CN114796031A - Composition for scalp care and preparation method and application thereof - Google Patents
Composition for scalp care and preparation method and application thereof Download PDFInfo
- Publication number
- CN114796031A CN114796031A CN202210353638.8A CN202210353638A CN114796031A CN 114796031 A CN114796031 A CN 114796031A CN 202210353638 A CN202210353638 A CN 202210353638A CN 114796031 A CN114796031 A CN 114796031A
- Authority
- CN
- China
- Prior art keywords
- composition
- parts
- taurine
- allantoin
- corn starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 119
- 210000004761 scalp Anatomy 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 114
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 110
- 229960003080 taurine Drugs 0.000 claims abstract description 57
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 55
- 229960000458 allantoin Drugs 0.000 claims abstract description 55
- 238000000855 fermentation Methods 0.000 claims abstract description 54
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- 241000235347 Schizosaccharomyces pombe Species 0.000 claims abstract description 21
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- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 18
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 18
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 18
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- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 18
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 18
- 229940057950 sodium laureth sulfate Drugs 0.000 description 18
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 18
- 241000235070 Saccharomyces Species 0.000 description 16
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 10
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- 229960003885 sodium benzoate Drugs 0.000 description 9
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- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 2
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- 239000003906 humectant Substances 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
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- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
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- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical group S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- -1 uroacitinin Chemical compound 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and discloses a composition for scalp care and a preparation method and application thereof. The composition comprises the following components: taurine, a secondary split yeast fermentation product filtrate, hydrolyzed corn starch and allantoin. The composition has obvious improvement on the moisture retention and repair effects of the composition on skin and the inhibition on inflammatory factors through the synergistic interaction of the taurine, the urea acid, the secondary fission yeast fermentation product filtrate and the corn starch; can be used in shampoo for reducing irritation of shampoo to skin. Therefore, the composition has the effects of moisturizing, resisting inflammation, relieving and repairing when being applied to scalp care, and also has the characteristics of simple preparation method and easiness in industrial production.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and relates to a composition for scalp care and a preparation method and application thereof.
Background
The scalp is exposed to the environment every day, and a plurality of potential factors, such as ultraviolet rays, air pollutants and the like can cause the skin barrier to be damaged by damaging the stratum corneum, so that the scalp is stimulated to have inflammation reactions or cell damage, such as redness, pruritus, stabbing pain and the like.
The existing scalp care products for cleaning the scalp generally contain a surfactant, essence and a preservative, which are easy to cause the damage of the scalp barrier.
Accordingly, there is a need to provide a scalp care product that provides soothing anti-inflammatory to the scalp.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. To this end, the present invention provides a composition for scalp care, which has moisturizing, soothing, anti-inflammatory, and repair effects on the scalp, a preparation method thereof, and use thereof.
A first aspect of the present invention provides a composition for scalp care, the composition comprising the following components: taurine, a secondary fission yeast fermentation product filtrate, hydrolyzed corn starch and allantoin.
The taurine is sulfamic acid existing in most animal tissues, and can be used for reducing skin oil secretion, absorbing skin oil and controlling skin oil secretion for a long time; the yeast bifidus fermentation product filtrate is fermentation product filtrate obtained by fermenting and post-treating bifidobacterium, and can be used for improving skin conditions; the hydrolyzed corn starch is a natural humectant and skin conditioner, can keep hair moist and has a certain itching relieving effect; the allantoin has effects of protecting skin and hair tissue, hydrophilizing, absorbing water and preventing water from diffusing, can lock water in skin, keep moisture and elasticity, and make hair be unhappy, and can promote tissue growth, soften cuticle protein and promote skin metabolism.
The first aspect of the invention reduces the stimulation effect of the outside on the scalp by allantoin by the following specific mechanism: allantoin is a hydantoin derivative, has poor water solubility, good lipid solubility and small molecular weight, can easily penetrate through stratum corneum and intercellular lipid components to generate interaction such as hydrogen bond, van der waals force and the like, and reduces the effect of a surfactant on intercellular lipid when penetrating into stratum corneum, thereby reducing irritation.
