CN113383790A - Environment-friendly potassium hydrogen persulfate compound disinfectant and production process thereof - Google Patents
Environment-friendly potassium hydrogen persulfate compound disinfectant and production process thereof Download PDFInfo
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- CN113383790A CN113383790A CN202110839409.2A CN202110839409A CN113383790A CN 113383790 A CN113383790 A CN 113383790A CN 202110839409 A CN202110839409 A CN 202110839409A CN 113383790 A CN113383790 A CN 113383790A
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- sodium chloride
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- -1 potassium hydrogen persulfate compound Chemical class 0.000 title claims description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 98
- 239000011780 sodium chloride Substances 0.000 claims abstract description 49
- 239000002245 particle Substances 0.000 claims abstract description 40
- 238000013270 controlled release Methods 0.000 claims abstract description 26
- HDMGAZBPFLDBCX-UHFFFAOYSA-M potassium;sulfooxy sulfate Chemical compound [K+].OS(=O)(=O)OOS([O-])(=O)=O HDMGAZBPFLDBCX-UHFFFAOYSA-M 0.000 claims abstract description 20
- 229910021538 borax Inorganic materials 0.000 claims abstract description 17
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 claims abstract description 17
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000001509 sodium citrate Substances 0.000 claims abstract description 17
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 17
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 17
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 17
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 42
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 30
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 30
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 30
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 20
- 238000005303 weighing Methods 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 239000000049 pigment Substances 0.000 claims description 12
- 239000007779 soft material Substances 0.000 claims description 12
- 239000011343 solid material Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims description 9
- 240000001592 Amaranthus caudatus Species 0.000 claims description 9
- 235000012735 amaranth Nutrition 0.000 claims description 9
- 239000004178 amaranth Substances 0.000 claims description 9
- 238000009835 boiling Methods 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000009775 high-speed stirring Methods 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 8
- 244000144972 livestock Species 0.000 abstract description 7
- 238000009360 aquaculture Methods 0.000 abstract description 5
- 244000144974 aquaculture Species 0.000 abstract description 5
- 244000144977 poultry Species 0.000 abstract description 5
- 241000251468 Actinopterygii Species 0.000 abstract description 3
- 208000035143 Bacterial infection Diseases 0.000 abstract description 3
- 241000238557 Decapoda Species 0.000 abstract description 3
- 208000004232 Enteritis Diseases 0.000 abstract description 3
- 208000032843 Hemorrhage Diseases 0.000 abstract description 3
- 239000003651 drinking water Substances 0.000 abstract description 3
- 235000020188 drinking water Nutrition 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000003975 animal breeding Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 12
- 239000013068 control sample Substances 0.000 description 10
- 229960003943 hypromellose Drugs 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 244000052769 pathogen Species 0.000 description 8
- 102220487426 Actin-related protein 2/3 complex subunit 3_K15M_mutation Human genes 0.000 description 7
- 238000013112 stability test Methods 0.000 description 7
- 239000007789 gas Substances 0.000 description 6
- 239000002085 irritant Substances 0.000 description 6
- 231100000021 irritant Toxicity 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000009395 breeding Methods 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000005457 optimization Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000007407 African swine fever Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000282898 Sus scrofa Species 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000000643 oven drying Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 description 2
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 238000012851 eutrophication Methods 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- KRAHLZAGPKKBSW-UHFFFAOYSA-N tetrasodium;dioxidophosphanyl phosphite Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])OP([O-])[O-] KRAHLZAGPKKBSW-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000012425 OXONE® Substances 0.000 description 1
- 241000202347 Porcine circovirus Species 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002973 irritant agent Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- HJKYXKSLRZKNSI-UHFFFAOYSA-I pentapotassium;hydrogen sulfate;oxido sulfate;sulfuric acid Chemical compound [K+].[K+].[K+].[K+].[K+].OS([O-])(=O)=O.[O-]S([O-])(=O)=O.OS(=O)(=O)O[O-].OS(=O)(=O)O[O-] HJKYXKSLRZKNSI-UHFFFAOYSA-I 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/14—Boron; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of animal breeding disinfection, in particular to an environment-friendly oxone compound disinfectant and a production process thereof. Contains single potassium hydrogen persulfate, sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate and sodium chloride controlled release particles; can be used for sterilizing livestock and poultry house, air and drinking water. Preventing and treating bacterial diseases of fish and shrimp in aquaculture, such as hemorrhage, gill rot, enteritis, etc. Is a disinfectant which is beneficial to environmental protection, has good stability and long disinfection action time.
