CN114795992A - Composition for preventing and treating skin photodamage and preparation method thereof - Google Patents
Composition for preventing and treating skin photodamage and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of skin care compositions, in particular to a composition for preventing and treating skin photodamage and a preparation method thereof, wherein the composition comprises lavender total flavonoids, pigeon egg whole egg powder, a fat-soluble thickener, a water-soluble thickener, a fat-soluble humectant, a water-soluble humectant, an emulsifier, an emollient, a preservative, a pH regulator and water, and is obtained according to the following method: uniformly stirring a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, uniformly stirring a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase, adding the oil phase into the water phase, adding the lavender total flavonoids and the pigeon egg whole egg powder, and uniformly mixing. The composition for preventing and treating skin photodamage can effectively inhibit the phenomena of rough skin and skin damage of mice caused by ultraviolet radiation, and can finally effectively prevent the skin photodamage of the mice induced by medium-wave ultraviolet.
Description
Technical Field
The invention relates to the technical field of skin care compositions, in particular to a composition for preventing and treating skin photodamage and a preparation method thereof.
Background
The skin is covered on the body surface, is used as the largest organ of the human body, is in direct contact with the external environment, and is the first protective barrier for resisting various external physical, chemical, biological and other stimuli. Among them, ultraviolet rays in the environment are a critical factor causing skin damage. With the improvement of living standard, people have higher requirements on the appearance and the state of skin. After the body is stimulated by medium-wave ultraviolet light for a long time, the injury reactions such as inflammatory reaction, oxidative damage, photocarcinogenesis and the like can occur, the phenomena that the epidermis and the dermis of the skin at the exposure part are rough and thickened in different degrees are shown, the skin of a serious person is loose, folds are thickened and deepened, hyperpigmentation or telangiectasia locally occurs, and even various benign or malignant tumors can occur. At present, medicaments for inhibiting skin photodamage, such as vitamins, signal channel regulators and the like, are provided, but the development of skin care products in the modern medical field still has a larger gap.
Lavender is the dry aerial part of Lavandula angustifolia (Lavandula angustifolia Mill.) belonging to Labiatae, is a rare Chinese medicinal material and food spice, and is abundant in Lavender resource in Xinjiang Yili. The lavender total flavonoids can effectively remove superoxide anion free radicals, hydroxyl free radicals and DPPH, and have an antioxidation effect on linoleic acid, so the lavender total flavonoids have a strong in-vitro antioxidation effect. Skin photodamage is caused by excessive ultraviolet irradiation to the skin, the body will generate oxidative stress, Reactive Oxygen Species (ROS) are generated excessively in the body or the body can remove the ROS slowly, so that a large amount of ROS accumulation, oxidation and oxidation resistance systems lose balance in the body, and skin tissues are damaged. Therefore, the lavender total flavonoids may have biological activity in the aspects of protecting skin from photodamage and the like.
Pigeon eggs are regarded in the traditional Chinese medicine as having the efficacies of tonifying qi and blood, tonifying liver and kidney, clearing heat and removing toxicity and the like, and are called animal ginseng. In the report of the basic nutritional index parameters of pigeon eggs, the contents of glutamic acid and proline are high, wherein glutamic acid has the effect of protecting skin from being wet, and proline is the main amino acid for synthesizing collagen, so that the content of the collagen of pigeon eggs is very high. Collagen has low antigenicity and biodegradability as a protein, and plays a very important role in the body. The iron content in the mineral elements and the polyunsaturated fatty acid content in the fatty acid composition are both high, so the pigeon eggs have obvious advantages in the nutritional aspects of maintaining beauty and keeping young and the like. The pigeon egg powder is an excellent product refined from pure fresh pigeon eggs, is a protein resource with rich source and high quality, and has the characteristics of high utilization rate and the like of the essential amino acid components contained in the pigeon eggs, and can promote skin cell migration, thereby accelerating wound healing.
Disclosure of Invention
The invention provides a composition for preventing and treating skin photodamage and a preparation method thereof, overcomes the defects of the prior art, can effectively inhibit the phenomena of rough skin and skin damage of mice caused by ultraviolet radiation, and can finally effectively prevent the skin photodamage of the mice induced by medium-wave ultraviolet.
One of the technical schemes of the invention is realized by the following measures: a composition for preventing and treating skin photodamage comprises, by weight, 6-12 parts of lavender total flavonoids, 2-4 parts of whole egg powder of pigeon eggs, 0.2-12.0 parts of fat-soluble thickening agent, 0-0.5 part of water-soluble thickening agent, 0-8.3 parts of fat-soluble humectant, 2-15 parts of water-soluble humectant, 0-19 parts of emulsifier, 2.0-17.5 parts of emollient, 0-0.8 part of preservative, 0-0.2 part of pH regulator and 50-92 parts of water, and is obtained according to the following method:
step one, uniformly stirring required amounts of a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, and uniformly stirring required amounts of a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase; secondly, adding an oil phase into the water phase under the condition of stirring to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and the whole egg powder of the pigeon eggs into the mixed emulsion, and uniformly mixing to obtain the composition for preventing and treating the skin photodamage.
The following is a further optimization or/and improvement of one of the above-mentioned technical solutions of the invention:
the fat-soluble thickener is one of octadecanol and liquid paraffin.
The water-soluble thickener is carbomer.
The fat-soluble humectant is one or more of ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165).
The water-soluble humectant is more than one of glycerol, sodium hyaluronate and tween-80.
The emulsifier is one or more of glyceryl monostearate, triethanolamine, stearic acid, glyceryl monostearate and span-60.
The emollient is one or more of isooctyl palmitate, meadowfoam seed oil, polydimethylsiloxane, cetearyl alcohol and white vaseline.
The antiseptic is one of butyl p-hydroxybenzoate and methyl hydroxybenzoate.
The pH regulator is aminomethyl propanol.
In the first step, the stirring time is 30min to 60min, and the stirring temperature is 45 ℃ to 80 ℃.
In the second step, the stirring time is 30min to 60min, and the stirring temperature is 30 ℃ to 60 ℃.
In the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
The second technical scheme of the invention is realized by the following measures: a preparation method of a composition for preventing and treating skin photodamage comprises the following raw materials, by weight, 6-12 parts of lavender total flavonoids, 2-4 parts of pigeon egg powder, 0.2-12.0 parts of fat-soluble thickening agent, 0-0.5 part of water-soluble thickening agent, 0-8.3 parts of fat-soluble humectant, 2-15 parts of water-soluble humectant, 0-19 parts of emulsifier, 2.0-17.5 parts of emollient, 0-0.8 part of preservative, 0-0.2 part of pH regulator and 50-92 parts of water, and is carried out according to the following method:
step one, uniformly stirring required amounts of a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, and uniformly stirring required amounts of a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase; secondly, adding an oil phase into the water phase under the condition of stirring to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and the whole egg powder of the pigeon eggs into the mixed emulsion, and uniformly mixing to obtain the composition for preventing and treating the skin photodamage.
The following is further optimization or/and improvement of the second technical scheme of the invention:
the fat-soluble thickener is one of octadecanol and liquid paraffin.
The water-soluble thickener is carbomer.
The fat-soluble humectant is one or more of ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165).
The water-soluble humectant is more than one of glycerol, sodium hyaluronate and tween-80.
The emulsifier is one or more of glyceryl monostearate, triethanolamine, stearic acid, glyceryl monostearate and span-60.
The emollient is one or more of isooctyl palmitate, meadowfoam seed oil, polydimethylsiloxane, cetearyl alcohol and white vaseline.
The antiseptic is one of butyl p-hydroxybenzoate and methyl hydroxybenzoate.
The pH regulator is aminomethyl propanol.
In the first step, the stirring time is 30min to 60min, and the stirring temperature is 45 ℃ to 80 ℃.
In the second step, the stirring time is 30min to 60min, and the stirring temperature is 30 ℃ to 60 ℃.
In the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
Compared with the prior art, the invention has the advantages that:
in the raw materials of the composition for preventing and treating the skin photodamage, the lavender total flavonoids have a stronger effect of preventing the skin photodamage, the amino acids contained in the pigeon eggs can accelerate wound healing, the iron element in mineral elements and the polyunsaturated fatty acid content are high, so that the pigeon eggs have unique advantages in the aspect of skin care, and the composition prepared by combining the amino acids and the mineral elements can be effectively used for preventing and treating the skin photodamage.