The second aspect of the invention carries out anti-inflammation through taurine, and the specific mechanism is as follows: taurine is one of the most abundant free amino acids in the mammalian body, is a compound with antioxidant and anti-inflammatory properties, participates in a plurality of biological and physiological processes, contains taurine in different depths of the skin, has good water solubility and small molecular weight, is easy to permeate through a skin water channel, and further has the anti-inflammatory property.
In the third aspect of the invention, the damage of the skin is repaired in time by the secondary fission yeast fermentation product filtrate, and the specific mechanism is as follows: the yeast bifidus fermentation product filtrate is obtained by fermenting bifidobacterium, is rich in various nutrient substances such as polysaccharide and vitamins, has the function of anti-inflammatory repair, and can repair the damage of a surfactant in shampoo to the skin in time.
The fourth aspect of the invention blocks the penetration of the surfactant to the skin by hydrolyzing the corn starch by the specific mechanism: the hydrolyzed corn starch is a macromolecular polysaccharide substance, has slightly poor permeability, and can play a certain role in blocking and buffering the permeation of the surfactant in the shampoo on the surface of the skin.
Therefore, the invention at least realizes the prevention and isolation of the permeation of the surfactant to the skin through the mutual coordination of the allantoin, the taurine, the secondary fission yeast fermentation product filtrate and the hydrolyzed corn starch; steric effects reduce the interaction of surfactants with skin cell-to-cell lipids; timely repairing the reactions of pruritus, inflammation and the like caused by the existing irritation.
According to some embodiments of the invention, the composition comprises, by weight, 0.1 to 20 parts taurine, 60 to 90 parts saccharomyces bifidus fermentation product filtrate, 0.5 to 10 parts hydrolyzed corn starch, 0.1 to 3 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 0.5 to 18 parts taurine, 65 to 90 parts saccharomyces bifidus fermentation product filtrate, 0.7 to 9 parts hydrolyzed corn starch, 0.1 to 3 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 0.6 to 15 parts taurine, 65 to 90 parts saccharomyces bifidus fermentation product filtrate, 1 to 8 parts hydrolyzed corn starch, 0.5 to 2.5 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 0.8 to 12 parts taurine, 68 to 90 parts saccharomyces bifidus fermentation product filtrate, 1 to 7 parts hydrolyzed corn starch, 1 to 2 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 0.1 to 20 parts taurine, 70 to 90 parts saccharomyces bifidus fermentation product filtrate, 1 to 7 parts hydrolyzed corn starch, 0.1 to 2 parts allantoin, and 0 to 28.8 parts water.
According to some embodiments of the invention, the composition comprises, by weight, 5 to 15 parts taurine, 80 to 90 parts saccharomyces bifidus fermentation product filtrate, 4 to 5 parts hydrolyzed corn starch, 1 to 2 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 1-2 parts taurine, 85-90 parts saccharomyces bifidus fermentation, 1-1.5 parts hydrolyzed corn starch, 1-1.5 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 8-10 parts taurine, 70-85 parts saccharomyces bifidus fermentation, 3-5 parts hydrolyzed corn starch, 0.8-1.2 parts allantoin.
According to some embodiments of the invention, the composition comprises, by weight, 9.5 to 12 parts taurine, 75 to 85 parts saccharomyces bifidus fermentation, 4 to 6 parts hydrolyzed corn starch, 1.5 to 2.5 parts allantoin.
According to some embodiments of the invention, the composition comprises, in parts by weight, 9.5 to 10.5 parts taurine, 65 to 75 parts saccharomyces bifidus fermentation, 6.5 to 8.5 parts hydrolyzed corn starch, 0.9 to 1.2 parts allantoin.
According to some embodiments of the invention, the composition further comprises water, the water being deionized water.
According to some embodiments of the invention, the composition comprises, by weight, 0.1 to 20 parts taurine, 70 to 90 parts saccharomyces bifidus fermentation product filtrate, 1 to 7 parts hydrolyzed corn starch, 0.1 to 2 parts allantoin, and 1 to 28.8 parts water.
According to some embodiments of the invention, the composition comprises, by weight, 5 to 15 parts taurine, 80 to 90 parts saccharomyces bifidus fermentation product filtrate, 4 to 5 parts hydrolyzed corn starch, 1 to 2 parts allantoin, and 3 to 12 parts water.
