒、肠道病毒、麻疹病毒、乙型肝炎病毒、丙型肝炎病毒、人乳头瘤病毒、甲型H1N1流感病毒、人类T细胞白血病病毒。
所述细菌包括：嗜血杆菌(Hemophilus)、假单胞菌(Pseudomxonas)、链球菌(Streptococcus)、葡萄球菌(Staphylococcus)、奈瑟菌(Neisseria)、韦荣球菌(Veillonella)等。
本发明还提供了一种药物，其包括本发明所述的中药组合物、中药提取物或所述制备方法制得的提取物。
所述药物中还包括药学上可接受的辅料；
所述药学上可接受的辅料为矫味剂、填充剂、润滑剂、防腐剂、助悬剂、食用色素、稀释剂、乳化剂、崩解剂或增塑剂中的一种或两者以上的混合物；
所述药物的剂型为注射剂、片剂、丸剂、口服液剂、胶囊剂、糖浆剂、滴丸剂或颗粒剂。
本发明还提供了一种治疗治疗炎症和/或纤维化的方法，其为给予本发明所述的药物。所述给予的方式为注射或口服。
本发明中，所述炎症为由细菌、病毒等病原微生物感染导致的炎症；所述纤维化为感染导致的纤维化；所述纤维化为肾纤维化、肝纤维化、肺纤维化或心肌纤维化。肺纤维化的发生会影响呼吸，引起呼吸困难，严重时出现呼吸衰竭，所述治疗还包括对肺纤维化导致的呼吸衰竭的治疗。肾纤维化的发生会影响机体对水、电解质和酸碱的调节，严重时出现肾功能衰竭，所述治疗还包括对肾纤维化导致的肾功能衰竭的治疗。
本发明提供了连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁中至少一种在制备调节炎症和/或纤维化相关信号通路的药物中的应用；其中任意一种单一药材都能够作用于调节炎症和/或纤维化相关信号通路中的至少一条。以上述15种药材组成的组合物，能够作用于8条与炎症和/或纤维化相关的信号通路，各组分缺一不可，相互配合产生了增效协同作用。
附图说明
图1示15种中药在肾小管上皮细胞种对8条相关通路的富集情况；
图2示实施例2～5的药物对8条相关通路的影响；
图3示实施例2(组方)和对比例1～4的药物对8条相关通路的影响。
具体实施方式
本发明提供了调节炎症和/或纤维化相关信号通路的中药及其应用，本领域技术人员可以借鉴本文内容，适当改进工艺参数实现。特别需要指出的是，所有类似的替换和改动对本领域技术人员来说是显而易见的，它们都被视为包括在本发明。本发明的方法及应用已经通过较佳实施例进行了描述，相关人员明显能在不脱离本发明内容、精神和范围内对本文的方法和应用进行改动或适当变更与组合，来实现和应用本发明技术。
本发明检测涉及8条信号通路，共检测三千余种基因，其中各信号通路中具有代表性的基因如表1：
表1信号通路及代表性基因
本发明采用的试材皆为普通市售品，皆可于市场购得。
下面结合实施例，进一步阐述本发明：
实施例1
中药提取物的制备，具体过程为：
1、分别称取中药连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁。
2、制备方法：上述药物粉碎后，分别称取10g，各药物分别用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述13种各种中药提取物的冻干粉。
称取一定质量冻干粉，溶于DMSO中制成提取物母液，母液浓度是20mg/mL，制备终浓度100μg/mL的中药提取物，-20℃保存。
实施例2～5
中药组合物的制备，具体过程为：
1、分别称取中药连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁。
2、制备方法：上述药物均单独制备。
分别称取各药物10g，用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述13种各种中药提取物的冻干粉。按照表1所示配比称取各提取物的冻干粉，溶于DMSO中制成各中药提取物母液，母液浓度是20mg/mL，制备终浓度100μg/mL的中药提取物，-20℃保存。
表2实施例2～5的组合物的配比(g)
| 实施例2 | 实施例3 | 实施例4 | 实施例5 | |
| 连翘 | 10 | 5 | 30 | 9 |
| 葛根 | 10 | 6 | 30 | 12 |
| 当归 | 10 | 6 | 15 | 9 |
| 生地黄 | 10 | 10 | 20 | 12 |
| 桃仁 | 10 | 5 | 24 | 6 |
| 红花 | 10 | 3 | 15 | 6 |
| 枳壳 | 10 | 3 | 15 | 6 |
| 甘草 | 10 | 2 | 15 | 9 |
| 法半夏 | 10 | 3 | 15 | 6 |
| 陈皮 | 10 | 2 | 15 | 6 |
| 党参 | 10 | 9 | 30 | 15 |
| 炙黄芪 | 10 | 9 | 30 | 15 |
| 茯苓 | 10 | 6 | 30 | 12 |
| 广藿香 | 10 | 3 | 20 | 9 |
| 砂仁 | 10 | 3 | 6 | 6 |
3、上述中药组合物如应用于病人，则采用水煎剂的制备方法，煎煮二次，各30min，合并煎液服用。
对比例1
以现有技术中的六味地黄汤作为阳性对照，制备方法为：
