CN114901297A - 用于原位产生逆转录病毒的生产者病毒 - Google Patents

用于原位产生逆转录病毒的生产者病毒 Download PDF

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Publication number
CN114901297A
CN114901297A CN202080087854.1A CN202080087854A CN114901297A CN 114901297 A CN114901297 A CN 114901297A CN 202080087854 A CN202080087854 A CN 202080087854A CN 114901297 A CN114901297 A CN 114901297A
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virus
protein
promoter
construct
retroviral
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CN202080087854.1A
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Chinese (zh)
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斯蒂芬·H·索恩
丹尼尔·J·伯德
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Caliwell Immunotherapy
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Caliwell Immunotherapy
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
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    • C12Y207/07—Nucleotidyltransferases (2.7.7)
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
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    • C12N2710/24011—Poxviridae
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/10011—Retroviridae
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/10011—Retroviridae
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    • C12N2795/10011—Details dsDNA Bacteriophages
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080087854.1A 2019-10-16 2020-10-16 用于原位产生逆转录病毒的生产者病毒 Pending CN114901297A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916095P 2019-10-16 2019-10-16
US62/916,095 2019-10-16
PCT/US2020/056130 WO2021076998A1 (en) 2019-10-16 2020-10-16 Producer viruses for generation of retroviruses in situ

Publications (1)

Publication Number Publication Date
CN114901297A true CN114901297A (zh) 2022-08-12

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CN202080087854.1A Pending CN114901297A (zh) 2019-10-16 2020-10-16 用于原位产生逆转录病毒的生产者病毒

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US (1) US20220220505A1 (https=)
EP (1) EP4051302A4 (https=)
JP (1) JP2022551753A (https=)
KR (1) KR20220082033A (https=)
CN (1) CN114901297A (https=)
AU (1) AU2020366460A1 (https=)
CA (1) CA3151982A1 (https=)
WO (1) WO2021076998A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113661236A (zh) * 2019-01-07 2021-11-16 卡利威尔免疫治疗公司 治疗癌症的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250369012A1 (en) * 2022-06-21 2025-12-04 Skyline Therapeutics Limited Recombinant aav for the gene therapy of sma disease

Citations (4)

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Publication number Priority date Publication date Assignee Title
US6352856B1 (en) * 1998-01-16 2002-03-05 Baxter Vaccine Ag Chimeric poxvirus comprising sequences of a retroviral vector component
US6440422B1 (en) * 1995-07-04 2002-08-27 Gsf-Forschungszentrum Fur Umwelt Und Gesenudheit Gmbh Recombinant MVA virus, and the use thereof
CN106029891A (zh) * 2013-12-20 2016-10-12 牛津生物医学（英国）有限公司 病毒载体生产系统
CN109890965A (zh) * 2016-07-19 2019-06-14 匹兹堡大学联邦系统高等教育 靶向stat3的溶瘤病毒

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US20060057553A1 (en) * 2000-05-30 2006-03-16 Estuardo Aguilar-Cordova Chimeric viral vectors for gene therapy
ATE437221T1 (de) * 2001-05-14 2009-08-15 Gbp Ip Llc Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie
GB0702695D0 (en) * 2007-02-12 2007-03-21 Ark Therapeutics Ltd Production of vectors
KR20180133395A (ko) * 2016-02-25 2018-12-14 메모리얼 슬로안 케터링 캔서 센터 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440422B1 (en) * 1995-07-04 2002-08-27 Gsf-Forschungszentrum Fur Umwelt Und Gesenudheit Gmbh Recombinant MVA virus, and the use thereof
US6352856B1 (en) * 1998-01-16 2002-03-05 Baxter Vaccine Ag Chimeric poxvirus comprising sequences of a retroviral vector component
CN106029891A (zh) * 2013-12-20 2016-10-12 牛津生物医学（英国）有限公司 病毒载体生产系统
US20160333373A1 (en) * 2013-12-20 2016-11-17 Oxford Biomedica (Uk) Limited Viral Vector Production System
CN109890965A (zh) * 2016-07-19 2019-06-14 匹兹堡大学联邦系统高等教育 靶向stat3的溶瘤病毒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YONG CHEN等: "Cholesterol Supplementation During Production Increases the Infectivity of Retroviral and Lentiviral Vectors Pseudotyped with the Vesicular Stomatitis Virus Glycoprotein (VSV-G)", BIOCHEM ENG J, 15 May 2009 (2009-05-15), pages 199 - 207, XP026006760, DOI: 10.1016/j.bej.2008.12.004 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113661236A (zh) * 2019-01-07 2021-11-16 卡利威尔免疫治疗公司 治疗癌症的方法

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WO2021076998A1 (en) 2021-04-22
EP4051302A1 (en) 2022-09-07
KR20220082033A (ko) 2022-06-16
AU2020366460A1 (en) 2022-03-24
EP4051302A4 (en) 2024-03-13
US20220220505A1 (en) 2022-07-14
CA3151982A1 (en) 2021-04-22
JP2022551753A (ja) 2022-12-13

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