The composition for preventing and treating skin photodamage can prevent the generation of oxidase in the skin of the back of a mouse, improve the biological activity of skin antioxidant enzyme, effectively play an anti-inflammatory role, reduce the expression of proinflammatory factors, reduce the accumulation of lipid peroxidation products, inhibit oxidative stress reaction, effectively inhibit the phenomena of rough skin and skin damage of the mouse caused by ultraviolet radiation, and finally effectively prevent the skin photodamage of the mouse induced by medium-wave ultraviolet.
Drawings
Fig. 1 is a diagram showing the appearance of a mouse having skin photodamage-preventing composition for preventing and treating skin photodamage prepared in example 13 of the present invention.
Fig. 2 is a diagram of an epidermal layer of a mouse having photodamage from skin, which is prevented by the composition for preventing and treating photodamage from skin prepared in example 13 of the present invention.
Fig. 3 is a diagram of the dermis layer of a mouse with skin photodamage prevention of the composition for skin photodamage prevention prepared in example 13 of the present invention.
Fig. 4 is a diagram of the follicular layer of a mouse with the composition for preventing and treating skin photodamage prepared in example 13 of the present invention for preventing and treating skin photodamage.
Fig. 5 is an appearance view of a mouse having skin photodamage-preventing composition for preventing skin photodamage prepared in comparative example 1 of the present invention.
Fig. 6 is a diagram of an epidermal layer of a mouse having photo-damage of the skin, which is prevented by the composition for preventing and treating photo-damage of the skin according to comparative example 1 of the present invention.
Fig. 7 is a diagram of the dermis layer of a mouse having skin photo-damage prevention of the composition for preventing skin photo-damage prepared in comparative example 1 of the present invention.
Fig. 8 is a diagram of a hair follicle layer of a mouse having skin photodamage prevented by the composition for preventing and treating skin photodamage prepared by comparative example 1 of the present invention.
Detailed Description
The present invention is not limited by the following examples, and specific embodiments may be determined according to the technical solutions and practical situations of the present invention. The various chemical reagents and chemical articles mentioned in the invention are all the chemical reagents and chemical articles which are well known and commonly used in the prior art, unless otherwise specified; the percentages in the invention are mass percentages unless otherwise specified; the solution in the present invention is an aqueous solution in which the solvent is water, for example, a hydrochloric acid solution is an aqueous hydrochloric acid solution, unless otherwise specified; the normal temperature and room temperature in the present invention generally mean a temperature of 15 ℃ to 25 ℃, and are generally defined as 25 ℃.
The invention is further described below with reference to the following examples:
example 1: the composition for preventing and treating skin photodamage comprises, by weight, 6-12 parts of lavender total flavonoids, 2-4 parts of whole egg powder of pigeon eggs, 0.2-12.0 parts of fat-soluble thickening agent, 0-0.5 part of water-soluble thickening agent, 0-8.3 parts of fat-soluble humectant, 2-15 parts of water-soluble humectant, 0-19 parts of emulsifier, 2.0-17.5 parts of emollient, 0-0.8 part of preservative, 0-0.2 part of pH regulator and 50-92 parts of water, and is obtained according to the following method:
step one, uniformly stirring required amounts of a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, and uniformly stirring required amounts of a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase; secondly, adding an oil phase into the water phase under the condition of stirring to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and the whole egg powder of the pigeon eggs into the mixed emulsion, and uniformly mixing to obtain the composition for preventing and treating the skin photodamage.
In the invention, the lavender total flavone is obtained by a method disclosed in the publication No. CN201110067605.9 entitled preparation method of lavender total flavone; the pigeon egg whole egg powder is obtained by the method disclosed in publication No. CN202110234902.1 entitled Pigeon egg whole egg powder and preparation method thereof.
Example 2: as optimization of the above embodiment, the fat-soluble thickener is one of octadecanol and liquid paraffin.
Example 3: as an optimization of the above example, the water soluble thickener is carbomer.
Example 4: in the optimization of the embodiment, the fat-soluble humectant is more than one of ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165).
Example 5: as optimization of the embodiment, the water-soluble humectant is more than one of glycerin, sodium hyaluronate and tween-80.
Example 6: as the optimization of the embodiment, the emulsifier is more than one of glyceryl monostearate, triethanolamine, stearic acid, glyceryl monostearate and span-60.
Example 7: in the optimization of the embodiment, the emollient is more than one of isooctyl palmitate, meadowfoam seed oil, polydimethylsiloxane, cetearyl alcohol and white vaseline.
