CN114989302A - 人源化或嵌合cd3抗体 - Google Patents

人源化或嵌合cd3抗体 Download PDF

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Publication number
CN114989302A
CN114989302A CN202210585379.1A CN202210585379A CN114989302A CN 114989302 A CN114989302 A CN 114989302A CN 202210585379 A CN202210585379 A CN 202210585379A CN 114989302 A CN114989302 A CN 114989302A
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CN
China
Prior art keywords
seq
antibody
cdr2
cdr1
cdr3 sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202210585379.1A
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English (en)
Chinese (zh)
Inventor
R.拉德马克
I.阿尔廷塔斯
P.恩格伯特斯
J.舒尔曼
P.帕伦
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Genmab AS
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Genmab AS
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Filing date
Publication date
Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
Application filed by Genmab AS filed Critical Genmab AS
Publication of CN114989302A publication Critical patent/CN114989302A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202210585379.1A 2015-07-15 2016-07-14 人源化或嵌合cd3抗体 Pending CN114989302A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500414 2015-07-15
DKPA201500413 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
EPPCT/EP2016/050296 2016-01-08
CN201680054638.0A CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680054638.0A Division CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Publications (1)

Publication Number Publication Date
CN114989302A true CN114989302A (zh) 2022-09-02

Family

ID=57757079

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210585379.1A Pending CN114989302A (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体
CN201680054638.0A Active CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680054638.0A Active CN108368172B (zh) 2015-07-15 2016-07-14 人源化或嵌合cd3抗体

Country Status (14)

Country Link
US (4) US11359015B2 (uk)
EP (1) EP3322727A1 (uk)
JP (2) JP2018526981A (uk)
KR (1) KR20180030635A (uk)
CN (2) CN114989302A (uk)
AU (2) AU2016293073B2 (uk)
BR (1) BR112018000696A2 (uk)
CA (1) CA2992380A1 (uk)
EA (1) EA201890305A1 (uk)
IL (2) IL256562B1 (uk)
MX (2) MX2018000347A (uk)
NZ (1) NZ739028A (uk)
UA (1) UA128057C2 (uk)
WO (1) WO2017009442A1 (uk)

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SG10201800982QA (en) 2013-07-05 2018-03-28 Genmab As Humanized or chimeric cd3 antibodies
JP7261379B2 (ja) 2016-06-20 2023-04-20 カイマブ・リミテッド 抗ｐｄ－ｌ１抗体
WO2018162749A1 (en) 2017-03-09 2018-09-13 Genmab A/S Antibodies against pd-l1
US11668021B2 (en) 2017-05-09 2023-06-06 Yale University Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
AR112257A1 (es) 2017-06-21 2019-10-09 Gilead Sciences Inc Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos
SG11202008399QA (en) 2018-03-12 2020-09-29 Genmab As Antibodies
CN112334484A (zh) * 2018-03-14 2021-02-05 诺维莫尼公司 抗-CD3ε抗体及其应用方法
SG11202111329SA (en) * 2019-06-07 2021-12-30 Adimab Llc High affinity anti-cd3 antibodies, and methods for their generation and use
CA3146123A1 (en) * 2019-07-29 2021-02-04 Russell B. Wilson Antibodies to candida and uses thereof
US20230257479A1 (en) 2019-09-12 2023-08-17 Genmab A/S Bispecific antibodies binding to 5t4 and cd3 for use in treatment of cancer
US20210292418A1 (en) 2020-03-18 2021-09-23 Genmab A/S Antibodies
WO2021224499A1 (en) * 2020-05-08 2021-11-11 Genmab A/S Bispecific antibodies against cd3 and cd20
WO2022053654A1 (en) 2020-09-10 2022-03-17 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
IL301096A (en) 2020-09-10 2023-05-01 Genmab As Bispecific antibodies against CD3 and CD20 for the treatment of chronic lymphocytic leukemia
US20230365714A1 (en) 2020-10-02 2023-11-16 Genmab A/S Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3
JP2024519212A (ja) 2021-05-07 2024-05-09 ジェンマブ エー／エス Ｂ７ｈ４およびｃｄ３に結合する二重特異性抗体を含む薬学的組成物
CN113527493B (zh) * 2021-07-20 2023-10-27 广州爱思迈生物医药科技有限公司 一种b7-h3抗体及其应用
IL311805A (en) 2021-10-08 2024-05-01 Genmab As Antibodies that bind to CD30 and CD3
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer

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WO2015001085A1 (en) * 2013-07-05 2015-01-08 Genmab B.V. Humanized or chimeric cd3 antibodies

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Also Published As

Publication number Publication date
JP2018526981A (ja) 2018-09-20
UA128057C2 (uk) 2024-03-27
KR20180030635A (ko) 2018-03-23
IL310467A (en) 2024-03-01
US11359015B2 (en) 2022-06-14
US20230027394A1 (en) 2023-01-26
AU2016293073B2 (en) 2022-12-22
CN108368172B (zh) 2022-06-14
CN108368172A (zh) 2018-08-03
EP3322727A1 (en) 2018-05-23
JP2022023862A (ja) 2022-02-08
MX2018000347A (es) 2018-03-14
CA2992380A1 (en) 2017-01-19
EA201890305A1 (ru) 2018-07-31
BR112018000696A2 (pt) 2018-09-18
AU2016293073A1 (en) 2018-02-01
IL256562B1 (en) 2024-03-01
MX2022011002A (es) 2022-10-07
US20190284278A1 (en) 2019-09-19
US20220380464A1 (en) 2022-12-01
IL256562A (en) 2018-02-28
AU2023201733A1 (en) 2023-07-13
NZ739028A (en) 2023-05-26
WO2017009442A1 (en) 2017-01-19
US20220389101A1 (en) 2022-12-08

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