CN114948769A - Emulsified smearing mask with relieving and repairing effects - Google Patents

Emulsified smearing mask with relieving and repairing effects Download PDF

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Publication number
CN114948769A
CN114948769A CN202210519010.0A CN202210519010A CN114948769A CN 114948769 A CN114948769 A CN 114948769A CN 202210519010 A CN202210519010 A CN 202210519010A CN 114948769 A CN114948769 A CN 114948769A
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skin
soothing
mask
emulsified
sodium hyaluronate
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CN114948769B (en
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胡志娟
韩婷婷
杨素珍
王先浩
李硕
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Shandong Furida Biological Co ltd
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Shandong Furida Biological Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses an emulsified smearing mask with a relieving and repairing effect. According to the invention, mild skin-friendly hydrogenated lysolecithin is used as a main emulsifier, sodium hyaluronate and plant extract complex (active ingredients are artemisia capillaris extract and quinoa seed extract) are used as a relieving and repairing combination, and an emollient, vegetable oil (shea butter and jojoba seed oil) and mixed alcohol and the like are matched, so that various uncomfortable symptoms of skin can be relieved mildly, a skin fat membrane and a skin barrier can be repaired, and the prepared smearing mask is simple in component, mild and non-irritant, and can achieve instant and long-acting relieving and repairing effects.

Description

Emulsified smearing mask with soothing and repairing effects
Technical Field
The invention relates to the technical field of cosmetics, in particular to an emulsified smearing facial mask with a soothing and repairing effect.
Background
Skin sensitivity refers to subjective feeling and symptoms induced by susceptibility to various factors, namely high skin reactivity, poor tolerance and even susceptibility to allergy. The sensitive skin is mainly characterized in that: is drier, easy to be tense and red; the skin can feel itching, desquamation, even burning, stabbing pain and the like after being slightly stimulated, and the reason for the itching, the desquamation, the burning, the stabbing pain and the like is mainly the damage of the skin barrier and the weakening of the barrier function caused by exogenous factors.
The human skin barrier is located in the uppermost stratum corneum of the skin, which is composed of keratinocytes and lipids in the intercellular regions, and is based primarily on epidermal lipid components. Lipid among epidermal cells of sensitive muscles is mainly a fat-soluble component such as ceramide, cholesterol, fatty acid and the like, and has a cement function in a skin brick wall structure, and the loss of the lipid can cause the increase of skin water loss (TEWL), the reduction of the water content of stratum corneum and the low skin barrier function, so that the skin can be easily stimulated by various factors to cause sensitive symptoms.
The applying facial mask serving as a cosmetic carrier can be better attached to the skin, so that continuous nutrition can be better absorbed by the skin, the effect is exerted, and meanwhile, the dosage can be adjusted or the regional nursing of special parts can be carried out according to the requirement. Most of the existing smearing facial masks on the market are gel-type smearing facial masks without grease, cannot play a role in repairing sebum and lipid, and meanwhile, the gel-type facial masks seal the skin for a long time, so that the skin is overhydrated, the skin permeability is increased, and the skin is more easily stimulated; on the other hand, the effective components used by the cosmetic are only stacked by a large amount of components to relieve the allergic reaction or repair the damaged skin, but the superposition of the large amount of components for long-term use can cause the tolerance of the skin to be reduced, the barrier to be damaged, and the potential 'irritant components' in the cosmetic to enter the skin, so that the allergic pathological reaction is repeatedly caused. There is therefore a need to develop a mild, simple formulation emulsion-type facial mask product that can both alleviate the sensitive symptoms and help the skin repair the barrier quickly.
Disclosure of Invention
Aiming at the technical difficulties, the invention prepares the emulsified smearing facial mask with the effect of relieving and repairing. According to the invention, mild skin-friendly hydrogenated lysolecithin is used as a main emulsifier, sodium hyaluronate and plant extract complex are used as a relieving and repairing combination, and an emollient, vegetable oil, mixed alcohol and the like are matched, so that various uncomfortable symptoms of skin can be relieved mildly, a skin lipid membrane and a skin barrier can be repaired, and the prepared smearing facial mask is simple in component, mild and non-irritating, and can achieve instant and long-acting relieving and repairing effects.