Example 8: as an optimization of the above embodiment, the preservative is one of butylparaben and methylparaben.
Example 9: as an optimization of the above example, the pH adjusting agent is aminomethyl propanol.
Example 10: as optimization of the above embodiment, in the first step, the stirring time is 30min to 60min, and the stirring temperature is 45 ℃ to 80 ℃.
Example 11: as the optimization of the above embodiment, in the second step, the stirring time is 30min to 60min, and the stirring temperature is 30 ℃ to 60 ℃.
Example 12: in the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
Example 13: the composition for preventing and treating skin photodamage comprises, by weight, 6 parts of lavender total flavonoids, 2 parts of pigeon egg whole egg powder, 0.2 part of octadecanol, 0.5 part of carbomer, 2 parts of glycerol, 1.2 parts of emulsifier (1 part of glyceryl monostearate and 0.2 part of triethanolamine), 2 parts of isooctyl palmitate, 0.1 part of butyl p-hydroxybenzoate and 70.4 parts of water, and is obtained by the following method:
firstly, mixing and stirring carbomer, glycerol, butyl p-hydroxybenzoate and water with required amounts for 30min under the condition of a water bath at 45 ℃ to obtain a water phase, and mixing and stirring octadecanol, glyceryl monostearate, triethanolamine and isooctyl palmitate with required amounts for 30min under the condition of a water bath at 80 ℃ to obtain an oil phase; secondly, adding an oil phase into the water phase at 30 ℃, mixing and stirring for 45min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at 45 ℃, mixing and stirring for 30min to obtain the composition for preventing and treating skin photodamage.
Example 14: the composition for preventing and treating skin photodamage comprises, by weight, 12 parts of lavender total flavonoids, 4 parts of whole egg powder of pigeon eggs, 1.0 part of octadecanol, 0.5 part of carbomer, 10 parts of glycerol, 6.0 parts of emulsifier (5 parts of glycerin monostearate and 1.0 part of triethanolamine), 6 parts of isooctyl palmitate, 0.1 part of butyl p-hydroxybenzoate and 92 parts of water, and is obtained by the following method:
firstly, mixing and stirring carbomer, glycerol, butyl p-hydroxybenzoate and water with required amounts for 60min under the condition of a water bath at 45 ℃ to obtain a water phase, and mixing and stirring octadecanol, glyceryl monostearate, triethanolamine and isooctyl palmitate with required amounts for 60min under the condition of a water bath at 80 ℃ to obtain an oil phase; secondly, adding an oil phase into the water phase at 60 ℃, mixing and stirring for 45min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at 45 ℃, mixing and stirring for 60min to obtain the composition for preventing and treating skin photodamage.
Example 15: the composition for preventing and treating skin photodamage comprises, by weight, 9 parts of lavender total flavonoids, 3 parts of pigeon egg whole egg powder, 0.5 part of octadecanol, 0.5 part of carbomer, 6 parts of glycerol, 4 parts of emulsifiers (3.2 parts of glycerin monostearate and 0.8 part of triethanolamine), 4 parts of isooctyl palmitate, 0.1 part of butyl p-hydroxybenzoate and 80 parts of water, and is obtained by the following method:
firstly, mixing and stirring carbomer, glycerol, butyl p-hydroxybenzoate and water in required amounts for 45min under the condition of a water bath at 45 ℃ to obtain a water phase, and mixing and stirring octadecanol, glyceryl monostearate, triethanolamine and isooctyl palmitate in required amounts for 45min under the condition of a water bath at 80 ℃ to obtain an oil phase; secondly, adding an oil phase into the water phase at 45 ℃, mixing and stirring for 45min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at 45 ℃, and mixing and stirring for 45 ℃ to obtain the composition for preventing and treating skin photodamage.
