CN114846051A - 合成方法和中间体 - Google Patents

合成方法和中间体 Download PDF

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Publication number
CN114846051A
CN114846051A CN202080089979.8A CN202080089979A CN114846051A CN 114846051 A CN114846051 A CN 114846051A CN 202080089979 A CN202080089979 A CN 202080089979A CN 114846051 A CN114846051 A CN 114846051A
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compound
formula
salt
preparing
converted
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Chinese (zh)
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马赫什·帕勒拉
加纳帕蒂·雷迪·帕穆拉帕蒂
简·斯宾克
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Protiva Biotherapeutics Inc
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Protiva Biotherapeutics Inc
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
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    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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CN202080089979.8A 2019-12-20 2020-12-17 合成方法和中间体 Pending CN114846051A (zh)

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US201962951836P 2019-12-20 2019-12-20
US62/951,836 2019-12-20
PCT/US2020/065666 WO2021127214A1 (en) 2019-12-20 2020-12-17 Synthetic processes and intermediates

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EP (1) EP4077473A4 (https=)
JP (2) JP2023510109A (https=)
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CN (1) CN114846051A (https=)
AU (1) AU2020408039A1 (https=)
BR (1) BR112022012226A2 (https=)
CA (1) CA3165101A1 (https=)
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CA3020585A1 (en) * 2016-04-11 2017-10-19 Arbutus Biopharma Corporation Targeted nucleic acid conjugate compositions
CN118591552A (zh) * 2022-01-30 2024-09-03 成都凌泰氪生物技术有限公司 一种配体、其制备方法及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5923998A (en) 1997-01-31 1998-08-25 Avid Therapeutics Inc. 2-benzoylamino-3-phenylpropenamide derivatives and methods of using the same
GB0505969D0 (en) * 2005-03-23 2005-04-27 Novartis Ag Organic compounds
US8921381B2 (en) 2010-10-04 2014-12-30 Baruch S. Blumberg Institute Inhibitors of secretion of hepatitis B virus antigens
WO2013058824A1 (en) * 2011-04-07 2013-04-25 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
JP5977347B2 (ja) 2011-07-01 2016-08-24 バルーク エス．ブルームバーグ インスティテュート Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
ES2575398T3 (es) 2012-03-31 2016-06-28 F. Hoffmann-La Roche Ag 4-Metil-dihidropirimidinas novedosas para el tratamiento y la profilaxis de la infección por el virus de la hepatitis B
WO2014089296A2 (en) 2012-12-06 2014-06-12 Institute For Hepatitis And Virus Research Functionalized benzamide derivatives as antiviral agents against hbv infection
BR112015015584A2 (pt) 2012-12-27 2017-12-12 Baruch S Blumberg Inst novos agentes antivirais contra infecção por hbv
CA3020585A1 (en) * 2016-04-11 2017-10-19 Arbutus Biopharma Corporation Targeted nucleic acid conjugate compositions
MX2019012280A (es) * 2017-04-11 2020-01-23 Arbutus Biopharma Corp Composiciones dirigidas.
WO2019051257A2 (en) * 2017-09-11 2019-03-14 Arbutus Biopharma Corporation METHODS OF TREATING HEPATITIS B TYPE INFECTIONS
EP3873530A4 (en) * 2018-11-02 2022-11-09 Genevant Sciences GmbH THERAPEUTIC PROCESSES

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