The technical scheme of the invention is as follows: an emulsified type smearing facial mask with soothing and repairing effects comprises oil phase, water phase and soothing and repairing composition;
the oil phase comprises the following components in percentage by mass: 0.1-1% of hydrogenated lysolecithin, 2-10% of vegetable oil and fat and 0.5-2% of mixed alcohol;
the soothing composition comprises the following components in percentage by mass: 2 to 5 percent of plant extract compound and 0.05 to 0.3 percent of sodium hyaluronate composition; the plant extract compound contains artemisia capillaris thunb extract and quinoa seed extract, the mass ratio of the artemisia capillaris extract to the quinoa seed extract is 5:5-10, the preferential 5:8 is realized, and the total content of the artemisia capillaris extract to the quinoa seed extract in the plant extract compound is 10-30%, and the preferential 20%;
the water phase comprises the following components in percentage by mass: 3-8% of emollient, 0.1-1.5% of thickening agent and the balance of water.
The formula of the facial mask can be further added with a preservative, and the dosage (mass percentage) of the preservative in the facial mask is as follows: 0.1-2 percent of preservative, wherein the preservative is preferably compounded by p-hydroxyacetophenone and hexanediol according to the mass ratio of 1: 1.
The preferred proportion of the emulsified smearing mask of the invention is as follows (mass percentage): 0.3% of hydrogenated lysolecithin, 6% of vegetable oil, 1.5% of mixed alcohol, 3% of plant extract compound, 0.2% of sodium hyaluronate composition, 5% of emollient, 0.8% of thickening agent, 1% of preservative and the balance of water.
Further, the plant extract compound is prepared from butanediol, a compound of an artemisia capillaris extract and a quinoa seed extract and water according to a mass ratio of 2-4:0.8-1.2:1, and preferably according to a mass ratio of 3:1: 1.
Further, the vegetable oil and fat is prepared from shea butter: the jojoba seed oil is compounded according to the volume ratio of 1:1-4, preferably according to the volume ratio of 1: 2.
Further, the sodium hyaluronate composition is a composition of high molecular weight (molecular weight 140-.
Further, the artemisia capillaris extract is obtained by crude extraction of artemisia capillaris with water as a solvent, purification with an alumina chromatographic column, adsorption of phenylpropanoids in an extracting solution with macroporous adsorption resin, and elution with a butanediol solution, wherein the content of phenylpropanoids in the obtained extract is more than 0.3%.
Further, the quinoa seed extract comprises the following main active ingredients: saponin and polysaccharide, wherein the weight ratio of the total saponin to the total polysaccharide is 1:5-1:10, and the total content of the total saponin and the total polysaccharide in the quinoa seed extract is 1-3%.
Further, the emollient provides moisture retention, skin conditioning, etc. functional ingredients, including one or more of butylene glycol, propylene glycol, glycerin, xylitol-based glucoside, anhydroxylitol, xylitol, etc. in combination; preferably, the emollient is glycerin.
Further, the thickening agent plays a role in thickening, and includes, but is not limited to, one or more of carbomer sodium, sodium polyacrylate, xanthan gum, hydroxyethyl cellulose and the like, and preferably the thickening polymer with emulsification promoting effect, such as EMT10 of French Saybolt or carbomer sodium.
The raw materials and the functions are as follows:
hydrogenated lysolecithin: phospholipase A1 or A2 is used as a hydrolase to act on water-treated soybean lecithin (1, 2-diacylglycerol phospholipid), and fatty acid ester components of the phospholipid are partially hydrolyzed and modified to obtain 2-monoacylglycerol phospholipid or 1-monoacylglycerol phospholipid. Compared with common soybean lecithin: (1) the oil-in-water type emulsibility is enhanced, (2) the stability of emulsification under acidic condition and coexistence with salt is improved; compared with common emulsifier, the emulsifier is milder, and has effects of keeping moisture and reducing irritation.
Vegetable oil and fat: the skin-care cream is compounded by shea butter and jojoba seed oil, wherein the shea butter contains fat with biomass-triterpene alcohol with high proportion compared with other vegetable oil or vegetable fat, and the ingredient can help wound healing when skin has wound or inflammation. The unique water-locking and moisture-keeping characteristics of the skin care product can make the skin smooth and soft. Jojoba seed oil plays a role of a skin moistening agent, is similar to sebum of skin, moistens non-greasy skin, does not block acne and has strong permeability, and can be well mixed with the sebum to form a layer of breathable film on the surface layer of the skin to prevent water loss.
Mixing alcohol: called cetearyl alcohol, plays roles of thickening and stabilizing emulsification.
Plant extract complex: contains herba Artemisiae Scopariae (Artemisia capillaris) extract and quinoa (Chenopodium quinoa) seed extract, and the composition has effects of relieving and repairing, inhibiting TRPV-1 receptor and inflammatory factors PEG-8 and 1L-1 in skin, promoting cell proliferation and migration, and repairing epidermal cell barrier. The artemisia capillaris extract mainly contains phenylpropanoids and is mainly used for inhibiting the expression of skin inflammatory factors, inhibiting TRPV-1 receptors and relieving discomfort symptoms of skin; the quinoa (Chenopodium quinoa) seed extract is rich in active ingredients such as polyphenol, flavone, saponin, polysaccharide, polypeptide and the like, is usually used for resisting glycation and oxidation of skin, and has the effects of stimulating collagen regeneration, further restoring vitality of cells and carrying out metabolism in a young state. According to the invention, after the two plant extracts are compounded with the sodium hyaluronate with different molecular weights, the skin soothing and repairing effect can be obviously improved, and a good synergistic effect is displayed.
Sodium hyaluronate composition: the composition of the high molecular weight and low molecular weight sodium hyaluronate and the hydrolyzed sodium hyaluronate plays roles in locking water, replenishing water, and supplementing skin dermis hyaluronic acid, thereby promoting cell metabolism renewal.
The preparation method of the emulsified smearing mask is characterized by comprising the following steps:
s1: preparation of the oil phase
Mixing hydrogenated lysolecithin, vegetable oil and fat and mixed alcohol, heating to 75-85 ℃, and stirring until no solid particles exist in a liquid state;
s2: preparation of aqueous phase
Mixing emollient, thickener and water, stirring, and heating to 75-85 deg.C;
s3: homogenizing
Mixing the oil phase and the water phase, and homogenizing;
s4: stirring, cooling and adding preservative
Stirring the homogenized material liquid, cooling to 60-70 deg.C, and adding antiseptic;
s5: preparation of emulsified smearing mask
Stirring and cooling to 40-50 ℃, adding the plant extract compound and the sodium hyaluronate composition, mixing and stirring uniformly to obtain the emulsified facial mask.
Preferably, the stirring speed of the steps S2 and S5 is 500 +/-100 rpm, and the stirring time is 8-12 min.
Preferably, the homogenizing speed of step S3 is 800 +/-100 rpm, and the homogenizing time is 3-5 min.
The invention has the technical effects that: the emulsified smearing facial mask with the relieving and repairing effects, which is prepared by the invention, adopts the natural biological emulsifier hydrogenated lysolecithin as the main emulsifier, is low in dosage, good in emulsifying effect and smooth in skin feel, and reduces the irritation of the conventional emulsifier to the skin; the natural shea butter and jojoba seed oil are used as the emollient, so that the emollient has the effects of moisturizing and nourishing, can repair epidermal lipid and increase skin irritation resistance after long-term use, and can relieve skin inflammation and moisturize and repair by combining artemisia capillaris extract, quinoa seed extract and sodium hyaluronate. The 10 raw materials have synergistic interaction, and can play a better role in relieving various uncomfortable symptoms of the skin and repairing a sebum membrane and a skin barrier. The formula of the smearing facial mask disclosed by the invention is simple in components, no redundant burden is brought to the skin, and an instant and long-acting relieving and repairing effect can be achieved after the smearing facial mask is used.
Drawings
FIG. 1 is a graph showing the rate of change in the mean values of skin hemoglobin values of the experimental group (example 2), control group 1 and control group 3 relative to the initial values; in the figure, "+" indicates that the test value and the initial value have significant difference at the time point, and P is less than or equal to 0.05; "x" indicates that there was a significant difference P <0.001 between the test value and the initial value at that time point;
FIG. 2 shows the results of the immediate relief lactate stinging score test between the experimental group (example 2) and the control group (control group 2); in the figure, ". indicates that there was a significant difference between the experimental group and the control group at that time point, P < 0.0001; ". indicates that there is a significant difference between the test value and the initial value at this time point (0.0001. ltoreq. P < 0.001); "n.s." means no significant difference;
FIG. 3 is a graph showing the rate of change of lactic acid prick scores in the experimental group (example 2), control group 1 and control group 2; in the figure, ". indicates that there is a significant difference between the test value and the initial value at that time point, P < 0.0001;
FIG. 4 is a red-zone improvement image of a face of a volunteer using the product immediately;
fig. 5 is a red-zone improvement image of the face of a volunteer after long-term use of the product.
Detailed Description
The present invention is further illustrated by the following detailed description and the accompanying drawings, it being understood that the following description is illustrative only and not limiting of the invention.
Hydrogenated lysolecithin: available from Tsuji Oil Mills co., ltd., model SLP-LPC 70H; mixing alcohol: also called cetearyl ALCOHOL, tradename CETYL-STEATYL ALCOHOL 30:70 from Emery corporation, to achieve thickening and stabilizing emulsification.
The plant extract compound is prepared from butanediol, a compound of an artemisia capillaris thumb extract and a quinoa seed extract and water according to the mass ratio of 3:1:1, wherein the mass ratio of the artemisia capillaris thumb extract to the quinoa seed extract is 5: 8; artemisia capillaris extract: the artemisia capillaris is subjected to crude extraction by using water as a solvent, purified by using an alumina chromatographic column, adsorbed by using macroporous adsorption resin and finally eluted by using a butanediol solution to obtain the extract, wherein the content of phenylpropanoids in the extract is more than or equal to 0.3 percent. The quinoa seed extract mainly comprises the following active ingredients: saponins and polysaccharides, wherein the weight ratio of total saponins to total polysaccharides is 1:5-1:10, and the total content of total saponins and total polysaccharides in the quinoa seed extract is about 2%.
The sodium hyaluronate composition comprises: the composition of high molecular weight (molecular weight 140-.
Example 1: 0.1% of hydrogenated lysolecithin, 0.5% of shea butter, 2% of jojoba seed oil, 1% of mixed alcohol, 0.2% of sodium carbomer, 3% of glycerol, 2% of plant extract compound, 0.05% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
Example 2: 0.3% of hydrogenated lysolecithin, 2% of shea butter, 4% of jojoba seed oil, 1.5% of mixed alcohol, 0.8% of carbomer sodium, 5% of glycerol, 3% of plant extract compound, 0.2% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
Example 3: 1% of hydrogenated lysolecithin, 5% of shea butter, 5% of jojoba seed oil, 2% of mixed alcohol, 1.5% of carbomer sodium, 8% of glycerol, 5% of plant extract compound, 0.3% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
Control group 1: 0.3% of hydrogenated lysolecithin, 2% of shea butter, 4% of jojoba seed oil, 1.5% of mixed alcohol, 0.8% of carbomer sodium, 5% of glycerol, 1% of artemisia capillaris extract, 0.2% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
Control group 2: 0.3% of hydrogenated lysolecithin, 2% of shea butter, 4% of jojoba seed oil, 1.5% of mixed alcohol, 0.8% of sodium carbomer, 5% of glycerol, 2% of quinoa seed extract, 0.2% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
Control group 3: 0.3% of hydrogenated lysolecithin, 2% of shea butter, 4% of jojoba seed oil, 1.5% of mixed alcohol, 0.8% of carbomer sodium, 5% of glycerol, 0.2% of hyaluronic acid composition, 0.5% of p-hydroxyacetophenone, 0.5% of hexanediol and the balance of water.
The human efficacy test was performed below with the experimental group (example 2) and the control groups 1 to 3.
1. Test information
Grouping principle: the skin self-evaluation table is used for ensuring that the skin states of two groups of people are similar to each other as much as possible;
volunteer gender: each group had 27 women and 3 men;
age of volunteer: 20-55 years old;
test area: a face;
and (3) testing environment: temperature: 20.0-22.0 ℃; relative humidity: 40% -60%;
and (3) testing period: 28 days;
the sample using method comprises the following steps: the sample of the example 2 is used for replacing a daily facial mask in an experimental group, and the sample of the control group is used for replacing the daily facial mask in a control group;
it is administered for 1 time every other day, and the rest skin care habits are unchanged for 28 days.