Example 16: the composition for preventing and treating skin photodamage comprises, by weight, 6 parts of lavender total flavonoids, 2 parts of pigeon egg powder, 5 parts of liquid paraffin, 0.1 part of carbomer, 2.1 parts of fat-soluble moisturizer (0.1 part of ceramide, 2 parts of glyceryl monostearate polyoxyethylene (ARLACLE 165)), 8.1 parts of water-soluble moisturizer (8 parts of glycerin and 0.1 part of sodium hyaluronate), 8.5 parts of emollient (4 parts of meadowfoam seed oil, 4 parts of polydimethylsiloxane and 0.5 part of cetostearyl alcohol), 0.1 part of aminomethyl propanol and 50 parts of water, and is obtained according to the following method:
the preparation method comprises the first step of mixing and stirring carbomer, water-soluble humectants (glycerin and sodium hyaluronate), aminomethyl propanol and water for 30min at 80 ℃ to obtain a water phase, mixing and stirring liquid paraffin, fat-soluble humectants (ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165) and emollients (meadowfoam seed oil, polydimethylsiloxane and cetearyl alcohol) for 30min at 80 ℃ to obtain an oil phase, the second step of adding the oil phase into the water phase at 30 ℃ to mix and stir for 30min to obtain a mixed emulsion, and the third step of adding lavender total flavonoids and pigeon egg powder at 40 ℃ to the mixed emulsion to mix and stir for 30min to obtain the composition for preventing and treating skin photodamage.
Example 17: the composition for preventing and treating skin photodamage comprises, by weight, 12 parts of lavender total flavonoids, 4 parts of pigeon egg powder, 9 parts of liquid paraffin, 0.3 part of carbomer, 8.3 parts of fat-soluble moisturizer (0.3 part of ceramide, 8 parts of glyceryl monostearate polyoxyethylene (ARLACLE 165)), 12.5 parts of water-soluble moisturizer (12 parts of glycerin and 0.5 part of sodium hyaluronate), 17.5 parts of emollient (8 parts of meadowfoam seed oil, 8 parts of polydimethylsiloxane and 1.5 parts of cetostearyl alcohol), 0.2 part of aminomethyl propanol and 60 parts of water, and is obtained according to the following method:
the preparation method comprises the following steps of firstly, mixing carbomer, water-soluble moisturizers (glycerin and sodium hyaluronate), aminomethyl propanol and water in required amounts at 80 ℃ and stirring for 60min to obtain a water phase, mixing and stirring liquid paraffin, fat-soluble moisturizers (ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165) and emollients (meadowfoam seed oil, polydimethylsiloxane and cetearyl alcohol) in required amounts at 80 ℃ and stirring for 60min to obtain an oil phase, secondly, adding the oil phase into the water phase at 60 ℃ and stirring for 60min to obtain a mixed emulsion, and thirdly, adding lavender total flavonoids and pigeon egg powder in required amounts at 55 ℃ into the mixed emulsion and stirring for 60min to obtain the composition for preventing and treating skin photodamage.
Example 18: the composition for preventing and treating skin photodamage comprises, by weight, 9 parts of lavender total flavonoids, 3 parts of pigeon egg powder, 7 parts of liquid paraffin, 0.2 part of carbomer, 5 parts of fat-soluble moisturizer (0.2 part of ceramide, 4.8 parts of glyceryl monostearate polyoxyethylene (ARLACLE 165)), 10 parts of water-soluble moisturizer (9.8 parts of glycerin and 0.2 part of sodium hyaluronate), 13 parts of emollient (6 parts of white flowery knotweed seed oil, 6 parts of polydimethylsiloxane and 1 part of cetostearyl alcohol), 0.15 part of aminomethyl propanol and 55 parts of water, and is obtained according to the following method:
the preparation method comprises the first step of mixing carbomer, water-soluble moisturizers (glycerin and sodium hyaluronate), aminomethyl propanol and water for 45min at 80 ℃ to obtain a water phase, mixing liquid paraffin, fat-soluble moisturizers (ceramide and glyceryl monostearate polyoxyethylene (ARLACLE 165) and emollients (meadowfoam seed oil, polydimethylsiloxane and cetearyl alcohol) for 45min at 80 ℃ in a water bath to obtain an oil phase, the second step of adding the oil phase into the water phase at 45 ℃ to mix for 45min to obtain a mixed emulsion, and the third step of adding lavender total flavonoids and pigeon egg powder to the mixed emulsion at 50 ℃ to mix for 45min to obtain the composition for preventing and treating skin photodamage.
