CN114788527B - Iodic acid mixed solution disinfectant, preparation method and application thereof in pig house disinfection - Google Patents
Iodic acid mixed solution disinfectant, preparation method and application thereof in pig house disinfection Download PDFInfo
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- CN114788527B CN114788527B CN202210502311.2A CN202210502311A CN114788527B CN 114788527 B CN114788527 B CN 114788527B CN 202210502311 A CN202210502311 A CN 202210502311A CN 114788527 B CN114788527 B CN 114788527B
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 64
- QFWPJPIVLCBXFJ-UHFFFAOYSA-N glymidine Chemical compound N1=CC(OCCOC)=CN=C1NS(=O)(=O)C1=CC=CC=C1 QFWPJPIVLCBXFJ-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000011259 mixed solution Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 30
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 48
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 42
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 24
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 20
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract description 19
- -1 perfluoroalkyl sulfonamide Chemical class 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000002738 chelating agent Substances 0.000 claims abstract description 13
- 150000004671 saturated fatty acids Chemical class 0.000 claims abstract description 13
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 8
- 229940124530 sulfonamide Drugs 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 22
- 239000011630 iodine Substances 0.000 claims description 21
- 229910052740 iodine Inorganic materials 0.000 claims description 21
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 11
- FUVKFLJWBHVMHX-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide Chemical compound NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F FUVKFLJWBHVMHX-UHFFFAOYSA-N 0.000 claims description 6
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 6
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- RRRXPPIDPYTNJG-UHFFFAOYSA-N perfluorooctanesulfonamide Chemical compound NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RRRXPPIDPYTNJG-UHFFFAOYSA-N 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 4
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 claims description 4
- 239000005639 Lauric acid Substances 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- 235000003441 saturated fatty acids Nutrition 0.000 claims description 3
- 229940080236 sodium cetyl sulfate Drugs 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 2
- 229940071870 hydroiodic acid Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 239000002609 medium Substances 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 235000013675 iodine Nutrition 0.000 description 21
- 238000012360 testing method Methods 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 241000282898 Sus scrofa Species 0.000 description 7
- 244000144972 livestock Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 2
- 238000009313 farming Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 208000007407 African swine fever Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- ZVVHPYOYQRQSJH-UHFFFAOYSA-N [I].OC(=O)C1=CC=CC=C1O Chemical compound [I].OC(=O)C1=CC=CC=C1O ZVVHPYOYQRQSJH-UHFFFAOYSA-N 0.000 description 1
- BMSXLMLHAVJLRR-UHFFFAOYSA-N [I].OC(=O)CC(O)(CC(O)=O)C(O)=O Chemical compound [I].OC(=O)CC(O)(CC(O)=O)C(O)=O BMSXLMLHAVJLRR-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 229910000450 iodine oxide Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- AFSVSXMRDKPOEW-UHFFFAOYSA-N oxidoiodine(.) Chemical compound I[O] AFSVSXMRDKPOEW-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Abstract
The invention discloses an iodic acid mixed solution disinfectant, a preparation method and application thereof in pig house disinfection, wherein the disinfectant comprises the following raw materials: phosphoric acid, sulfuric acid, iodide, iodine, chelating agent, medium and short chain saturated fatty acid and water, wherein the chelating agent comprises N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate. The disinfectant disclosed by the invention has the characteristics of good disinfection effect, stable product quality, small environmental pollution, low production cost and the like, and the disinfection effect reaches and exceeds the level of imported brand products, so that the disinfectant is suitable for mass production.
Description
[ field of technology ]
The invention belongs to the technical field of disinfectant preparation, and particularly relates to a preparation method of an iodic acid mixed solution disinfectant with phosphoric acid, sulfuric acid, iodide, iodine, a chelating agent and medium-short chain saturated fatty acid as components and application of the iodic acid mixed solution disinfectant in disinfection of pig houses.
[ background Art ]
In order to reduce huge economic loss caused by diseases, and simultaneously continuously improve the overall level of the pig farming industry in China, and effectively and fully prevent and control the occurrence and transmission of diseases in the farming process, the disinfectant special for preventing and controlling the foot-and-mouth disease of pigs and African swine fever diseases is prepared.