A second aspect of the invention provides a process for the preparation of the above composition.
The preparation method comprises the following steps: mixing the components to obtain the composition.
According to some embodiments of the invention, the method of preparing comprises the steps of: mixing taurine, hydrolyzed corn starch and the secondary fission yeast fermentation product filtrate, adding the rest components after dissolving, and further mixing to obtain the composition.
According to some embodiments of the invention, the method of preparing comprises the steps of: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate in advance, and stopping heating when the temperature is between 40 and 55 ℃; then adding allantoin, and stirring for 15-30 min under heat preservation to obtain the composition.
According to some embodiments of the invention, the method of preparing comprises the steps of: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate in advance, and stopping heating when the temperature is between 45 and 52 ℃; then adding allantoin and water, and stirring for 15-30 min under heat preservation to obtain the composition.
A third aspect of the present invention provides the use of the above composition in a cosmetic for scalp care.
According to some embodiments of the invention, the cosmetic comprises 8% to 20% by weight of the composition.
According to some embodiments of the invention, the cosmetic is at least one of a shampoo, a conditioner, a serum, or a hair mask.
According to a fourth aspect of the invention, shampoo is provided, which comprises the composition.
According to some embodiments of the invention, the shampoo comprises 8 wt% to 20 wt% of the composition.
According to some embodiments of the invention, the shampoo has anti-inflammatory and soothing effects on the scalp.
Therefore, the beneficial effects of the invention include:
1. the composition has obvious improvement on the moisture retention and repair effects of skin and the inhibition on inflammatory factors under the synergistic effect of taurine, urea acid, the secondary fission yeast fermentation product filtrate and corn starch; after being applied to the shampoo, the irritation of the shampoo to the skin can be weakened; therefore, the composition has the effects of moisturizing, resisting inflammation, relieving and repairing when being applied to scalp care;
2. the preparation method of the composition is simple and easy for industrial production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below.
The present invention will be further illustrated with reference to the following examples. The following examples are merely preferred embodiments of the present invention and should not be construed as limiting the scope of the invention as claimed.
Example 1
A composition for scalp care comprises 1% taurine, 90% yeast fermentation filtrate, 1% hydrolyzed corn starch, 1% allantoin and 7% water.
The preparation method of the composition comprises the following steps: at room temperature, adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate in advance, and stopping heating when heating to 50 ℃; then adding allantoin and water, and stirring for 20 minutes under heat preservation to obtain the composition.
Example 2
A composition for scalp care comprises, by weight, 10% taurine, 80% yeast fermentation filtrate, 4% hydrolyzed corn starch, 1% allantoin, and 5% water.
The preparation method of the composition comprises the following steps: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃ and stopping heating; then adding allantoin and water, and stirring for 20 minutes under heat preservation to obtain the composition.
Example 3
A composition for scalp care comprises, by weight, 10% taurine, 80% yeast fermentation filtrate, 5% hydrolyzed corn starch, 2% allantoin, and 3% water.
The preparation method of the composition comprises the following steps: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃ and stopping heating; then adding allantoin and water, and stirring for 20 minutes under heat preservation to obtain the composition.
Example 4
A composition for scalp care comprises, by weight, 10% taurine, 70% yeast fermentation filtrate, 7% hydrolyzed corn starch, 1% allantoin, and 12% water.
The preparation method of the composition comprises the following steps: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃ and stopping heating; then adding allantoin and water, and stirring for 20 minutes under heat preservation to obtain the composition.
Comparative example 1
A composition for scalp care comprises 90 wt% of a fermentation product filtrate of Saccharomyces bifidus, 1 wt% of hydrolyzed corn starch, 1 wt% of allantoin, and 8 wt% of deionized water.
The preparation method of the composition comprises the following steps: adding hydrolyzed corn starch into the secondary cracking yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃, and stopping heating; then adding allantoin and deionized water, stirring for 20 minutes under heat preservation to obtain the composition.
Comparative example 2
A composition for scalp care comprises 1% taurine, 1% hydrolyzed corn starch, 1% allantoin and 97% deionized water.
The preparation method of the composition comprises the following steps: heating taurine and hydrolyzed corn starch to 50 ℃ at room temperature, and stopping heating; then adding allantoin and deionized water, and stirring for 20 minutes under heat preservation to obtain the composition.
Comparative example 3
A composition for scalp care comprises 1% of taurine, 90% of a fermentation product filtrate of saccharomyces bifidus, 1% of allantoin and 8% of deionized water in percentage by weight.
The preparation method of the composition comprises the following steps: adding taurine into the secondary fission yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃, and stopping heating; then adding allantoin and deionized water, and stirring for 20 minutes under heat preservation to obtain the composition.
Comparative example 4
A composition for scalp care comprises 1% of taurine, 90% of a yeast fermentation product filtrate of saccharomyces bifidus, 1% of hydrolyzed corn starch and 8% of deionized water in percentage by weight.
The preparation method of the composition comprises the following steps: adding taurine and hydrolyzed corn starch into the secondary fission yeast fermentation product filtrate at room temperature in advance, heating to 50 ℃ and stopping heating; then adding deionized water, keeping the temperature and stirring for 20 minutes to obtain the composition.
Comparative example 5
A composition for scalp care comprises 1% by weight of taurine and 99% by weight of deionized water.
The preparation method of the composition comprises the following steps: mixing taurine and deionized water at room temperature to obtain the composition.
Comparative example 6
A composition for scalp care comprises 70 wt% of a saccharomyces bifidus fermentation product filtrate and 30 wt% of deionized water.
The preparation method of the composition comprises the following steps: mixing the secondary cracking yeast fermentation product filtrate at room temperature with deionized water to obtain the composition.
Comparative example 7
A composition for scalp care comprises 1% of hydrolyzed corn starch and 99% of deionized water by weight percentage.
The preparation method of the composition comprises the following steps: mixing the hydrolyzed corn starch and deionized water at room temperature, heating to 50 deg.C, and stirring to obtain the composition.
Comparative example 8
A composition for scalp care comprises, by weight, 1% allantoin and 99% deionized water.
The preparation method of the composition comprises the following steps: mixing allantoin and deionized water at room temperature, and stirring to obtain the composition.
Comparative example 9
A composition for scalp care comprises, by weight, 3% allantoin and 97% deionized water.
The preparation method of the composition comprises the following steps: mixing allantoin and deionized water at room temperature, and stirring to obtain the composition.
Application example 1
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 10% of the composition of example 1 and 61.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the embodiment 1, and uniformly stirring to obtain the shampoo.
Application example 2
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 12% of the composition of example 2 and 59.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the embodiment 2, and uniformly stirring to obtain the shampoo.
Application example 3
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 15% of the composition of example 3 and 56.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) and cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the embodiment 3, and uniformly stirring to obtain the shampoo.
Application example 4
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 13% of the composition of example 4, and 58.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) and cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the embodiment 4, and uniformly stirring to obtain the shampoo.
Application comparative example 1
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 10% the composition of comparative example 1, and 61.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the comparative example 1, and uniformly stirring to obtain the shampoo.
Comparative application example 2
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 12% the composition of comparative example 2, and 59.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the comparative example 2, and uniformly stirring to obtain the shampoo.
Comparative application example 3
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 15% of the composition of comparative example 3, and 56.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the comparative example 3, and uniformly stirring to obtain the shampoo.
Application comparative example 4
A shampoo comprising, in weight percent, 10% cocamidopropyl betaine, 2% decyl glucoside, 12% sodium laureth sulfate, 0.6% polyquaternium-10, 0.1% PPG-3 octyl ether, 0.2% sorbitan caprylate, 2.0% cocamidomethyl MEA, 0.4% sodium benzoate, 0.4% phenoxyethanol, 0.2% sodium citrate, 0.2% citric acid, 0.1% disodium EDTA, 0.5% perfume, 13% of the composition of comparative example 4, and 58.3% deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 ℃, adding the essence, phenoxyethanol and the composition in the comparative example 4, and uniformly stirring to obtain the shampoo.
Comparative application example 5
A shampoo comprises, by weight, 10% of cocamidopropyl betaine, 2% of decyl glucoside, 12% of sodium laureth sulfate, 0.6% of polyquaternium-10, 0.1% of PPG-3 octyl ether, 0.2% of sorbitan caprylate, 2.0% of cocamidomethyl MEA, 0.4% of sodium benzoate, 0.4% of phenoxyethanol, 0.2% of sodium citrate, 0.2% of citric acid, 0.1% of disodium EDTA, 0.5% of essence and 71.3% of deionized water.
The preparation method of the shampoo comprises the following steps:
(1) adding deionized water, polyquaternium-10, PPG-3 octyl ether and sorbitan caprylate at room temperature, uniformly dispersing, and then heating;
(2) heating to 80-85 deg.C, stopping heating, adding decyl glucoside, cocamidomethyl MEA, cocamidopropyl betaine, sodium laureth sulfate, sodium benzoate, sodium citrate, citric acid, and disodium EDTA, maintaining the temperature for 20-30 min until completely dissolved, and cooling;
(3) cooling to 45-50 deg.C, adding essence and phenoxyethanol, and stirring to obtain the shampoo.
Performance testing
1. Evaluation of moisturizing efficacy
The test method comprises the following steps: 42 healthy volunteers were selected, aged 20-50 years, and divided into 14 groups. At constant temperature (22 + -1 deg.C), relative humidity of 50 + -5%, resting for 1 hr at (2 + -0.1) mg/cm 2 Amounts the compositions of examples 1-4 and comparative examples 1-9 were applied to the left forearm (4 cm. times.4 cm) and the right forearm (4 cm. times.4 cm) of each of the subjects of groups 1-13, respectively. Subjects in group 14 served as blank controls without smearing any sample. The skin hydration state was measured at 1 hour and 3 hours after the application of the sample, and the evaluation results were expressed as a hydration average value (in a.u.). The test results are shown in table 1.
TABLE 1
| Group of | Skin hydration degree of 1h | Skin hydration degree of 3h | Group of | Skin hydration degree of 1h | Skin hydration degree of 3h |
| Example 1 | 52.56 | 44.76 | Comparative example 1 | 37.58 | 30.35 |
| Example 2 | 56.32 | 46.55 | Comparative example 2 | 42.45 | 32.82 |
| Example 3 | 54.27 | 45.89 | Comparative example 3 | 43.65 | 32.26 |
| Example 4 | 55.59 | 46.23 | Comparative example 4 | 36.31 | 29.13 |
| Comparative example 5 | 34.61 | 33.74 | |||
| Comparative example 6 | 30.95 | 30.28 | |||
| Comparative example 7 | 32.79 | 31.29 | |||
| Comparative example 8 | 31.35 | 30.62 | |||
| Comparative example 9 | 32.01 | 30.71 | |||
| Blank control group | 25.76 | 25.32 |
According to table 1, taurine, uracidin, the saccharomyces cerevisiae fermentation product filtrate and corn starch in the composition for scalp care of the present invention have a synergistic effect on the skin moisturizing performance of the composition, and the corresponding moisturizing effect is significantly weaker in the comparative examples lacking taurine or lacking allantoin. When any one of taurine, a secondary fission yeast fermentation product filtrate, hydrolyzed corn starch and allantoin is added alone, the moisturizing effect is poorer than that of the composition. When the amount of allantoin added is too high, the expected better moisturizing effect is not obtained for the corresponding composition.
2. Evaluation of repair efficacy
The test method comprises the following steps: 130 healthy subjects were selected and divided into 13 groups. After cleansing the face every morning and evening, the compositions of examples 1 to 4 and comparative examples 1 to 9 were each applied by pressing uniformly to the face of each group of subjects and massaged until absorption. It is administered twice daily, once in the morning and once in the evening. The subjects had to use no cosmetics, drugs and nutraceuticals that had an effect on the outcome during the trial. Subjects were followed before (week 0) and 2 weeks after product use. Subject evaluation (questionnaires) was performed by a professional investigator on each subject prior to use and at each follow-up visit. Each subject should avoid vigorous exercise before each test and take a rest for 20min in a stable indoor environment. The investigators evaluated the indexes including erythema, desquamation, smoothness, and roughness of the skin at the test sites, each of which was evaluated according to the degree thereof from 0 point (very good) to 9 points (very poor), and the repair efficacy of the product was evaluated by comparing the two dimensions of the improvement rate of the feeling of tightness and the feeling of itching before and after the use of the product. The evaluation results are shown in table 2.
TABLE 2
According to the table 2, under the synergistic effect of taurine, urea acid, the secondary fission yeast fermentation product filtrate and corn starch, the compositions of the examples 1 to 4 have obvious repair effect, and effectively improve the skin tightness and pruritus; the comparative examples lacking taurine or lacking allantoin were significantly less effective in repair; when any one of taurine, a secondary fission yeast fermentation product filtrate, hydrolyzed corn starch and allantoin is added alone, the improvement rate of the tightness and the itching feeling is weaker than that of the composition. When the amount of allantoin added is too high, the expected better improvement rate of the feeling of tightness and itching is not obtained.
3. Inflammatory factor inhibitory assay
The compositions of examples 1 to 4 and the compositions of comparative examples 1 to 9 were used as samples, respectively. RAW264.7 mouse macrophages were adjusted to 1 × 10 5 The cells were inoculated in 6-well plates at 2 mL/well and incubated in a cell incubator for 24 h. After discarding the original medium, 2mL of complete medium containing 5. mu.g/mL of LPS, and 2mL of complete medium containing 5. mu.g/mL of LPS and containing samples of 5%, 10%, 12.5%, 16.67%, and 20% by mass, respectively, were added, and the culture was continued for 24 hours. Cell supernatants were collected and assayed for TNF-a content by ELISA kit instructions. Each group is provided with three multiple holes. Each sample was tested for inhibition of LPS-induced secretion of TNF-a, a macrophage inflammatory factor in RAW264.7 mice at a mass fraction of 10%. The test results are shown in table 3.
TABLE 3
| Sample (I) | TNF-a secretion inhibition rate/%) | Sample (I) | TNF-a secretion inhibition rate/%) |
| Example 1 | 72.25 | Comparative example 1 | 35.67 |
| Example 2 | 70.88 | Comparative example 2 | 39.56 |
| Example 3 | 70.36 | Comparative example 3 | 40.68 |
| Example 4 | 71.27 | Comparative example 4 | 36.25 |
| Comparative example 5 | 30.56 | ||
| Comparative example 6 | 22.39 | ||
| Comparative example 7 | 20.57 | ||
| Comparative example 8 | 19.32 | ||
| Comparative example 9 | 19.46 |
According to the table 3, under the synergistic effect of taurine, urea acid, the secondary fission yeast fermentation product filtrate and corn starch, the compositions of the examples 1 to 4 have obvious inhibition effect on the secretion of the cell inflammatory factor TNF-a; the comparative examples lacking taurine or lacking allantoin had significantly weaker inhibitory effects on inflammatory factors than the examples and also than the other comparative examples; when any one of taurine, a secondary fission yeast fermentation product filtrate, hydrolyzed corn starch and allantoin is added independently, the inhibition rate of TNF-a is weaker than that of the composition; when the amount of allantoin to be added is too high, the expected better TNF-a inhibitory effect is not obtained, and therefore, the amount of allantoin to be added can be reduced from the viewpoint of economic cost.
4. Multi-effect scalp care shampoo irritation test
Evaluation of the response using an erythrocyte hemolysis assayMildness of shampoos of examples 1 to 4 and comparative examples 1 to 5. Diluting each shampoo with normal saline to obtain solutions with mass fractions of 0.1%, 0.2%, 0.3%, 0.5%, 1%, 2%, 10% and 20%, and volume of 2 mL. Uniformly mixing 500 mu L of prepared sample and 500 mu L of erythrocyte with the mass fraction of 2%, setting a negative control (normal saline) and a positive control (1% SDS) and setting a control (normal saline) and a positive control (1% SDS) in each group, setting 3 parallels in each group, standing in a biochemical incubator at 37 ℃ for incubation for 3h, centrifuging the samples of each group respectively, taking 10 mu L of supernatant and 90 mu L of normal saline, placing the supernatant and the 90 mu L of normal saline in a 96-well plate, and uniformly mixing to measure the absorbance values at 410, 540 and 575 nm. The average value of each group was taken to calculate the concentration of the test substance (HC) that caused hemolysis of 50% of erythrocytes 50 ) Ratio (L/D) to the denaturation rate (DI) of hemoglobin. According to irritation evaluation criteria: L/D>100, no irritation; 10<Micro-stimulation property when L/D is less than or equal to 100; 1<L/D is less than or equal to 10: mild irritation; 0.1<L/D is less than or equal to 1: moderate irritability; L/D is less than or equal to 0.1: and (4) evaluating the irritation grading of the shampoos of each group. The test results are shown in table 4.
TABLE 4
| Group of | L/D | Irritation grading | Group of | L/D | Irritation grading |
| Application example 1 | 67.27 | Micro-stimulation property | Application comparative example 1 | 3.97 | Mild irritation |
| Application example 2 | 65.76 | Micro-stimulation property | Comparative application example 2 | 5.93 | Mild irritation |
| Application example 3 | 65.27 | Micro-stimulation property | Comparative application example 3 | 5.48 | Mild irritation |
| Application example 4 | 66.39 | Micro-stimulation property | Application comparative example 4 | 6.21 | Mild irritation |
| Comparative application example 5 | 1.26 | Mild irritation |
According to Table 4, the shampoos using the compositions of examples 1-4 were less irritating under the synergistic effect of taurine, uroacitinin, diltiazem fermentation product filtrate and corn starch, while the shampoos using the compositions lacking taurine, or lacking diltiazem fermentation product filtrate, or lacking hydrolyzed corn starch, or lacking allantoin were still slightly irritating.
Therefore, the composition for scalp at least achieves the beneficial effects of preventing and isolating the penetration of the surfactant to the skin, reducing the interaction of the surfactant and lipid among skin cells due to the steric hindrance effect and timely repairing the reactions of pruritus, inflammation and the like caused by the generated irritation under the synergistic action of the allantoin, the taurine, the secondary fission yeast fermentation product filtrate and the hydrolyzed corn starch. Specifically, the composition has obviously improved moisture retention, repair effect and inhibition on inflammatory factors on skin; after being applied to shampoo, the composition has obvious reduction on the irritation of the skin. Therefore, the composition has the effects of moisturizing, resisting inflammation, relieving and repairing when being applied to scalp care.
Finally, it should be noted that the above embodiment modes are only used for illustrating the technical solutions of the present invention and are not limited, and although the present application is described in detail with reference to the above preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A composition for scalp care comprising the following components: taurine, a secondary fission yeast fermentation product filtrate, hydrolyzed corn starch and allantoin.
2. The composition of claim 1, comprising, in parts by weight, 0.1 to 20 parts taurine, 60 to 90 parts yeast bifidus fermentation product filtrate, 0.5 to 10 parts hydrolyzed corn starch, 0.1 to 3 parts allantoin.
3. The composition of claim 1, comprising, in parts by weight, 0.5 to 18 parts taurine, 65 to 90 parts yeast bifidus fermentation product filtrate, 0.7 to 9 parts hydrolyzed corn starch, 0.1 to 3 parts allantoin.
4. The composition of claim 1, comprising, by weight, 0.6 to 15 parts taurine, 65 to 90 parts yeast bifidus fermentation product filtrate, 1 to 8 parts hydrolyzed corn starch, 0.5 to 2.5 parts allantoin.
5. The composition of claim 1, comprising, by weight, 0.8 to 12 parts taurine, 68 to 90 parts yeast fermentation product filtrate, 1 to 7 parts hydrolyzed corn starch, 1 to 2 parts allantoin.
6. A process for the preparation of a composition according to any one of claims 1 to 5, characterized in that it comprises the following steps:
mixing the components to obtain the composition.
7. Use of a composition according to any one of claims 1 to 5 in cosmetics for scalp care.
8. Use according to claim 7, characterized in that said cosmetic comprises from 8% to 20% by weight of said composition.
9. The use of claim 7, wherein the cosmetic is at least one of a shampoo, a conditioner, a serum, or a hair mask.
10. A shampoo comprising the composition of any of claims 1 to 5.
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