Example 19: the composition for preventing and treating skin photodamage comprises, by weight, 6 parts of lavender total flavonoids, 2 parts of pigeon egg whole egg powder, 10 parts of liquid paraffin, 9 parts of water-soluble humectant (8 parts of glycerin and 801 parts of tween), 10 parts of emulsifier (8 parts of stearic acid, 1 part of glyceryl monostearate and span-601), 8 parts of white vaseline, 0.2 part of methylparaben and 50 parts of water, and is obtained according to the following method:
firstly, mixing and stirring water-soluble humectant (glycerol and Tween-80), methylparaben and water for 30min at the temperature of 80 ℃ to obtain a water phase, and mixing and stirring liquid paraffin, emulsifier (stearic acid, glyceryl monostearate and span-60) and white vaseline for 30min at the temperature of 80 ℃ to obtain an oil phase; secondly, adding an oil phase into the water phase at the temperature of 30 ℃, mixing and stirring for 30min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at 40 ℃, mixing and stirring for 30min to obtain the composition for preventing and treating skin photodamage.
Example 20: the composition for preventing and treating skin photodamage comprises, by weight, 12 parts of lavender total flavonoids, 4 parts of pigeon egg whole egg powder, 12 parts of liquid paraffin, 15 parts of water-soluble humectant (12 parts of glycerin and tween-803), 19 parts of emulsifier (12 parts of stearic acid, 3 parts of glyceryl monostearate and span-604), 12 parts of white vaseline, 0.8 part of methylparaben and 60 parts of water, and is obtained by the following method:
firstly, mixing and stirring required amounts of water-soluble humectant (glycerol and Tween-80), methylparaben and water for 60min under the condition of 80 ℃ water bath to obtain a water phase, and mixing and stirring required amounts of liquid paraffin, emulsifier (stearic acid, glyceryl monostearate and span-60) and white vaseline for 60min under the condition of 80 ℃ water bath to obtain an oil phase; secondly, adding an oil phase into the water phase at 60 ℃, mixing and stirring for 60min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at the temperature of 55 ℃, mixing and stirring for 60min to obtain the composition for preventing and treating skin photodamage.
Example 21: the composition for preventing and treating skin photodamage comprises, by weight, 9 parts of lavender total flavonoids, 3 parts of pigeon egg whole egg powder, 11 parts of liquid paraffin, 12 parts of water-soluble humectant (10 parts of glycerin and tween-802 parts), 14 parts of emulsifier (10 parts of stearic acid, 2 parts of glyceryl monostearate and span-602 parts), 10 parts of white vaseline, 0.5 part of methylparaben and 55 parts of water, and is obtained according to the following method:
firstly, mixing and stirring required amounts of water-soluble humectant (glycerol and Tween-80), methylparaben and water for 45min under the condition of 80 ℃ water bath to obtain a water phase, and mixing and stirring required amounts of liquid paraffin, emulsifier (stearic acid, glyceryl monostearate and span-60) and white vaseline for 45min under the condition of 80 ℃ water bath to obtain an oil phase; secondly, adding an oil phase into the water phase at 45 ℃, mixing and stirring for 45min to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and pigeon egg whole egg powder into the mixed emulsion at 50 ℃, mixing and stirring for 45min to obtain the composition for preventing and treating skin photodamage.
Comparative example 1: the composition for preventing and treating skin photodamage comprises, by weight, 4 parts of lavender total flavonoids and 4 parts of pigeon egg whole egg powder (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 1: 1), and the rest components and the preparation method are the same as those in embodiment 13 of the invention (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 3: 1).
Comparative example 2: the composition for preventing and treating skin photodamage comprises, by weight, 4 parts of lavender total flavonoids and 4 parts of pigeon egg whole egg powder (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 1: 1), and the rest components and the preparation method are the same as those in embodiment 16 of the invention (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 3: 1).
Comparative example 3: the composition for preventing and treating skin photodamage comprises, by weight, 4 parts of lavender total flavonoids and 4 parts of pigeon egg whole egg powder (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 1: 1), and the rest components and the preparation method are the same as those in embodiment 19 (the mass ratio of the lavender total flavonoids to the pigeon egg whole egg powder is 3: 1).
The compositions for preventing and treating skin photodamage prepared in examples 13 to 21 of the present invention can effectively inhibit the phenomena of rough skin and skin damage of mice caused by ultraviolet radiation, and finally can effectively prevent the skin photodamage of mice induced by medium-wave ultraviolet. The compositions for preventing and treating skin photodamage prepared in example 13 of the present invention and comparative example 1 (hereinafter, referred to as composition 1 and composition 2, respectively) were used for the skin photodamage test of mice.
Test subjects: 30 SPF-grade female healthy Kunming mice are 6-8 weeks old, have the body weight of 18-22 g, the temperature of 23-25 ℃ and the relative humidity of 50-60 percent, are raised in a single cage, and freely obtain food and water.
