JPWO2021065898A1 - - Google Patents
Info
- Publication number
- JPWO2021065898A1 JPWO2021065898A1 JP2021551303A JP2021551303A JPWO2021065898A1 JP WO2021065898 A1 JPWO2021065898 A1 JP WO2021065898A1 JP 2021551303 A JP2021551303 A JP 2021551303A JP 2021551303 A JP2021551303 A JP 2021551303A JP WO2021065898 A1 JPWO2021065898 A1 JP WO2021065898A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019179727 | 2019-09-30 | ||
| JP2019179727 | 2019-09-30 | ||
| PCT/JP2020/036868 WO2021065898A1 (ja) | 2019-09-30 | 2020-09-29 | アゼパン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021065898A1 true JPWO2021065898A1 (https=) | 2021-04-08 |
| JP7678756B2 JP7678756B2 (ja) | 2025-05-16 |
Family
ID=75338310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021551303A Active JP7678756B2 (ja) | 2019-09-30 | 2020-09-29 | アゼパン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230087342A1 (https=) |
| EP (1) | EP4039331A4 (https=) |
| JP (1) | JP7678756B2 (https=) |
| KR (1) | KR20220071223A (https=) |
| CN (1) | CN114761082A (https=) |
| AU (1) | AU2020360928A1 (https=) |
| CA (1) | CA3152485A1 (https=) |
| WO (1) | WO2021065898A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022210479A1 (ja) * | 2021-03-29 | 2022-10-06 | 日本ケミファ株式会社 | アゼパン誘導体のκオピオイド受容体関連疾患の治療、改善又は予防のための使用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008143263A1 (ja) * | 2007-05-22 | 2008-11-27 | Astellas Pharma Inc. | １位置換テトラヒドロイソキノリン化合物 |
| JP2010511717A (ja) * | 2006-12-05 | 2010-04-15 | ニューロジェシックス， インコーポレイテッド | プロドラッグおよびその作成ならびに使用方法 |
| JP2015500245A (ja) * | 2011-12-05 | 2015-01-05 | マリンクロッド エルエルシー | ７員環ラクタムモルヒナンの製造のためのプロセス |
| WO2020085234A1 (ja) * | 2018-10-22 | 2020-04-30 | 日本ケミファ株式会社 | モルヒナン誘導体 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US963460A (en) | 1910-02-23 | 1910-07-05 | Peter N Moore | Roller side bearing. |
| JP2525552Y2 (ja) | 1990-10-26 | 1997-02-12 | 株式会社間組 | シャワールームユニット |
| GB9118597D0 (en) | 1991-08-30 | 1991-10-16 | Biocompatibles Ltd | Polymer treatments |
| ES2121988T3 (es) | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| CA2296329A1 (en) | 1997-07-24 | 1999-02-04 | Masakazu Nakano | Aminocycloalkane compounds |
| JP2008179554A (ja) | 2007-01-24 | 2008-08-07 | Toray Ind Inc | ピロール縮合モルヒナン誘導体およびその医薬用途 |
| WO2010021149A1 (ja) | 2008-08-21 | 2010-02-25 | 武田薬品工業株式会社 | 酸分泌抑制スピロ化合物 |
| MX2011009571A (es) | 2009-03-13 | 2011-10-19 | Boehringer Ingelheim Int | Inhibidores de beta-secretasa. |
| EP2311823A1 (en) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
| MA40171A (fr) * | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| CA2960280A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted piperidine compounds |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| WO2018125716A1 (en) * | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
| CA3055194A1 (en) | 2017-03-02 | 2018-09-07 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
| JPWO2019045006A1 (ja) * | 2017-08-31 | 2020-10-01 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| JP7348714B2 (ja) | 2018-03-30 | 2023-09-21 | 古河電気工業株式会社 | カーボンナノチューブ線材、カーボンナノチューブ被覆電線、カーボンナノチューブ線材の製造方法及びカーボンナノチューブ被覆電線の加工方法 |
-
2020
- 2020-09-29 EP EP20871687.8A patent/EP4039331A4/en not_active Withdrawn
- 2020-09-29 CN CN202080082166.6A patent/CN114761082A/zh active Pending
- 2020-09-29 CA CA3152485A patent/CA3152485A1/en active Pending
- 2020-09-29 AU AU2020360928A patent/AU2020360928A1/en not_active Abandoned
- 2020-09-29 KR KR1020227013317A patent/KR20220071223A/ko not_active Ceased
- 2020-09-29 WO PCT/JP2020/036868 patent/WO2021065898A1/ja not_active Ceased
- 2020-09-29 US US17/762,134 patent/US20230087342A1/en not_active Abandoned
- 2020-09-29 JP JP2021551303A patent/JP7678756B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010511717A (ja) * | 2006-12-05 | 2010-04-15 | ニューロジェシックス， インコーポレイテッド | プロドラッグおよびその作成ならびに使用方法 |
| WO2008143263A1 (ja) * | 2007-05-22 | 2008-11-27 | Astellas Pharma Inc. | １位置換テトラヒドロイソキノリン化合物 |
| JP2015500245A (ja) * | 2011-12-05 | 2015-01-05 | マリンクロッド エルエルシー | ７員環ラクタムモルヒナンの製造のためのプロセス |
| WO2020085234A1 (ja) * | 2018-10-22 | 2020-04-30 | 日本ケミファ株式会社 | モルヒナン誘導体 |
Non-Patent Citations (4)
| Title |
|---|
| BIOORG. MED. CHEM., vol. 24, JPN6024045320, 2016, pages 2199 - 2205, ISSN: 0005571698 * |
| CHEM. PHARM. BULL., vol. 18, JPN6024045319, 1970, pages 1269 - 1273, ISSN: 0005571699 * |
| ISHIKAWA, KYOKO ET AL: "C-homomorphinan derivatives as lead compounds to obtain safer and more clinically useful analgesics", CHEM. PHARM. BULL., vol. 65, JPN6020046208, 2017, pages 920 - 929, ISSN: 0005571697 * |
| SUZUKI, SHINYA ET AL.: "Discovery of highly selective kappa-opioid receptor agnists: 10 alpha-hydroxy TRK-820 derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, JPN6019049737, 2017, pages 3920 - 3924, ISSN: 0005571696 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114761082A (zh) | 2022-07-15 |
| WO2021065898A1 (ja) | 2021-04-08 |
| EP4039331A4 (en) | 2024-01-17 |
| KR20220071223A (ko) | 2022-05-31 |
| JP7678756B2 (ja) | 2025-05-16 |
| US20230087342A1 (en) | 2023-03-23 |
| AU2020360928A1 (en) | 2022-04-14 |
| CA3152485A1 (en) | 2021-04-08 |
| EP4039331A1 (en) | 2022-08-10 |
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