2 skin hemoglobin value
2.1 measuring instrument: skin melanin and heme tester Mexameter MX18 (CK, germany);
2.2 measurement principle: the instrument is based on the absorption principle, and is used for specially measuring the contents of melanin and heme (two components responsible for skin color) of the skin by emitting a certain amount of light with three wavelengths by an internal probe, receiving and measuring the light reflected by the skin by a receiver, and calculating the amount of the light absorbed by the skin by a microprocessor.
2.3 measurement requirements: the average was taken 3 times of the test.
2.4 parameter interpretation: lower values indicate less hemoglobin in the test area and less pronounced skin redness.
The results of the skin hemoglobin value test before, 14 days after and 28 days after the samples of the experimental group (example 2), the control group 1 and the control group 3 are shown in table 1 and fig. 1. The smaller the skin heme value is, the lower the skin redness is, and the better the product soothing effect is.
Table 1: descriptive statistics of skin hemoglobin values (n ═ 30)
Figure BDA0003642500570000061
2.5 conclusion
Through skin heme value tests, the experimental group (14-day change rate-6.65%) can obviously reduce skin heme (P is more than or equal to 0.0001 and less than or equal to 0.001) and improve the allergic symptoms of skin redness compared with the control group 3 (14-day change rate 1.425%) and the control group 1 (14-day change rate-1.47%), and the artemisia capillaris extract and the quinoa seed extract are laterally proved to play very important roles in improving the skin redness.
3 lactic acid sting test
3.1 immediate relief test
3.1.1 measurement area: a face.
3.1.2 measurement principle: at room temperature, 50 μ L of a 10% lactic acid solution was applied to the nasolabial folds and either cheek, and the subjects were asked for subjective symptoms at 2.5min and 5min, respectively, and scored by 4 points (0 points no tingling sensation, 1 points mild stinging, 2 points moderate stinging, and 3 points severe stinging). Then adding the fractions of the two times, and if the total score is more than or equal to 3, the lactic acid stabbing pain reaction is positive.
3.1.3 test and control 2 samples immediately after use, the results of the lactate stinging score test are shown in FIG. 2. A lower score indicates a higher degree of skin tolerance to lactic acid challenge and a better immediate soothing effect of the product.
3.2 Long-term relief test
3.2.1 samples from the experimental group (example 2), control 1 and control 2 were used before and after 28 days, and the results of the lactate stinging score test are shown in Table 2 and FIG. 3. A lower score indicates a higher degree of skin tolerance to lactic acid challenge and a better product soothing effect.
Table 2: lactic sting score descriptive statistics (n ═ 30)
Figure BDA0003642500570000071
3.3 conclusion
Experimental groups lactic acid stimulation the volunteer subjective scores in the experiment were significantly reduced (P <0.0001), and all sensitive muscle volunteers tried as mild and non-irritating. And (3) proving that: compared with a control group, the experimental group has immediate and long-acting relieving effect and repairing effect, the product is suitable for sensitive skin, the relieving effect (change rate-52.47%) of the experimental group is obviously better than that (change rate-20.52%) of the control group 1 and that (change rate-5.1%) of the control group 2, and the synergistic effect of the artemisia capillaris extract and the quinoa seed extract in relieving and repairing is proved.
4 percutaneous water loss
4.1 measuring instrument: transdermal moisture loss tester Vapormeter SWL5001 (Delfin corporation, finland).
4.2 measurement principle: the instrument indirectly measures the density gradient of skin evaporation of moisture through the epidermis from two pairs of sensors (temperature and relative humidity) within a hollow cylinder based on the diffusion law discovered by Adolf Fick in 1855, and then expresses the amount of evaporation by microprocessor analysis.
4.3 measurement requirements: the average was taken 3 times of the test.
4.4 parameter interpretation: lower values indicate less transdermal water loss in units: g/(h.m) 2 )。
4.5 results of the test for water dispersion through epidermis before, 14 days after and 28 days after the use of the sample in the experimental group and the control group are shown in tables 4 and 5. The smaller the water dispersion loss through epidermis is, the less the water loss of skin is, and the better the repairing effect of the product is.
Table 4: experimental group statistics of water dispersion through epidermis (n ═ 30)
Figure BDA0003642500570000072
Table 5: comparative group descriptive statistics of water loss through epidermis (n ═ 30)
Figure BDA0003642500570000073
Figure BDA0003642500570000081
Remarking: "*": significant difference (0.01 is not less than P is not less than 0.05), ". indicates that the tested value has significant difference (0.0001 is not less than P is less than 0.001).