The disinfection work is one of the important links for preventing and controlling the occurrence of various epidemic diseases, and is a main means for cutting off the transmission of pathogenic microorganisms. The disinfectant can kill various pathogens, reduce environmental pollution, cut off transmission paths, and play an important role in preventing occurrence and spread of diseases. Along with the gradual improvement of the recognition of the importance of disinfection, the disinfection drugs are increasingly used in practical work.
The disinfectant occupies a large proportion in various medicines for the breeding industry, and occupies more than one third of the total yield.
The disinfectant used for pig farm disinfection is various, and can be classified into aldehydes, halogens, iodines, alkalines, peroxidation, phenols, quaternary ammonium salts and alcohols according to the components, and the disinfection effects of the disinfectants are different. The selection of a reasonably effective disinfectant becomes one of the key factors in disinfection success or failure. The iodine-containing disinfectant is an actual non-toxic disinfectant, has no irritation to skin and mucous membrane, has special iodine odor, is easy to volatilize, and has quick action time and good virus killing effect.
The iodine acid solution is a strong acid disinfectant with very good disinfection effect in iodine-containing disinfectants, the main component of the strong acid disinfectant is iodine, and the strong acid disinfectant is an aqueous solution prepared from iodine, iodide, sulfuric acid, phosphoric acid and other inorganic matters and organic matters according to a certain proportion, and is dark brown liquid.
Wang Yu (CN 103222476A) discloses a phosphoric acid solution disinfectant for aquaculture, which is an aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid, polyoxyethylene nonylphenol ether, polyvinylpyrrolidone and the like, and is specially used for killing pathogens in water bodies and on the surfaces of cultured animals. Zhang Weiyuan (CN 102626105A) discloses an iodic acid disinfectant which is also an aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid, absolute ethyl alcohol, sodium dodecyl sulfate and the like, and is specially used for disinfecting surgical operation sites, livestock houses, livestock product processing places and appliances. Xu Jiqing (CN 106937646A) discloses a method for preparing an iodic acid mixed solution, which comprises the steps of preparing a tertiary amine compound of phosphoric acid, sulfuric acid, iodine, iodide, hydrogen peroxide and a cyclic group as a stabilizer and octanol polyoxyethylene ether as an emulsifier. The stabilizer is added in the preparation reaction process, so that the stability of the prepared iodic acid mixed solution can be effectively improved. Liu Qijun (CN 106376560A) discloses a charged foam type iodic acid disinfectant which is also an aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid and absolute ethyl alcohol, wherein betaine is used as a foaming agent, and coconut fatty acid diethanolamide and nonylphenol polyoxyethylene ether are used as surfactants. Chinese patent CN105557752a discloses a salicylic acid-iodine foam disinfectant and a preparation method thereof, and chinese patent CN105660622a discloses a citric acid-iodine foam disinfectant and a preparation method thereof, wherein the foam disinfectant is prepared from iodine, potassium iodide, a foaming agent, a foam stabilizer, an organic acid and a solvent.
Although numerous iodic acid solution disinfectants are developed in China, the defect of unstable product quality exists, and the main disadvantage is that the existing preparation process of the iodic acid solution disinfectants can not completely stabilize iodine in a prepared system, so that iodine is extremely volatile under the condition of strong acid, and the content of effective iodine is reduced.
[ invention ]
The invention provides an iodic acid mixed solution disinfectant, a preparation method and application thereof in pig house disinfection, and aims to solve the problems of unstable disinfection effect and the like in the existing iodic acid solution disinfectant.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
an iodic acid mixed solution disinfectant comprises the following raw materials: phosphoric acid, sulfuric acid, iodide, iodine, chelating agent, medium and short chain saturated fatty acid and water, wherein the chelating agent comprises N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate.
Further, the iodic acid mixed solution disinfectant comprises the following raw materials in parts by weight: 10-20% of phosphoric acid, 5-10% of sulfuric acid, 5-10% of iodide, 2-3% of iodine, 20-25% of chelating agent, 1-5% of medium and short chain saturated fatty acid and the balance of water.
Further, the mass fraction of the phosphoric acid is 95% -98%.
Further, the iodide comprises one or more of potassium iodide and hydroiodic acid.
Further, the mass ratio of the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide to the higher fatty alcohol sulfate is (5-20) to (5-20).
Further, the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide includes one or more of N- [3- (dimethylamino) propyl ] perfluorobutyl sulfonamide, N- [3- (dimethylamino) propyl ] perfluorooctyl sulfonamide, N- [3- (diethylamino) propyl ] perfluorobutyl sulfonamide, and N- [3- (diethylamino) propyl ] perfluorooctyl sulfonamide.