熟地、山茱萸、山药、牡丹皮、泽泻、茯苓。各药物分别称取10g，分别用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述5种各种中药提取物的冻干粉。称取一定质量冻干粉，溶于DMSO中制成提取物母液，母液浓度是20mg/mL，各组分按照等比例配比，以终浓度100μg/mL中药提取物处理细胞。
对比例2
以现有技术中的参芪地黄汤作为阳性对照，制备方法为：
人参、黄芪、熟地、山药、茯苓、丹皮、山茱萸。各药物分别称取10g，分别用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述5种各种中药提取物的冻干粉。称取一定质量冻干粉，溶于DMSO中制成提取物母液，母液浓度是20mg/mL，各组分按照等比例配比，以终浓度100μg/mL中药提取物处理细胞。
对比例3
以现有技术中的四君子汤作为阳性对照，制备方法为：
人参、白术、茯苓、甘草。各药物分别称取10g，分别用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述5种各种中药提取物的冻干粉。称取一定质量冻干粉，溶于DMSO中制成提取物母液，母液浓度是20mg/mL，各组分按照等比例配比，以终浓度100μg/mL中药提取物处理细胞。
对比例4
以现有技术中的金匮肾气丸作为阳性对照，制备方法为：
熟地、山茱萸、山药、牡丹皮、泽泻、茯苓、桂枝、附子、牛膝、车前子。各药物分别称取10g，分别用150mL的90％乙醇，标准索氏回流提取3h，提取液浓缩20min至体积为2mL，利用冻干机减压冻干24h，分别制成上述5种各种中药提取物的冻干粉。称取一定质量冻干粉，溶于DMSO中制成提取物母液，母液浓度是20mg/mL，各组分按照等比例配比，以终浓度100μg/mL中药提取物处理细胞。
功效验证
一、单味药物对关键通路的影响
利用HTS2(基于高通量测序的高通量筛选)技术，HK2人肾小管上皮细胞上对3000余个基因的表达情况，继而对和炎症和纤维化相关的多条通路进行富集分析，具体实验过程为：
1.分别利用实施例1中制备的中药提取物即连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁的提取物，100μg/mL浓度处理诱导的HK2人肾小管上皮细胞24小时。
2.细胞裂解，加入基因特异性探针结合mRNA，并利用DNA连接酶将结合成功的一对探针连接。
3.将连接成功的探针洗脱，利用PCR技术进行扩增和建库测序。
4.数据处理：以溶剂对照DMSO处理组为对照组，药物处理组与对照组比较，计算相关通路基因及背景基因的Fold change。
5.进行GSEA(Gene set enrichment analysis)信号通路富集分析，FDR<0.25，认为通路被显著调控。
结果如图1所示，其展示了15种中药在肾小管上皮细胞种对8条相关通路的富集情况：包括通路细胞因子-细胞因子受体相互作用、紧密连接、抗利尿激素调节的水重吸收、醛固酮调节的钠重吸收、近曲小管碳酸氢盐重吸收、HIF-1信号通路、钙离子信号通路和神经活性配体-受体相互作用。红色表示该通路显著上调，蓝色表示该通路显著下调，白色表示无影响。
结果显示，中药组合物中，当归、炙黄芪、桃仁、陈皮、连翘、地黄、枳壳、茯苓、党参、葛根均可调控炎症和纤维化相关通路：细胞因子-细胞因子受体相互作用，砂仁、甘草、法半夏、当归、地黄可调节纤维化相关通路紧密连接。砂仁、甘草、地黄可调控水钠的重吸收通路，包括抗利尿激素调节的水重吸收和醛固酮调节的钠重吸收，砂仁、广藿香可显著调节酸碱失衡相关通路，即近曲小管碳酸氢盐重吸收，法半夏、当归、炙黄芪和桃仁可显著调节应激相关通路，即HIF-1信号通路，红花、砂仁、甘草、当归、陈皮和连翘可以改善钙离子信号通路，红花、砂仁和甘草可以调节神经活性物质和受体的相互作用通路，即神经活性配体-受体相互作用。此中药组合物可显著调节多条与炎症和纤维化相关的通路，改善肾功能，保肾护肾。
二、实施例2～5对关键通路的影响
方法与(一)相同，实施例2、3、4、5的药物，分别按照表1组合物的配比，每种药物以终浓度100μg/mL处理诱导的THP1细胞24小时。结果如图2所示，红色表示该通路显著上调，蓝色表示该通路显著下调，白色表示无影响。结果表明：实施例2、3、4、5，均可显著调节炎症、纤维化相关通路、神经活性物质和受体的相互作用通路和应激的HIF-1信号通路，调控水、钠重吸收通路，改善酸碱失衡及钙离子信号通路，实施例2和4效果较强。
三、实施例2和对比例1～4的药物对关键通路的影响
方法与(一)相同，实施例2(组方)和对比例1～4的药物，分别以100μg/mL浓度处理诱导的THP1细胞24小时。结果如图3所示，红色表示该通路显著上调，蓝色表示该通路显著下调，白色表示无影响。结果表明：与实施例2所示的药物相比，对比例1～4的药物作用的靶点较少，例如，六味地黄丸对醛固酮调节的钠重吸收、紧密连接、近曲小管碳酸氢盐重吸收和HIF-1信号通路无调节作用；参芪地黄汤对醛固酮调节的钠重吸收、近曲小管碳酸氢盐重吸收和紧密连接无调节作用；四君子汤对近曲小管碳酸氢盐重吸收无调节作用；金匮肾气丸对醛固酮调节的钠重吸收、HIF-1信号通路和近曲小管碳酸氢盐重吸收无调节作用。
以上仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (8)