4.6 conclusion
Based on the results of the instrumental tests, the examples showed a significant reduction in transdermal water loss compared to before use, and showed good skin barrier repair, while the changes in the control groups 1-3 were not significant, over a 28 day test period.
5 questionnaire survey
5.1 efficacy of 30 volunteers on the samples was collected 14 days later, 28 days later using the preferred example 2 samples;
5.2 effect evaluation feedback results, the results are shown in Table 6;
5.3 headcount-the number of people who selected the option/total number of answers x 100%.
5.4 the effect rate of the population is equal to the sum of the ratio of the number of persons who answer the comparison agreement and the number of persons who have very agreed under the investigation index.
Table 6: volunteers self-rated the results after sample application (n is 30)
Figure BDA0003642500570000082
Figure BDA0003642500570000091
5.5 conclusion
Based on the self-assessment of 30 sensitive muscle volunteers, in a test period of 28 days, the sample of the embodiment shows that the skin dryness is relieved, the skin smoothness and moisture are improved, the phenomena of flushing and itching of the skin are reduced, the skin barrier capacity and tolerance are improved, the skin glossiness is improved, the integral state of the skin is improved, and the skin is mild and has no stimulation.
6 facial red zone shot
6.1 measuring instrument: VISIA (CanField corporation, usa);
6.2 measurement area: the face is right.
6.3 measurement principle: the instrument combines an advanced digital photographic technology, has three light sources of standard light, UV light and cross polarized light, can detect parameters of skin spots, wrinkles, textures, pores, ultraviolet spots, brown spots, purpura and red areas, and improves the visual degree of skin analysis.
6.4 parameter interpretation: the lighter the red picture is, the less noticeable the redness of the skin is.
6.5 selecting 1 volunteer who improves the reddish area of the instant product as shown in FIG. 4, and selecting 1 volunteer who improves the reddish area of the face after using the product for a long time as shown in FIG. 5.
6.6 conclusion
It can be seen from the photograph of the red area of the face that the sample of example 2 can significantly improve the red area of the face in real time and for a long time, and repair the skin barrier.

Claims (10)

1. An emulsified type smearing facial mask with soothing and repairing effects comprises oil phase, water phase and soothing and repairing composition;
the oil phase comprises the following components in the facial mask: 0.1-1% of hydrogenated lysolecithin, 2-10% of vegetable oil and fat and 0.5-2% of mixed alcohol;
the components of the soothing composition and the dosage of the soothing composition in the mask are as follows: 2-5% of plant extract compound and 0.05-0.3% of sodium hyaluronate composition; the plant extract compound contains artemisia capillaris extract and quinoa seed extract, and the mass ratio of the artemisia capillaris extract to the quinoa seed extract is 5:5-10, and the total content of the plant extract compound is 10-30%;
the water phase comprises the following components in percentage by weight in the mask: 3-8% of emollient, 0.1-1.5% of thickening agent and the balance of water.
2. An emulsified cosmetic pack having soothing and healing effects as claimed in claim 1, wherein a preservative is added to said pack in an amount of: 0.1 to 2 percent.
3. The emulsified applying mask with soothing and repairing effects as claimed in claim 2, wherein the preservative is compounded from p-hydroxyacetophenone and hexanediol.
4. An emulsified smearing mask with a soothing and repairing effect as claimed in any one of claims 1 to 3, which is characterized by comprising the following components in parts by weight: 0.3% of hydrogenated lysolecithin, 6% of vegetable oil, 1.5% of mixed alcohol, 3% of plant extract compound, 0.2% of sodium hyaluronate composition, 5% of emollient, 0.8% of thickening agent, 1% of preservative and the balance of water.
5. The emulsified smearing type mask with the soothing and repairing effects as claimed in claim 1, wherein the plant extract compound is prepared by compounding butanediol, a compound of artemisia capillaris extract and quinoa seed extract and water according to a mass ratio of 2-4:0.8-1.2: 1.
6. The emulsified type spread mask having a soothing and restoring effect as claimed in claim 1, wherein said vegetable oil is a vegetable oil consisting of shea butter: the jojoba seed oil is compounded according to the volume ratio of 1: 1-4.