Further, the higher fatty alcohol sulfate comprises one or more of sodium laurylsulfate, sodium stearyl sulfate and sodium cetyl sulfate.
Further, the medium and short chain saturated fatty acid comprises one or more of caproic acid, sorbic acid, caprylic acid, capric acid, undecanoic acid and lauric acid.
The invention also provides a preparation method of the iodic acid mixed solution disinfectant, which comprises the following steps: sequentially adding iodine and iodide to react, adding a mixed chelating agent, reacting for a certain time, adding medium and short chain saturated fatty acid, stirring uniformly, adding sulfuric acid and phosphoric acid again, and adding the balance of water after complete uniformity to obtain the iodic acid mixed solution disinfectant.
Compared with the prior art, the invention has the following technical advantages:
(1) The invention relates to a mixed solution of iodic acid as a veterinary disinfectant suitable for disinfecting a raw pigsty, which is characterized by comprising iodine, iodide, a mixed chelating agent, medium and short chain saturated fatty acids, phosphoric acid with the concentration of 98% by weight and sulfuric acid with the concentration of 85% by weight, wherein the phosphoric acid is 10% -20%, the sulfuric acid is 5% -10%, the iodide is 5% -10%, the iodine is 2% -3%, the chelating agent is 20% -25%, the medium and short chain saturated fatty acids are 1% -5%, and the balance is water. The invention can prevent iodine from volatilizing while increasing the solubility of iodine, and greatly improves the content of effective iodine.
(2) The invention relates to a preparation method of a mixed solution of livestock disinfectant iodic acid, which is suitable for pig house disinfection, wherein iodine and iodide are sequentially added to react to generate normal-valence iodides (I) 2 ，IO - ，IO - 2 ，IO - 3 ，IO - 4 ) Adding a mixed chelating agent, reacting for a certain time, adding medium and short chain saturated fatty acid, stirring uniformly, and adding sulfuric acid and phosphoric acid again. After the preparation method is completely uniform, the balance of water is added, the preparation method has low requirements on equipment, the process operation is simple, the quality stability of the obtained product is good, and when the disinfection test is carried out by taking escherichia coli and staphylococcus aureus as examples, the disinfection effect is better than that of the foreign brand-30 disinfectant.
(3) In order to overcome the adverse factors and prepare the disinfectant with higher disinfection effect, the invention firstly prepares atomic iodine into normal-valence iodine oxide (I 2 ，IO - ， IO - 2 ，IO - 3 ，IO - 4 ). This is because the higher the content of the oxyiodide, the stronger the sterilizing ability, and the killing of infectious diseases and the likeThe higher the killing power. The oxyiodide is reacted with N- [3- (dialkylamino) propyl ] in the presence of a strong acid]The perfluoroalkyl sulfonamide and the higher fatty alcohol sulfate react in a chelation reaction to generate chelate iodine, and then the intermediate and short chain saturated fatty acid, sulfuric acid and phosphoric acid are added to prepare the iodic acid disinfectant. The obtained product has the disinfection effect reaching and exceeding the level of imported brand products through detection, and the preparation technology has obvious progress.
(4) The invention provides an iodic acid mixed solution disinfectant, a preparation method and application thereof in the disinfection of pig houses, which can solve the problems of unstable disinfection effect and the like in the existing iodic acid solution disinfectant.
[ detailed description ] of the invention
For a better understanding of the present invention, reference is made to the following examples, which are included within the scope of the present invention, but are not intended to limit the scope of the present invention.
The present invention will be described in detail by way of specific examples, which are not intended to limit the scope of the present invention in any way.
Example 1
A preparation method of iodic acid mixed solution disinfectant comprises the following steps:
respectively weighing 3g of iodine, 5g of potassium iodide, 5g of water and 5g of phosphoric acid, fully mixing for 30min, and completely dissolving the iodine in the potassium iodide. Then 20g N- [3- (dimethylamino) propyl ] perfluorobutyl sulfonamide and 5g sodium lauryl sulfate were added and stirred for 3 hours. Then 2g of sorbic acid was added under stirring. Then, 10g of sulfuric acid was added while stirring, and then 5g of phosphoric acid was added again. After being completely uniform, 40g of water is added to obtain 100g of mixed solution of livestock disinfectant iodic acid which is suitable for disinfecting the pigsty. The mass fraction of the phosphoric acid is 98%; the mass fraction of the sulfuric acid is 85%.
Example 2
A preparation method of iodic acid mixed solution disinfectant comprises the following steps:
2.5g of iodine, 7g of potassium iodide, 5g of water and 5g of sulfuric acid are respectively weighed and fully mixed for 30min, and the iodine is completely dissolved in the potassium iodide. 10g N- [3- (dimethylamino) propyl ] perfluorooctyl sulfonamide and 15g sodium stearyl sulfate were then added and stirred for 3 hours. Then 1g of octanoic acid was added under stirring. 2.5g of sulfuric acid was added while stirring, and 15g of phosphoric acid was added again. After being completely uniform, the mixed solution is added with 37g of water to obtain 100g of mixed solution of livestock disinfectant iodic acid which is suitable for the disinfection of the pigsty. The mass fraction of the phosphoric acid is 98%; the mass fraction of the sulfuric acid is 85%.
Example 3
A preparation method of iodic acid mixed solution disinfectant comprises the following steps:
3g of iodine, 5g of hydriodic acid, 5g of water and 10g of phosphoric acid are respectively weighed and fully mixed for 30min, and the iodine is completely dissolved in the hydriodic acid. 15g N- [3- (diethylamino) propyl ] perfluorobutyl sulfonamide and 10g sodium cetyl sulfate were then added and stirred for 3 hours. 3g of undecanoic acid were then added with stirring. Then, 5g of sulfuric acid was added while stirring, and then 20g of phosphoric acid was added again. After being completely uniform, the mixed solution is added with 24g of water to obtain 100g of mixed solution of livestock disinfectant iodic acid which is suitable for the disinfection of the pigsty. The mass fraction of the phosphoric acid is 98%; the mass fraction of the sulfuric acid is 85%.
Example 4
A preparation method of iodic acid mixed solution disinfectant comprises the following steps:
2g of iodine, 10g of hydriodic acid, 5g of water and 10g of sulfuric acid are respectively weighed and fully mixed for 30min, and the iodine is completely dissolved in the hydriodic acid. 5g N- [3- (diethylamino) propyl ] perfluorooctyl sulfonamide and 20g sodium stearyl sulfate were then added and stirred for 3 hours. 5g of lauric acid were then added with stirring. Then 10g of phosphoric acid was added while stirring. After being completely uniform, the mixed solution is added with 33g of water to obtain 100g of mixed solution of livestock disinfectant iodic acid which is suitable for the disinfection of the pigsty. The mass fraction of the phosphoric acid is 98%; the mass fraction of the sulfuric acid is 85%.
1. Product stability test
The stability of the product of the present invention was evaluated according to the accelerated test conditions specified in the "animal drug stability test technical Specification", the products prepared in examples 1 to 4 were analyzed for iodine and total acid amount (see Table 1, table 2), and a total of 6 months, 6 batches of tests were performed, with test time of each: month 9 of 2021, month 9 of 2021 9/2021, 10/2021 and 11/2021.
TABLE 1 determination of available iodine (%, g/g)
| Group of experiments | 20210609 | 20210709 | 20210809 | 20210909 | 20211009 | 20211109 |
| Example 1 | 2.78 | 2.78 | 2.79 | 2.78 | 2.78 | 2.79 |
| Example 2 | 2.75 | 2.76 | 2.75 | 2.75 | 2.75 | 2.76 |
| Example 3 | 2.77 | 2.77 | 2.78 | 2.78 | 2.78 | 2.77 |
| Example 4 | 2.75 | 2.76 | 2.76 | 2.75 | 2.75 | 2.75 |
TABLE 2 determination of total acid content (%, g/g)
| Group of experiments | 20210609 | 20210709 | 20210809 | 20210909 | 20211009 | 20211109 |
| Example 1 | 28.9 | 28.8 | 28.8 | 28.9 | 28.9 | 28.8 |
| Example 2 | 28.8 | 28.8 | 28.8 | 28.8 | 28.8 | 28.8 |
| Example 3 | 29.2 | 29.2 | 29.1 | 29.1 | 29.2 | 29.2 |
| Example 4 | 28.7 | 28.7 | 28.6 | 28.6 | 28.7 | 28.8 |
The results in tables 1 and 2 show that the product stability is good, and the technical problem of poor stability of the existing disinfectant product can be solved.