Description
Technical Field
The invention relates to the technical field of animal breeding disinfection, in particular to an environment-friendly oxone compound disinfectant and a production process thereof.
Background
With the rapid development of intensive live pig breeding industry in China, new epidemic diseases continuously appear and pathogen variation and virulence of old epidemic diseases are enhanced, so that live pig diseases are frequent, Pseudorabies virus (PRV), porcine circovirus (PVC) and Porcine Reproductive and Respiratory Syndrome (PRRS) of pigs appear successively in recent 20 years, African Swine Fever (ASF) exists, particularly since 2018, the pigs are only infected with the ASF, the death rate is 100%, and huge loss is brought to the live pig breeding industry. It is obvious that a reasonable epidemic control system needs to be established, and measures such as decontamination, disinfection, isolation, purification, quarantine, insect killing and the like are respectively adopted. Therefore, the biological safety control work in livestock and poultry breeding industry is increasingly severe, the disinfection of livestock houses and the surrounding environment is an essential measure for preventing epidemic diseases, and the selection of disinfectants is particularly important.
The potassium hydrogen persulfate composite powder is a high-efficiency and broad-spectrum disinfectant with strong killing effect on bacteria and viruses, and is also a disinfectant commonly used by livestock and poultry and aquaculture enterprises. The disinfectant has strong oxidizability, continuously generates hypochlorous acid, nascent oxygen, oxidation and chlorination pathogens through chain reaction after water is dissolved, interferes with DNA and RNA synthesis of the pathogens, enables protein of the pathogens to be coagulated and denatured, further interferes with activity of a pathogen enzyme system, influences metabolism of the pathogen enzyme system, increases permeability of cell membranes, causes loss of enzyme and nutrient substances, and dissolves and breaks the pathogens, and further kills the pathogens.
In recent 10 years, compound oxone disinfectant has been developed, and some patents have appeared, and from the published patents, the prior art of document 1 (application No. 201010144652.4 compound oxone disinfectant) shows that 1, surfactant is compounded by sodium alkyl benzene sulfonate and sodium alkyl sulfate, and after the disinfectant is dissolved in water, the sodium alkyl sulfate is hydrolyzed, so that the pH value is reduced, and the risk of unqualified detection exists. 2. Simultaneously, other effects of the surfactant are reduced, and the synergistic effect of the surfactant cannot be exerted. 3. The formula has no auxiliary agent, the dispersion of the components is influenced during mixing, and the uniformity of the product is poor. 4. The slow-release formula is lack of scientificity, and the water insolubility of the ethyl cellulose affects the clarity and the atomization effect of the product; 5. the process is complex, the main components need coating, the efficiency is low, the cost is high, and the product stability is also a problem. Document 2 (application No. 200310110649.0 water-soluble composite potassium hydrogen persulfate powder disinfectant) shows that 1, after sterilization, the pollution to the environment is worried about, the residual phosphorus becomes an important source of nutrient components of variant superbacteria, and the difficulty of sewage treatment of breeding enterprises is increased. Particularly, after the aquatic product is used, the residual phosphorus can cause eutrophication of a water body, the growth of aquatic plants is accelerated, the water body is anoxic, and the aquaculture is greatly damaged; 2. the flammability and explosiveness of sodium hexametaphosphate are major potential safety hazards in the production and transportation links; 3. the product stability is poor.