Grouping tests: 30 female Kunming mice were randomly divided into 3 groups of 10, each group being a blank group (no UVB irradiation), a model group (UVB irradiation), a prevention group 1 (composition 1 or composition 2+ was applied first and then UVB irradiation), a prevention group 2 (composition 2+ was applied first and then UVB irradiation), a treatment group 1 (composition 1 or composition 2 was applied first and then UVB irradiation), and a treatment group 2 (composition 2 was applied first and then UVB irradiation).
Establishing a mouse skin photodamage model: all hairs on the back of the neck of the mouse were shaved with a shaver 1 day before the irradiation, and then the naps of the neck were removed by applying depilatory cream so that the exposed area of the back was about 4cm × 2cm, which was confirmedThe irradiation distance is determined as that the mouse deviates from the irradiation lamp by 20cm, and the irradiation intensity of UVB is 13mw/cm 2 Continuously irradiating for 1 week, wherein the irradiation time of day 1 and the last day is 10min, the irradiation time of the other 5 days is 15 min, and the total irradiation dose is 74.1J/cm 2 . A large amount of pigmentation, scales, erythema and wrinkles appear in the back irradiation area of the mouse, and even fester, scab and leather-like touch feel appear on the local part of the mouse, which indicates that the model group mouse skin light injury model is successfully constructed.
Administration: before the experiment begins, the ultraviolet phototherapy instrument is started in advance to be preheated for 5 min. Prevention group 1: firstly, the composition 1 is evenly smeared on the naked skin of a mouse, and the mouse is irradiated in an ultraviolet lamp illumination box after 10min, so that the prevention group 2: firstly, uniformly smearing the composition 2 on the naked skin of a mouse, and irradiating in an ultraviolet lamp illumination box after 10 min; treatment group 1: firstly, ultraviolet irradiation is carried out for 10min, and then the composition 1 is uniformly coated; treatment group 2: firstly, ultraviolet irradiation is carried out for 10min, and then the composition 2 is uniformly coated; the compositions were applied to the prophylactic groups 1 to 2 and the therapeutic groups 1 to 21 time per day for 7 days. Meanwhile, a blank group is set up: equal amounts of saline were given and the model groups were left uncoated.
And (3) test results: the appearances, epidermis layers, dermis layers and follicle layers of the mice in each group after 7 days are shown in fig. 1 to 8, wherein the appearances of the mice are photographed by a camera, the epidermis layers, dermis layers and follicle layers of the mice are detected by a UV light skin detector (model number M-12 USB), fig. 1 to 4 are the appearances, the epidermis layers, the dermis layers and the follicle layers of the mice for preventing and treating skin photodamage prepared by the composition for preventing and treating skin photodamage prepared by the embodiment 13 of the present invention, and fig. 5 to 8 are the appearances, the epidermis layers, the dermis layers and the follicle layers of the mice for preventing and treating skin photodamage prepared by the comparative example 1 of the present invention.
As can be seen from fig. 1 to 4, compared to the model group, the appearance, epidermal layer, dermal layer and hair follicle layer of the mice in the prevention group 1 and the treatment group 1 were significantly reduced, and the mice had only wrinkles, a small amount of scales and less pigmentation, and were able to effectively suppress the phenomena of rough skin and skin damage caused by uv radiation. As can be seen from fig. 5 to 8, the mice in the prevention group 2 and the treatment group 2 had slightly reduced degrees of apparent lesions, and a large amount of scales, pigmentation, petechiae, and ecchymosis remained more evident, compared to the model group. The composition for preventing and treating skin photodamage prepared by the invention has the best effect of preventing and treating skin photodamage when the ratio of the lavender total flavonoids to the pigeon egg whole egg powder in the raw materials is 3: 1.
In conclusion, the composition for preventing and treating skin photodamage can prevent the generation of oxidase in the skin of the back of a mouse, improve the biological activity of skin antioxidant enzyme, effectively play an anti-inflammatory role, reduce the expression of proinflammatory factors, reduce the accumulation of lipid peroxidation products, inhibit oxidative stress reaction, effectively inhibit the phenomena of rough skin and skin damage of the mouse caused by ultraviolet radiation, and finally effectively prevent the skin photodamage of the mouse induced by medium-wave ultraviolet rays.
