CN114828850A - 化合物在制药中的应用 - Google Patents

化合物在制药中的应用 Download PDF

Info

Publication number
CN114828850A
CN114828850A CN202080084613.1A CN202080084613A CN114828850A CN 114828850 A CN114828850 A CN 114828850A CN 202080084613 A CN202080084613 A CN 202080084613A CN 114828850 A CN114828850 A CN 114828850A
Authority
CN
China
Prior art keywords
compound
mixture
cre
added
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080084613.1A
Other languages
English (en)
Inventor
魏霞蔚
黄志刚
丁照中
魏于全
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Jiake Biotechnology Co ltd
Original Assignee
Medshine Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc filed Critical Medshine Discovery Inc
Publication of CN114828850A publication Critical patent/CN114828850A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

涉及式(I)化合物及其药学上可接受的盐在制药领域中的用途，尤其是在制备治疗肺炎药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202080084613.1A 2019-12-19 2020-12-18 化合物在制药中的应用 Pending CN114828850A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911316803 2019-12-19
CN2019113168037 2019-12-19
PCT/CN2020/137612 WO2021121387A1 (zh) 2019-12-19 2020-12-18 化合物在制药中的应用

Publications (1)

Publication Number Publication Date
CN114828850A true CN114828850A (zh) 2022-07-29

Family

ID=76478494

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080084613.1A Pending CN114828850A (zh) 2019-12-19 2020-12-18 化合物在制药中的应用

Country Status (4)

Country Link
US (1) US20230022708A1 (zh)
EP (1) EP4079305A4 (zh)
CN (1) CN114828850A (zh)
WO (1) WO2021121387A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023091438A1 (en) * 2021-11-18 2023-05-25 Merck Sharp & Dohme Llc Chromane amidine monobactam antibiotics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017106064A1 (en) * 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
WO2017206947A1 (zh) * 2016-06-03 2017-12-07 南京明德新药研发股份有限公司 新型β-内酰胺酶抑制剂
WO2019144969A1 (zh) * 2018-01-29 2019-08-01 南京明德新药研发股份有限公司 用于治疗细菌感染的单环β-内酰胺化合物
CN113227088A (zh) * 2018-12-18 2021-08-06 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA918014B (en) 1990-11-05 1992-07-29 Squibb & Sons Inc Heteroaroyl derivatives of monocyclic beta-lactam antibiotics
US5250691A (en) 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
DK1322648T3 (da) 2000-09-14 2005-10-31 Pantherix Ltd 3-(heteroarylacetamido)-2-oxo-azetidin-1-sulfonsyrederivater som antibakterielle midler
RS52068B (en) 2005-12-07 2012-06-30 Basilea Pharmaceutica Ag. USEFUL MANOBACTAM ANTIBIOTICS
MX2009009918A (es) 2007-03-23 2009-10-19 Basilea Pharmaceutica Ag Medicamentos combinados para el tratamiento de infecciones bacterianas.
CN102325769A (zh) 2008-12-19 2012-01-18 美国辉瑞有限公司 单卡波姆
UY34585A (es) 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
CN106164072B (zh) 2014-03-24 2019-10-01 诺华股份有限公司 用于治疗细菌感染的单环内酰胺有机化合物
EA037569B1 (ru) 2015-09-23 2021-04-15 Новартис Аг Соли монобактамного антибиотика и их применение
MA43811A (fr) * 2016-03-07 2018-11-28 Merck Sharp & Dohme Composés d'arylmonobactame bicycliques et leurs méthodes d'utilisation pour le traitement des infections bactériennes
EP3558987A1 (en) * 2016-12-21 2019-10-30 AiCuris GmbH & Co. KG COMBINATION THERAPY WITH AMIDINE SUBSTITUTED ß-LACTAM COMPOUNDS AND ß-LACTAMASE INHIBITORS FOR INFECTIONS WITH ANTIBIOTIC RESISTANT BACTERIAL STRAINS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017106064A1 (en) * 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
WO2017206947A1 (zh) * 2016-06-03 2017-12-07 南京明德新药研发股份有限公司 新型β-内酰胺酶抑制剂
WO2019144969A1 (zh) * 2018-01-29 2019-08-01 南京明德新药研发股份有限公司 用于治疗细菌感染的单环β-内酰胺化合物
CN113227088A (zh) * 2018-12-18 2021-08-06 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用

Also Published As

Publication number Publication date
EP4079305A1 (en) 2022-10-26
WO2021121387A1 (zh) 2021-06-24
US20230022708A1 (en) 2023-01-26
EP4079305A4 (en) 2024-01-10

Similar Documents

Publication Publication Date Title
CN111511737B (zh) 用于治疗细菌感染的单环β-内酰胺化合物
JP4024309B2 (ja) 新規な感染症治療薬
CN106661084A (zh) 大环广谱抗生素
WO2006123792A1 (ja) トリ－、テトラ－置換－３－アミノピロリジン誘導体
JP2004534859A (ja) ドラスタチン１０誘導体類
KR102450071B1 (ko) 마크로시클릭 광범위 항생제
CN109715630A (zh) β-内酰胺酶抑制剂化合物
KR20010085490A (ko) 이노신 모노포스페이트 디하이드로게나제 저해제로서의옥스아미드
TW201028161A (en) Novel antibacterial agents for the treatment of gram positive infections
TW201434848A (zh) 巨環廣效抗生素
CN108727406A (zh) 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
CN114828850A (zh) 化合物在制药中的应用
CN114728902A (zh) 作为金属-β-内酰胺酶抑制剂的1-氨基磺酰基-2-羧基吡咯衍生物
TW201731844A (zh) 羥基烷基噻二唑衍生物
CN108026133A (zh) 有效对抗多药耐药细菌的新的氨基糖苷抗生素
CN113227088B (zh) 单环β-内酰胺化合物在制药中的应用
KR100488284B1 (ko) 시스-치환된 아미노사이클로프로판 유도체 및 이를 함유하는 항균약
CN109843894A (zh) β-内酰胺酶抑制剂
CN114787158B (zh) 磺酰脲环取代的单环β-内酰胺类抗生素
EP2531487A1 (en) Aryl benzylamine compounds
WO2016185200A1 (en) Antibacterial agent
CN118076594A (zh) 用于治疗细菌感染的磺酰基哌嗪基化合物
JP2023544643A (ja) バクチオ－ル誘導体、その薬学的に許容される塩及びその調製方法並びに用途
WO1991009860A1 (en) New carbapenem derivative
AU2002328910A1 (en) Dolastatin 10 derivatives

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40069085

Country of ref document: HK

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20230921

Address after: 518052 b37, 11th floor, Xihai Mingzhu building, No. 1 Taoyuan East Road, dawangshan community, Nantou street, Nanshan District, Shenzhen, Guangdong

Applicant after: Shenzhen Jiake Biotechnology Co.,Ltd.

Address before: 210032 room 218, business office building, No.9 Gaoxin Road, Jiangbei new district, Nanjing City, Jiangsu Province

Applicant before: Nanjing Mingde New Drug Development Co.,Ltd.