Disclosure of Invention
The invention aims to provide an environment-friendly oxone compound disinfectant and a production process thereof.
The purpose of the invention is realized by the following ways: an environment-friendly potassium hydrogen persulfate compound disinfectant comprises the following components in percentage by weight: 35-65% of single potassium hydrogen persulfate, 5-23% of sodium dodecyl benzene sulfonate, 6-21% of sodium citrate, 4-10% of sulfamic acid, 5-14% of sodium tetraborate, 3-6% of sodium chloride controlled release particles and 0.15-0.3% of pigment.
As further optimization of the invention, the composition comprises the following components in percentage by weight: 52.8 percent of single potassium hydrogen persulfate, 15 percent of sodium dodecyl benzene sulfonate, 10 percent of sodium citrate, 8 percent of sulfamic acid, 10 percent of sodium tetraborate, 4 percent of sodium chloride controlled release particles and 0.2 percent of amaranth.
As a further optimization of the invention, the pigment is amaranth.
A production process of an environment-friendly potassium hydrogen persulfate compound disinfectant comprises the following process steps: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate, sodium chloride controlled release particles and pigment according to the proportion, placing the particles and the pigment in a mixer, and mixing for 15 minutes; weighing single potassium hydrogen persulfate according to the proportion, and mixing the single potassium hydrogen persulfate with the materials in a mixer for 25 minutes.
As a further optimization of the invention, the preparation process of the sodium chloride controlled release particles is as follows:
step one, proportioning: the adhesive comprises solid materials and an adhesive, wherein the solid materials are sodium chloride and hydroxypropyl methylcellulose, and the solid materials comprise the following components in parts by weight: the ratio of hydroxypropyl methylcellulose is 1: 0.5-2, and the adhesive is a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5; the ratio of the adhesive to the solid material is 4-6: 100 in parts by weight.
Step two, preparing particle cores: crushing sodium chloride to 80 meshes, weighing the sodium chloride powder and hydroxypropyl methylcellulose according to a proportion, placing the sodium chloride powder and the hydroxypropyl methylcellulose into a high-speed stirring mixer, stirring for 5 minutes, adding a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5 into the mixture under the stirring state to prepare a soft material, extruding and granulating the soft material by 24 meshes, and drying the soft material at 50-55 ℃;
step three, coating: putting the particle cores into a fluidized bed, preheating for 10 minutes at 45 ℃, spraying the opadry solution, and boiling and drying at 50-55 ℃ to increase the weight of the particle cores by 16-18%.
As a further optimization of the invention, the Opadry solution in the third step is obtained by dissolving 200g of Opadry in 75% ethanol and diluting to 10000ml with 75% ethanol.
Compared with the prior art, the invention discloses an environment-friendly potassium hydrogen persulfate compound disinfectant and a production process thereof, wherein the environment-friendly potassium hydrogen persulfate compound disinfectant comprises the following steps: the method has the following innovation:
first, prescription innovation
1. The prior art comprises the following steps: sodium hexametaphosphate or sodium pyrophosphite is used as an auxiliary agent, so that the dispersibility of each material is better, but the environment is greatly influenced by the existence of phosphate; especially, the air sterilization of the live stock affects the absorption of calcium of the piglets; the water body is disinfected, which causes water body eutrophication and is not favorable for raising aquatic animals.
1. The technology of the patent: the sodium tetraborate is used as an auxiliary agent, has better dispersibility on various materials, does not have the harm of phosphate, generates boric acid under an acidic condition (PH 2-3), is a good disinfectant, insecticide and hemostatic, and has a synergistic disinfection effect in a prescription. Has synergistic therapeutic effect on bacterial diseases such as hemorrhage, gill rot and enteritis of fish and shrimp in aquaculture.
Second, technological innovation
1. The prior art comprises the following steps: is prepared by mixing sodium alkylsulfonate, sodium alkylsulfate, citric acid, sodium citrate, sulfamic acid, sodium hexametaphosphate (or sodium pyrophosphite), sodium silicate, sodium chloride and the like. After moisture absorption, a chain reaction occurs quickly to generate irritant gas, so that the stability of the product is poor.