The technical characteristics form an embodiment of the invention, which has strong adaptability and implementation effect, and unnecessary technical characteristics can be increased or decreased according to actual needs to meet the requirements of different situations.
Claims (9)
1. A composition for preventing and treating skin photodamage is characterized by comprising, by weight, 6-12 parts of lavender total flavonoids, 2-4 parts of whole pigeon egg powder, 0.2-12.0 parts of fat-soluble thickening agent, 0-0.5 part of water-soluble thickening agent, 0-8.3 parts of fat-soluble humectant, 2-15 parts of water-soluble humectant, 0-19 parts of emulsifier, 2.0-17.5 parts of emollient, 0-0.8 part of preservative, 0-0.2 part of pH regulator and 50-92 parts of water, and is obtained by the following method:
step one, uniformly stirring required amounts of a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, and uniformly stirring required amounts of a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase; secondly, adding an oil phase into the water phase under the condition of stirring to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and the whole egg powder of the pigeon eggs into the mixed emulsion, and uniformly mixing to obtain the composition for preventing and treating the skin photodamage.
2. The composition for preventing and treating photodamage to skin according to claim 1, wherein the fat-soluble thickener is one of stearyl alcohol, liquid paraffin; or/and the water-soluble thickening agent is carbomer; or/and the fat-soluble humectant is more than one of ceramide and glyceryl monostearate polyoxyethylene.
3. The composition for preventing and treating photodamage to skin according to claim 1 or 2, wherein the water-soluble humectant is one or more of glycerin, sodium hyaluronate and tween-80; or/and the emulsifier is more than one of glyceryl monostearate, triethanolamine, stearic acid, glyceryl monostearate and span-60; or/and the emollient is more than one of isooctyl palmitate, white chinlon oil, polydimethylsiloxane, cetearyl alcohol and white vaseline.
4. The composition for preventing and treating photodamage to skin according to claim 1 or 2, wherein the preservative is one of butylparaben and methylparaben; or/and the pH regulator is aminomethyl propanol; or/and in the first step, the stirring time is 30min to 60min, and the stirring temperature is 45 ℃ to 80 ℃.
5. The composition for preventing and treating photodamage to skin according to claim 3, wherein the preservative is one of butyl paraben and methylparaben; or/and the pH regulator is aminomethyl propanol; or/and in the first step, the stirring time is 30min to 60min, and the stirring temperature is 45 ℃ to 80 ℃.
6. The composition for preventing and treating photo damage to skin according to claim 1, 2 or 5, wherein in the second step, the stirring time is 30min to 60min, and the stirring temperature is 30 ℃ to 60 ℃; or/and in the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
7. The composition for preventing and treating skin photodamage according to claim 3, wherein in the second step, the stirring time is 30 to 60min, and the stirring temperature is 30 to 60 ℃; or/and in the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
8. The composition for preventing and treating skin photodamage according to claim 4, wherein in the second step, the stirring time is 30 to 60min, and the stirring temperature is 30 to 60 ℃; or/and in the third step, the stirring time is 30min to 60min, and the stirring temperature is 40 ℃ to 55 ℃.
9. A method for preparing a composition for preventing and treating skin photodamage according to any one of claims 2 to 8, wherein the raw materials comprise, by weight, 6 to 12 parts of lavender total flavonoids, 2 to 4 parts of whole pigeon egg powder, 0.2 to 12.0 parts of fat-soluble thickener, 0 to 0.5 part of water-soluble thickener, 0 to 8.3 parts of fat-soluble humectant, 2 to 15 parts of water-soluble humectant, 0 to 19 parts of emulsifier, 2.0 to 17.5 parts of emollient, 0 to 0.8 part of preservative, 0 to 0.2 part of pH regulator and 50 to 92 parts of water, according to the following method:
step one, uniformly stirring required amounts of a water-soluble thickener, a water-soluble humectant, a preservative, a pH regulator and water to obtain a water phase, and uniformly stirring required amounts of a fat-soluble thickener, a fat-soluble humectant, an emulsifier and an emollient to obtain an oil phase; secondly, adding an oil phase into the water phase under the condition of stirring to obtain a mixed emulsion; and thirdly, adding the required amount of lavender total flavonoids and the whole egg powder of the pigeon eggs into the mixed emulsion, and uniformly mixing to obtain the composition for preventing and treating the skin photodamage.
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