CN114761082A - 氮杂环庚烷衍生物 - Google Patents

氮杂环庚烷衍生物 Download PDF

Info

Publication number
CN114761082A
CN114761082A CN202080082166.6A CN202080082166A CN114761082A CN 114761082 A CN114761082 A CN 114761082A CN 202080082166 A CN202080082166 A CN 202080082166A CN 114761082 A CN114761082 A CN 114761082A
Authority
CN
China
Prior art keywords
group
optionally substituted
ddd
compound
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080082166.6A
Other languages
English (en)
Chinese (zh)
Inventor
渡边义一
齐藤大祐
林田康平
山元广平
并木真悠
茂木雄三
谷田诚浩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of CN114761082A publication Critical patent/CN114761082A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202080082166.6A 2019-09-30 2020-09-29 氮杂环庚烷衍生物 Pending CN114761082A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019179727 2019-09-30
JP2019-179727 2019-09-30
PCT/JP2020/036868 WO2021065898A1 (ja) 2019-09-30 2020-09-29 アゼパン誘導体

Publications (1)

Publication Number Publication Date
CN114761082A true CN114761082A (zh) 2022-07-15

Family

ID=75338310

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080082166.6A Pending CN114761082A (zh) 2019-09-30 2020-09-29 氮杂环庚烷衍生物

Country Status (8)

Country Link
US (1) US20230087342A1 (https=)
EP (1) EP4039331A4 (https=)
JP (1) JP7678756B2 (https=)
KR (1) KR20220071223A (https=)
CN (1) CN114761082A (https=)
AU (1) AU2020360928A1 (https=)
CA (1) CA3152485A1 (https=)
WO (1) WO2021065898A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022210479A1 (ja) * 2021-03-29 2022-10-06 日本ケミファ株式会社 アゼパン誘導体のκオピオイド受容体関連疾患の治療、改善又は予防のための使用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US963460A (en) 1910-02-23 1910-07-05 Peter N Moore Roller side bearing.
JP2525552Y2 (ja) 1990-10-26 1997-02-12 株式会社間組 シャワールームユニット
GB9118597D0 (en) 1991-08-30 1991-10-16 Biocompatibles Ltd Polymer treatments
ES2121988T3 (es) 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
CA2296329A1 (en) 1997-07-24 1999-02-04 Masakazu Nakano Aminocycloalkane compounds
BRPI0719937A2 (pt) 2006-12-05 2014-03-11 Neurogesx Inc Pró-fármacos e métodos de fazer e de usar os mesmos
JP2008179554A (ja) 2007-01-24 2008-08-07 Toray Ind Inc ピロール縮合モルヒナン誘導体およびその医薬用途
MX2009012610A (es) * 2007-05-22 2009-12-11 Astellas Pharma Inc Compuesto de tetrahidroisoquinolina 1-sustituido.
WO2010021149A1 (ja) 2008-08-21 2010-02-25 武田薬品工業株式会社 酸分泌抑制スピロ化合物
MX2011009571A (es) 2009-03-13 2011-10-19 Boehringer Ingelheim Int Inhibidores de beta-secretasa.
EP2311823A1 (en) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
US20130144053A1 (en) 2011-12-05 2013-06-06 Mallinckrodt Llc Process for the Production of Seven-Membered Lactam Morphinans
MA40171A (fr) * 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés d'azamophinan et leur utilisation
CA2960280A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Substituted piperidine compounds
ES2870920T3 (es) 2016-06-21 2021-10-28 X4 Pharmaceuticals Inc Inhibidores de CXCR4 y usos de los mismos
WO2018125716A1 (en) * 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
KR20190117582A (ko) 2017-02-10 2019-10-16 쥐원 쎄라퓨틱스, 인크. 벤조티오펜 에스트로겐 수용체 조정제
CA3055194A1 (en) 2017-03-02 2018-09-07 Assembly Biosciences, Inc. Cyclic sulfamide compounds and methods of using same
JPWO2019045006A1 (ja) * 2017-08-31 2020-10-01 国立大学法人 筑波大学 モルヒナン誘導体
JP7348714B2 (ja) 2018-03-30 2023-09-21 古河電気工業株式会社 カーボンナノチューブ線材、カーボンナノチューブ被覆電線、カーボンナノチューブ線材の製造方法及びカーボンナノチューブ被覆電線の加工方法
JP2022017604A (ja) 2018-10-22 2022-01-26 日本ケミファ株式会社 モルヒナン誘導体

Also Published As

Publication number Publication date
WO2021065898A1 (ja) 2021-04-08
EP4039331A4 (en) 2024-01-17
KR20220071223A (ko) 2022-05-31
JP7678756B2 (ja) 2025-05-16
JPWO2021065898A1 (https=) 2021-04-08
US20230087342A1 (en) 2023-03-23
AU2020360928A1 (en) 2022-04-14
CA3152485A1 (en) 2021-04-08
EP4039331A1 (en) 2022-08-10

Similar Documents

Publication Publication Date Title
CN113227068B (zh) Glp-1r激动剂及其用途
JP7262553B2 (ja) Ｉｒａｋ４阻害剤としての二環式ヘテロシクリル誘導体
CN111377917B (zh) 杂环类化合物、中间体、其制备方法及应用
CN109790161B (zh) 具有glp-1受体激动剂作用的吡唑并吡啶衍生物
CN107207514B (zh) 稠环杂芳基化合物及其作为trk抑制剂的用途
CN107849015B (zh) 作为pad4抑制剂的苯并咪唑衍生物
JP6795588B2 (ja) ブロモドメイン阻害薬としての使用のためのピリジノンジカルボキサミド
CN116390917B (zh) Mrgx2拮抗剂
CN102656158A (zh) 新的杂环丙烯酰胺类化合物及其作为药物的用途
CN105658653A (zh) 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
WO2019205983A1 (zh) 氧杂螺环类化合物及其制备方法和用途
CN115348961A (zh) 杂环pad4抑制剂
TW201734020A (zh) 布魯頓氏酪胺酸激酶抑制劑及其使用方法
TW202317106A (zh) 作為egfr抑制劑之取代胺基吡啶化合物
CN101663276A (zh) 用作激酶抑制剂的2-氨基吡啶衍生物
WO2020085234A1 (ja) モルヒナン誘導体
CN114761082A (zh) 氮杂环庚烷衍生物
WO2019045006A1 (ja) モルヒナン誘導体
WO2021132524A1 (ja) エポキシアゼパン誘導体
WO2022210479A1 (ja) アゼパン誘導体のκオピオイド受容体関連疾患の治療、改善又は予防のための使用
HK40071875A (en) Azepan derivative
CN107406461B (zh) 杂环炔烃衍生物及其作为mGluR5受体调节剂的用途
WO2026013291A1 (en) Inhibitors of rna methyltransferase
HK40118125A (zh) Egfr抑制剂和其用途
WO2024204554A1 (ja) スピロ環状モルヒナン誘導体

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination