CN114867708A - 从多羟基酚合成苄基醚的方法 - Google Patents

从多羟基酚合成苄基醚的方法 Download PDF

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Publication number
CN114867708A
CN114867708A CN202180003988.5A CN202180003988A CN114867708A CN 114867708 A CN114867708 A CN 114867708A CN 202180003988 A CN202180003988 A CN 202180003988A CN 114867708 A CN114867708 A CN 114867708A
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China
Prior art keywords
benzyl
benzyl ether
organic solvent
trihydroxyacetophenone
polyhydric phenol
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CN202180003988.5A
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English (en)
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黄培培
陈锦辉
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Quanzhou Haichuang Pharmaceutical Technology Co ltd
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Quanzhou Haichuang Pharmaceutical Technology Co ltd
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Publication of CN114867708A publication Critical patent/CN114867708A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring

Abstract

公开了一种从多羟基酚合成苄基醚的方法，其特征在于，所述方法包括在碱和催化剂的存在下，在添加水的有机溶剂中使所述多羟基酚与苄基化试剂反应，从而获得完全苄基化的苄基醚。公开的方法简单，生产成本低，产物收率高，减少了溶剂的使用以及对环境造成的污染，从而在工业放大的过程中，易于实施。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202180003988.5A 2020-12-04 2021-12-03 从多羟基酚合成苄基醚的方法 Pending CN114867708A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020114145270 2020-12-04
CN202011414527 2020-12-04
PCT/CN2021/135325 WO2022117071A1 (zh) 2020-12-04 2021-12-03 从多羟基酚合成苄基醚的方法

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CN114867708A true CN114867708A (zh) 2022-08-05

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CN (1) CN114867708A (zh)
WO (1) WO2022117071A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05262674A (ja) * 1992-03-19 1993-10-12 Nippon Paper Ind Co Ltd フロログルシン型フェノールのベンジルエーテルの合成法
CN100999449A (zh) * 2006-12-29 2007-07-18 大连联化医药技术有限公司 一种脂肪环苄基醚的制备方法
CN102344345A (zh) * 2011-07-28 2012-02-08 南京师范大学 一种芳醚化合物的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05262674A (ja) * 1992-03-19 1993-10-12 Nippon Paper Ind Co Ltd フロログルシン型フェノールのベンジルエーテルの合成法
CN100999449A (zh) * 2006-12-29 2007-07-18 大连联化医药技术有限公司 一种脂肪环苄基醚的制备方法
CN102344345A (zh) * 2011-07-28 2012-02-08 南京师范大学 一种芳醚化合物的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUN HAOPENG,ET AL.: "Studies on gambogic acid (IV): Exploring structureeactivity relationship with IkB kinase-beta (IKKb)" *

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WO2022117071A1 (zh) 2022-06-09

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