CN114788527A - Iodic acid mixed solution disinfectant, preparation method and application thereof in live pig breeding house disinfection - Google Patents
Iodic acid mixed solution disinfectant, preparation method and application thereof in live pig breeding house disinfection Download PDFInfo
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- CN114788527A CN114788527A CN202210502311.2A CN202210502311A CN114788527A CN 114788527 A CN114788527 A CN 114788527A CN 202210502311 A CN202210502311 A CN 202210502311A CN 114788527 A CN114788527 A CN 114788527A
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- acid
- disinfectant
- iodic
- propyl
- iodine
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 71
- QFWPJPIVLCBXFJ-UHFFFAOYSA-N glymidine Chemical compound N1=CC(OCCOC)=CN=C1NS(=O)(=O)C1=CC=CC=C1 QFWPJPIVLCBXFJ-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000011259 mixed solution Substances 0.000 title claims abstract description 26
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 22
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 238000009395 breeding Methods 0.000 title description 6
- 230000001488 breeding effect Effects 0.000 title description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 60
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 52
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 30
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract description 22
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 21
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- -1 perfluoroalkyl sulfonamide Chemical class 0.000 claims abstract description 17
- 239000002738 chelating agent Substances 0.000 claims abstract description 14
- 150000004671 saturated fatty acids Chemical class 0.000 claims abstract description 14
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 8
- 229940124530 sulfonamide Drugs 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 5
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 30
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 19
- 229910052740 iodine Inorganic materials 0.000 claims description 19
- 239000011630 iodine Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 7
- FUVKFLJWBHVMHX-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide Chemical compound NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F FUVKFLJWBHVMHX-UHFFFAOYSA-N 0.000 claims description 6
- 230000000249 desinfective effect Effects 0.000 claims description 6
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 6
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 6
- 229940071870 hydroiodic acid Drugs 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- RRRXPPIDPYTNJG-UHFFFAOYSA-N perfluorooctanesulfonamide Chemical compound NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RRRXPPIDPYTNJG-UHFFFAOYSA-N 0.000 claims description 6
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 claims description 4
- 239000005639 Lauric acid Substances 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 229960002446 octanoic acid Drugs 0.000 claims description 3
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims description 2
- 229940080236 sodium cetyl sulfate Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 description 13
- 238000012360 testing method Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910000450 iodine oxide Inorganic materials 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- AFSVSXMRDKPOEW-UHFFFAOYSA-N oxidoiodine(.) Chemical compound I[O] AFSVSXMRDKPOEW-UHFFFAOYSA-N 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 208000007407 African swine fever Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- ZVVHPYOYQRQSJH-UHFFFAOYSA-N [I].OC(=O)C1=CC=CC=C1O Chemical compound [I].OC(=O)C1=CC=CC=C1O ZVVHPYOYQRQSJH-UHFFFAOYSA-N 0.000 description 1
- BMSXLMLHAVJLRR-UHFFFAOYSA-N [I].OC(=O)CC(O)(CC(O)=O)C(O)=O Chemical compound [I].OC(=O)CC(O)(CC(O)=O)C(O)=O BMSXLMLHAVJLRR-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 235000013613 poultry product Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an iodic acid mixed solution disinfectant, a preparation method and application thereof in live pig colony house disinfection, wherein the disinfectant comprises the following raw materials: phosphoric acid, sulfuric acid, iodide, iodine, chelating agents, middle-short chain saturated fatty acid and water, wherein the chelating agents comprise N- [3- (dialkyl amino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate ester salt. The disinfectant of the invention has the characteristics of good disinfection effect, stable product quality, small environmental pollution, low production cost and the like, the disinfection effect of the disinfectant reaches and exceeds the level of imported brand products, and the disinfectant is suitable for large-scale production.
Description
[ technical field ] A method for producing a semiconductor device
The invention belongs to the technical field of disinfectant preparation, and particularly relates to a preparation method of an iodic acid mixed solution disinfectant using phosphoric acid, sulfuric acid, iodide, iodine, a chelating agent and medium-short chain saturated fatty acid as components and application of the disinfectant in live pig breeding house disinfection.
[ background ] A method for producing a semiconductor device
In order to reduce the huge economic loss caused by diseases, simultaneously continuously improve the overall level of the domestic pig breeding industry and effectively and fully prevent and control the occurrence and the spread of the diseases in the breeding process, the invention prepares the special disinfectant for preventing and controlling the foot-and-mouth disease of the live pigs and the African swine fever diseases.