2. Test of the bacterial killing effect of the product
The method utilizes the foreign import products containing iodine which are accepted in the current production market and have the best disinfection effect on the pigsty (Lei Yunfeng, the ninth university of south Beijing agriculture, livestock veterinary academy of years, 2015) of the hundred-30 disinfectant was compared with the product of the present invention.
(one) Minimum Inhibition (MIC) assay
Referring to the 'disinfection technical Specification 2008 edition', a test tube dilution method is adopted to dilute the disinfectant into test solutions with different concentrations. Diluting the concentration of the bacterial suspension to 10 5-6 CUF/mL, disinfectant with different concentrations of 2.5mL, bacterial suspension of 2.5mL, and standing for 30min at room temperature after the disinfectant and the bacterial suspension are mixed uniformly. 20 mu L of the mixture was pipetted into the nutrient broth and incubated for 24h at 37 ℃. The control group (control) is Baisheng-30 disinfectant. The test was repeated five times and the results thereof are summarized in the following table.
From the above table, it can be seen that: the MIC of the disinfectant product and the control product of the invention to escherichia coli and staphylococcus aureus is 0.3%, and the inhibition capability is the same.
(II) minimum Sterilization concentration (MBC) determination
Referring to the 'disinfection technical Specification 2008 edition', a transparent and clear test tube observed by naked eyes is inoculated on a nutrient agar plate and cultured in a constant temperature box at 37 ℃ for 24 hours, and the result is recorded, so that the minimum sterilizing concentration (MBC) of the medicine is the most of no bacterial growth on the nutrient agar plate. The test was repeated five times and the results thereof are summarized in the following table.
From the above table, it can be seen that: the disinfectant product and the reference products of the invention are respectively 0.5 percent of MBC, the reference products are respectively 0.5 percent of MBC of the escherichia coli and 0.8 percent of MBC of the staphylococcus aureus, thus the disinfectant product has stronger sterilization capability to the staphylococcus aureus than the reference products, and the obvious progress of the technology for preparing the disinfectant product is highlighted.
It should not be considered that the implementation of the invention is limited to these descriptions, but that it is possible for a person skilled in the art to which the invention pertains to make several simple deductions or substitutions without departing from the idea of the invention, all of which should be considered as belonging to the scope of protection of the invention as defined in the appended claims.
Claims (5)
1. The iodic acid mixed solution disinfectant is characterized by comprising the following raw materials in parts by weight: 10-20% of phosphoric acid, 5-10% of sulfuric acid, 5-10% of iodide, 2-3% of iodine, 20-25% of chelating agent, 1-5% of medium and short chain saturated fatty acid and the balance of water, wherein the chelating agent comprises N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate, and the mass ratio of the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide to the higher fatty alcohol sulfate is (5-20): (5-20);
the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide comprises one or more of N- [3- (dimethylamino) propyl ] perfluorobutyl sulfonamide, N- [3- (dimethylamino) propyl ] perfluorooctyl sulfonamide, N- [3- (diethylamino) propyl ] perfluorobutyl sulfonamide and N- [3- (diethylamino) propyl ] perfluorooctyl sulfonamide;
the higher fatty alcohol sulfate comprises one or more of sodium laurylsulfate, sodium stearyl sulfate and sodium cetyl sulfate;
the preparation method of the iodic acid mixed solution disinfectant comprises the following steps: sequentially adding iodine and iodide to react, adding a mixed chelating agent, reacting for a certain time, adding medium and short chain saturated fatty acid, stirring uniformly, adding sulfuric acid and phosphoric acid again, and adding the balance of water after complete uniformity to obtain the iodic acid mixed solution disinfectant.
2. The iodic acid mixed solution disinfectant according to claim 1, wherein the mass fraction of phosphoric acid is 95% -98%.
3. The mixed iodic acid solution disinfectant according to claim 1, wherein said iodide comprises one or more of potassium iodide and hydroiodic acid.
4. The iodic acid mixed solution disinfectant according to claim 1, wherein said medium short chain saturated fatty acids comprise one or more of caproic acid, sorbic acid, caprylic acid, capric acid, undecanoic acid, lauric acid.
5. Use of the iodic acid mixed solution disinfectant according to any of claims 1-4 for disinfecting a pig house.
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