CN114939078A - Multi-effect anti-aging composition and preparation method thereof - Google Patents
Multi-effect anti-aging composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a multi-effect anti-aging composition and a preparation method thereof, and the effective components of the multi-effect anti-aging additive comprise teprenone, collagen, hydroxypropyl tetrahydropyrane triol and diamond micropowder. The diamond powder adjusts the metabolism of the skin, resists the invasion of foreign substances, mildly removes old waste cutin and ensures that the skin has smoother and brighter sense; collagen forms a protective film on the surface of skin, so that the aged skin injury can be quickly repaired; the hydroxypropyl tetrahydropyrane triol can strengthen and strengthen the dermis and epidermis connecting layer, so that the exchange of the dermis and the epidermis is more active, and the metabolism of the skin is accelerated; the hydroxypropyl tetrahydropyrane triol and the collagen can increase the generation of collagen, elastin and mucopolysaccharide, increase the elasticity and firmness of skin and reduce wrinkles; the teprenone can prolong the service life of fibroblasts, keep the cells young, realize the synergistic effect, synergistically improve the skin aging problem from multiple aspects, comprehensively improve the skin from outside to inside, and effectively delay the skin aging.
Description
Technical Field
The invention belongs to the field of skin care products, and particularly relates to a multi-effect anti-aging composition and a preparation method thereof
Background
Skin aging refers to the aging damage of skin function, which reduces the protection ability and regulation ability of skin to human body, so that the skin can not adapt to the change of internal and external environment, and the change of overall appearance conditions such as color, luster, shape, texture, etc. appears. Aging of the skin is classified into intrinsic aging and extrinsic aging. Endogenous aging refers to the natural aging of the skin with aging, a natural process, which has been described systematically by the theory of natural cross-linking of biomolecules. The theory, when demonstrating the molecular mechanisms of aging of organisms, points out: organisms are unstable chemical systems and belong to dissipative structures. Various biomolecules in the system have a large number of active groups, and the active groups must interact with each other to generate chemical reaction, so that the biomolecules are slowly crosslinked to tend to be stable in chemical activity. With the lapse of time, the degree of crosslinking is continuously increased, the active groups of the biomolecules are continuously consumed and reduced, the original molecular structure is gradually changed, and the accumulation of the changes can cause the aging phenomenon of the biological tissues. It is manifested as whitening of the skin, fine wrinkles, decreased elasticity, skin laxity, etc. The most prominent cause of extrinsic aging is photoaging due to sun exposure. Skin discoloration manifested as wrinkles, loose skin, roughness, yellowish or grayish yellow, telangiectasia, formation of pigmented spots, and the like. In the case of the Chinese market, aging resistance has shown a trend towards more and more youthfulness. Survey data from the first financial group show that 59.2% begin to stress aging by age 20-30 years, and 19.64% of younger people aged 20 to 25 feel "anxious" to aging. At the same time, 28% of the time after 00 has begun to use anti-aging products. Therefore, anti-aging cosmetics are the most market-demanding class of cosmetics among functional cosmetic products.
The skin aging inducing factors are numerous, and people develop a plurality of anti-aging skin care products, but the skin care products can only improve the skin aging problem in one aspect, improve the aging by stimulating cell regeneration, and have poor and difficult lasting effect.
The consumer has a higher demand for efficacy due to the positive attitude against aging. At present, many cosmetics cannot meet the requirement of consumers for being very effective, so that part of consumers begin to turn to seeking for the help of medical beauty, the market scale of medical beauty is increased day by day, but in recent years, medical and patient disputes occur in the medical beauty market sometimes, and the effect is greatly reduced due to improper postoperative care, so that consumers very need safe and effective anti-aging products.
Disclosure of Invention
Aiming at the technical defects, the invention researches the whole process of aging occurrence, finds corresponding solutions from outside to inside and from time to space, so that the composition has excellent anti-aging effect, is very safe through multiple experiments, and meets the safe and efficient demands of consumers on anti-aging products.
The technical scheme adopted by the invention is as follows:
in a first aspect of the present invention, there is provided:
the multi-effect anti-aging additive comprises, by mass, 0.004-0.06 parts of teprenone, 0.005-0.5 parts of collagen, 0.15-10 parts of hydroxypropyl tetrahydropyran triol and 0.01-1 part of diamond micropowder.
In some examples of the multi-effect anti-aging additive, the effective components of the additive comprise 0.03-0.06 part of teprenone, 0.02-0.5 part of collagen, 5-10 parts of hydroxypropyl tetrahydropyrane triol and 0.5-1 part of diamond micropowder.
In some examples of the pleiotropic anti-aging additive, the collagen is recombinant human collagen.
In a second aspect of the present invention, there is provided:
the multi-effect anti-aging skin care product consists of auxiliary materials acceptable by the skin care product and an effect additive, wherein the effect additive is the multi-effect anti-aging additive in the first aspect of the invention.
In some examples of the multi-effect anti-aging skin care product, the additive amount of the multi-effect anti-aging additive in the multi-effect anti-aging skin care product is 1-12%.
In some examples of the multi-effect anti-aging skin care product, the cosmetically acceptable adjuvant is selected from at least one of dimethicone PEG-10/15 crosspolymer, lauryl PEG-10 tris (trimethylsiloxy) silylethyl dimethicone, cetyl ethylhexanoate, propylheptyl octanoate, ethylhexyl hydrofolate, magnesium sulfate, pentanediol, hexanediol, glycerin.
In some examples of the multi-effect anti-aging skin care product, the multi-effect anti-aging skin care product is a cream, a lotion, an emulsion, a mask.
In some examples of the multi-effect anti-aging skin care product, the essence cream is facial essence cream or eye essence cream; the essence is facial essence and eye essence; the lotion is facial lotion or neck lotion.
In a third aspect of the present invention, there is provided:
a method for preparing a multi-effect anti-aging skin care product comprises the following steps:
s1) uniformly mixing collagen and hydroxypropyl tetrahydropyrane triol with partial auxiliary materials, and dissolving for later use to obtain a solution A;
s2) mixing the diamond micropowder and part of the auxiliary materials uniformly, then further adding the rest auxiliary materials, and homogenizing to obtain a homogeneous body B;
s3) mixing the solution A and the homogenate B, and homogenizing to obtain the multi-effect anti-aging skin care product.
In some examples of the preparation method, the rotation speed of the homogenizing in the steps S2) and/or S3) is 1000-3000 rpm.
The beneficial effects of the invention are:
the multi-effect anti-aging composition provided by some examples of the invention can synergistically improve the skin aging problem from multiple aspects, comprehensively improve the skin aging from outside to inside, and effectively delay the skin aging. Particularly, on the surface of the skin and above the cuticle, the diamond powder adjusts the metabolism of the skin, increases the energy of the skin, resists the invasion of foreign substances, mildly removes old waste cutin and ensures that the skin has smoother and brighter sense; collagen, which forms a protective film on the surface of the skin, resists the invasion of foreign substances, quickly repairs the injury formed by the aged skin and completes the skin epidermal barrier; in the dermis and epidermis connecting layer, the hydroxypropyl tetrahydropyrane triol can strengthen the dermis and epidermis connecting layer, so that the exchange of the dermis and the epidermis is more active, and the metabolism of the skin is accelerated; in the dermis, the hydroxypropyl tetrahydropyrane triol and the collagen can increase the generation of collagen, elastin and mucopolysaccharide, increase the elasticity and the compactness of skin and reduce wrinkles, and the teprenone can prolong the service life of fibroblasts, stabilize cell genes and keep the youth activity of cells. Therefore, the composition aims at aging, layer by layer action, multiple repair and multiple-effect aging resistance, so that the final product has very obvious effect, has biological safety and can not damage the skin.
Drawings
FIG. 1 is a graph comparing the change of skin wrinkles (canthus) before and after 28 days of use in volunteers.
Detailed Description
In a first aspect of the present invention, there is provided:
the multi-effect anti-aging additive comprises, by mass, 0.004-0.06 parts of teprenone, 0.005-0.5 parts of collagen, 0.15-10 parts of hydroxypropyl tetrahydropyran triol and 0.01-1 part of diamond micropowder.
The diamond micropowder is fine powder obtained by grinding diamond, and has a particle size of 1-30 μm and a cosmetic grade.
In some examples of the multi-effect anti-aging additive, the effective components of the additive comprise 0.03-0.06 part of teprenone, 0.02-0.5 part of collagen, 5-10 parts of hydroxypropyl tetrahydropyrane triol and 0.5-1 part of diamond micropowder. Within the dosage range, the product has better multi-effect anti-aging effect.
In some examples of the pleiotropic anti-aging additive, the collagen is recombinant human collagen. The recombinant human collagen has better effect and is a better choice.
In a second aspect of the present invention, there is provided:
the multi-effect anti-aging skin care product consists of auxiliary materials acceptable by the skin care product and an effect additive, wherein the effect additive is the multi-effect anti-aging additive in the first aspect of the invention.
In some examples of the multi-effect anti-aging skin care product, the multi-effect anti-aging additive is added into the multi-effect anti-aging skin care product in an amount of 1-12%. The addition amount can be adjusted according to the needs.
The auxiliary materials have the function of better dispersing and stabilizing the functional components and the like. In some examples of the multi-effect anti-aging skin care product, the cosmetically acceptable adjuvant is selected from at least one of dimethicone PEG-10/15 crosspolymer, lauryl PEG-10 tris (trimethylsiloxy) silylethyl dimethicone, cetyl ethylhexanoate, propylheptyl octanoate, ethylhexyl hydrofolate, magnesium sulfate, pentanediol, hexanediol, glycerin.
In some examples of the multi-effect anti-aging skin care product, the multi-effect anti-aging skin care product is a cream, a serum, an emulsion, a mask.
In some examples of the multi-effect anti-aging skin care product, the essence cream is facial essence cream or eye essence cream; the essence is facial essence and eye essence; the lotion is facial lotion or neck lotion.
In a third aspect of the present invention, there is provided:
a method for preparing a multi-effect anti-aging skin care product comprises the following steps:
s4) uniformly mixing collagen and hydroxypropyl tetrahydropyrane triol with partial auxiliary materials, and dissolving for later use to obtain a solution A;
s5) mixing the diamond micropowder and part of the auxiliary materials uniformly, then further adding the rest auxiliary materials, and homogenizing to obtain a homogeneous body B;
s6) mixing the solution A and the homogenate B, and homogenizing to obtain the multi-effect anti-aging skin care product.
In some examples of the preparation method, the rotation speed of the homogenizing in the steps S2) and/or S3) is 1000-3000 rpm.
The technical scheme of the invention is further explained by combining the examples.
The preparation and efficacy of the multi-effect anti-aging skin care product are exemplified by essence cream.
The compositions of the different examples are shown in table 1.
TABLE 1
Description of the drawings: in the table, S represents examples and D represents comparative examples. The preparation method of each example is as follows:
adding raw materials with the serial number of 9-17 into a container, and stirring until the solid is completely dissolved for later use to obtain a solution A;
adding the raw materials 8 and 2 into a dry container, stirring and dispersing uniformly, adding the raw materials 1-7, homogenizing to obtain a homogeneous body B, slowly adding the solution A into the homogeneous body B under the stirring condition, and homogenizing to obtain the essence cream after the addition is finished.
1. Comparative example 1 is an essence cream prepared by replacing the composition of the present invention in the essence cream of example 2 of the present invention with retinol, which is a star ingredient in anti-aging products currently on the market.
2. Comparative example 2 is the essence cream prepared by replacing the composition of the invention in the essence cream of example 2 of the invention with palmitoyl pentapeptide which is used in anti-aging products in the market at present and has a good anti-aging effect in an equal proportion.
3. Comparative example 3 is an essence cream obtained by removing teprenone from the essence cream of example 2 according to the present invention.
4. Comparative example 4 is the essence cream obtained by removing diamond micropowder from the essence cream of example 2 of the present invention.
5. Comparative example 5 is an essence cream obtained by removing hydroxypropyl tetrahydropyrane triol from the essence cream of example 2 of the present invention.
6. Comparative example 6 is an essence cream obtained by removing recombinant human collagen from the essence cream of example 2 of the present invention.
7. Comparative example 7 is the anti-aging essence cream with international brand which is sold on the market at present and has good public praise.
Efficacy verification
(I) efficacy test
Firstly, a testing instrument:
1. the invention uses a finland Delfin elastometer which is lightly pressed against the skin with an indenter. When an external force is applied to the skin, the skin resists changes in its shape and the response of the skin under short term loading indicates its immediate elastic properties, resulting in an elasticity value for the skin.
2. Using Delfin antrera 3D photography in finland, antrera 3D used innovative optical methods and complex mathematical algorithms to acquire three-dimensional images. This allows data to be extracted from the image relating to the three-dimensional shape of the skin, which will enable quantification of the effect of the treatment and monitoring of the situation over time. For example, the texture, smoothness of the skin, and depth and width of fine lines and wrinkles are measured. With its multispectral analysis, the ant software can also measure pigmentation and redness, which will provide meaningful information about sun damage, veins, etc.
3. The percutaneous water loss meter, Delfin VapoMeter SWL5201, finland, was used, the VapoMeter having a cylindrical chamber with relative humidity and temperature sensors inside. Shortly after the instrument was brought into contact with the skin, there was a linear increase in relative humidity (RH%) in the measurement cavity. TEWL values were calculated from the increase in RH%. In the measurement gap, the measurement chamber is passively ventilated. The VapoMeter uses a closed-chamber measurement principle, so the measurement is not affected by the gas flow in the chamber. The measurement time is short, ensuring the minimum of the blockage of normal evaporation.
II, experimental principle:
TEWL value, transdermal water loss (TEWL), measures the change in the vapor pressure of moisture adjacent to the skin surface. TEWL values represent the loss of water from the stratum corneum and are an important criterion for evaluating the barrier function of the stratum corneum. A lower TEWL value of the skin indicates a better barrier function of the skin and vice versa. The efficacy of the moisturizing and repairing cosmetic can be evaluated by testing the value of skin moisture loss TEWL, and the moisturizing and repairing cosmetic can also be applied to allergic patch test, contact dermatitis and physical therapyMonitoring of burns and new tissue, finding in time whether the protective function of the skin has been destroyed. The unit of TEWL is: g/hm 3 。
Thirdly, testing the population:
each group comprises 20 persons, 9 groups of volunteers with the age of 30-65 years and meeting the experimental requirements.
Fourthly, testing conditions:
subjects rested for 30 minutes at room temperature 21 ± 1 ℃, relative humidity 50 ± 10%, and were monitored dynamically in real time and were retested for relevant data.
Fifthly, an experimental process:
the experiment is divided into 9 groups, wherein the 1 st group uses the whole face of the invention in the embodiment 1, the second group uses the whole face of the invention in the embodiment 3, the third group uses the whole face of the comparison example 8, the 4-9 groups use the left face of the invention in the embodiment 2, and the right face of each group is respectively coated with the comparison examples 1-6; the face is rubbed 2 times in the morning and evening every day for 4 weeks, the skin elasticity ISE value, the percutaneous water loss rate TEWL value, the average value WRC (mm) of the skin wrinkle length, the average value WRK (mm) of the wrinkle width and the average value WRS (mm) of the wrinkle depth are recorded, then, one part of each volunteer face, the left forehead, the right forehead, the eye corner and the cheek is photographed by an Antera3D, and the whole is stored.
Sixthly, experimental results:
1. skin transdermal water loss Rate (TEWL) test
The test sets the subject's TEWL at week 0 as TEWL0, week 4 as TEWL4, with the TEWL change being Δ TEWL, Δ TEWL being TEWL4-TEWL0, Δ TEWL rate of change being (TEWL4-TEWL0)/TEWL0 + 100%, Δ TEWL rate of change being negative and the lower the number, indicating less moisture loss in the skin after four weeks of use of the product, i.e. better skin barrier function repair, better moisture retention, and healthier skin, table 2 shows the average value of the TEWL change for each group of 20 people after 4 weeks of use compared to the initial value.
TABLE 2
| Group of | Delta TEWL rate of change (%) | Group of | Delta TEWL rate of change (%) |
| Example 1 | -7.54 | Comparative example 3 | -8.51 |
| Example 2 | -14.62 | Comparative example 4 | -10.38 |
| Example 3 | -25.43 | Comparative example 5 | -7.79 |
| Comparative example 1 | 14.73 | Comparative example 6 | -5.46 |
| Comparative example 2 | 2.25 | Comparative example 7 | -6.95 |
The results in table 2 illustrate that:
1) the delta TEWL change rate value, example 1 > example 2 > example 3, therefore, it can be shown that as the addition ratio of the composition of the invention is increased, the delta TEWL change rate value is correspondingly reduced, namely, the less the skin moisture is lost, the more complete the stratum corneum barrier function of the skin is, the better the capability of the skin for resisting the external environment, the less the skin moisture is lost, and the more healthy, moist and full the skin is.
2) The delta TEWL change rate value of the comparative example 1 is 14.73%, which shows that the skin loses moisture and increases after the essence cream of the comparative example 1 is used, namely, the barrier function of the skin cuticle is gradually weakened, the skin becomes more fragile and dry, and the moisture of the skin is more easily lost.
3) The delta TEWL change rate value of comparative example 2 was 2.25%, that is, the increase of the moisture loss rate of the essence cream of comparative example 2 was not obvious, which indicates that the skin barrier function recovery is not well affected by using the essence cream of comparative example 2.
4) It is understood from comparative example 2 and comparative examples 3 to 6 that removal of any one of teprenone, collagen, hydroxypropyl tetrahydropyran triol and diamond micropowder increases the Δ TEWL value, i.e., the skin moisture is more likely to be lost, and the recovery of the stratum corneum barrier function of the skin is not as excellent as that of example 2. The teprenone, the collagen, the hydroxypropyl tetrahydropyrane triol and the diamond micropowder have good synergistic effect.
5) The delta TEWL change values of the compositions in the examples 1-3 are smaller than those of the comparative example 7, so that the composition disclosed by the invention is better than the anti-aging essence cream of the market international brand in the capacity of reducing the skin moisture loss and also better than the anti-aging essence cream of the market international brand in the capacity of keeping the skin moisture and repairing the skin stratum corneum barrier.
2. Skin Elasticity (ISE) test
The test set the subject's measured ISE at week 0 as ISE0 and ISE at week 4 as ISE4 with the ISE change value Δ ISE which is ISE4-ISE0, Δ ISE change rate (ISE4-ISE0)/ISE0 100%, Δ ISE change rate is positive and higher values indicate more increase in skin elasticity value around the product used, higher skin elasticity and more firmer and more elastic skin, and table 3 shows the average Δ ISE change rate values for 20 people per group compared to the initial values after 4 weeks of use.
TABLE 3
| Group of | Delta ISE Change Rate (%) | Group of | Delta ISE Change Rate (%) |
| Example 1 | 10.31 | Comparative example 3 | 15.44 |
| Example 2 | 23.43 | Comparative example 4 | 20.33 |
| Example 3 | 34.32 | Comparative example 5 | 12.46 |
| Comparative example 1 | 18.44 | Comparative example 6 | 8.83 |
| Comparative example 2 | 15.36 | Comparative example 7 | 7.58 |
As can be seen from table 3:
1) the ISE change rate, example 1 < example 2 < example 3, shows that as the addition ratio of the composition of the invention increases, the change rate of the elasticity value of the composition also increases greatly, thus showing that in the addition range of the composition of the invention, the higher the addition amount of each component, the more the elasticity of the skin increases, and the firmer and fuller the skin.
2) The delta ISE change rate value of comparative example 1 < the delta ISE change rate value of example 2, which indicates that the skin elasticity-increasing effect of the composition of the present invention is inferior to that of the composition of the present invention when the composition of the present invention is replaced with retinol, a commercially available anti-aging star ingredient, and the amount of retinol added is the highest amount added.
3) The delta ISE change value of comparative example 2 < delta ISE change value of example 2, indicating that the composition of the present invention was changed to a commercially available peptide in an amount similar to that of example 2, and the skin elasticity-increasing effect was far less than that of the composition of the present invention.
4) Comparative examples 3 to 6 are essence creams prepared by removing any one of the compositions of the present invention in example 2, and the delta ISE change rate is smaller than that of example 2 by comparing with example 2, so that it can be shown that any removal of a certain component of the composition of the present invention results in a smaller delta ISE change rate, and the skin elasticity is not increased as much as that of example 2 of the present invention. The teprenone, the collagen, the hydroxypropyl tetrahydropyrane triol and the diamond micropowder have good synergistic effect.
5) The delta ISE change values of the examples 1-3 are all larger than that of the comparative example 7, so that the composition disclosed by the invention is better than the anti-aging essence cream of the commercial international brand in the capability of increasing the skin elasticity within the adding amount range, and the cosmetics prepared by using the composition disclosed by the invention have more excellent effects of increasing the skin elasticity and compacting the skin.
3. Skin wrinkle Length (WRC value), average wrinkle Width (WRK), average wrinkle depth (WRS) test
The test sets the average value of the wrinkle length, width and depth of the 0 th week measured by a subject as WRC0, WRK0 and WRS0, the average value of the wrinkle length, width and depth of the 4 th week measured by the subject as WRC4, WRK4 and WRS4, the wrinkle change values are Δ WRC, Δ WRK and Δ WRS, Δ WRC is WRC4-WRC0, Δ WRK is WRK4-WRK0, WRS is WRS4-WRS 0; Δ WRC rate of change (WRC4-WRC0)/WRC0 × 100%, (WRK4-WRK0)/WRK0 × 100%, (WRS4-WRS0)/WRS0 × 100%; the change rates of delta WRC, delta WRK and delta WRS are negative numbers, and the lower the numerical value is, the shorter the wrinkle length of the skin is, the narrower the wrinkle width is, the shallower the wrinkle depth is, the better the product has the capability of delaying the wrinkles of the skin, and the smoother and younger the skin is. The results are shown in Table 4 and FIG. 1. Table 4 shows the average wrinkle length, width, depth change rate values for each group of 20 people compared to the initial values after 4 weeks of use.
TABLE 4
| Group of | Δ WRC Rate of Change (%) | Δ WRK Change (%) | Δ WRS Change ratio (%) |
| Example 1 | -17.10 | -7.46 | -8.49 |
| Example 2 | -28.66 | -14.51 | -13.52 |
| Example 3 | -45.43 | -20.62 | -21.20 |
| Comparative example 1 | -20.55 | -10.53 | -10.14 |
| Comparative example 2 | -18.34 | -11.72 | -10.82 |
| Comparative example 3 | -15.64 | -9.67 | -9.61 |
| Comparative example 4 | -22.38 | -12.81 | -11.94 |
| Comparative example 5 | -16.82 | -8.26 | -7.25 |
| Comparative example 6 | -13.37 | -7.75 | -5.16 |
| Comparative example 7 | -10.25 | -5.48 | -6.01 |
As can be seen from table 4:
1) the change rate values of Δ WRC, Δ WRK and Δ WRS, example 1 > example 2 > example 3, thus it can be shown that as the addition ratio of the composition of the present invention is increased, the change rate values of Δ WRC, Δ WRK and Δ WRS become smaller, namely, the shorter the wrinkle length of the skin, the narrower the width and the shallower the depth, the less obvious the wrinkles of the whole skin become, and the more excellent the anti-aging effect of the product becomes.
2) The values of change Δ WRC,. DELTA.WRK,. DELTA.WRS of comparative example 1 are greater than those of example 2, indicating that the skin is less able to reduce wrinkles overall after the use of the cream of comparative example 1 than the skin is able to reduce wrinkles overall by the composition of the present invention of example 2, i.e., the composition of the present invention is better than 1% retinol at reducing the overall level of wrinkles.
3) The change rate values of Δ WRC, Δ WRK, and Δ WRS of comparative example 2 are greater than those of example 2, indicating that the skin has less overall skin wrinkle reduction capability after the essence cream of comparative example 2, i.e., the composition of the present invention is superior to the same amount of palmitoyl pentapeptide-4 in reducing the overall wrinkle level.
4) Comparative examples 3 to 6 are essence creams prepared by removing any one of the compositions of the present invention in example 2, and compared with example 2, the change rates of Δ WRC, Δ WRK, and Δ WRS are all larger than those of example 2, so it can be shown that any removal of a certain component of the composition of the present invention will increase the corresponding change rates of Δ WRC, Δ WRK, and Δ WRS, i.e., the overall level of wrinkles on the skin, and therefore any removal of a component of the composition of the present invention will reduce the anti-wrinkle effect of the product, i.e., any component of the composition of the present invention will have a positive effect on the anti-aging effect of the final product.
5) The change rate values of Δ WRC, Δ WRK, and Δ WRS of examples 1-3 are all smaller than those of comparative example 7, thus demonstrating that the composition of the present invention has better capability of reducing the whole level of skin wrinkles than the commercial international brand anti-aging essence cream in the addition amount range, i.e. better anti-wrinkle and anti-aging effects than the commercial international brand anti-aging essence cream.
6) Before and after selecting a part of facial wrinkle images of volunteers using the facial wrinkle image obtained in example 2 of the present invention, as shown in fig. 1 in detail, it can be seen visually that the whole level of facial wrinkles is reduced after the facial skin is treated with the essence cream prepared in example of the present invention, indicating that the anti-wrinkle effect of the composition of the present invention is very excellent.
(II) safety test (human body skin patch experiment)
1. The number of tested persons: total 40, 20 men and 20 women, age between 18-60 years.
2. Health condition: the skin of the subject is healthy, the allergic history of the skin disease does not exist, and the voluntary selection standard of the subject is met.
3. The test method comprises the following steps: selecting a qualified spot tester, putting about 0.020-02025g of a test product in the spot tester in a closed spot-sticking experiment mode, externally sticking a special adhesive tape on the back of a test subject, coating 11 coating points on each test subject, removing the test product after 24 hours, observing skin reactions after 0.5, 24 and 48 hours respectively, grading according to skin reaction grading standards in cosmetic hygiene standards, wherein the evaluation standards are shown in table 5, calculating the average value, and recording the result in table 6.
TABLE 5 Standard Table for testing skin spots on human body
TABLE 6 Scoring results of Patch test
| Grade of rating | 0.5(h) | 24(h) | 48(h) |
| Example 1 | 0 | 0 | 0 |
| Example 2 | 0 | 0 | 0 |
| Example 3 | 0 | 0 | 0 |
| Comparative example 1 | 3 | 2 | 2 |
| Comparative example 2 | 0 | 0 | 0 |
| Comparative example 3 | 0 | 0 | 0 |
| Comparative example 4 | 0 | 0 | 0 |
| Comparative example 5 | 0 | 0 | 0 |
| Comparative example 6 | 0 | 0 | 0 |
| Comparative example 7 | 1 | 0 | 0 |
As can be seen from Table 6, the ingredients of the composition of the present invention are very safe, very skin friendly, mild and non-irritating, while comparative example 1 is more irritating.
The foregoing is a more detailed description of the invention and is not to be taken in a limiting sense. It will be apparent to those skilled in the art that simple deductions or substitutions without departing from the spirit of the invention are within the scope of the invention.
Claims (10)
1. The multi-effect anti-aging additive comprises, by mass, 0.004-0.06 parts of teprenone, 0.005-0.5 parts of collagen, 0.15-10 parts of hydroxypropyl tetrahydropyran triol and 0.01-1 part of diamond micropowder.
2. The multi-effect anti-aging additive as claimed in claim 1, wherein the effective components comprise 0.03-0.06 parts of teprenone, 0.02-0.5 parts of collagen, 5-10 parts of hydroxypropyl tetrahydropyran triol and 0.5-1 part of diamond micropowder.
3. The multi-effect anti-aging additive according to claim 1 or 2, wherein the collagen is recombinant human collagen.
4. A multi-effect anti-aging skin care product comprises auxiliary materials acceptable for skin care products and an effect additive, and is characterized in that the effect additive is the multi-effect anti-aging additive disclosed by any one of claims 1-3.
5. The multi-effect anti-aging skin care product according to claim 4, wherein the multi-effect anti-aging additive is added into the multi-effect anti-aging skin care product in an amount of 1-12%.
6. The multi-effect anti-aging skin care product according to claim 4, wherein the skin care acceptable excipients are selected from at least one of dimethicone PEG-10/15 crosspolymer, lauryl PEG-10 tris (trimethylsiloxy) silylethyl dimethicone, cetyl ethylhexanoate, propylheptyl caprylate, ethylhexyl hydrof olivate, magnesium sulfate, pentanediol, hexylene glycol, glycerin.
7. The multi-effect anti-aging skin care product according to claim 4, wherein the multi-effect anti-aging skin care product is an essence cream, an essence, an emulsion, a facial mask.
8. The multi-effect anti-aging skin care product according to claim 7, wherein the essence cream is facial essence cream or eye essence cream; the essence is facial essence and eye essence; the lotion is facial lotion or neck lotion.
9. A method for preparing a multi-effect anti-aging skin care product comprises the following steps:
s1) uniformly mixing collagen and hydroxypropyl tetrahydropyrane triol with partial auxiliary materials, and dissolving for later use to obtain a solution A;
s2) mixing the diamond micropowder and part of the auxiliary materials uniformly, then further adding the rest auxiliary materials, and homogenizing to obtain a homogeneous body B;
s3) mixing the solution A and the homogenate B, and homogenizing to obtain the multi-effect anti-aging skin care product.
10. The method of claim 9, wherein the homogenizing in step S2) and/or S3) is performed at 1000-3000 rpm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115708792A (en) * | 2022-11-30 | 2023-02-24 | 武汉二十四桥生物科技有限公司 | Repairing and anti-aging composition capable of generating hyaluronic acid through double targets and reducing skin collagen loss, and preparation method and application thereof |
| CN117679344A (en) * | 2023-12-19 | 2024-03-12 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773130A (en) * | 2020-07-17 | 2020-10-16 | 贝乐科(上海)生物科技有限公司 | Hydroxypropyl tetrahydropyrane triol compound and preparation method and application thereof |
| CN111920716A (en) * | 2020-08-18 | 2020-11-13 | 云南贝泰妮生物科技集团股份有限公司 | Raw material capable of improving skin aging symptom and preparation process thereof |
| CN113117051A (en) * | 2021-04-14 | 2021-07-16 | 湖南群腾生物科技有限公司 | Anti-aging transdermal polypeptide preparation and preparation method thereof |
| CN113425611A (en) * | 2021-08-10 | 2021-09-24 | 东晟源研究院(广州)有限公司 | Anti-aging composition for four-dimensional tissue repair through teprenone and application thereof |
| CN113876609A (en) * | 2021-10-29 | 2022-01-04 | 湖北省麦诗特生物科技有限公司 | Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and polypeptide protein and application thereof |
| CN114306095A (en) * | 2021-12-16 | 2022-04-12 | 中科(广州)再生医学科技开发有限公司 | Micro-needle patch for resisting wrinkles and preserving moisture and preparation method and application thereof |
-
2022
- 2022-06-20 CN CN202210694991.2A patent/CN114939078B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773130A (en) * | 2020-07-17 | 2020-10-16 | 贝乐科(上海)生物科技有限公司 | Hydroxypropyl tetrahydropyrane triol compound and preparation method and application thereof |
| CN111920716A (en) * | 2020-08-18 | 2020-11-13 | 云南贝泰妮生物科技集团股份有限公司 | Raw material capable of improving skin aging symptom and preparation process thereof |
| CN113117051A (en) * | 2021-04-14 | 2021-07-16 | 湖南群腾生物科技有限公司 | Anti-aging transdermal polypeptide preparation and preparation method thereof |
| CN113425611A (en) * | 2021-08-10 | 2021-09-24 | 东晟源研究院(广州)有限公司 | Anti-aging composition for four-dimensional tissue repair through teprenone and application thereof |
| CN113876609A (en) * | 2021-10-29 | 2022-01-04 | 湖北省麦诗特生物科技有限公司 | Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and polypeptide protein and application thereof |
| CN114306095A (en) * | 2021-12-16 | 2022-04-12 | 中科(广州)再生医学科技开发有限公司 | Micro-needle patch for resisting wrinkles and preserving moisture and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 上海庭璨进出口有限公司: "忆思贝 白金级兰花焕彩面", Retrieved from the Internet <URL:国产普通化妆品备案信息> * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115708792A (en) * | 2022-11-30 | 2023-02-24 | 武汉二十四桥生物科技有限公司 | Repairing and anti-aging composition capable of generating hyaluronic acid through double targets and reducing skin collagen loss, and preparation method and application thereof |
| CN115708792B (en) * | 2022-11-30 | 2024-02-13 | 武汉二十四桥生物科技有限公司 | Double-target hyaluronic acid generation and skin collagen loss reduction repairing and anti-aging composition, and preparation method and application thereof |
| CN117679344A (en) * | 2023-12-19 | 2024-03-12 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
| CN117679344B (en) * | 2023-12-19 | 2024-05-24 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
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