The disinfection work is one of the important links for preventing and controlling various epidemic diseases and is a main means for cutting off the propagation of pathogenic microorganisms. The disinfectant can kill various pathogens, reduce environmental pollution, cut off transmission path, and play an important role in preventing the occurrence and spread of diseases. Along with the gradual improvement of the understanding of people on the importance of disinfection, the use of disinfection medicines is more and more extensive in practical work.
The disinfectant accounts for a large proportion of various breeding medicines, and accounts for more than one third of the total yield.
The disinfectant used for disinfecting pig farms is various in types, and can be classified into aldehydes, halogens, iodides, alkalies, peroxides, phenols, quaternary ammonium salts and alcohols according to different components, and the disinfecting effects of the disinfectants are different. The selection of a reasonably effective disinfectant becomes one of the key factors for the success or failure of disinfection. The iodine-containing disinfectant is a practical non-toxic disinfectant, has no irritation to skin and mucous membrane, has special iodine odor, is volatile, has quick action time and good virus killing effect.
The iodic acid solution is a strong acid disinfectant with excellent disinfection effect in iodine-containing disinfectants, the main component of the strong acid disinfectant is iodine, and the strong acid disinfectant is a dark brown liquid which is a water solution prepared from inorganic substances such as iodine, iodide, sulfuric acid, phosphoric acid and the like and organic substances according to a certain proportion.
Wangyu et al (CN103222476A) invented a phosphoric acid solution disinfectant for sterilizing aquaculture, which uses aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid, polyoxyethylene nonyl phenyl ether and polyvinylpyrrolidone, etc., and is specially used for killing pathogens in water and on the surfaces of cultured animals. Zhang Weiyuan, et al (CN102626105A) invented an iodic acid disinfectant, which is an aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid, anhydrous ethanol, sodium dodecyl sulfate, etc., and is specially used for disinfection of surgical operation parts, livestock and poultry houses, livestock and poultry product processing places and appliances. Xuqiqing, et al (CN106937646A) invented the preparation method of mixed solution of iodic acid, which is prepared from phosphoric acid, sulfuric acid, iodine, iodide, hydrogen peroxide, cyclic group tertiary amine compound as stabilizer and octanol polyoxyethylene ether as emulsifier. The stabilizer is added in the preparation reaction process, so that the stability of the prepared iodic acid mixed solution can be effectively improved. Liu Ji et al (CN106376560A) invented a charged foam iodic acid disinfectant, which is also an aqueous solution prepared from iodine, potassium iodide, sulfuric acid, phosphoric acid, anhydrous ethanol, betaine as a foaming agent and coconut oil fatty acid diethanolamide and nonylphenol polyoxyethylene ether as surfactants. Chinese patent CN105557752A discloses a salicylic acid iodine foam type disinfectant and a preparation method thereof, and Chinese patent CN105660622A discloses a citric acid iodine foam type disinfectant and a preparation method thereof, wherein the foam type disinfectant is prepared from iodine, potassium iodide, a foaming agent, a foam stabilizer, an organic acid and a solvent.
Although a plurality of iodic acid solution disinfectants are developed in China, the disinfectant has the defect of unstable product quality, and the preparation process of the current iodic acid solution disinfectants is mainly characterized in that iodine is not completely stabilized in a prepared system, so that the iodine is extremely volatile under the condition of strong acid, and the content of effective iodine is reduced.
[ summary of the invention ]
The invention provides an iodic acid mixed solution disinfectant, a preparation method and application thereof in live pig colony house disinfection, and aims to solve the problems of unstable disinfection effect and the like in the conventional iodic acid mixed solution disinfectant.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
an iodic acid mixed solution disinfectant comprises the following raw materials: phosphoric acid, sulfuric acid, iodide, iodine, chelating agents, middle and short chain saturated fatty acids and water, wherein the chelating agents comprise N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate.
Further, the iodic acid mixed solution disinfectant comprises the following raw materials in parts by weight: 10-20% of phosphoric acid, 5-10% of sulfuric acid, 5-10% of iodide, 2-3% of iodine, 20-25% of chelating agent, 1-5% of medium-short chain saturated fatty acid and the balance of water.
Further, the mass fraction of the phosphoric acid is 95-98%.
Further, the iodide comprises one or more of potassium iodide and hydroiodic acid.
Furthermore, the mass ratio of the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide to the higher fatty alcohol sulfate is (5-20) to (5-20).
Further, the N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide comprises one or more of N- [3- (dimethylamino) propyl ] perfluorobutyl sulfonamide, N- [3- (dimethylamino) propyl ] perfluorooctyl sulfonamide, N- [3- (diethylamino) propyl ] perfluorobutyl sulfonamide and N- [3- (diethylamino) propyl ] perfluorooctyl sulfonamide.
Further, the higher fatty alcohol sulfate salt comprises one or more of sodium lauryl sulfate, sodium stearyl sulfate and sodium cetyl sulfate.
Further, the medium-short chain saturated fatty acid comprises one or more of caproic acid, sorbic acid, caprylic acid, capric acid, undecanoic acid and lauric acid.
The invention also provides a preparation method of the iodic acid mixed solution disinfectant, which comprises the following steps: and sequentially adding the iodine and the iodide to react, adding the mixed chelating agent, reacting for a certain time, adding the medium-short chain saturated fatty acid, uniformly stirring, adding the sulfuric acid and the phosphoric acid again, and adding the balance of water after completely and uniformly stirring to prepare the iodic acid mixed solution disinfectant.
Compared with the prior art, the invention has the following technical advantages:
(1) the invention relates to a veterinary disinfectant iodic acid mixed solution suitable for disinfecting live pig houses, which is characterized by comprising iodine, iodide, a mixed chelating agent, medium-short chain saturated fatty acid, phosphoric acid with the concentration of 98% by weight and sulfuric acid with the concentration of 85% by weight, wherein 10% -20% of phosphoric acid, 5% -10% of sulfuric acid, 5% -10% of iodide, 2% -3% of iodine, 20% -25% of chelating agent, 1% -5% of medium-short chain saturated fatty acid and the balance of water. The invention can avoid the volatilization of iodine while increasing the solubility of iodine, thereby greatly improving the content of effective iodine.
(2) The preparation method of the mixed solution of the veterinary disinfectant iodic acid suitable for sterilizing live pig houses comprises the step of sequentially adding the iodine and the iodide to react to generate the water-soluble iodine oxide (I) with positive valence 2 ，IO - ，IO - 2 ，IO - 3 ，IO - 4 ) Then adding mixed chelating agent, reacting for a certain time, adding medium-short chain saturated fatty acid, stirring uniformly, and adding sulfuric acid and phosphoric acid again. After the mixture is completely uniform, the rest of water is added, the preparation method has low requirement on equipment, the process operation is simple, the obtained product has good quality stability, and the disinfection effect is superior to that of the foreign famous brand Baisheng-30 disinfectant when disinfection tests are carried out by taking escherichia coli and staphylococcus aureus as examples.
(3) The invention aims to overcome the above disadvantages and prepareThe disinfectant with higher disinfecting effect is prepared by preparing iodine oxide (I) with positive valence from iodine atom 2 ，IO - ， IO - 2 ，IO - 3 ，IO - 4 ). This is because the higher the content of the iodine oxide, the higher the sterilizing power, and the higher the sterilizing power against infectious diseases and the like. Further reacting the oxidized iodide with N- [3- (dialkylamino) propyl group in the presence of a strong acid]The perfluoroalkyl sulfonamide and the higher fatty alcohol sulfate have chelation reaction to generate chelate iodine, and then the middle and short chain saturated fatty acid, the sulfuric acid and the phosphoric acid are added to prepare the iodic acid disinfectant. The obtained product is detected to have a disinfection effect reaching and exceeding the level of imported brand products, and the preparation technology has obvious progress.
(4) The invention provides an iodic acid mixed solution disinfectant, a preparation method and application thereof in disinfection of live pig houses, which can solve the problems of unstable disinfection effect and the like in the existing iodic acid solution disinfectant.
[ detailed description ] A
In order to facilitate a better understanding of the invention, the following examples are given to illustrate, but not to limit the scope of the invention.
The present invention is illustrated in detail below by means of specific examples, which do not in any way limit the scope of protection of the invention.
Example 1
A method for preparing an iodic acid mixed solution disinfectant comprises the following steps:
3g of iodine, 5g of potassium iodide, 5g of water and 5g of phosphoric acid are weighed respectively and mixed fully for 30min, and the iodine is completely dissolved in the potassium iodide. Then 20g N- [3- (dimethylamino) propyl ] perfluorobutanesulfonamide and 5g sodium lauryl sulfate were added and stirred for 3 h. Then, 2g of sorbic acid was added while stirring. Then, 10g of sulfuric acid was added thereto under stirring, and 5g of phosphoric acid was added again. After the mixture is completely uniform, 40g of water is added to obtain 100g of mixed solution of the veterinary disinfectant iodic acid which is suitable for disinfecting the live pig housing. The mass fraction of the phosphoric acid is 98 percent; the mass fraction of the sulfuric acid is 85%.
Example 2
A method for preparing an iodic acid mixed solution disinfectant comprises the following steps:
2.5g of iodine, 7g of potassium iodide, 5g of water and 5g of sulfuric acid are respectively weighed and fully mixed for 30min, and the iodine is completely dissolved in the potassium iodide. Then, 10g N- [3- (dimethylamino) propyl ] perfluorooctylsulfonamide and 15g sodium stearyl sulfate were added, and the mixture was stirred for 3 hours. Then, 1g of octanoic acid was added under stirring. Then, 2.5g of sulfuric acid was added thereto under stirring, and 15g of phosphoric acid was added again. After the mixture is completely uniform, 37g of water is added to obtain 100g of mixed solution of disinfectant iodic acid for livestock suitable for sterilizing live pig houses. The mass fraction of the phosphoric acid is 98 percent; the mass fraction of the sulfuric acid is 85%.
Example 3
A method for preparing an iodic acid mixed solution disinfectant comprises the following steps:
3g of iodine, 5g of hydroiodic acid, 5g of water and 10g of phosphoric acid are respectively weighed and fully mixed for 30min, and the iodine is completely dissolved in the hydroiodic acid. Then 15g N- [3- (diethylamino) propyl ] perfluorobutanesulfonamide and 10g sodium cetyl sulphate were added and the mixture was stirred for 3 h. Then 3g of undecanoic acid was added with stirring. Further, 5g of sulfuric acid was added under stirring, and 20g of phosphoric acid was added again. After the mixture is completely uniform, 24g of water is added, and 100g of mixed solution of disinfectant iodic acid for livestock, which is suitable for sterilizing live pig houses, is obtained. The mass fraction of the phosphoric acid is 98 percent; the mass fraction of the sulfuric acid is 85%.
Example 4
A method for preparing an iodic acid mixed solution disinfectant comprises the following steps:
2g of iodine, 10g of hydroiodic acid, 5g of water and 10g of sulfuric acid are weighed respectively and mixed fully for 30min, and the iodine is completely dissolved in the hydroiodic acid. Then 5g N- [3- (diethylamino) propyl ] perfluorooctylsulfonamide and 20g sodium stearyl sulfate were added, and the mixture was stirred for 3 hours. Then 5g of lauric acid was added under stirring. 10g of phosphoric acid was further added thereto while stirring. After the mixture is completely uniform, 33g of water is added to obtain 100g of mixed solution of disinfectant iodic acid for livestock, which is suitable for sterilizing live pig houses. The mass fraction of the phosphoric acid is 98 percent; the mass fraction of the sulfuric acid is 85%.
Product stability test
The stability of the product of the present invention and the veterinary drug import quality standards were evaluated according to the accelerated test conditions specified in the veterinary drug stability test technical Specification, and the iodine and total acid content of the products prepared in examples 1 to 4 were analyzed (see tables 1 and 2), and 6-lot tests were performed for 6 months in total for 6 test periods, respectively: 9 days 6 and 9 months in 2021, 9 days 7 and 9 months in 2021, 9 days 9 and 9 months in 2021, 9 days 10 and 9 months in 2021, and 9 days 11 and 9 months in 2021.
TABLE 1 determination of available iodine (%, g/g)
| Experimental groups | 20210609 | 20210709 | 20210809 | 20210909 | 20211009 | 20211109 |
| Example 1 | 2.78 | 2.78 | 2.79 | 2.78 | 2.78 | 2.79 |
| Example 2 | 2.75 | 2.76 | 2.75 | 2.75 | 2.75 | 2.76 |
| Example 3 | 2.77 | 2.77 | 2.78 | 2.78 | 2.78 | 2.77 |
| Example 4 | 2.75 | 2.76 | 2.76 | 2.75 | 2.75 | 2.75 |
TABLE 2 determination of the Total acid amount (%, g/g)
| Experimental groups | 20210609 | 20210709 | 20210809 | 20210909 | 20211009 | 20211109 |
| Example 1 | 28.9 | 28.8 | 28.8 | 28.9 | 28.9 | 28.8 |
| Example 2 | 28.8 | 28.8 | 28.8 | 28.8 | 28.8 | 28.8 |
| Example 3 | 29.2 | 29.2 | 29.1 | 29.1 | 29.2 | 29.2 |
| Example 4 | 28.7 | 28.7 | 28.6 | 28.6 | 28.7 | 28.8 |
The results in tables 1 and 2 show that the product has good stability and can solve the technical problem of poor stability of the existing disinfectant product.
Secondly, the product is tested for the effect of killing bacteria
Compared with the product of the invention, the Baisheng-30 disinfectant which is recognized in the current production market and contains iodine foreign imported products (Leiyun Feng, the collection of the academic annual meeting of the ninth Nanjing agriculture university animal husbandry and veterinarian in 2015) with the best disinfection effect on the live pig colony house is utilized.
(ii) Minimum Inhibition (MIC) assay
Referring to 2008 edition of disinfection technical Specification, a test tube dilution method is adopted to dilute the disinfectant into test solutions with different concentrations. Diluting the bacterial suspension to 10 5-6 CUF/mL, 2.5mL of disinfectant with different concentrations and 2.5mL of bacterial suspension, and standing for 30min at room temperature after uniformly mixing the disinfectant and the bacterial suspension. mu.L of the mixture was aspirated and inoculated into nutrient broth and incubated in an incubator at 37 ℃ for 24 hours. Baisheng-30 disinfectant was used as control (control). The test was repeated five times, and the results are summarized in the following table.
From the above table, it can be seen that: the MIC of the disinfectant product and the MIC of the reference substance of the invention to escherichia coli and staphylococcus aureus are both 0.3 percent, and the inhibition capacities are the same.
(II) Minimum Bactericidal Concentration (MBC) determination
According to 2008 edition of disinfection technical specification, transparent and clear test tubes observed by eyes are inoculated on nutrient agar plates and cultured in a thermostat at 37 ℃ for 24 hours, and the result is recorded, wherein the Minimum Bactericidal Concentration (MBC) of the medicine is the minimum without bacterial growth on the nutrient agar plates. The test was repeated five times, and the results are summarized in the following table.
From the above table, it can be seen that: the MBC of the disinfectant product and the reference products of escherichia coli and staphylococcus aureus is 0.5%, the MBC of the reference product to escherichia coli is 0.5%, and the MBC of the reference product to staphylococcus aureus is 0.8%.
The above description should not be taken as limiting the invention to the specific embodiments, but rather, as will be readily apparent to those skilled in the art to which the invention pertains, numerous simplifications or substitutions may be made without departing from the spirit of the invention, which should be construed to fall within the scope of the invention as defined in the claims appended hereto.
Claims (10)
1. The iodic acid mixed solution disinfectant is characterized by comprising the following raw materials: phosphoric acid, sulfuric acid, iodide, iodine, chelating agents, middle and short chain saturated fatty acids and water, wherein the chelating agents comprise N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide and higher fatty alcohol sulfate.
2. The iodic acid mixed solution disinfectant as claimed in claim 1, which comprises the following raw materials in parts by weight: 10-20% of phosphoric acid, 5-10% of sulfuric acid, 5-10% of iodide, 2-3% of iodine, 20-25% of chelating agent, 1-5% of medium-short chain saturated fatty acid and the balance of water.
3. The disinfectant for mixed iodic acid solution as set forth in claim 1 or 2, wherein the phosphoric acid is 95-98% by mass.
4. The disinfectant according to claim 1 or 2, wherein said iodide comprises one or more of potassium iodide and hydroiodic acid.
5. The disinfectant for mixed iodic acid solution as defined in claim 1 or 2, wherein the mass ratio of N- [3- (dialkylamino) propyl ] perfluoroalkyl sulfonamide to higher fatty alcohol sulfate is (5-20) to (5-20).
6. The disinfectant solution mixture iodic acid as set forth in claim 5, wherein said N- [3- (dialkylamino) propyl ] perfluoroalkylsulfonamide comprises one or more of N- [3- (dimethylamino) propyl ] perfluorobutylsulfonamide, N- [3- (dimethylamino) propyl ] perfluorooctylsulfonamide, N- [3- (diethylamino) propyl ] perfluorobutylsulfonamide, and N- [3- (diethylamino) propyl ] perfluorooctylsulfonamide.
7. The disinfectant solution mixture iodic acid solution as set forth in claim 5, wherein said higher fatty alcohol sulfate salt comprises one or more of sodium lauryl sulfate, sodium stearyl sulfate, and sodium cetyl sulfate.
8. The disinfectant for mixed iodic acid solution as defined in claim 1 or 2, wherein said medium-short chain saturated fatty acid comprises one or more of caproic acid, sorbic acid, caprylic acid, capric acid, undecanoic acid, and lauric acid.
9. The method for preparing the disinfectant solution of mixed iodic acid according to any one of claims 1 to 8, comprising the following steps: sequentially adding the iodine and the iodide to react, adding the mixed chelating agent, reacting for a certain time, adding the medium-short chain saturated fatty acid, uniformly stirring, adding the sulfuric acid and the phosphoric acid again, and adding the balance of water after the mixture is completely uniform to prepare the iodic acid mixed solution disinfectant.
10. Use of the disinfectant solution mixture of iodic acid prepared by the method of claim 9 for disinfecting piggeries.
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