1.一种中药组合物，其特征在于，由连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁组成。
2.根据权利要求1所述的中药组合物，其特征在于，由如下质量份的组分组成：连翘5～30份、葛根6～30份、当归6～15份、生地黄10～20份、桃仁5～24份、红花3～15份、枳壳3～15份、甘草2～15份、法半夏3～15份、陈皮2～15份、党参9～24份、炙黄芪9～30份、茯苓6～30份、广藿香3～20份、砂仁3～6份组成。
3.一种中药提取物，其特征在于，由权利要求1或2所述的中药组合物提取获得。
4.权利要求3所述的中药提取物的制备方法，其特征在于，包括：将连翘、葛根、当归、生地黄、桃仁、红花、枳壳、甘草、法半夏、陈皮、党参、炙黄芪、茯苓、广藿香、砂仁以90vol％乙醇水溶液进行标准索氏回流提取，所得提取液干燥，制得提取物。
5.权利要求1或2所述的中药组合物、权利要求3所述的中药提取物或权利要求4所述制备方法制得的提取物，在制备治疗炎症和/或纤维化的药物中的应用。
6.根据权利要求5所述的应用，其特征在于，所述治疗包括：调节炎症和/或纤维化相关信号通路；
所述炎症和/或纤维化相关信号通路包括：
细胞因子-细胞因子受体相互作用、紧密连接、抗利尿激素调节的水重吸收、醛固酮调节的钠重吸收、近曲小管碳酸氢盐重吸收、HIF-1信号通路、钙离子信号通路、神经活性物质和受体的相互作用通路。
7.根据权利要求6所述的应用，其特征在于，所述调节包括上调HIF-1信号通路、神经活性配体-受体相互作用、钙离子信号通路、近曲小管碳酸氢盐重吸收；下调细胞因子-细胞因子受体相互作用、醛固酮调节的钠重吸收、紧密连接、抗利尿激素调节的水重吸收。
8.一种药物，其特征在于，包括权利要求1或2所述的中药组合物、权利要求3所述的中药提取物或权利要求4所述制备方法制得的提取物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210615395.0A CN115025188B (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210615395.0A CN115025188B (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
| CN202010588510.0A CN111643628A (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010588510.0A Division CN111643628A (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115025188A true CN115025188A (zh) | 2022-09-09 |
| CN115025188B CN115025188B (zh) | 2023-09-22 |
Family
ID=72344287
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210615395.0A Active CN115025188B (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
| CN202010588510.0A Pending CN111643628A (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010588510.0A Pending CN111643628A (zh) | 2020-06-24 | 2020-06-24 | 调节炎症和/或纤维化相关信号通路的中药及其应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN115025188B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112289378A (zh) * | 2020-11-02 | 2021-01-29 | 博奥生物集团有限公司 | 中药组合物的确定方法以及其药效的确定方法 |
| CN113209156B (zh) * | 2021-03-25 | 2024-09-06 | 山西普德药业有限公司 | 一种人参复合中药组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369307A (zh) * | 2002-02-07 | 2002-09-18 | 应天明 | 治疗乙肝后肝纤维化和肝硬化的中药组合物及其制造方法 |
| CN110859932A (zh) * | 2019-11-21 | 2020-03-06 | 博奥生物集团有限公司 | 抗肾纤维化的药物及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205016B (zh) * | 2011-05-20 | 2013-08-14 | 辽宁中医药大学 | 一种治疗动脉粥样硬化引起的痰浊血瘀冠心病的药物 |
| CN102600423B (zh) * | 2012-02-09 | 2014-03-19 | 青岛华仁技术孵化器有限公司 | 用于治疗肝纤维化的中药制备方法 |