7. The emulsified smearing type mask with the soothing and repairing effects as claimed in claim 1, wherein the sodium hyaluronate composition is a composition of high molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate and hydrolyzed sodium hyaluronate, and the mass ratio of the high molecular weight sodium hyaluronate to the low molecular weight sodium hyaluronate is 1:0.8-1.2: 0.8-1.2; the molecular weight of the high molecular weight sodium hyaluronate is 140-145 million Dalton, and the molecular weight of the low molecular weight sodium hyaluronate is 20-40 million Dalton.
8. The emulsified skin pack having a soothing and repairing effect as claimed in claim 1, wherein said emollient is a combination of one or more ingredients selected from the group consisting of butylene glycol, propylene glycol, glycerin, xylitol-based glucoside, dehydrated xylitol and xylitol.
9. The emulsified skin mask with soothing and repairing effects as claimed in claim 1, wherein the thickener is one or more of carbomer sodium, sodium polyacrylate, xanthan gum and hydroxyethyl cellulose.
10. A method for preparing an emulsion type application mask with a soothing and repairing effect as claimed in any one of claims 1 to 3 and 5 to 9, which comprises the following steps:
s1: preparation of the oil phase
Mixing hydrogenated lysolecithin, vegetable oil and fat and mixed alcohol, heating to 75-85 ℃, and stirring until no solid particles exist in a liquid state;
s2: preparation of aqueous phase
Mixing emollient, thickener and water, stirring, and heating to 75-85 deg.C;
s3: homogenizing
Mixing the oil phase and the water phase, and homogenizing;
s4: stirring, cooling and adding preservative
Stirring the homogenized material liquid, cooling to 60-70 deg.C, and adding antiseptic;
s5: preparation of emulsified smearing mask
Stirring and cooling to 40-50 ℃, adding the plant extract compound and the sodium hyaluronate composition, mixing and stirring uniformly to obtain the emulsified facial mask.
CN202210519010.0A 2022-05-13 2022-05-13 Emulsified smearing mask with relieving and repairing effects Active CN114948769B (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003327599A (en) * 2002-03-08 2003-11-19 Nitta Gelatin Inc Collagen derived from fish, method for producing the same and application thereof
WO2012059702A1 (en) * 2010-11-05 2012-05-10 Sophim Process for producing an emulsifying composition based on hydrogenated lecithin
WO2019098746A2 (en) * 2017-11-17 2019-05-23 (주)아모레퍼시픽 Transparent cosmetic composition
KR102011837B1 (en) * 2018-10-10 2019-10-21 주식회사 네오캠코리아 Cosmetic composition comprising extract of Artemisia capillaris using heat-tinc extract method and low-temperature ripening
CN111110596A (en) * 2020-02-18 2020-05-08 广州栋方生物科技股份有限公司 Sebum membrane bionic composition and preparation method thereof
CN112754951A (en) * 2021-02-10 2021-05-07 广州市雅彩盛生物科技有限公司 Cosmetic for repairing skin barrier and preparation method thereof
CN113398016A (en) * 2021-07-30 2021-09-17 上海新高姿化妆品有限公司 Skin soothing and repairing composition and cosmetic composition

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003327599A (en) * 2002-03-08 2003-11-19 Nitta Gelatin Inc Collagen derived from fish, method for producing the same and application thereof
WO2012059702A1 (en) * 2010-11-05 2012-05-10 Sophim Process for producing an emulsifying composition based on hydrogenated lecithin
WO2019098746A2 (en) * 2017-11-17 2019-05-23 (주)아모레퍼시픽 Transparent cosmetic composition
KR102011837B1 (en) * 2018-10-10 2019-10-21 주식회사 네오캠코리아 Cosmetic composition comprising extract of Artemisia capillaris using heat-tinc extract method and low-temperature ripening
CN111110596A (en) * 2020-02-18 2020-05-08 广州栋方生物科技股份有限公司 Sebum membrane bionic composition and preparation method thereof
CN112754951A (en) * 2021-02-10 2021-05-07 广州市雅彩盛生物科技有限公司 Cosmetic for repairing skin barrier and preparation method thereof
CN113398016A (en) * 2021-07-30 2021-09-17 上海新高姿化妆品有限公司 Skin soothing and repairing composition and cosmetic composition

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