2. The technology of the patent: only special process treatment is carried out on sodium chloride, and a preparation formula, a production process and technical parameters for preparing the sodium chloride controlled-release particles are disclosed. Before the product is dissolved in water, the chain reaction can be effectively prevented, and the stability of the product is good.
Third, application innovation
1. The prior art comprises the following steps: the disinfectant is mainly used for disinfecting livestock and poultry houses, air, drinking water and the like.
2. The technology of the patent: besides being used for disinfecting livestock and poultry houses, air, drinking water and the like, the pesticide also has obvious insecticidal effect and is more beneficial to biological safety guarantee; has good therapeutic effect on bacterial diseases such as hemorrhage, gill rot and enteritis of fish and shrimp in aquaculture.
Fourth, stability study:
1. the purpose of the test is as follows: this patent technical sample surveys with the commercial product stability.
2. The test basis is as follows: guidelines for the stability test of the raw materials and preparations in the Chinese pharmacopoeia (2015 edition)
3. Test method
3.1 test specimens
3.1.1 control test samples: control test sample 1, oxone complex product (prepared as provided in document 1), referred to as control 1; control sample 2, oxone complex product (prepared as provided in document 2), is referred to as control 2.
3.1.2 samples: samples 1, 2, and 3 were prepared as described above.
3.2 stability test
3.2.1 accelerated stability test
A control test sample and 3 batches of samples (sample 1, sample 2 and sample 3) are taken and placed for 6 months according to a commercial package under the conditions of temperature (40 +/-2) DEG C and relative humidity of 75 +/-5 percent, and samples are taken once at the end of 1, 2, 3 and 6 months during the test period, so that the change of properties (whether moisture absorption exists or not and pungent smell exists) and the content of active ingredients are mainly examined.
3.2.2 Long term stability test
A control test sample and 3 batches of samples (sample 1, sample 2 and sample 3) are taken and placed under the conditions of temperature (25 +/-2) DEG C and relative humidity 60 +/-10% for 12 months according to a commercial package, and samples are taken once at the end of 0, 3, 6, 9 and 12 months during the test period, so that the characters (color, moisture absorption and pungent odor) and the content change rate of the effective active ingredients are mainly examined.
3.3 investigation detection method
3.1 Properties: sensory detection, namely visual inspection of color and the presence or absence of moisture absorption; smelling the nose has no pungent smell.
3.2 the method for detecting the content of the effective active ingredients comprises the following steps: taking 1 g of a sample to be tested into an iodine measuring bottle, adding 100ml of purified water for dissolving, adding about 1 g of potassium iodide for dissolving, adding 10ml of 10% acetic acid, covering the iodine measuring bottle, adding a small amount of purified water for sealing, standing in the dark for 5 minutes, taking out, titrating by using 0.1mol/L sodium thiosulfate standard solution, adding 2ml of new starch indicator liquid when the end point is reached, and dripping to light red. (equivalent to 3.545mg of available chlorine per 1ml of 0.1mol/L standard solution of sodium thiosulfate) the content of the effective active ingredient was calculated.
4.4 test results: the results of the accelerated stability test are shown in table 1; the long term stability results are shown in table 2.
4.4.1 accelerated stability test results show that: the samples 1, 2 and 3 have no color change, do not generate irritating gas phenomenon and have stable properties when stored for one month, two months, three months and six months under the conditions of high temperature and high humidity temperature (40 +/-2) DEG C and relative humidity of 75 +/-5 percent. The content change rate of the effective active ingredients is less than 5 percent; under the condition of high temperature and high humidity for one month, the control sample has no color change, no irritant gas generation, stable properties and stable content of effective active ingredients; the second month of the control sample 2 has irritant gas generation, and the third month of the control sample 1 has irritant gas generation; the change rate of the effective active ingredient content in the third month of the control sample 2 is close to 10%, the change rate of the effective active ingredient content in the sixth month of the control sample 1 exceeds 10%, and the control sample 1 and the control sample 2 have fading and faint color and pungent odor in the sixth month. The content change rates of the effective active ingredients of the sample 1, the sample 2 and the sample 3 are respectively 4.1 percent, 3.5 percent and 3.6 percent after being stored for six months under the high-temperature and high-humidity condition; the content change rates of the effective active ingredients of the control sample 1 and the control sample 2 are 12.0% and 18.7%, respectively, after the storage for six months under the high-temperature and high-humidity condition.
4.4.2 Long-term stability test results show that: the samples 1, 2 and 3 are placed at the temperature of 25 +/-2 ℃ and the relative humidity of 60 +/-10% for 12 months, and the detection results at the end of O, three, six, nine and twelve months show that: the character is stable, and the content change rate of the effective active ingredients is less than 3%; control 1 had irritant gas generation by the end of the ninth month and control 2 had irritant gas generation by the end of the sixth month; control 1 showed discoloration at the end of the twelfth month and control 2 showed discoloration at the end of the ninth month; the rate of change of the content of the effective active ingredient in the control 1 was 9.50% at the end of the twelfth month, and the rate of change of the content of the effective active ingredient in the control 2 was 19.20% at the end of the twelfth month.
Therefore, the stability of the product of the patent technology is superior to that of the product of the prior art.
Detailed Description
The invention relates to an environment-friendly potassium hydrogen persulfate compound disinfectant, which comprises the following components in percentage by weight: 35-65% of single potassium hydrogen persulfate, 5-23% of sodium dodecyl benzene sulfonate, 6-21% of sodium citrate, 4-10% of sulfamic acid, 5-14% of sodium tetraborate, 3-6% of sodium chloride controlled release particles and 0.15-0.3% of pigment.
The optimal proportioning scheme comprises the following components in percentage by weight: 52.8 percent of single potassium hydrogen persulfate, 15 percent of sodium dodecyl benzene sulfonate, 10 percent of sodium citrate, 8 percent of sulfamic acid, 10 percent of sodium tetraborate, 4 percent of sodium chloride controlled release particles and 0.2 percent of amaranth.
The pigment is amaranth.
A production process of an environment-friendly potassium hydrogen persulfate compound disinfectant comprises the following process steps: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate, sodium chloride controlled release particles and pigment according to the proportion, placing the particles and the pigment in a mixer, and mixing for 15 minutes; weighing single potassium hydrogen persulfate according to the proportion, and mixing the single potassium hydrogen persulfate with the materials in a mixer for 25 minutes.
The preparation process of the sodium chloride controlled-release particles comprises the following steps:
step one, proportioning: the adhesive comprises a solid material and an adhesive, wherein the solid material is sodium chloride and hydroxypropyl methylcellulose (K15M), and the solid material comprises the following components in parts by weight: the ratio of hydroxypropyl methylcellulose is 1: 0.5-2, and the adhesive is a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5; the ratio of the adhesive to the solid material is 4-6: 100 in parts by weight.
Step two, preparing particle cores: crushing sodium chloride to 80 meshes, weighing the sodium chloride powder and hydroxypropyl methylcellulose according to a proportion, placing the sodium chloride powder and the hydroxypropyl methylcellulose into a high-speed stirring mixer, stirring for 5 minutes, adding a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5 into the mixture under the stirring state to prepare a soft material, extruding and granulating the soft material by 24 meshes, and drying the soft material at 50-55 ℃;
step three, coating: putting the particle cores into a fluidized bed, preheating for 10 minutes at 45 ℃, spraying the opadry solution, and boiling and drying at 50-55 ℃ to increase the weight of the particle cores by 16-18%. The Opadry solution is prepared by dissolving 200g of Opadry in 75% ethanol, and diluting to 10000ml with 75% ethanol.
1. EXAMPLE 1 (sample 1)
1.1 raw materials comprise, by weight, 46% of potassium monopersulfate, 13% of sodium dodecyl benzene sulfonate, 11% of sodium citrate, 10% of sulfamic acid, 14% of sodium tetraborate, 6% of sodium chloride controlled release particles and 0.25% of amaranth.
1.2 Process for preparing sodium chloride controlled Release granules
1.2.1 sodium chloride controlled release granule formulation: 1000g of sodium chloride; 500g of hydroxypropyl methylcellulose (K15M); 60g of a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5 as a binder.
1.2.2 preparation of the particle cores: pulverizing sodium chloride to 80 mesh, weighing sodium chloride powder and hypromellose (K15M) according to the prescription, placing in a high-speed stirring mixer, stirring for 5min, adding appropriate amount of 1.5% hypromellose E5 75% ethanol solution under stirring, making into soft material, granulating by 24 mesh extrusion, and oven drying at 50-55 deg.C.
1.2.3 coating process: putting the particle core into a boiling fluidized bed, preheating for 20min at 45 (DEG C), spraying Opadry solution (200 g of Opadry dissolved in 75% ethanol and diluted to 10000 ml), and boiling and drying at 50-55 (DEG C) until the weight of the particle core is increased by 16%.
1.3 mixing method:
1.3.1 premixing: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate and sodium chloride controlled release particles according to the prescription, and mixing for 15min in a mixer.
1.3.2 Total mix: weighing potassium hydrogen persulfate according to the prescription, placing in a mixer, mixing with the above materials for 25min, and packaging.
2. EXAMPLE 2 (sample 2)
2.1 raw materials comprise 53 percent of single potassium hydrogen persulfate, 15 percent of sodium dodecyl benzene sulfonate, 10 percent of sodium citrate, 8 percent of sulfamic acid, 10 percent of sodium tetraborate, 4 percent of sodium chloride controlled release particles and 0.25 percent of amaranth.
2.2 Process for preparing sodium chloride controlled Release granules
2.2.1 sodium chloride controlled release granule formulation: 1000g of sodium chloride; 1000g of hypromellose (K15M); adhesive 1.5% hypromellose E5 in 100g of 75% ethanol.
2.2.2 preparation of the particle cores: pulverizing sodium chloride to 80 mesh, weighing sodium chloride powder and hypromellose (K15M) according to the prescription, placing in a high-speed stirring mixer, stirring for 5min, adding appropriate amount of 1.5% hypromellose E5 75% ethanol solution under stirring, making into soft material, granulating by 24 mesh extrusion, and oven drying at 50-55 deg.C.
2.2.3 coating process: putting the particle core into a boiling fluidized bed, preheating for 20min at 45 (DEG C), spraying Opadry solution (200 g of Opadry dissolved in 75% ethanol and diluted to 10000 ml), and boiling and drying at 50-55 (DEG C) until the weight of the particle core is increased by 18%.
2.3 mixing method:
2.3.1 premixing: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate and sodium chloride controlled release particles according to the prescription, and mixing for 15min in a mixer.
2.3.2 Total mix: weighing potassium hydrogen persulfate according to the prescription, placing in a mixer, mixing with the above materials for 25min, and packaging.
3. EXAMPLE three (sample 3)
3.1 raw materials comprise, by weight, 65% of single potassium hydrogen persulfate, 7% of sodium dodecyl benzene sulfonate, 6% of sodium citrate, 7% of sulfamic acid, 10% of sodium tetraborate, 5% of sodium chloride controlled release particles and 0.25% of amaranth.
3.2 preparation of sodium chloride controlled release granules
3.2.1 sodium chloride controlled release granule formulation: 1000g of sodium chloride; 2000g of hypromellose (K15M); adhesive 1.5% hypromellose E5 in 180g of 75% ethanol.
3.2.2 preparation of the particle cores: pulverizing sodium chloride to 80 mesh, weighing sodium chloride powder and hypromellose (K15M) according to the prescription, placing in a high-speed stirring mixer, stirring for 5min, adding appropriate amount of 1.5% hypromellose E5 75% ethanol solution under stirring, making into soft material, granulating by 24 mesh extrusion, and oven drying at 50-55 deg.C.
3.2.3 coating process: putting the particle core into a boiling fluidized bed, preheating for 20min at 45 (DEG C), spraying Opadry solution (200 g of Opadry dissolved in 75% ethanol and diluted to 10000 ml), and boiling and drying at 50-55 (DEG C) until the weight of the particle core is increased by 16%.
3.3 mixing method:
3.3.1 premixing: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate and sodium chloride controlled release particles according to the prescription, and mixing for 15min in a mixer.
3.3.2 Total mix: weighing potassium hydrogen persulfate according to the prescription, placing in a mixer, mixing with the above materials for 25min, and packaging.
Claims (6)
1. An environment-friendly potassium hydrogen persulfate compound disinfectant is characterized in that: the composition comprises the following components in percentage by weight: 35-65% of single potassium hydrogen persulfate, 5-23% of sodium dodecyl benzene sulfonate, 6-21% of sodium citrate, 4-10% of sulfamic acid, 5-14% of sodium tetraborate, 3-6% of sodium chloride controlled release particles and 0.15-0.3% of pigment.
2. The environment-friendly oxone complex disinfectant as claimed in claim 1, wherein: the composition comprises the following components in percentage by weight: 52.8 percent of single potassium hydrogen persulfate, 15 percent of sodium dodecyl benzene sulfonate, 10 percent of sodium citrate, 8 percent of sulfamic acid, 10 percent of sodium tetraborate, 4 percent of sodium chloride controlled release particles and 0.2 percent of amaranth.
3. The environment-friendly oxone complex disinfectant as claimed in claim 1 or 2, wherein: the pigment is amaranth.
4. The production process of the environment-friendly oxone compound disinfectant as claimed in claim 1 or 2, wherein the process steps are as follows: weighing sodium dodecyl benzene sulfonate, sodium citrate, sulfamic acid, sodium tetraborate, sodium chloride controlled release particles and pigment according to the proportion, placing the particles and the pigment in a mixer, and mixing for 15 minutes; weighing single potassium hydrogen persulfate according to the proportion, and mixing the single potassium hydrogen persulfate with the materials in a mixer for 25 minutes.
5. The production process of the environment-friendly oxone complex disinfectant as claimed in claim 4, wherein the preparation process of the sodium chloride controlled-release granules is as follows:
step one, proportioning: the adhesive comprises solid materials and an adhesive, wherein the solid materials are sodium chloride and hydroxypropyl methylcellulose, and the solid materials comprise the following components in parts by weight: the ratio of hydroxypropyl methylcellulose is 1: 0.5-2, and the adhesive is a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5; according to the weight part ratio, the ratio of the adhesive to the solid material is 4-6: 100, and in the second step, the preparation of the particle core: crushing sodium chloride to 80 meshes, weighing the sodium chloride powder and hydroxypropyl methylcellulose according to a proportion, placing the sodium chloride powder and the hydroxypropyl methylcellulose into a high-speed stirring mixer, stirring for 5 minutes, adding a 75% ethanol solution of 1.5% hydroxypropyl methylcellulose E5 into the mixture under the stirring state to prepare a soft material, extruding and granulating the soft material by 24 meshes, and drying the soft material at 50-55 ℃;
step three, coating: putting the particle cores into a fluidized bed, preheating for 10 minutes at 45 ℃, spraying the opadry solution, and boiling and drying at 50-55 ℃ to increase the weight of the particle cores by 16-18%.
6. The process for producing an environment-friendly oxone complex disinfectant as claimed in claim 5, wherein the opadry solution in the third step is obtained by dissolving 200g opadry in 75% ethanol and diluting to 10000ml with 75% ethanol.
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Cited By (1)
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