| CN102988650A (zh) * | 2012-11-20 | 2013-03-27 | 王玮 | 一种治疗慢性肾炎的药物及其制备方法 |
| CN104524383A (zh) * | 2015-01-05 | 2015-04-22 | 张成卫 | 治疗矽肺的中药 |
| CN107537009A (zh) * | 2016-06-29 | 2018-01-05 | 殷学臣 | 一种治疗肝炎、肝硬化脾大、肝癌的中药配方 |
| CN106421603A (zh) * | 2016-10-26 | 2017-02-22 | 黔西南州神力中草药应用开发研究所 | 一种治疗心血管疾病的药物及其制备方法 |
| CN106362092B (zh) * | 2016-10-26 | 2019-09-03 | 河北医科大学第三医院 | 一种治疗肝纤维化的益气活血中药组合物 |
| CN107375670A (zh) * | 2017-07-26 | 2017-11-24 | 四川易创生物科技有限公司 | 一种治疗病毒性心肌炎的中药组合物及其制备方法 |
-
2020
- 2020-06-24 CN CN202210615395.0A patent/CN115025188B/zh active Active
- 2020-06-24 CN CN202010588510.0A patent/CN111643628A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1369307A (zh) * | 2002-02-07 | 2002-09-18 | 应天明 | 治疗乙肝后肝纤维化和肝硬化的中药组合物及其制造方法 |
| CN110859932A (zh) * | 2019-11-21 | 2020-03-06 | 博奥生物集团有限公司 | 抗肾纤维化的药物及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 温燕等: "加味参苓白术散治疗慢性非特异性结肠炎57例临床观察" * |
| 石艳芬等: "血府逐瘀汤联合恩替卡韦治疗慢性乙型肝炎肝纤维化临床观察" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111643628A (zh) | 2020-09-11 |
| CN115025188B (zh) | 2023-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107303383B (zh) | 一种对多种症状具有功效的中药组合物及其衍生物和制品 | |
| CN1326554C (zh) | 一种抗肿瘤药 | |
| CN103784820B (zh) | 用于治疗心血瘀阻型冠心病的中药配方及中药胶囊 | |
| CN103768537B (zh) | 用于治疗气滞血瘀型心绞痛的中药组合物 | |
| CN101773637A (zh) | 一种广谱抗病毒纳米中药及其生产方法 | |
| CN115025188B (zh) | 调节炎症和/或纤维化相关信号通路的中药及其应用 | |
| CN103784888A (zh) | 治疗气虚血瘀型冠状动脉粥样硬化性心脏病的中药 | |
| CN101773655A (zh) | 一种抗艾滋病纳米中药及其生产方法 | |
| CN105126045A (zh) | 一种治疗更年期综合征的中药组合物 | |
| CN101496892B (zh) | 一种治疗心脑血管疾病的口服中成药 | |
| CN104189473A (zh) | 一种治疗结核病的药物组合物及其制备方法 | |
| CN103705731B (zh) | 一种治疗慢性酒精中毒性肝病的中药组合物 | |
| CN109876127B (zh) | 一种养血当归胶囊及其制备方法 | |
| CN1332707C (zh) | 与西药结合治疗乙肝的中草药煎剂 | |
| CN102488809A (zh) | 一种用于治疗肝癌的中药及其制备方法 | |
| CN105288128A (zh) | 一种治疗糖尿病肾病的中药组合物及其制备方法 | |
| CN111643649A (zh) | 防治免疫相关疾病的中药材及其组合物 | |
| CN105126022A (zh) | 一种治疗鱼鳞病的药物及其制备方法 | |
| CN104840629A (zh) | 用于治疗猫黄疸的药物组合物及其制备方法 | |
| CN109364213A (zh) | 一种治疗肝纤维化的复方中药 | |
| CN104127826A (zh) | 一种治疗慢性酒精中毒性肝病的中药组合物 | |
| CN103536835A (zh) | 一种健脾消食药物的制备方法 | |
| CN111529664A (zh) | 中药及其在制备防治免疫相关疾病的药物中的应用 | |
| CN103110764A (zh) | 一种治疗急性热毒炽盛型带状疱疹的药物 | |
| CN116870095B (zh) | 一种治疗糖尿病的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |