CN114869819A - Composition with anti-wrinkle effect and preparation method thereof - Google Patents
Composition with anti-wrinkle effect and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
The invention discloses a composition with an anti-wrinkle effect and a preparation method thereof, and belongs to the technical field of cosmetics. The composition with the anti-wrinkle effect comprises the following components: sodium hyaluronate, yeast extract, sunflower seed extract, rose extract, hydrolyzed soy protein, sesame seed oil, cetostearyl alcohol and water. The invention adopts a plurality of plant extracts for compounding, has high safety, good product stability and good anti-wrinkle effect, and has good market prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a composition with an anti-wrinkle effect and a preparation method thereof.
Background
The wrinkle is caused by many reasons, namely, the metabolism of a human body begins to slow down along with the increase of age, the moisture and subcutaneous fat are reduced, the elastic fiber becomes thick gradually, and the skin becomes wrinkled and glossy and fades. The aging of the skin is the prominent expression of the aging of the whole body, wherein the aging of the skin on the face is particularly obvious, the number of fibroblasts in the human body is gradually reduced, the secreted collagen and the elastic fibrin are gradually reduced and broken by oxidation, the supporting effect on the skin is eliminated, the inhomogeneous collapse is caused, the dermis layer begins to be thinned, the elasticity of the skin is deteriorated, and wrinkles begin to be gradually generated. Furthermore, the ultraviolet rays in the sunlight also damage the dermis, causing it to dry and form small breaks, appearing as fine wrinkles on the outside. Furthermore, habitual facial movements can exacerbate the appearance of wrinkles. For example, people who like deep thinking have more wrinkles between the forehead and the brow; the feelings are rich, the laughter loves crying is easy to appear, and the tail veins of the eyes are easy to appear. And environmental pollution and working pressure, smoking and drinking, weight change and the like can cause the generation of wrinkles. Therefore, there is a high demand for skin care products having anti-wrinkle effect.
In the cosmetic market, the Chinese herbal medicine cosmetics account for about 30-40%, people have more comprehensive skin care requirements, and the cosmetics which are natural, safe and small in side effect are more favored by consumers. Because the traditional pure compound has high development difficulty, long period and high cost and is easy to generate larger irritation, the natural Chinese herbal medicine has the advantages of higher safety, easier preparation and the like. For example, chinese patent application CN201910553174.3 discloses a moisturizing and anti-wrinkle composition and skin care product. The moisturizing and anti-wrinkle composition is prepared by compounding sodium hyaluronate, low-molecular-weight sodium hyaluronate and high-molecular-weight sodium hyaluronate which are prepared according to a certain proportion, maltooligosaccharide glucoside, Artocarpus heterophyllus extract and other seven components, so that each component can generate obvious coordination and synergism effects, a skin care product containing the moisturizing and anti-wrinkle composition can moisturize through hydration of small-molecular moisturizing components and skin, and water is locked through large-molecular moisturizing components; meanwhile, the anti-aging component promotes the generation of hyaluronic acid, improves the skin elasticity, increases the synthesis of collagen and elastic fiber, promotes the cell activity, reduces the muscle contraction, has obvious moisturizing and anti-wrinkle effects, and has short period of effect display and obvious and lasting effect.
Sunflower seed oil is an important base oil raw material of cosmetics and has the function of lubricating skin. Has activating effect on peroxidase-activated receptor, and has antiinflammatory effect for promoting skin wound healing; can promote decomposition of fat cells, and has effect of reducing weight; has certain inhibition effect on tyrosinase and certain whitening effect. The rose extract has the functions of moistening, beautifying and protecting skin in cosmetics. Calycoris, also known as herba Hyperici Japonici, folium Hylotelephii Erycinae, herba Lysimachiae Foenumgraeci, tiger penis, and testis Et penis Tylophorae Ovatae, etc., and biennial herbs, up to 1.5 m, are dense and thick, light gray yellow, star-shaped hairs. The basal cauline leaves and the cauline leaves at the lower part are reversely coated with needle-shaped rectangular circles, the basal part is gradually narrowed to form a short handle shape with the length of 15 cm and the width of 6 cm, the edge is provided with shallow round teeth, the upper cauline leaves are gradually narrowed to gradually change into the rectangular circles to oval rectangular circles, and the basal part is downwards extended to form narrow fins. The extract contains various functional components, has the effects of diminishing inflammation, stopping bleeding, clearing heat, detoxifying and the like, is used in daily chemical products, has the effects of astringing pores and moistening skin, and enables the skin to maintain a young state. In addition, the research proves that the composition has the efficacy of ultraviolet protection.
Aiming at the current situation that the anti-wrinkle effect of the traditional Chinese medicine extract cosmetics is uneven, the application provides a novel composition with the anti-wrinkle effect and a preparation method thereof.
Disclosure of Invention
The invention aims to provide a novel composition with an anti-wrinkle effect and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
firstly, the invention provides a composition with anti-wrinkle effect, which comprises the following components: sodium hyaluronate, yeast extract, sunflower seed extract, rose extract, hydrolyzed soy protein, sesame seed oil, cetostearyl alcohol and water.
Preferably, the composition with the anti-wrinkle effect comprises the following components in percentage by weight:
5-15% of sodium hyaluronate, 8-15% of yeast extract, 0.5-5% of sunflower seed extract, 10-15% of rose extract, 0.2-1% of hydrolyzed soybean protein, 0.5-5% of sesame seed oil, 0.5-1.5% of cetearyl alcohol and water.
Further preferably, the composition with anti-wrinkle effect comprises the following components in percentage by weight:
10% of sodium hyaluronate, 10-12% of yeast extract, 1-3% of sunflower seed extract, 12% of rose extract, 0.4-0.6% of hydrolyzed soybean protein, 1-3% of sesame seed oil, 0.8-1.2% of cetearyl alcohol and water.
Most preferably, the composition with anti-wrinkle effect comprises the following components in percentage by weight:
10% of sodium hyaluronate, 11% of yeast extract, 2% of sunflower seed extract, 12% of rose extract, 0.5% of hydrolyzed soybean protein, 2% of sesame seed oil, 1.0% of cetearyl alcohol and water.
Preferably, the composition with anti-wrinkle effect further comprises a mullein extract.
Further preferably, the weight ratio of the mullein extract to the sunflower seed extract is 1-3: 1, more preferably 1.5: 1.
experiments prove that the anti-wrinkle effect of the composition can be further improved by adding the mullein extract, and the weight ratio of the mullein extract to the sunflower seed extract is 1-3: the anti-wrinkle effect is best when 1 hour.
Furthermore, the invention provides a preparation method of the composition with the anti-wrinkle effect, which comprises the following steps:
(1) adding sunflower seed extract, mullein extract, oleum Sesami, hydrolyzed soybean protein, cetostearyl alcohol and water into a stirring pot, heating, adding yeast extract, homogenizing, and cooling;
(2) and cooling, putting the rose extract and the sodium hyaluronate into a mixer according to the formula dosage, and stirring to obtain the composition with the anti-wrinkle effect.
Preferably, in step (1), the temperature of the heating is 70-80 ℃.
Preferably, in step (1), the homogenization conditions are as follows: homogenizing at 1200-.
Preferably, in the step (2), the stirring conditions are as follows: stirring slowly at normal temperature for 0.5-1 h. Wherein the content of the first and second substances,
slow stirring is usually at a stirring speed of 500r/min or less.
Finally, the invention provides application of the composition with the anti-wrinkle effect in preparing skin care products.
Wherein the skin care product is at least one of toner, smoothing toner, firming toner, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleaning foam, cleaning water, facial mask, pressed powder, body lotion, body cream, body oil and body milk.
The invention has the beneficial effects that:
the invention provides a composition with an anti-wrinkle effect, which has a good anti-wrinkle effect; the formula composition is simple, and the safety is improved by compounding the traditional Chinese medicine extract components; meanwhile, the product has high stability and is convenient to store and transport; the raw materials are widely available and easily available in the market, and the method has good application prospect.
Detailed Description
The present invention will be further explained with reference to specific examples in order to make the technical means, the technical features, the technical objectives and the effects of the present invention easier to understand, but the following examples are only preferred embodiments of the present invention, and not all embodiments of the present invention. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention. In the following examples, unless otherwise specified, all the operations were performed by conventional methods, all the equipments were performed by conventional methods, and the materials of the equipments used in the respective examples were the same.
The extract used in the invention can be directly purchased from the raw materials on the market, and can also be extracted by a certain process.
In the examples described below, sodium hyaluronate was purchased from Yabao chemical Co., Ltd, Guangzhou, under the trade designation "article number
YBJC018；
Extract of yeast lysate was purchased from Guangzhou Ministry of Biotechnology, Inc.;
sunflower seed extract was purchased from blue reputation trade, ltd, guangzhou;
the rose extract was obtained from Guangzhou Ming Picture Biotech limited;
hydrolyzed soy protein was purchased from guangzhou blue reputation trade ltd;
the sesame seed oil is purchased from Yabao chemical Co., Ltd, Guangzhou, and has the product number of YBZT 006;
cetostearyl alcohol was purchased from yabao chemical limited, guangzhou under the cat # YBJC 009;
the mullein extract is prepared by the following process: extracting herba Verbasci Thapsi (provided by Yabao chemical industry) with 50% methanol at a ratio of 1: 10, heating the extracting solution in water bath at the temperature of 60 ℃, and concentrating the extracting solution into 1/3 with the original volume to obtain a mullein extract for later use;
the water used was deionized water.
Example 1 preparation of extract
(1) Weighing sunflower seed extract, mullein extract, oleum Sesami, hydrolyzed soybean protein, cetearyl alcohol, and appropriate amount of water, placing into a stirring pot, heating to 75 deg.C, adding yeast lysate extract, and homogenizing with homogenizer for 5min (homogenizing speed is 8000 r/min);
(2) and cooling, putting the rose extract and the sodium hyaluronate into a mixer, and slowly stirring at normal temperature for 0.5h to prepare the composition with the anti-aging effect.
The specific formulation is shown in the following table:
table 1.
Result detection
1. Safety test
The human skin closed patch test was performed according to the human skin patch test specified in the technical standards for cosmetic safety (2015 edition). 35 volunteers are selected, and no suspicious reaction or positive reaction is caused on the formula product of the invention, so that the product of the invention is proved to be safe and has no adverse reaction.
2. And (3) stability detection:
the detection method comprises the following steps: cold and hot test in turn, seal the storage 24h at 45 ℃, 25 ℃, 15 ℃ with the gained product in proper order, circulate 5 times after, place 12h at 25 ℃, thin scribble the product on the black observation board with the corresponding product of the new preparation of the same method, compare the outward appearance, the classification is as follows:
table 2.
| Color (transparency) | Precipitation of | Layering | Uniformity of smearing (compare with original product) | |
| 0 | Without change | Is free of | Is free of | Are identical to each other |
| 1 | Slight changes | Small amount and difficult discrimination | Slight delamination | Slight unevenness of application |
| 2 | Is obviously changed | Obvious precipitation | Apparent delamination | Obviously difficult to be evenly coated |
The test results are as follows:
table 3.
The results in Table 3 show that the formulas A to L have good stability, and have no problems of precipitation, discoloration, layering and the like after cold and hot alternation experiments.
3. Anti-wrinkle Effect test
The detection method comprises the following steps: skin elasticity test
130 volunteers, age 43-55 years female, were selected and randomly divided into 13 groups of 10 each using the products prepared by formulas a-L, one group without any product at the test site as a control. When in use, 1mL of the product is uniformly applied to the inner side of the whole forearm (about 10cm from the root of the palm and about 5X 10cm in area), and massaged until the product is completely absorbed, and the product is used once a day in the morning and at night and is continuously used for 4 weeks, during which no other skin care products are used on the part. The control group was scrubbed with clean water every morning and evening. The skin elasticity tester measures the elasticity value of the applied part before using the product and after 4 weeks of use. The test of the same subject is carried out by the same instrument and the same tester. Before each measurement, the probe is cleaned, and meanwhile, the tested person washes the part to be tested by using clear water, keeps relaxing, sits still for 10min and receives the test.
Skin elasticity increase rate (after use elasticity value-before use elasticity value)/before use elasticity value × 100%
Changes in the subject's elastic values for formulation B are shown in the following table:
table 4.
| Subject number | Elasticity value before use | Elasticity value after use | Elasticity increase value | Skin elasticity improvement Rate (%) |
| 1 | 0.594 | 0.668 | 0.074 | 12.46％ |
| 2 | 0.436 | 0.48 | 0.044 | 10.09％ |
| 3 | 0.416 | 0.467 | 0.051 | 12.26％ |
| 4 | 0.534 | 0.591 | 0.057 | 10.67％ |
| 5 | 0.452 | 0.49 | 0.038 | 8.41％ |
| 6 | 0.483 | 0.545 | 0.062 | 12.84％ |
| 7 | 0.521 | 0.574 | 0.053 | 10.17％ |
| 8 | 0.514 | 0.553 | 0.039 | 7.59％ |
| 9 | 0.479 | 0.541 | 0.062 | 12.94％ |
| 10 | 0.558 | 0.609 | 0.051 | 9.14％ |
It can be seen that after the product B is used by a test subject, the skin elasticity is obviously improved, the elasticity improvement value can reach 0.074, and the elasticity improvement rate can reach 12.94%. The compositions of the present application were demonstrated to achieve significant anti-wrinkle effects.
The subject's elastic values for formula G vary as shown in the following table:
table 5.
It can be seen that the skin elasticity improvement value of the subject using the product G is further improved relative to the subject using the product B, the skin elasticity improvement value can reach 0.127, and the skin elasticity improvement rate can reach 21.82%. It was demonstrated that the addition of mullein extract further improved skin elasticity.
The results of all formulations were as follows:
table 6.
| Formulation of | Skin elasticity improvement Rate (%) |
| Control | -0.24±1.32 |
| A | 9.51±3.37 |
| B | 10.66±1.92 |
| C | 10.83±1.73 |
| D | 11.75±1.66 |
| E | 11.59±2.38 |
| F | 14.37±1.82 |
| G | 15.12±3.82 |
| H | 14.61±2.14 |
| I | 13.90±1.54 |
| J | 3.85±2.14 |
| K | 1.34±0.85 |
| L | 2.72±1.13 |
The results show that the average skin elasticity improvement rate of the products in the formulas A to I can reach more than 9 percent, and the products have good anti-wrinkle effect. Wherein, the average skin elasticity improvement rate of the formula F-I can reach more than 13 percent, however H, I is not suitable for use in consideration of the cost problem in batch production, and comprehensively, the formula F, G has the best anti-wrinkle effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. The composition with the anti-wrinkle effect is characterized by comprising the following components: sodium hyaluronate, yeast extract, sunflower seed extract, rose extract, hydrolyzed soy protein, sesame seed oil, cetostearyl alcohol and water.
2. The composition with anti-wrinkle effect according to claim 1, wherein preferably the composition with anti-wrinkle effect comprises the following components in percentage by weight:
5-15% of sodium hyaluronate, 8-15% of yeast extract, 0.5-5% of sunflower seed extract, 10-15% of rose extract, 0.2-1% of hydrolyzed soybean protein, 0.5-5% of sesame seed oil, 0.5-1.5% of cetearyl alcohol and water.
3. The composition with anti-wrinkle effect according to claim 2, wherein the composition with anti-wrinkle effect comprises the following components in percentage by weight:
10% of sodium hyaluronate, 10-12% of yeast extract, 1-3% of sunflower seed extract, 12% of rose extract, 0.4-0.6% of hydrolyzed soybean protein, 1-3% of sesame seed oil, 0.8-1.2% of cetearyl alcohol and water.
4. The composition with anti-wrinkle effect according to claim 1, further comprising a mullein extract.
5. The composition with anti-wrinkle effect according to claim 4, wherein the weight ratio of the mullein extract to the sunflower seed extract is 1-3: 1.
6. the composition with anti-wrinkle effect according to claim 5, wherein the weight ratio of the mullein extract to the sunflower seed extract is 1.5: 1.
7. method for the preparation of a composition with anti-wrinkle effect according to any of claims 1 to 6, characterized in that it comprises the following steps:
(1) adding sunflower seed extract, mullein extract, oleum Sesami, hydrolyzed soybean protein, cetostearyl alcohol and water into a stirring pot, heating, adding yeast extract, homogenizing, and cooling;
(2) and cooling, putting the rose extract and the sodium hyaluronate into a mixer according to the formula dosage, and stirring to obtain the composition with the anti-wrinkle effect.
8. The method according to claim 7, wherein in the step (1), the heating temperature is 70-80 ℃, and the homogenizing conditions are as follows: homogenizing at 1200-.
9. The production method according to claim 7, wherein in the step (2), the stirring conditions are: stirring slowly at normal temperature for 0.5-1 h.
10. Use of the composition having an anti-wrinkle effect according to any one of claims 1 to 6 for the preparation of a skin care product, which is at least one of a toner, a smoothing toner, a firming toner, a nourishing lotion, a nourishing cream, a massage cream, a essence, an eye cream, a cleansing foam, a cleansing water, a mask, a pack, a body lotion, a body cream, a body oil and a body milk.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101506602B1 (en) * | 2013-12-05 | 2015-03-30 | 주식회사 내추럴솔루션 | Cosmetic compositions comprising the extract of mullein for anti-oxidation, anti-wrinkle and anti-inflammation as an active ingredient |
| FR3075055A1 (en) * | 2017-12-18 | 2019-06-21 | Qiriness | 4-ACTIVE COMPLEX TO ENHANCE SKIN FLASH |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101506602B1 (en) * | 2013-12-05 | 2015-03-30 | 주식회사 내추럴솔루션 | Cosmetic compositions comprising the extract of mullein for anti-oxidation, anti-wrinkle and anti-inflammation as an active ingredient |
| FR3075055A1 (en) * | 2017-12-18 | 2019-06-21 | Qiriness | 4-ACTIVE COMPLEX TO ENHANCE SKIN FLASH |
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